|
AU2003251238A1
(en)
|
2002-08-07 |
2004-02-25 |
Umc Utrecht Holding B.V. |
Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
|
|
WO2010081856A1
(en)
*
|
2009-01-14 |
2010-07-22 |
Ablynx Nv |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
EP1587838B1
(en)
|
2003-01-10 |
2015-04-15 |
Ablynx N.V. |
Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation
|
|
SI2311874T1
(sl)
|
2004-07-22 |
2017-12-29 |
Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics |
Vezavne molekule
|
|
DK1836500T3
(da)
*
|
2005-01-14 |
2010-11-01 |
Ablynx Nv |
Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader
|
|
ES2852423T3
(es)
|
2005-05-20 |
2021-09-13 |
Ablynx Nv |
NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación
|
|
WO2008049881A2
(en)
*
|
2006-10-25 |
2008-05-02 |
Umc Utrecht Holding Bv |
Polypeptides and pharmaceutical compositions comprising the same for the prevention and treatment of complications associated with infectious diseases
|
|
US20100129354A1
(en)
*
|
2006-10-27 |
2010-05-27 |
Ablynx N.V. |
Intranasal delivery of polypeptides and proteins
|
|
WO2008074839A2
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
|
EP2102244A2
(en)
|
2006-12-19 |
2009-09-23 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
|
|
US9512236B2
(en)
|
2006-12-19 |
2016-12-06 |
Ablynx N.V. |
Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
JP2010518839A
(ja)
*
|
2007-02-21 |
2010-06-03 |
アブリンクス エン.ヴェー. |
血管内皮増殖因子に指向性を有するアミノ酸配列、及び過度の及び/もしくは病的な血管形成又は血管新生を特徴とする症状及び疾患を治療するためにこれを含むポリペプチド
|
|
CN101796072B
(zh)
*
|
2007-05-24 |
2014-09-24 |
埃博灵克斯股份有限公司 |
用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽
|
|
EP2173772A2
(en)
|
2007-07-03 |
2010-04-14 |
Ablynx N.V. |
Providing improved immunoglobulin sequences by mutating cdr and/or fr positions
|
|
EP2220120A2
(en)
|
2007-11-27 |
2010-08-25 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
US20110183861A1
(en)
*
|
2008-01-29 |
2011-07-28 |
Ablynn N.V. |
Methods to stabilize proteins and polypeptides
|
|
CN101965362A
(zh)
*
|
2008-03-05 |
2011-02-02 |
埃博灵克斯股份有限公司 |
新型抗原结合二聚体-复合物及其制备方法和应用
|
|
EP2252303A2
(en)
*
|
2008-03-21 |
2010-11-24 |
Ablynx NV |
Von willebrand factor specific binders and methods of use therefor
|
|
AU2009235467A1
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Single variable domains against the Notch pathways
|
|
EP2268668A1
(en)
|
2008-04-17 |
2011-01-05 |
Ablynx N.V. |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
|
US8444976B2
(en)
|
2008-07-02 |
2013-05-21 |
Argen-X B.V. |
Antigen binding polypeptides
|
|
GB2461546B
(en)
*
|
2008-07-02 |
2010-07-07 |
Argen X Bv |
Antigen binding polypeptides
|
|
WO2010010119A1
(en)
|
2008-07-22 |
2010-01-28 |
Ablynx Nv |
Amino acid sequences directed against multitarget scavenger receptors and polypeptides
|
|
WO2011026948A1
(en)
|
2009-09-03 |
2011-03-10 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
WO2010100135A1
(en)
|
2009-03-05 |
2010-09-10 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
|
|
US9265834B2
(en)
|
2009-03-05 |
2016-02-23 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
GB0905023D0
(en)
*
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
|
ES2551854T3
(es)
|
2009-04-30 |
2015-11-24 |
Ablynx N.V. |
Procedimiento para la producción de anticuerpos de dominio
|
|
HUE051430T2
(hu)
|
2009-07-10 |
2021-03-01 |
Ablynx Nv |
Eljárás variábilis domének elõállítására
|
|
US20110172398A1
(en)
*
|
2009-10-02 |
2011-07-14 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules for anti-angiogenesis therapy
|
|
US20120321640A1
(en)
|
2009-12-01 |
2012-12-20 |
Ablynx N.V. |
Von willebrand factor specific binding agents and uses thereof
|
|
EP2513145B1
(en)
|
2009-12-14 |
2018-01-24 |
Ablynx N.V. |
Single variable domain antibodies against ox40l, constructs and therapeutic use
|
|
WO2011083141A2
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Method for generation of immunoglobulin sequences by using lipoprotein particles
|
|
CN102781959A
(zh)
|
2010-02-05 |
2012-11-14 |
埃博灵克斯股份有限公司 |
能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽
|
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
|
PT3501499T
(pt)
|
2010-02-11 |
2022-11-22 |
Ablynx Nv |
Métodos e composições para a preparação de aerossóis
|
|
US20130012916A1
(en)
|
2010-02-11 |
2013-01-10 |
Glide Pharmaceutical Technologies Limited |
Delivery of immunoglobulin variable domains and constructs thereof
|
|
UY33253A
(es)
|
2010-03-03 |
2011-09-30 |
Boehringer Ingelheim Int |
Polipéptidos de unión a a-beta
|
|
US8937164B2
(en)
|
2010-03-26 |
2015-01-20 |
Ablynx N.V. |
Biological materials related to CXCR7
|
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
CN102906118B
(zh)
|
2010-05-20 |
2017-07-28 |
埃博灵克斯股份有限公司 |
与her3相关的生物材料
|
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
|
US11644471B2
(en)
|
2010-09-30 |
2023-05-09 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
DK2632946T3
(en)
|
2010-10-29 |
2018-03-12 |
Ablynx Nv |
PROCEDURE FOR MANUFACTURING VARIABLE IMMUNGLOBULIN SINGLE DOMAINS
|
|
EA202092589A3
(ru)
|
2010-11-08 |
2021-06-30 |
Аблинкс Н.В. |
Cxcr2-связывающие полипептиды
|
|
CN103917560B
(zh)
|
2011-03-28 |
2017-05-24 |
埃博灵克斯股份有限公司 |
双特异性抗‑cxcr7免疫球蛋白单可变结构域
|
|
ES2688591T3
(es)
|
2011-03-28 |
2018-11-05 |
Ablynx N.V. |
Método para producir formulaciones sólidas que comprenden dominios variables individuales de inmunoglobulina
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
EP3590950A1
(en)
|
2011-05-09 |
2020-01-08 |
Ablynx NV |
Method for the production of immunoglobulin single varible domains
|
|
WO2012163887A1
(en)
|
2011-05-27 |
2012-12-06 |
Ablynx Nv |
Inhibition of bone resorption with rankl binding peptides
|
|
IN2014CN00437A
(2)
|
2011-06-23 |
2015-04-03 |
Ablynx Nv |
|
|
DK2723769T4
(da)
|
2011-06-23 |
2022-09-05 |
Ablynx Nv |
Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
|
|
EP2944653A1
(en)
|
2011-06-23 |
2015-11-18 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
|
|
DK2974737T3
(da)
|
2011-06-23 |
2026-01-19 |
Ablynx Nv |
Fremgangsmåder til forudsigelse, påvisning og reduktion af en specifik proteininterferens i assays, der involverer variable immunglobulin-enkeltdomæner
|
|
SG2014010482A
(en)
*
|
2011-08-17 |
2014-04-28 |
Glaxo Group Ltd |
Modified proteins and peptides
|
|
EP2753644A1
(en)
|
2011-09-09 |
2014-07-16 |
Universiteit Utrecht Holding B.V. |
Broadly neutralizing vhh against hiv-1
|
|
US10138302B2
(en)
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
|
DE102011121237A1
(de)
|
2011-12-14 |
2013-06-20 |
Universitätsklinikum Hamburg-Eppendorf |
Einzeldomänen-Antikörper gegen Clostridium difficile Toxin CDTa
|
|
DE102011121238A1
(de)
|
2011-12-14 |
2013-06-20 |
Universitätsklinikum Hamburg-Eppendorf |
Einzeldomänen-antikörper gegen clostridium difficile toxine
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
ES2715279T3
(es)
|
2012-05-24 |
2019-06-03 |
Vib Vzw |
Dominios variables individuales inmunoglobulínicos anti-receptor de manosa de macrófagos para elegir como diana y obtener imágenes in vivo de macrófagos asociados a tumores
|
|
AP2014008145A0
(en)
*
|
2012-06-08 |
2014-12-31 |
Glenmark Pharmaceuticals Sa |
Humanized anti-trkA antibodies with animo acid substitutions
|
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
|
WO2014118297A1
(en)
|
2013-01-30 |
2014-08-07 |
Vib Vzw |
Novel chimeric polypeptides for screening and drug discovery purposes
|
|
PL2953973T3
(pl)
|
2013-02-05 |
2020-01-31 |
Vib Vzw |
Środki wiążące muskarynowy receptor acetylocholiny i ich zastosowania
|
|
JP6499090B2
(ja)
|
2013-03-15 |
2019-04-10 |
ブイアイビー ブイゼットダブリュVib Vzw |
心血管疾患において使用するための抗マクロファージマンノース受容体単一可変ドメイン
|
|
US10993420B2
(en)
|
2013-03-15 |
2021-05-04 |
Erasmus University Medical Center |
Production of heavy chain only antibodies in transgenic mammals
|
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
|
US10183988B2
(en)
|
2013-06-07 |
2019-01-22 |
Duke University |
Anti-Complement factor H antibodies
|
|
EP3008085A4
(en)
*
|
2013-06-13 |
2017-05-10 |
Biogen MA Inc. |
Anti-factor viii antibodies or uses thereof
|
|
JP6687525B2
(ja)
|
2014-01-30 |
2020-04-22 |
ブイアイビー ブイゼットダブリュVib Vzw |
オピオイド受容体結合剤およびその使用
|
|
EP3131929B1
(en)
*
|
2014-04-16 |
2022-06-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Antibodies for the prevention or the treatment of bleeding episodes
|
|
ES2900852T3
(es)
|
2014-05-16 |
2022-03-18 |
Ablynx Nv |
Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento
|
|
PL3248986T3
(pl)
|
2014-05-16 |
2022-05-16 |
Ablynx Nv |
Domeny zmienne immunoglobuliny
|
|
NL2013007B1
(en)
*
|
2014-06-16 |
2016-07-05 |
Ablynx Nv |
Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
|
EP3194976B1
(en)
|
2014-07-22 |
2020-04-01 |
Vib Vzw |
Methods to select agents that stabilize protein complexes
|
|
CN117138060A
(zh)
|
2014-10-07 |
2023-12-01 |
免疫医疗公司 |
抗体-药物缀合物的新辅助剂用途
|
|
MA41097A
(fr)
*
|
2014-12-05 |
2017-10-10 |
Glenmark Pharmaceuticals Sa |
Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses
|
|
AU2015366284B2
(en)
|
2014-12-19 |
2021-07-22 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
US10273305B2
(en)
|
2015-04-02 |
2019-04-30 |
Ablynx N.V. |
Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity
|
|
WO2016172427A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
PT3294768T
(pt)
|
2015-05-13 |
2019-11-05 |
Ablynx Nv |
Polipétidos de recrutamento de células t com base na reatividade do tcr alfa/beta
|
|
CA3155409A1
(en)
|
2015-05-13 |
2016-11-17 |
Ablynx N.V. |
T cell recruiting polypeptides based on cd3 reactivity
|
|
US10639307B2
(en)
|
2015-05-15 |
2020-05-05 |
Children's Medical Center Corporation |
Methods relating to the diagnosis and treatment of preeclampsia comprising administration of ADAMTS13 polypeptides
|
|
EA201792573A1
(ru)
|
2015-05-21 |
2018-04-30 |
Харпун Терапьютикс, Инк. |
Триспецифические связанные белки и способы их применения
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
CN108026582A
(zh)
|
2015-07-31 |
2018-05-11 |
米迪缪尼有限公司 |
用于治疗海帕西啶介导的病症的方法
|
|
NO2768984T3
(2)
|
2015-11-12 |
2018-06-09 |
|
|
|
CN115925919A
(zh)
|
2015-11-13 |
2023-04-07 |
埃博灵克斯股份有限公司 |
改进的血清白蛋白结合免疫球蛋白可变结构域
|
|
US10544222B2
(en)
*
|
2015-11-18 |
2020-01-28 |
Merck Sharp & Dohme Corp. |
PD1/CTLA4 binders
|
|
CR20180279A
(es)
|
2015-11-18 |
2018-08-24 |
Merck Sharp & Dohme |
Enlazadores de ctla4
|
|
CN120535622A
(zh)
|
2015-11-18 |
2025-08-26 |
埃博灵克斯股份有限公司 |
改进的血清白蛋白结合剂
|
|
WO2017089618A1
(en)
|
2015-11-27 |
2017-06-01 |
Ablynx Nv |
Polypeptides inhibiting cd40l
|
|
WO2017129630A1
(en)
*
|
2016-01-26 |
2017-08-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-vwf d'd3 single-domain antibodies and polypeptides comprising thereof
|
|
CA3022697A1
(en)
|
2016-05-02 |
2017-11-09 |
Ablynx Nv |
Treatment of rsv infection
|
|
AR108468A1
(es)
*
|
2016-05-13 |
2018-08-22 |
Medimmune Llc |
POLIPÉPTIDOS DE FUSIÓN CD40L-Fc Y MÉTODOS DE USO DE LOS MISMOS
|
|
CN116987189A
(zh)
|
2016-05-20 |
2023-11-03 |
哈普恩治疗公司 |
单链可变片段cd3结合蛋白质
|
|
JP7101621B2
(ja)
|
2016-05-20 |
2022-07-15 |
ハープーン セラピューティクス,インク. |
単一ドメイン血清アルブミン結合タンパク質
|
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
|
MX2018016413A
(es)
|
2016-06-23 |
2019-05-09 |
Ablynx Nv |
Ensayos farmacocineticos mejorados para dominios variables unicos de inmunoglobulina.
|
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
|
CA3043515A1
(en)
|
2016-11-16 |
2018-05-24 |
Ablynx Nv |
T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
|
|
EP3544629A4
(en)
|
2016-11-23 |
2020-06-17 |
Harpoon Therapeutics, Inc. |
PSMA TO BE TRISPECIFIC PROTEINS AND METHOD FOR USE THEREOF
|
|
CN110198955A
(zh)
|
2016-11-23 |
2019-09-03 |
哈普恩治疗公司 |
前列腺特异性膜抗原结合蛋白质
|
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
|
RU2022101604A
(ru)
|
2016-12-07 |
2022-03-29 |
Аблинкс Нв |
Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
|
|
HRP20241501T1
(hr)
|
2017-01-17 |
2025-01-03 |
Ablynx Nv |
Poboljšana veziva albumina u serumu
|
|
SG10202108972RA
(en)
|
2017-01-17 |
2021-09-29 |
Ablynx Nv |
Improved serum albumin binders
|
|
KR20200012823A
(ko)
|
2017-02-01 |
2020-02-05 |
예일 유니버시티 |
이뇨제 내성의 치료
|
|
EP3589662A4
(en)
|
2017-02-28 |
2020-12-30 |
Harpoon Therapeutics, Inc. |
INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN
|
|
CA3054623A1
(en)
|
2017-02-28 |
2018-09-07 |
Vib Vzw |
Means and methods for oral protein delivery
|
|
EP3602056A1
(en)
|
2017-03-31 |
2020-02-05 |
Ablynx N.V. |
Improved immunogenicity assays
|
|
US10865238B1
(en)
*
|
2017-05-05 |
2020-12-15 |
Duke University |
Complement factor H antibodies
|
|
WO2018206734A1
(en)
|
2017-05-11 |
2018-11-15 |
Vib Vzw |
Glycosylation of variable immunoglobulin domains
|
|
WO2018209304A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Msln targeting trispecific proteins and methods of use
|
|
AU2018265856B2
(en)
*
|
2017-05-12 |
2023-04-27 |
Harpoon Therapeutics, Inc. |
Mesothelin binding proteins
|
|
BR112019025097A2
(pt)
|
2017-06-02 |
2020-07-28 |
Merck Patent Gmbh |
imunoglobulinas de ligação a mmp13
|
|
TW202428621A
(zh)
|
2017-06-02 |
2024-07-16 |
德商麥克專利有限公司 |
與adamts5、mmp13及聚集蛋白聚醣結合的多肽
|
|
IL270908B1
(en)
|
2017-06-02 |
2026-04-01 |
Merck Patent Gmbh |
ADAMTS-binding immunoglobulins
|
|
EP3630818A1
(en)
|
2017-06-02 |
2020-04-08 |
Ablynx NV |
Aggrecan binding immunoglobulins
|
|
KR102625929B1
(ko)
|
2017-07-19 |
2024-01-16 |
브이아이비 브이지더블유 |
혈청 알부민 결합제
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
HRP20241268T1
(hr)
|
2017-10-13 |
2024-12-06 |
Harpoon Therapeutics, Inc. |
Trispecifični proteini i postupci primjene
|
|
CA3076791A1
(en)
|
2017-10-31 |
2019-05-09 |
Vib Vzw |
Novel antigen-binding chimeric proteins and methods and uses thereof
|
|
US20200199206A1
(en)
*
|
2017-12-08 |
2020-06-25 |
AC Thera, LLC |
Bacterial toxin-neutralizing nanobodies and methods of making and using the same
|
|
CA3087699A1
(en)
|
2018-01-05 |
2019-07-11 |
Corvidia Therapeutics, Inc. |
Methods for treating il-6 mediated inflammation without immunosuppression
|
|
US12037382B2
(en)
|
2018-02-05 |
2024-07-16 |
Stichting Vu |
Inverse agonistic anti-US28 antibodies
|
|
WO2019154867A1
(en)
|
2018-02-06 |
2019-08-15 |
Ablynx Nv |
Methods of treating initial episode of ttp with immunoglobulin single variable domains
|
|
WO2019156566A1
(en)
|
2018-02-12 |
2019-08-15 |
Umc Utrecht Holding B.V. |
Bispecific molecules comprising gamma-delta tcr and t-cell or nk cell binding domain
|
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
|
AR114269A1
(es)
|
2018-02-26 |
2020-08-12 |
Ablynx Nv |
Secuencias nucleotídicas mejoradas que codifican para péptidos de unión
|
|
EP3758742A1
(en)
|
2018-03-01 |
2021-01-06 |
Vrije Universiteit Brussel |
Human pd-l1-binding immunoglobulins
|
|
JP2021519093A
(ja)
|
2018-03-27 |
2021-08-10 |
ユーエムシー ユトレヒト ホールディング ビー.ブイ. |
微小血管血栓症の処置のための標的化血栓溶解
|
|
KR20210020903A
(ko)
|
2018-05-14 |
2021-02-24 |
하푼 테라퓨틱스, 인크. |
면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
|
|
WO2019226050A2
(en)
|
2018-05-24 |
2019-11-28 |
Wageningen Universiteit |
Novel viral anti-infective reagents
|
|
KR102101561B1
(ko)
*
|
2018-07-25 |
2020-04-20 |
가톨릭대학교 산학협력단 |
신생혈관 표적용 조영제 조성물 및 이의 제조방법
|
|
WO2020061482A1
(en)
|
2018-09-21 |
2020-03-26 |
Harpoon Therapeutics, Inc. |
Egfr binding proteins and methods of use
|
|
SG11202103022WA
(en)
|
2018-09-25 |
2021-04-29 |
Harpoon Therapeutics Inc |
Dll3 binding proteins and methods of use
|
|
EP3636657A1
(en)
|
2018-10-08 |
2020-04-15 |
Ablynx N.V. |
Chromatography-free antibody purification method
|
|
WO2020080941A1
(en)
|
2018-10-16 |
2020-04-23 |
Umc Utrecht Holding B.V. |
Anti- low-density lipoprotein receptor-related protein 5/6 antibodies
|
|
WO2020130838A2
(en)
|
2018-12-21 |
2020-06-25 |
Qvq Holding B.V. |
Antibodies for preventing or treating candidiasis
|
|
GB201901608D0
(en)
|
2019-02-06 |
2019-03-27 |
Vib Vzw |
Vaccine adjuvant conjugates
|
|
US11986536B2
(en)
|
2019-03-23 |
2024-05-21 |
Ablevia Biotech Gmbh |
Compound for the sequestration of undesirable antibodies in a patient
|
|
EP3715374A1
(en)
|
2019-03-23 |
2020-09-30 |
Ablevia biotech GmbH |
Compound for the sequestration of undesirable antibodies in a patient
|
|
AU2020253685B2
(en)
|
2019-04-02 |
2025-09-04 |
Nykode Therapeutics ASA |
Immune-stimulatory compositions and use thereof
|
|
CA3138642A1
(en)
|
2019-04-29 |
2020-11-05 |
Confo Therapeutics N.V. |
Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
|
|
US20220289837A1
(en)
|
2019-04-30 |
2022-09-15 |
Vib Vzw |
Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents
|
|
EP4591885A3
(en)
|
2019-05-01 |
2025-11-19 |
Novo Nordisk A/S |
Anti-il-6 antibody formulation
|
|
US12516128B2
(en)
|
2019-05-14 |
2026-01-06 |
Harpoon Therapeutics, Inc. |
EpCAM binding proteins and methods of use
|
|
US20220220197A1
(en)
|
2019-05-28 |
2022-07-14 |
Vib Vzw |
Cancer Treatment by Targeting Plexins in the Immune Compartment
|
|
EP3976067A1
(en)
|
2019-05-28 |
2022-04-06 |
Vib Vzw |
Cd8+ t-cells lacking plexins and their application in cancer treatment
|
|
US20220324947A1
(en)
|
2019-08-05 |
2022-10-13 |
Stichting Vu |
Identification and Elimination of HCMV-Infected Cells
|
|
WO2021039574A1
(ja)
*
|
2019-08-23 |
2021-03-04 |
株式会社カネカ |
O結合型糖鎖修飾が抑制された重鎖抗体
|
|
EP3799881A1
(en)
|
2019-10-04 |
2021-04-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Single domain antibodies specifically binding globo - series glycans
|
|
WO2021078786A1
(en)
|
2019-10-21 |
2021-04-29 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
|
BR112022009087A2
(pt)
|
2019-11-11 |
2022-07-26 |
Ibi Ag Innovative Bio Insecticides Ltd |
Nanocorpos para controle de insetos e usos dos mesmos
|
|
EP4065603A1
(en)
|
2019-11-27 |
2022-10-05 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
|
GB201918279D0
(en)
|
2019-12-12 |
2020-01-29 |
Vib Vzw |
Glycosylated single chain immunoglobulin domains
|
|
US20240027467A1
(en)
|
2019-12-20 |
2024-01-25 |
Vib Vzw |
Nanobody Exchange Chromatography
|
|
WO2021140205A1
(en)
|
2020-01-10 |
2021-07-15 |
Confo Therapeutics N.V. |
Methods for generating antibodies and antibody fragments and libraries comprising same
|
|
WO2021156490A2
(en)
|
2020-02-06 |
2021-08-12 |
Vib Vzw |
Corona virus binders
|
|
CA3170833A1
(en)
|
2020-02-21 |
2021-08-26 |
Harpoon Therapeutics, Inc. |
Flt3 binding proteins and methods of use
|
|
KR20230012464A
(ko)
|
2020-02-25 |
2023-01-26 |
브이아이비 브이지더블유 |
류신-풍부 반복 키나제 2 알로스테릭 조절제
|
|
JP2023523600A
(ja)
|
2020-04-22 |
2023-06-06 |
マブウェル (シャンハイ) バイオサイエンス カンパニー リミテッド |
ヒトプログラム細胞死リガンド1(pd-l1)を標的とする単一可変ドメイン抗体およびその誘導体
|
|
JP7765090B2
(ja)
*
|
2020-05-01 |
2025-11-06 |
ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
ナノボディ及びナノボディ親和性を同定するための組成物及び方法
|
|
WO2021229104A1
(en)
|
2020-05-15 |
2021-11-18 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
|
EP4172214A4
(en)
*
|
2020-06-26 |
2024-10-30 |
Monash University |
Anti-vwf antibodies and uses thereof
|
|
KR20230030644A
(ko)
*
|
2020-06-29 |
2023-03-06 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
항-단백질 단일-도메인 항체 및 이를 포함하는 폴리펩타이드
|
|
WO2022003156A1
(en)
|
2020-07-02 |
2022-01-06 |
Oncurious Nv |
Ccr8 non-blocking binders
|
|
AR122933A1
(es)
|
2020-07-10 |
2022-10-19 |
Novo Nordisk As |
Métodos para tratar la enfermedad cardiovascular
|
|
EP4216943A1
(en)
|
2020-09-24 |
2023-08-02 |
Vib Vzw |
Combination of p2y6 inhibitors and immune checkpoint inhibitors
|
|
WO2022063957A1
(en)
|
2020-09-24 |
2022-03-31 |
Vib Vzw |
Biomarker for anti-tumor therapy
|
|
MX2023003522A
(es)
|
2020-09-25 |
2023-04-19 |
Ablynx Nv |
Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l.
|
|
WO2022117569A1
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
|
|
WO2022117572A2
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
An ltbr agonist in combination therapy against cancer
|
|
EP4263612A4
(en)
*
|
2020-12-18 |
2025-04-02 |
Bioardis LLC |
Mesothelin binding molecules and uses thereof
|
|
US20240052031A1
(en)
*
|
2020-12-18 |
2024-02-15 |
Bioardis, Llc |
Cea6 binding molecules and uses thereof
|
|
KR20230123497A
(ko)
|
2020-12-18 |
2023-08-23 |
아블린쓰 엔.브이. |
IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
|
|
EP4263601A4
(en)
*
|
2020-12-18 |
2025-04-02 |
Bioardis LLC |
Epcam binding molecules and uses thereof
|
|
WO2022133050A1
(en)
*
|
2020-12-18 |
2022-06-23 |
Bioardis, Llc |
Gpc3 binding molecules and uses thereof
|
|
GB202020502D0
(en)
|
2020-12-23 |
2021-02-03 |
Vib Vzw |
Antibody composistion for treatment of corona virus infection
|
|
WO2022136693A1
(en)
*
|
2020-12-23 |
2022-06-30 |
Numab Therapeutics AG |
Antibody variable domains and antibodies having decreased immunogenicity
|
|
AU2021405066A1
(en)
*
|
2020-12-23 |
2023-06-22 |
Numab Therapeutics AG |
Antibody variable domains and antibodies having decreased immunogenicity
|
|
EP4267618A1
(en)
|
2020-12-24 |
2023-11-01 |
Vib Vzw |
Non-blocking human ccr8 binders
|
|
WO2022136647A1
(en)
|
2020-12-24 |
2022-06-30 |
Oncurious Nv |
Human ccr8 binders
|
|
US20240052045A1
(en)
|
2020-12-24 |
2024-02-15 |
Vib Vzw |
Murine cross-reactive human ccr8 binders
|
|
IL304929A
(en)
|
2021-02-05 |
2023-10-01 |
Vib Vzw [Be/Be |
Sarbevirus binders
|
|
CN117794566A
(zh)
|
2021-02-05 |
2024-03-29 |
Vib研究所 |
沙贝病毒结合剂
|
|
CN117241804A
(zh)
|
2021-02-17 |
2023-12-15 |
非营利性组织佛兰芒综合大学生物技术研究所 |
在癌症治疗中slc4a4的抑制
|
|
US20250263490A1
(en)
|
2021-02-19 |
2025-08-21 |
Vib Vzw |
Cation-Independent Mannose-6-Phosphate Receptor Binders
|
|
WO2022199804A1
(en)
|
2021-03-24 |
2022-09-29 |
Vib Vzw |
Nek6 inhibition to treat als and ftd
|
|
US20240369570A1
(en)
|
2021-04-09 |
2024-11-07 |
Stichting Radboud Universiteit |
Off the shelf proximity biotinylation enzyme
|
|
US20240261446A1
(en)
|
2021-05-17 |
2024-08-08 |
Université de Liège |
Anti-cd38 single domain antibodies in disease monitoring and treatment
|
|
WO2022258606A1
(en)
|
2021-06-07 |
2022-12-15 |
Gadeta B.V. |
Delta T-cell or Gamma T-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
|
|
EP4359421A1
(en)
|
2021-06-23 |
2024-05-01 |
Vib Vzw |
Means and methods for selection of specific binders
|
|
WO2023274183A1
(zh)
|
2021-06-29 |
2023-01-05 |
江苏先声药业有限公司 |
Cd16抗体及其应用
|
|
WO2023288217A2
(en)
*
|
2021-07-12 |
2023-01-19 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Methods and sytems for nanobody humanization
|
|
CA3228014A1
(en)
|
2021-07-30 |
2023-02-16 |
Vib Vzm |
Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
|
|
AU2022320667A1
(en)
|
2021-07-30 |
2024-03-14 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Anti-pvrig/anti-tigit bispecific antibody and application
|
|
US20240271186A1
(en)
|
2021-08-03 |
2024-08-15 |
Wageningen Universiteit |
Argonaute-based nucleic acid detection system
|
|
CN118696058A
(zh)
|
2021-12-03 |
2024-09-24 |
山东先声生物制药有限公司 |
抗bcma纳米抗体及其应用
|
|
AU2022409733A1
(en)
|
2021-12-17 |
2024-08-01 |
Ablynx Nv |
POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123
|
|
US20250145705A1
(en)
|
2021-12-31 |
2025-05-08 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Gprc5d antibody and application thereof
|
|
WO2023135198A1
(en)
|
2022-01-12 |
2023-07-20 |
Vib Vzw |
Human ntcp binders for therapeutic use and liver-specific targeted delivery
|
|
WO2023148397A1
(en)
|
2022-02-07 |
2023-08-10 |
Vib Vzw |
Engineered stabilizing aglycosylated fc-regions
|
|
WO2023198848A1
(en)
|
2022-04-13 |
2023-10-19 |
Vib Vzw |
An ltbr agonist in combination therapy against cancer
|
|
US20250313611A1
(en)
|
2022-05-18 |
2025-10-09 |
Vib Vzw |
Sarbecovirus spike s2 subunit binders
|
|
WO2023227594A1
(en)
|
2022-05-24 |
2023-11-30 |
Gadeta Bv |
Novel deltat-cell receptor chains, gammat-cell receptor chains, or parts thereof
|
|
TW202411253A
(zh)
|
2022-06-06 |
2024-03-16 |
大陸商山東先聲生物製藥有限公司 |
靶向bcma、gprc5d和t細胞的多特異性抗體及其應用
|
|
WO2023237541A1
(en)
|
2022-06-07 |
2023-12-14 |
Gadeta B.V. |
Delta t-cell or gamma t-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
|
|
WO2024003873A1
(en)
|
2022-06-30 |
2024-01-04 |
Intrexon Actobiotics Nv D/B/A Precigen Actobio |
Single variable domain antibodies against tumor necrosis factor-alpha
|
|
JP2025523630A
(ja)
|
2022-07-04 |
2025-07-23 |
ブイアイビー ブイゼットダブリュ |
血液-脳脊髄液関門通過抗体
|
|
AR129879A1
(es)
|
2022-07-08 |
2024-10-09 |
Novo Nordisk As |
Compuestos de isvd altamente potentes capaces de sustituir al fviii(a)
|
|
WO2024013402A1
(en)
|
2022-07-15 |
2024-01-18 |
Gadeta B.V. |
Novel soluble gamma t-cell (or soluble delta t-cell) receptor chains (or soluble gammadelta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
|
|
MA71603A
(fr)
|
2022-07-27 |
2025-05-30 |
Ablynx Nv |
Polypeptides se liant à un épitope spécifique du récepteur fc néonatal
|
|
WO2024068744A1
(en)
|
2022-09-27 |
2024-04-04 |
Vib Vzw |
Antivirals against human parainfluenza virus
|
|
EP4605077A1
(en)
|
2022-10-18 |
2025-08-27 |
Confo Therapeutics N.V. |
Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
|
|
EP4612180A1
(en)
|
2022-10-31 |
2025-09-10 |
Stichting Amsterdam UMC |
Single domain anti-cd169 antibodies
|
|
EP4615493A1
(en)
|
2022-11-08 |
2025-09-17 |
Stichting Amsterdam UMC |
Activation inducible antigen receptors for adoptive immunotherapy
|
|
EP4619156A1
(en)
|
2022-11-15 |
2025-09-24 |
Imec VZW |
Method and system for droplet manipulation
|
|
WO2024103251A1
(zh)
|
2022-11-15 |
2024-05-23 |
原启生物科技(上海)有限责任公司 |
抗afp/hla02 tcr样抗体及其用途
|
|
EP4634214A1
(en)
|
2022-12-15 |
2025-10-22 |
Aarhus Universitet |
Synthetic activation of multimeric transmembrane receptors
|
|
WO2024126685A1
(en)
*
|
2022-12-15 |
2024-06-20 |
Institut National de la Santé et de la Recherche Médicale |
Single-domain antibody targeting von wilebrand factor a3-domain
|
|
WO2024133301A1
(en)
|
2022-12-19 |
2024-06-27 |
Umc Utrecht Holding B.V. |
Btn2a1 binding peptide
|
|
AR131494A1
(es)
|
2022-12-23 |
2025-03-26 |
Ablynx Nv |
Vehículos de conjugación a base de proteína
|
|
WO2024156881A1
(en)
|
2023-01-27 |
2024-08-02 |
Vib Vzw |
CD8b-BINDING POLYPEPTIDES
|
|
WO2024156888A1
(en)
|
2023-01-27 |
2024-08-02 |
Vib Vzw |
Cd163-binding conjugates
|
|
WO2024165710A1
(en)
|
2023-02-09 |
2024-08-15 |
Seni-Preps B.V. |
Immunoglobulin single variable domains that inhibit urease and use thereof
|
|
JP2026506075A
(ja)
|
2023-02-17 |
2026-02-20 |
アブリンクス エン.ヴェー. |
新生児型fc受容体に結合するポリペプチド
|
|
WO2024175787A1
(en)
|
2023-02-24 |
2024-08-29 |
Vrije Universiteit Brussel |
Anti-inflammatory pannexin 1 channel inhibitors
|
|
US20240344078A1
(en)
|
2023-03-14 |
2024-10-17 |
Aarhus Universitet |
Genetically altered nfr5 receptor kinases
|
|
WO2024208816A1
(en)
|
2023-04-03 |
2024-10-10 |
Vib Vzw |
Blood-brain barrier crossing antibodies
|
|
EP4709753A1
(en)
|
2023-05-11 |
2026-03-18 |
Vib Vzw |
Slc4a4/nbce1 inhibitors
|
|
WO2024240162A1
(en)
|
2023-05-23 |
2024-11-28 |
Shanghai Allygen Biologics Co., Ltd. |
Pd-l1 and trop-2 targeting conjugates comprising effector molecules and uses thereof
|
|
WO2024251826A1
(en)
|
2023-06-05 |
2024-12-12 |
Vib Vzw |
Glyco-engineered antibody-drug-conjugates comprising an oxime linker
|
|
WO2024251981A1
(en)
|
2023-06-09 |
2024-12-12 |
Umc Utrecht Holding B.V. |
Detecting and/or modulating susceptibility to btn2a1 and/or btn3a1 targeting therapeutics
|
|
WO2024261344A1
(en)
|
2023-06-23 |
2024-12-26 |
Vib Vzw |
Novel binders targeting the multi-drug resistant pathogen acinetobacter baumannii
|
|
EP4483951A1
(en)
|
2023-06-30 |
2025-01-01 |
Université de Liège |
Single-domain antibody for inhibition of neutrophil elastase activity
|
|
GB202314424D0
(en)
|
2023-09-20 |
2023-11-01 |
Cambridge Entpr Ltd |
A conjugate
|
|
US20250129145A1
(en)
|
2023-09-22 |
2025-04-24 |
Ablynx N.V. |
Bi- and multivalent albumin binders
|
|
WO2025093683A1
(en)
|
2023-11-03 |
2025-05-08 |
Neuvasq Biotechnologies Sa |
Wnt7 signaling agonists
|
|
WO2025109176A1
(en)
|
2023-11-22 |
2025-05-30 |
Exevir Bio Bv |
Optimized sarbecovirus spike s2 subunit binders and compositions comprising the same
|
|
WO2025125577A1
(en)
|
2023-12-14 |
2025-06-19 |
Vib Vzw |
Antibodies against influenza b virus
|
|
TW202543670A
(zh)
|
2023-12-22 |
2025-11-16 |
比利時商艾伯霖克斯公司 |
用於核內投予之基於蛋白質的接合載劑
|
|
US20250236673A1
(en)
|
2023-12-22 |
2025-07-24 |
Ablynx N.V. |
Protein-based carriers for site-specific amine conjugation
|
|
WO2025154056A1
(en)
|
2024-01-21 |
2025-07-24 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect cda nanobodies and uses thereof
|
|
WO2025154058A1
(en)
|
2024-01-21 |
2025-07-24 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect hsp70 nanobodies and uses thereof
|
|
WO2025167664A1
(zh)
*
|
2024-02-07 |
2025-08-14 |
原启生物科技(上海)有限责任公司 |
Ror1抗原结合蛋白及其用途
|
|
WO2025181155A1
(en)
|
2024-02-26 |
2025-09-04 |
Vib Vzw |
Human beta-glucocerebrosidase binders and uses thereof
|
|
WO2025196308A1
(en)
|
2024-03-22 |
2025-09-25 |
Vib Vzw |
Means and methods for displaying fc-containing proteins on cells and selection thereof
|
|
WO2025219231A1
(en)
|
2024-04-15 |
2025-10-23 |
Vib Vzw |
Computer-implemented means and methods for the de novo design of antibodies targeting a specific epitope
|
|
US20260007757A1
(en)
|
2024-06-18 |
2026-01-08 |
Ablynx Nv |
Antibody-recruiting molecules
|
|
WO2026008664A1
(en)
|
2024-07-01 |
2026-01-08 |
Vib Vzw |
Allosteric modulators of inhibitory immune receptor complexes
|
|
WO2026027659A1
(en)
|
2024-07-31 |
2026-02-05 |
Seni-Preps B.V. |
Improved immunoglobulin single variable domains that inhibit urease and use thereof
|