BE904830A - Nouvelle composition d'activateur tissulaire du plasminogene. - Google Patents

Nouvelle composition d'activateur tissulaire du plasminogene.

Info

Publication number
BE904830A
BE904830A BE0/216711A BE216711A BE904830A BE 904830 A BE904830 A BE 904830A BE 0/216711 A BE0/216711 A BE 0/216711A BE 216711 A BE216711 A BE 216711A BE 904830 A BE904830 A BE 904830A
Authority
BE
Belgium
Prior art keywords
amino acid
new composition
tissue activator
acid sequence
plasminogen tissue
Prior art date
Application number
BE0/216711A
Other languages
English (en)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of BE904830A publication Critical patent/BE904830A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Composition pharmaceutique lyophilisée d'activateur tissulaire du plasminogène, et procédé pour la préparer par dessiccation sous vide d'une solution aqueuse congelée d'un pH de 2 à 5 contenant du t-PA mono- ou bicaténaire qui a la séquence des aminoacides indiquée à la Fig. 1 ou a la meme séquence des amino-acides, mais dans laquelle, notamment, l'aminoacide à la position 245 à partir de l'extrémité N-terminale de la sérine est la valine au lieu de la méthionine. La composition est antithrombotique.
BE0/216711A 1985-05-28 1986-05-27 Nouvelle composition d'activateur tissulaire du plasminogene. BE904830A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (1)

Publication Number Publication Date
BE904830A true BE904830A (fr) 1986-11-27

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216711A BE904830A (fr) 1985-05-28 1986-05-27 Nouvelle composition d'activateur tissulaire du plasminogene.

Country Status (22)

Country Link
US (2) US4929444A (fr)
JP (1) JPH0759517B2 (fr)
AU (1) AU567236B2 (fr)
BE (1) BE904830A (fr)
CA (1) CA1300008C (fr)
CH (1) CH665356A5 (fr)
DE (1) DE3617752A1 (fr)
DK (1) DK163173C (fr)
ES (2) ES8800601A1 (fr)
FI (1) FI85335C (fr)
FR (1) FR2583984B1 (fr)
GB (1) GB2176702B (fr)
GR (1) GR861366B (fr)
HU (1) HU195733B (fr)
IL (1) IL78938A (fr)
IT (1) IT1191926B (fr)
LU (1) LU86444A1 (fr)
NL (1) NL8601355A (fr)
NO (1) NO171345C (fr)
NZ (1) NZ216307A (fr)
PT (1) PT82646B (fr)
SE (1) SE462016B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU569429B2 (en) * 1985-05-28 1988-01-28 Wellcome Foundation Limited, The Aqueous acidic tissue plasminogen activator parenternal formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
BE1001425A4 (fr) * 1986-05-12 1989-10-31 Wellcome Found Utilisation de l'activateur tissulaire du plasminogene, son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association.
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (fr) * 1991-01-14 1992-07-23 Duke University SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
CN1202932A (zh) * 1995-10-23 1998-12-23 儿童医学中心公司 治疗用抗血管生成的组合物和方法
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DK0869970T3 (da) * 1995-12-13 2004-07-05 Abbott Lab Endothelcelleprolifereringsinhibitor og dens anvendelse
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
CA2528577C (fr) * 2003-06-20 2012-08-07 Illumina, Inc. Methodes et compositions utiles pour l'amplification et le genotypage du genome tout entier
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
CA2605631A1 (fr) * 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Procedes, compositions et articles manufactures permettant d'ameliorer la capacite de survie de cellules, de tissus, d'organes et d'organismes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (fr) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
NL191755C (nl) * 1982-10-29 1996-07-02 Mitsui Toatsu Chemicals Plasminogeenactivator en trombolytisch middel.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (fr) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha Solution aqueuse d'un activateur tissulaire du plasminogène dissous à une concentration élevée et un procédé d'obtention
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (fr) * 1985-02-09 1987-10-07 Beecham Group Plc Enzyme modifié et son procédé de préparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
GB2176702A (en) 1987-01-07
DK163173C (da) 1992-06-22
FR2583984A1 (fr) 1987-01-02
ES555353A0 (es) 1987-11-16
NO171345C (no) 1993-03-03
FI862227A0 (fi) 1986-05-27
JPH0759517B2 (ja) 1995-06-28
AU5796486A (en) 1986-12-04
SE462016B (sv) 1990-04-30
IL78938A0 (en) 1986-09-30
ES8802439A1 (es) 1988-06-01
NO171345B (no) 1992-11-23
IT8648065A0 (it) 1986-05-27
US4929444A (en) 1990-05-29
PT82646A (en) 1986-06-01
PT82646B (pt) 1989-01-30
CH665356A5 (de) 1988-05-13
GR861366B (en) 1986-09-29
FI85335B (fi) 1991-12-31
DK163173B (da) 1992-02-03
IT1191926B (it) 1988-03-31
SE8602405D0 (sv) 1986-05-27
NL8601355A (nl) 1986-12-16
ES8800601A1 (es) 1987-11-16
DE3617752A1 (de) 1986-12-04
DK246786A (da) 1986-11-29
DE3617752C2 (fr) 1988-06-30
IL78938A (en) 1993-02-21
FI85335C (fi) 1992-04-10
HUT41638A (en) 1987-05-28
HU195733B (en) 1988-07-28
GB2176702B (en) 1989-07-05
GB8612780D0 (en) 1986-07-02
JPH06183995A (ja) 1994-07-05
US4968617A (en) 1990-11-06
CA1300008C (fr) 1992-05-05
LU86444A1 (fr) 1986-12-05
NO862096L (no) 1986-12-01
SE8602405L (sv) 1986-11-29
DK246786D0 (da) 1986-05-27
FR2583984B1 (fr) 1989-06-02
FI862227L (fi) 1986-11-29
AU567236B2 (en) 1987-11-12
NZ216307A (en) 1989-10-27
ES557374A0 (es) 1988-06-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE WELLCOME FOUNDATION LTD

Effective date: 19950531