BE879174A - Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues - Google Patents

Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues Download PDF

Info

Publication number: BE879174A
Authority: BE; Belgium
Prior art keywords: emi; solution; sodium; compositions; sodium hydroxide
Prior art date: 1978-10-03

Application number

BE0/197458A

Other languages

English (en)

French (fr)

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-03

Filing date

1979-10-03

Publication date

1980-04-03

1979-10-03 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1980-04-03 Publication of BE879174A publication Critical patent/BE879174A/fr

Links

239000000203 mixture Substances 0.000 title claims description 19
238000000034 method Methods 0.000 title claims description 14
238000002347 injection Methods 0.000 title claims description 12
239000007924 injection Substances 0.000 title claims description 12
238000002360 preparation method Methods 0.000 title claims description 5
BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 title description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 48
239000000243 solution Substances 0.000 claims description 38
238000004108 freeze drying Methods 0.000 claims description 26
238000007710 freezing Methods 0.000 claims description 13
230000008014 freezing Effects 0.000 claims description 13
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 10
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 6
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 6
229910052708 sodium Inorganic materials 0.000 claims description 6
239000011734 sodium Substances 0.000 claims description 6
229960003022 amoxicillin Drugs 0.000 claims description 5
229960004920 amoxicillin trihydrate Drugs 0.000 claims description 4
238000001914 filtration Methods 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 2
229960001931 ampicillin sodium Drugs 0.000 claims 1
KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 claims 1
238000001035 drying Methods 0.000 description 28
239000000047 product Substances 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
238000010438 heat treatment Methods 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
238000001816 cooling Methods 0.000 description 4
239000002270 dispersing agent Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
229960002793 amoxicillin sodium Drugs 0.000 description 3
238000000354 decomposition reaction Methods 0.000 description 3
239000000706 filtrate Substances 0.000 description 3
238000002329 infrared spectrum Methods 0.000 description 3
ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000000725 suspension Substances 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
239000003513 alkali Substances 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
239000002585 base Substances 0.000 description 2
238000013461 design Methods 0.000 description 2
239000010419 fine particle Substances 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000002985 plastic film Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000000523 sample Substances 0.000 description 2
238000007086 side reaction Methods 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000000126 substance Substances 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
230000004913 activation Effects 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000008135 aqueous vehicle Substances 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 description 1
229960000603 cefalotin Drugs 0.000 description 1
229960001139 cefazolin Drugs 0.000 description 1
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
239000013043 chemical agent Substances 0.000 description 1
238000004891 communication Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000002788 crimping Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000011049 filling Methods 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
238000012792 lyophilization process Methods 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
150000003138 primary alcohols Chemical class 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

BE0/197458A 1978-10-03 1979-10-03 Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues BE879174A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL7809986A NL7809986A (nl)	1978-10-03	1978-10-03	Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan.

Publications (1)

Publication Number	Publication Date
BE879174A true BE879174A (fr)	1980-04-03

Family

ID=19831645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE0/197458A BE879174A (fr)	1978-10-03	1979-10-03	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues

Country Status (3)

Country	Link
JP (1)	JPS5562009A (da)
BE (1)	BE879174A (da)
NL (1)	NL7809986A (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60102710A (ja) *	1983-11-09	1985-06-06	Hitachi Ltd	油入電器の異常監視装置
JPH07178253A (ja) *	1993-12-22	1995-07-18	Nkk Corp	水上を自走可能な遊戯用乗り物
EP1838287B1 (en) *	2005-01-07	2012-05-23	Sandoz Ag	Process for preparing granulates comprising amoxicillin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5283915A (en) *	1976-01-01	1977-07-13	Beecham Group Ltd	Amoxycillin solution

1978
- 1978-10-03 NL NL7809986A patent/NL7809986A/nl not_active Application Discontinuation
1979
- 1979-10-03 JP JP12784879A patent/JPS5562009A/ja active Granted
- 1979-10-03 BE BE0/197458A patent/BE879174A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS5562009A (en)	1980-05-10
NL7809986A (nl)	1980-04-09
JPS646170B2 (da)	1989-02-02

Legal Events

Date

Code

Title

Description

1995-04-30

RE

Patent lapsed

Owner name: GIST-BROCADES N.V.

Effective date: 19941031

Publication	Publication Date	Title
BE1004229A5 (fr)	1992-10-13	Agents pharmaceutiques.
LU84935A1 (fr)	1983-11-23	Nouvelle forme d'ester de cefuroxime,procede pour sa preparation et composition pharmaceutique le contenant
KR880001208B1 (ko)	1988-07-11	액체 매질의 동결 방법 및 장치
EP2055197A1 (fr)	2009-05-06	Procédé d'évapocristallisation du maltitol
WO2018146210A1 (fr)	2018-08-16	Procede de purification de la vanilline naturelle
CH654207A5 (fr)	1986-02-14	Procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic.
LU81753A1 (fr)	1980-01-24	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues
BE879174A (fr)	1980-04-03	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues
JP2006096761A (ja)	2006-04-13	ホスホリパーゼ阻害剤の［［３−（２−アミノ−１，２−ジオキソエチル）−２−エチル−１−フェニルメチル）−１ｈ−インドール−４−イル］オキシ］酢酸ナトリウムを含む薬学的組成物
EP2133346A1 (fr)	2009-12-16	Procédé pour la fabrication d'un diester cyclique d'un acide alpha-hydroxylé
EP3148961B1 (fr)	2018-08-22	Procédé de préparation d'un sel d'acide acétylsalicylique et d'un acide aminé basique
FR2470765A1 (fr)	1981-06-12	Nouveaux sels d'addition d'acides du 4'-(9-acridinyl-amino)methanesulf-m-anisidide, leur procede de production et composition pharmaceutique les contenant
EP0116182B1 (fr)	1986-09-03	Procédé de préparation d'acide p-butoxyphénylacéthydroxamique à l'état finement divisé
CN101282908A (zh)	2008-10-08	制备冻干的碳酸氢钠的方法
FR2520378A1 (fr)	1983-07-29	Perfectionnements apportes aux procedes de preparations de suspensions de cellules fraiches stabilisees destinees a l'usage pharmaceutique, cosmetique ou alimentaire
LU84750A1 (fr)	1983-11-17	Nouvelles argiles modifiees,leur procede de preparation et compositions therapeutiques a base de ces argiles
CN116693385A (zh)	2023-09-05	一种肉桂酸肉桂酯催化合成及其制备方法
FI68055B (fi)	1985-03-29	Foerfarande foer framstaellning av ett snabbloesligt pulver avristallint cefalotinnatrium
BE887220A (fr)	1981-07-23	Compositions antitumeurs
FR2584740A1 (fr)	1987-01-16	Procede pour l'obtention de polymeres d'anthocyanosides de raisins (vitis vinifera l.)
LU83081A1 (fr)	1981-09-10	Compositions antitumeurs
BE861135A (fr)	1978-05-24	Preparation d'une poudre de cephalothine-sodium stable, pour administration parenterale
BE630595A (da)
FR2627487A1 (fr)	1989-08-25	Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant
BE554750A (da)