NL7809986A - Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan. - Google Patents

Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan. Download PDF

Info

Publication number: NL7809986A
Authority: NL; Netherlands
Prior art keywords: amoxicillin; sodium; excess; sodium hydroxide; preparations
Prior art date: 1978-10-03

Application number

NL7809986A

Other languages

English (en)

Dutch (nl)

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-03

Filing date

1978-10-03

Publication date

1980-04-09

1978-10-03 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1978-10-03 Priority to NL7809986A priority Critical patent/NL7809986A/nl

1979-09-25 Priority to PT70225A priority patent/PT70225A/pt

1979-09-27 Priority to EP79200545A priority patent/EP0009845B2/en

1979-09-27 Priority to DE7979200545T priority patent/DE2963947D1/de

1979-09-27 Priority to AT79200545T priority patent/ATE1692T1/de

1979-10-02 Priority to NO793164A priority patent/NO155009C/no

1979-10-02 Priority to IE1875/79A priority patent/IE48953B1/en

1979-10-02 Priority to FI793049A priority patent/FI68518C/fi

1979-10-02 Priority to GR60166A priority patent/GR71663B/el

1979-10-02 Priority to DK413279A priority patent/DK157660C/da

1979-10-03 Priority to LU81753A priority patent/LU81753A1/fr

1979-10-03 Priority to FR7924654A priority patent/FR2437835A1/fr

1979-10-03 Priority to ES484698A priority patent/ES484698A1/es

1979-10-03 Priority to BE0/197458A priority patent/BE879174A/fr

1979-10-03 Priority to JP12784879A priority patent/JPS5562009A/ja

1980-04-09 Publication of NL7809986A publication Critical patent/NL7809986A/nl

1985-04-23 Priority to US06/726,027 priority patent/US4607029A/en

Links

238000002360 preparation method Methods 0.000 title claims description 50
BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 title claims description 29
238000002347 injection Methods 0.000 title claims description 15
239000007924 injection Substances 0.000 title claims description 15
239000000203 mixture Substances 0.000 title claims description 7
238000004519 manufacturing process Methods 0.000 title claims 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 63
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 40
239000000243 solution Substances 0.000 claims description 38
229960003022 amoxicillin Drugs 0.000 claims description 27
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 27
238000000034 method Methods 0.000 claims description 25
235000011121 sodium hydroxide Nutrition 0.000 claims description 21
238000004108 freeze drying Methods 0.000 claims description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
229960004920 amoxicillin trihydrate Drugs 0.000 claims description 10
238000007710 freezing Methods 0.000 claims description 9
230000008014 freezing Effects 0.000 claims description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 6
239000011780 sodium chloride Substances 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 5
238000011049 filling Methods 0.000 claims description 3
238000009472 formulation Methods 0.000 claims description 3
238000011146 sterile filtration Methods 0.000 claims description 3
239000000725 suspension Substances 0.000 claims description 3
239000003518 caustics Substances 0.000 claims description 2
206010020751 Hypersensitivity Diseases 0.000 claims 1
208000026935 allergic disease Diseases 0.000 claims 1
229960002793 amoxicillin sodium Drugs 0.000 claims 1
239000003708 ampul Substances 0.000 claims 1
239000012267 brine Substances 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 claims 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims 1
238000001035 drying Methods 0.000 description 11
239000000047 product Substances 0.000 description 8
238000000354 decomposition reaction Methods 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
150000003839 salts Chemical class 0.000 description 5
241000234282 Allium Species 0.000 description 4
239000002270 dispersing agent Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
229960000723 ampicillin Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
-1 for example Chemical class 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000000843 powder Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000011734 sodium Substances 0.000 description 3
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
235000002732 Allium cepa var. cepa Nutrition 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
MOMWFXLCFJOAFX-UHFFFAOYSA-N OOOOOOOO Chemical compound OOOOOOOO MOMWFXLCFJOAFX-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 2
VUFGUVLLDPOSBC-XRZFDKQNSA-M cephalothin sodium Chemical compound [Na+].N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C([O-])=O)C(=O)CC1=CC=CS1 VUFGUVLLDPOSBC-XRZFDKQNSA-M 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000001816 cooling Methods 0.000 description 2
239000010419 fine particle Substances 0.000 description 2
238000007689 inspection Methods 0.000 description 2
235000010445 lecithin Nutrition 0.000 description 2
239000000787 lecithin Substances 0.000 description 2
229940067606 lecithin Drugs 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000004448 titration Methods 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
239000004381 Choline salt Substances 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
UTOGVBKEQYRZJE-UHFFFAOYSA-N PPPPPPPP Chemical compound PPPPPPPP UTOGVBKEQYRZJE-UHFFFAOYSA-N 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000008135 aqueous vehicle Substances 0.000 description 1
125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
229960001139 cefazolin Drugs 0.000 description 1
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
235000019417 choline salt Nutrition 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
238000009434 installation Methods 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
150000003138 primary alcohols Chemical class 0.000 description 1
150000003248 quinolines Chemical class 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
DKGAVHZHDRPRBM-UHFFFAOYSA-N tert-butyl alcohol Substances CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

NL7809986A 1978-10-03 1978-10-03 Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan. NL7809986A (nl)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
NL7809986A NL7809986A (nl)	1978-10-03	1978-10-03	Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan.
PT70225A PT70225A (en)	1978-10-03	1979-09-25	Process for the preparation of sodium amoxicillin preparations
EP79200545A EP0009845B2 (en)	1978-10-03	1979-09-27	Process for the manufacture of sodium amoxicillin preparations
DE7979200545T DE2963947D1 (en)	1978-10-03	1979-09-27	Process for the manufacture of sodium amoxicillin preparations
AT79200545T ATE1692T1 (de)	1978-10-03	1979-09-27	Verfahren zur herstellung von natriumoxicillinzusammensetzungen.
FI793049A FI68518C (fi)	1978-10-03	1979-10-02	Foerfarande foer framstaellning av natriumamoxicillin-preparat
IE1875/79A IE48953B1 (en)	1978-10-03	1979-10-02	Process for the manufacture of sodium amoxicillin preparations
NO793164A NO155009C (no)	1978-10-03	1979-10-02	Fremgangsmaate for fremstilling av natriumamoxicillin.
GR60166A GR71663B (da)	1978-10-03	1979-10-02
DK413279A DK157660C (da)	1978-10-03	1979-10-02	Fremgangsmaade til fremstilling af natriumamoxicillin
LU81753A LU81753A1 (fr)	1978-10-03	1979-10-03	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues
FR7924654A FR2437835A1 (fr)	1978-10-03	1979-10-03	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues
ES484698A ES484698A1 (es)	1978-10-03	1979-10-03	Procedimiento de obtencion de preparados de amoxicilina so- dica
BE0/197458A BE879174A (fr)	1978-10-03	1979-10-03	Procede de preparation d'amoxicilline sodique et de compositions d'amoxicilline sodique en doses a injecter et compositions ainsi obtenues
JP12784879A JPS5562009A (en)	1978-10-03	1979-10-03	Manufacture of ammoxysilinsodium medicine
US06/726,027 US4607029A (en)	1978-10-03	1985-04-23	Novel sodium amoxicillin preparations

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL7809986A NL7809986A (nl)	1978-10-03	1978-10-03	Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan.
NL7809986		1978-10-03

Publications (1)

Publication Number	Publication Date
NL7809986A true NL7809986A (nl)	1980-04-09

Family

ID=19831645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL7809986A NL7809986A (nl)	1978-10-03	1978-10-03	Werkwijze voor het bereiden van natrium amoxicilline geschikt voor injectiepreparaten, alsmede deze verbin- ding bevattende gedoseerde injectiepreparaten en de bereiding ervan.

Country Status (3)

Country	Link
JP (1)	JPS5562009A (da)
BE (1)	BE879174A (da)
NL (1)	NL7809986A (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60102710A (ja) *	1983-11-09	1985-06-06	Hitachi Ltd	油入電器の異常監視装置
JPH07178253A (ja) *	1993-12-22	1995-07-18	Nkk Corp	水上を自走可能な遊戯用乗り物
EP1838287B1 (en) *	2005-01-07	2012-05-23	Sandoz Ag	Process for preparing granulates comprising amoxicillin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5283915A (en) *	1976-01-01	1977-07-13	Beecham Group Ltd	Amoxycillin solution

1978
- 1978-10-03 NL NL7809986A patent/NL7809986A/nl not_active Application Discontinuation
1979
- 1979-10-03 JP JP12784879A patent/JPS5562009A/ja active Granted
- 1979-10-03 BE BE0/197458A patent/BE879174A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS646170B2 (da)	1989-02-02
BE879174A (fr)	1980-04-03
JPS5562009A (en)	1980-05-10

Legal Events

Date	Code	Title	Description
1981-06-01	BV	The patent application has lapsed

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KR930010623B1 (ko)	1993-11-02	백금계 항암화합물의 안정한 동결건조물의 제조방법
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US20090036406A1 (en)	2009-02-05	Injection
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CN1121875C (zh)	2003-09-24	适于冷冻干燥的药物组合物
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