ES8802318A1 - Procedimiento para la produccion de derivados del morfinano - Google Patents

Procedimiento para la produccion de derivados del morfinano

Info

Publication number: ES8802318A1
Authority: ES; Spain
Prior art keywords: hydrogen; syndrome; morphinan; derivatives; morphinan derivatives
Prior art date: 1985-05-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES555200A

Other languages

English (en)

Spanish (es)

Other versions

ES555200A0 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-23

Filing date

1986-05-21

Publication date

1988-05-01

1986-05-21 Application filed by Sandoz AG filed Critical Sandoz AG

1988-05-01 Publication of ES8802318A1 publication Critical patent/ES8802318A1/es

1988-05-01 Publication of ES555200A0 publication Critical patent/ES555200A0/es

Status Expired legal-status Critical Current

Links

INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title abstract 2
229940051807 opiod analgesics morphinan derivative Drugs 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
102000009151 Luteinizing Hormone Human genes 0.000 abstract 2
108010073521 Luteinizing Hormone Proteins 0.000 abstract 2
229940040129 luteinizing hormone Drugs 0.000 abstract 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 abstract 2
-1 ALLYL Chemical class 0.000 abstract 1
201000000736 Amenorrhea Diseases 0.000 abstract 1
206010001928 Amenorrhoea Diseases 0.000 abstract 1
102100028628 Bombesin receptor subtype-3 Human genes 0.000 abstract 1
101000695054 Homo sapiens Bombesin receptor subtype-3 Proteins 0.000 abstract 1
206010058359 Hypogonadism Diseases 0.000 abstract 1
201000007493 Kallmann syndrome Diseases 0.000 abstract 1
206010053142 Olfacto genital dysplasia Diseases 0.000 abstract 1
231100000540 amenorrhea Toxicity 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000002513 anti-ovulatory effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
208000000509 infertility Diseases 0.000 abstract 1
230000036512 infertility Effects 0.000 abstract 1
231100000535 infertility Toxicity 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
229960005181 morphine Drugs 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Addiction (AREA)
Psychiatry (AREA)
Hematology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ES555200A 1985-05-23 1986-05-21 Procedimiento para la produccion de derivados del morfinano Expired ES8802318A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3518525		1985-05-23

Publications (2)

Publication Number	Publication Date
ES8802318A1 true ES8802318A1 (es)	1988-05-01
ES555200A0 ES555200A0 (es)	1988-05-01

Family

ID=6271435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES555200A Expired ES8802318A1 (es)	1985-05-23	1986-05-21	Procedimiento para la produccion de derivados del morfinano

Country Status (18)

Country	Link
JP (1)	JPS61271275A (fr)
AU (1)	AU594954B2 (fr)
BE (1)	BE904796A (fr)
DK (1)	DK240386A (fr)
ES (1)	ES8802318A1 (fr)
FI (1)	FI862124L (fr)
FR (1)	FR2582309B1 (fr)
GB (1)	GB2175898B (fr)
GR (1)	GR861318B (fr)
HU (1)	HU196376B (fr)
IL (1)	IL78872A0 (fr)
IT (1)	IT1203791B (fr)
LU (1)	LU86435A1 (fr)
NL (1)	NL8601188A (fr)
NZ (1)	NZ216250A (fr)
PH (1)	PH23341A (fr)
SE (1)	SE8602308L (fr)
ZA (1)	ZA863873B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4857533A (en) *	1988-12-15	1989-08-15	Baker Cummins Pharmaceuticals, Inc.	Method of treatment for autoimmune diseases
US4863928A (en) *	1989-01-04	1989-09-05	Baker Cummins Pharmaceuticals, Inc.	Method of treatment for arthritic and inflammatory diseases
US4923875A (en) *	1989-07-10	1990-05-08	Baker Cummins Pharmaceuticals, Inc.	Method for treatment of mast cell-mediated dermatologic disorders
JP2906654B2 (ja) *	1989-11-28	1999-06-21	東レ株式会社	免疫抑制剤及びその製造方法
US5057322A (en) *	1990-08-10	1991-10-15	Baker Cummins Dermatologicals, Inc.	Method of treating mast cell disease
JP2525552B2 (ja) *	1992-01-23	1996-08-21	東レ株式会社	モルヒナン誘導体および医薬用途
KR100341950B1 (ko) *	1993-07-19	2002-11-29	도레이 가부시끼가이샤	뇌세포보호제
NZ268969A (en) *	1993-07-23	1997-06-24	Toray Industries	Morphinan derivatives and pharmaceutical compositions
HUP9900974A3 (en)	1996-01-10	2000-09-28	Smithkline Beecham Spa	Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
CN1535687A (zh) *	1996-11-25	2004-10-13	��ʽ��	止痒药物
WO1999005146A1 (fr) *	1997-07-25	1999-02-04	Toray Industries, Inc.	Remedes contre l'hyponatremie
US7501433B2 (en)	2002-05-17	2009-03-10	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
WO2003097608A2 (fr)	2002-05-17	2003-11-27	Jenken Biosciences, Inc.	Composes opioides et de type opioide et leurs utilisations
US7923454B2 (en)	2002-05-17	2011-04-12	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
JP4957489B2 (ja) *	2002-10-09	2012-06-20	東レ株式会社	含窒素環状置換基を有するモルヒナン誘導体またはその薬理学的に許容される酸付加塩を含有する医薬
US8017622B2 (en)	2003-05-16	2011-09-13	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
JP2011512360A (ja) *	2008-02-14	2011-04-21	アルカーメス，インコーポレイテッド	選択的オピオイド化合物
ES2631197T3 (es) *	2012-12-14	2017-08-29	Purdue Pharma Lp	Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
EP2931726B1 (fr) *	2012-12-14	2017-01-25	Purdue Pharma LP	Morphinanes spirocycliques et leur utilisation
AR096851A1 (es) *	2013-07-11	2016-02-03	H Lundbeck As	Sales que no forman hidratos ni solvatos de nalmefeno
CA2951697A1 (fr) *	2014-06-13	2015-12-17	Purdue Pharma L.P.	Derives d'azamophinan et leur utilisation

1986
- 1986-05-09 HU HU861934A patent/HU196376B/hu not_active IP Right Cessation
- 1986-05-12 NL NL8601188A patent/NL8601188A/nl not_active Application Discontinuation
- 1986-05-19 PH PH33785A patent/PH23341A/en unknown
- 1986-05-19 GB GB8612159A patent/GB2175898B/en not_active Expired
- 1986-05-21 FI FI862124A patent/FI862124L/fi not_active Application Discontinuation
- 1986-05-21 BE BE1/011493A patent/BE904796A/fr not_active IP Right Cessation
- 1986-05-21 NZ NZ216250A patent/NZ216250A/en unknown
- 1986-05-21 GR GR861318A patent/GR861318B/el unknown
- 1986-05-21 IL IL78872A patent/IL78872A0/xx unknown
- 1986-05-21 SE SE8602308A patent/SE8602308L/xx not_active Application Discontinuation
- 1986-05-21 AU AU57637/86A patent/AU594954B2/en not_active Expired - Fee Related
- 1986-05-21 ES ES555200A patent/ES8802318A1/es not_active Expired
- 1986-05-22 LU LU86435A patent/LU86435A1/fr unknown
- 1986-05-22 DK DK240386A patent/DK240386A/da not_active Application Discontinuation
- 1986-05-22 JP JP61118984A patent/JPS61271275A/ja active Pending
- 1986-05-23 ZA ZA863873A patent/ZA863873B/xx unknown
- 1986-05-23 IT IT48050/86A patent/IT1203791B/it active
- 1986-05-23 FR FR8607367A patent/FR2582309B1/fr not_active Expired

Also Published As

Publication number	Publication date
FI862124A7 (fi)	1986-11-24
NZ216250A (en)	1990-04-26
HUT41737A (en)	1987-05-28
GB2175898A (en)	1986-12-10
GB2175898B (en)	1989-07-05
FI862124L (fi)	1986-11-24
FI862124A0 (fi)	1986-05-21
NL8601188A (nl)	1986-12-16
AU5763786A (en)	1986-11-27
SE8602308L (sv)	1986-11-24
GB8612159D0 (en)	1986-06-25
DK240386D0 (da)	1986-05-22
BE904796A (fr)	1986-11-21
GR861318B (en)	1986-09-19
AU594954B2 (en)	1990-03-22
IT1203791B (it)	1989-02-23
LU86435A1 (fr)	1986-12-05
FR2582309A1 (fr)	1986-11-28
PH23341A (en)	1989-07-14
IT8648050A0 (it)	1986-05-23
ZA863873B (en)	1988-01-27
SE8602308D0 (sv)	1986-05-21
FR2582309B1 (fr)	1989-08-18
DK240386A (da)	1986-11-24
IL78872A0 (en)	1986-09-30
ES555200A0 (es)	1988-05-01
JPS61271275A (ja)	1986-12-01
HU196376B (en)	1988-11-28

Publication	Publication Date	Title
ES8801239A1 (es)	1987-12-16	Un procedimiento para la preparacion de derivados de naftaleno
RO75258A (fr)	1980-11-30	Procede pour la preparation des derives de imidazole
NL187808C (nl)	1992-01-16	Benzimidazoolderivaten met anthelmintische werking, preparaten die deze bevatten, alsmede werkwijze voor het bereiden daarvan.
ES8708235A1 (es)	1987-10-01	Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida
IT7825850A0 (it)	1978-07-18	Processo per la preparazione di polivinilbutirrale con proprieta'migliorate.
IT7848628A0 (it)	1978-03-28	Procedimento per la produzione di derivati benzimidazolici
IT1124740B (it)	1986-05-14	Composti pirimidonici utili come antagonisti di istamina h2 e procedimento per prepararli
RO72349A (fr)	1981-08-30	Procede pour la preparation des derives d'imidazole a action pharmacologique
IT1216772B (it)	1990-03-14	Derivati di indolo ,procedimento per prepararli e composizioni farmaceutiche che li contengono per il trattamento di emicrania
CS189713B2 (en)	1979-04-30	Method of preparing novel pharmaceutically active benzimidazole derivatives
MX3866E (es)	1981-08-26	Metodo mejorado para preparar derivados de imidazoles n-alquil sustituidos
IL54480A (en)	1982-04-30	Benzimidazole derivatives,their preparation and anthelmintic compositions containing them
ES406966A1 (es)	1975-09-16	Procedimiento para preparar derivados de sulfamatos de pi- rimidinas.
FR1309877A (fr)	1962-11-23	Procédé de préparation du méthyl chloroforme
IL50892A (en)	1981-02-27	2-(5-tetrazolyl-or 5-tetrazolylalkyl)imidazoles and benzimidazoles, process for their preparation and pharmaceutical compositions containing them
IT1111058B (it)	1986-01-13	Procedimento per la preparazione di derivati di piperidina in particolare moranolina
RO69406A (fr)	1982-09-09	Procede pour la preparation des derives de 1,2,4-oxadiazin-5-one
SE7602542L (sv)	1976-09-15	3-(alfa-iminobensyl)-4-hydroxi-2(lh)-pyridoner
CH610016A5 (en)	1979-03-30	Retaining device for small parts to be treated by electroplating
IT1060328B (it)	1982-07-10	Struttura circuitale per la traduzione di testi di programma in sequenze di istrizioni eseguibili dall macchina
JPS5257183A (en)	1977-05-11	Process for preparing novel benzomorphan derivatives
ES387500A1 (es)	1973-05-01	Procedimiento para la obtencion de derivados de la dehidro-3, 4 isoquinoleina.
YU203376A (en)	1982-10-31	Process for obtaining pharmacologically useful benzimidazole compounds
FR1332528A (fr)	1963-07-19	Procédé de coupe de col et revers de vêtements
JPS5253595A (en)	1977-04-30	Apparatus for polishing rod-like articles