BE901963A - Forme dosee d'etoposide a usage oral. - Google Patents
Forme dosee d'etoposide a usage oral.Info
- Publication number
- BE901963A BE901963A BE0/214666A BE214666A BE901963A BE 901963 A BE901963 A BE 901963A BE 0/214666 A BE0/214666 A BE 0/214666A BE 214666 A BE214666 A BE 214666A BE 901963 A BE901963 A BE 901963A
- Authority
- BE
- Belgium
- Prior art keywords
- oral use
- etoposide
- acid
- dosed form
- etopsoside
- Prior art date
Links
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 title abstract 2
- 229960005420 etoposide Drugs 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008297 liquid dosage form Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Forme dosée liquide propre à l'administration par voie orale de l'étopsoside, qui est suffisamment concentrée pour etre présentée dans une capsule et qui assure une meilleure absorption du médicament comparé à celle atteinte avec les formulations àusage oral déjà connues. La composition pharmaceutique comprend de l'étoposide, du polyéthylèneglycol, de l'acide taurocholique, de l'éthanol et un acide hydrosoluble, qui est par préférence l'acide citrique.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59114484A | 1984-03-19 | 1984-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE901963A true BE901963A (fr) | 1985-09-18 |
Family
ID=24365235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214666A BE901963A (fr) | 1984-03-19 | 1985-03-18 | Forme dosee d'etoposide a usage oral. |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS60209516A (fr) |
| KR (1) | KR850006136A (fr) |
| AT (1) | AT392904B (fr) |
| AU (1) | AU571308B2 (fr) |
| BE (1) | BE901963A (fr) |
| CA (1) | CA1238578A (fr) |
| CH (1) | CH662731A5 (fr) |
| DE (1) | DE3509741A1 (fr) |
| DK (1) | DK164535C (fr) |
| EG (1) | EG17521A (fr) |
| ES (1) | ES8702140A1 (fr) |
| FI (1) | FI84023C (fr) |
| FR (1) | FR2561104B1 (fr) |
| GB (1) | GB2155789B (fr) |
| GR (1) | GR850688B (fr) |
| IE (1) | IE58340B1 (fr) |
| IL (1) | IL74615A (fr) |
| IT (1) | IT1187640B (fr) |
| LU (1) | LU85812A1 (fr) |
| MY (1) | MY101916A (fr) |
| NL (1) | NL8500739A (fr) |
| NO (1) | NO170569C (fr) |
| NZ (1) | NZ211078A (fr) |
| OA (1) | OA07968A (fr) |
| PT (1) | PT80131B (fr) |
| SE (1) | SE8501312L (fr) |
| YU (1) | YU45243B (fr) |
| ZA (1) | ZA851935B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
| JPS61189230A (ja) * | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | エトポシド製剤 |
| DE3629386A1 (de) * | 1986-08-29 | 1988-03-03 | Scherer Gmbh R P | Gelatinekapseln und verfahren zu ihrer herstellung |
| US4927638A (en) * | 1986-10-08 | 1990-05-22 | Bristol-Myers Company | Etoposide solutions |
| US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
| US5376381A (en) * | 1988-02-25 | 1994-12-27 | The Liposome Company, Inc. | Integrity protected gelatin |
| JP2000247911A (ja) * | 1999-02-26 | 2000-09-12 | Hisamitsu Pharmaceut Co Inc | 大腸用吸収促進剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH580255A5 (fr) * | 1974-06-04 | 1976-09-30 | Calinter Sa | |
| DE2452785A1 (de) * | 1974-11-07 | 1976-05-13 | Universal Oil Prod Co | Verfahren zum betrieb einer verbrennungsmaschine |
| FR2358144A1 (fr) * | 1976-07-13 | 1978-02-10 | Lipha | Nouvelle composition medicamenteuse pour le traitement de la lithiase biliaire |
| JPS5940137B2 (ja) * | 1976-10-14 | 1984-09-28 | 武田薬品工業株式会社 | 経口投与用医薬組成物 |
| FR2410504A1 (fr) * | 1977-12-05 | 1979-06-29 | Air Liquide | Procede de reglage de securite d'un reacteur chimique et installation de reaction d'oxydation mettant en oeuvre ce procede |
| DE2809543A1 (de) * | 1978-03-06 | 1979-09-13 | Werner Henke | Verfahren und vorrichtung zum neutralisieren von gasen bei oel- und gasbohrungen |
| JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
-
1985
- 1985-02-08 NZ NZ211078A patent/NZ211078A/en unknown
- 1985-02-20 AU AU38975/85A patent/AU571308B2/en not_active Ceased
- 1985-03-05 FR FR8503221A patent/FR2561104B1/fr not_active Expired
- 1985-03-14 NL NL8500739A patent/NL8500739A/nl not_active Application Discontinuation
- 1985-03-14 IT IT19897/85A patent/IT1187640B/it active
- 1985-03-14 ZA ZA851935A patent/ZA851935B/xx unknown
- 1985-03-15 FI FI851040A patent/FI84023C/fi not_active IP Right Cessation
- 1985-03-15 IL IL74615A patent/IL74615A/xx unknown
- 1985-03-15 YU YU420/85A patent/YU45243B/xx unknown
- 1985-03-15 IE IE68685A patent/IE58340B1/en not_active IP Right Cessation
- 1985-03-15 NO NO851022A patent/NO170569C/no unknown
- 1985-03-16 EG EG164/85A patent/EG17521A/xx active
- 1985-03-18 JP JP60054088A patent/JPS60209516A/ja active Pending
- 1985-03-18 ES ES541370A patent/ES8702140A1/es not_active Expired
- 1985-03-18 SE SE8501312A patent/SE8501312L/ not_active Application Discontinuation
- 1985-03-18 BE BE0/214666A patent/BE901963A/fr not_active IP Right Cessation
- 1985-03-18 CA CA000476750A patent/CA1238578A/fr not_active Expired
- 1985-03-18 GB GB08506943A patent/GB2155789B/en not_active Expired
- 1985-03-18 PT PT80131A patent/PT80131B/pt not_active IP Right Cessation
- 1985-03-18 DE DE19853509741 patent/DE3509741A1/de not_active Withdrawn
- 1985-03-18 KR KR1019850001736A patent/KR850006136A/ko not_active Ceased
- 1985-03-18 LU LU85812A patent/LU85812A1/fr unknown
- 1985-03-18 DK DK122285A patent/DK164535C/da not_active IP Right Cessation
- 1985-03-19 CH CH1223/85A patent/CH662731A5/de not_active IP Right Cessation
- 1985-03-19 AT AT819/85A patent/AT392904B/de not_active IP Right Cessation
- 1985-03-19 OA OA58543A patent/OA07968A/fr unknown
- 1985-03-19 GR GR850688A patent/GR850688B/el unknown
-
1987
- 1987-09-29 MY MYPI87002211A patent/MY101916A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: BRISTOL-MYERS CY Effective date: 19940331 |