BE1003305A4 - Derives de la benzazepine et de la benzothiazepine. - Google Patents

Derives de la benzazepine et de la benzothiazepine. Download PDF

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Publication number
BE1003305A4
BE1003305A4 BE8900666A BE8900666A BE1003305A4 BE 1003305 A4 BE1003305 A4 BE 1003305A4 BE 8900666 A BE8900666 A BE 8900666A BE 8900666 A BE8900666 A BE 8900666A BE 1003305 A4 BE1003305 A4 BE 1003305A4
Authority
BE
Belgium
Prior art keywords
benzothiazepine
benzazepine
derivatives
compounds
general formula
Prior art date
Application number
BE8900666A
Other languages
English (en)
Inventor
David Floyd
John Thomas Hunt
Spencer David Kimball
John Krapcho
Jagabandhu Das
George Charles Rovnyak
Joel Charles Barrish
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of BE1003305A4 publication Critical patent/BE1003305A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Les composés de formule générale suivante montrent une activité vasodilatatrice : où X peut être -S- ou -CH2- et où R2 est
BE8900666A 1988-06-20 1989-06-20 Derives de la benzazepine et de la benzothiazepine. BE1003305A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20852188A 1988-06-20 1988-06-20
US07/353,806 US4902684A (en) 1988-06-20 1989-05-22 Benzazepine and benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
BE1003305A4 true BE1003305A4 (fr) 1992-02-25

Family

ID=26903265

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900666A BE1003305A4 (fr) 1988-06-20 1989-06-20 Derives de la benzazepine et de la benzothiazepine.

Country Status (29)

Country Link
US (1) US4902684A (fr)
JP (1) JP2793674B2 (fr)
KR (1) KR970002633B1 (fr)
CN (1) CN1027262C (fr)
AT (1) AT398567B (fr)
AU (1) AU614399B2 (fr)
BE (1) BE1003305A4 (fr)
CA (1) CA1336975C (fr)
CH (1) CH681723A5 (fr)
EG (1) EG19071A (fr)
ES (1) ES2016467A6 (fr)
FI (1) FI94246C (fr)
FR (1) FR2632953B1 (fr)
GB (1) GB2231329B (fr)
GR (1) GR1002099B (fr)
HU (1) HU210929B (fr)
IE (1) IE64242B1 (fr)
IL (1) IL90515A (fr)
IT (1) IT1230884B (fr)
LU (1) LU87865A1 (fr)
NL (1) NL8920642A (fr)
NO (1) NO179449C (fr)
NZ (1) NZ229612A (fr)
PL (1) PL162313B1 (fr)
PT (1) PT90914B (fr)
RU (1) RU2090562C1 (fr)
SE (1) SE9004060L (fr)
WO (1) WO1989012633A1 (fr)
YU (1) YU121389A (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008284A (en) * 1989-02-15 1991-04-16 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US4963671A (en) * 1989-11-20 1990-10-16 E. R. Squibb & Sons, Inc. Process for resolving chiral intermediates used in making calcium channel blockers
US5112969A (en) * 1990-04-02 1992-05-12 Merrell Dow Pharmaceuticals Inc. Cyano esters and azepinones
IT1240686B (it) * 1990-04-27 1993-12-17 Luso Farmaco Inst Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
IT1244878B (it) * 1990-12-11 1994-09-12 Lusochimica Spa Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
ATE228115T1 (de) * 1991-06-28 2002-12-15 Smithkline Beecham Corp Bizyklische fibrinogenantagonisten
IT1255545B (it) * 1992-10-23 1995-11-09 Procedimento per la preparazione di diltiazem
CA2098446A1 (fr) * 1992-09-30 1994-03-31 Eckard Weber 2,5-dihydro-2,5-dioxo-1h-azepines et 2,5-dihydro-2-oxo-1h-azepines et leur utilisation comme antagonistes des recepteurs de l'acide amine excitateur et de la glycine
AU691829B2 (en) * 1993-07-16 1998-05-28 Merck & Co., Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
US5854233A (en) * 1993-09-08 1998-12-29 Pharmacy And Therapeutic Advisory Consultancy Ltd. Method of treating liver disease and like indications with vasodilating agents
US6174917B1 (en) 1993-09-08 2001-01-16 Pharmacy And Therapeutic Advisory Consultancy Ltd. Method of treating liver disease and like indications with vasodilating agents
FI963784A0 (fi) * 1994-03-24 1996-09-23 Merrell Pharma Inc Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
US5580867A (en) * 1994-09-09 1996-12-03 Universite De Montreal Myocardial protection during ischemia and reperfusion
GB9423172D0 (en) 1994-11-17 1995-01-04 Wellcom Foundation The Limited Hypolipidemic benzothiazepines
CN1125064C (zh) * 1996-12-10 2003-10-22 艾博特公司 3－吡啶基对映体及其作为镇痛剂的用途
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB9907895D0 (en) * 1999-04-08 1999-06-02 Texas A & M Univ Sys Novel ligands for chiral catalysis
US6472533B1 (en) 1999-04-08 2002-10-29 The Texas A & M University System Ligands for chiral catalysis
RU2301800C2 (ru) * 2002-04-19 2007-06-27 Аризона Боард Оф Ридженс Он Бихав Оф Зе Юниверсити Оф Аризона Способ модулирования фототоксичности
TWI289141B (en) * 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312691A (en) * 1963-08-23 1967-04-04 Ciba Geigy Corp 2, 3, 4, 5-tetrahydro-1-benzazepin-2-ones
EP0205334A2 (fr) * 1985-06-12 1986-12-17 E.R. Squibb & Sons, Inc. Dérivés de benzazépine
EP0229329A1 (fr) * 1985-12-12 1987-07-22 E.R. Squibb & Sons, Inc. Dérivés de benzazépine
EP0256888A1 (fr) * 1986-08-20 1988-02-24 McNeilab, Inc. Benzothiazépines vasodilatatrices substituées par aralkyle

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS59191036A (ja) * 1983-04-14 1984-10-30 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
GB2154577A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co 1,5-benzothiazepines
GB2154578A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co Novel 1,5-benzothiazepine derivatives and processes for preparing the same
US4590188A (en) * 1984-02-18 1986-05-20 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and their pharmaceutical use
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
US4748239A (en) * 1985-06-12 1988-05-31 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2597097B1 (fr) * 1986-04-15 1988-12-02 Synthelabo Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
US4694002A (en) * 1986-08-21 1987-09-15 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4752645A (en) * 1986-10-09 1988-06-21 E. R. Squibb & Sons, Inc. Benzazepine derivatives
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312691A (en) * 1963-08-23 1967-04-04 Ciba Geigy Corp 2, 3, 4, 5-tetrahydro-1-benzazepin-2-ones
EP0205334A2 (fr) * 1985-06-12 1986-12-17 E.R. Squibb & Sons, Inc. Dérivés de benzazépine
EP0229329A1 (fr) * 1985-12-12 1987-07-22 E.R. Squibb & Sons, Inc. Dérivés de benzazépine
EP0256888A1 (fr) * 1986-08-20 1988-02-24 McNeilab, Inc. Benzothiazépines vasodilatatrices substituées par aralkyle

Also Published As

Publication number Publication date
KR970002633B1 (en) 1997-03-06
GR1002099B (en) 1995-12-28
GR890100410A (el) 1990-05-11
FI94246C (fi) 1995-08-10
HU210929B (en) 1995-09-28
AT398567B (de) 1994-12-27
NL8920642A (nl) 1990-06-01
CA1336975C (fr) 1995-09-12
WO1989012633A1 (fr) 1989-12-28
IE64242B1 (en) 1995-07-26
PT90914B (pt) 1994-12-30
LU87865A1 (de) 1991-12-16
PL162313B1 (pl) 1993-09-30
FR2632953A1 (fr) 1989-12-22
ATA901089A (de) 1994-05-15
YU121389A (en) 1991-04-30
IT8920933A0 (it) 1989-06-20
PT90914A (pt) 1989-12-29
IT1230884B (it) 1991-11-08
JPH04502002A (ja) 1992-04-09
HUT59908A (en) 1992-07-28
GB2231329B (en) 1992-10-21
GB9002587D0 (en) 1990-08-29
US4902684A (en) 1990-02-20
IL90515A0 (en) 1990-01-18
NZ229612A (en) 1992-07-28
FI94246B (fi) 1995-04-28
ES2016467A6 (es) 1990-11-01
RU2090562C1 (ru) 1997-09-20
CN1039585A (zh) 1990-02-14
GB2231329A (en) 1990-11-14
JP2793674B2 (ja) 1998-09-03
IL90515A (en) 1994-07-31
KR920700207A (ko) 1992-02-19
SE9004060D0 (sv) 1990-12-19
NO905485L (no) 1991-02-19
NO179449C (no) 1996-10-09
NO905485D0 (no) 1990-12-19
EG19071A (en) 1994-07-30
CN1027262C (zh) 1995-01-04
IE891957L (en) 1989-12-20
CH681723A5 (fr) 1993-05-14
NO179449B (no) 1996-07-01
FR2632953B1 (fr) 1992-05-29
SE9004060L (sv) 1992-06-20
FI900813A0 (fi) 1990-02-19
HU894298D0 (en) 1991-01-28
AU614399B2 (en) 1991-08-29
AU3859389A (en) 1990-01-12

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: E.R. *SQUIBB & SONS INC.

Effective date: 20020630