BG102510A - Инхибитори на металпротеиназа, фармацевтични състави, които ги съдържат, и фармацевтичното им приложение и методи и междинни съединения, използвани иза тяхното получаване - Google Patents

Инхибитори на металпротеиназа, фармацевтични състави, които ги съдържат, и фармацевтичното им приложение и методи и междинни съединения, използвани иза тяхното получаване

Info

Publication number
BG102510A
BG102510A BG102510A BG10251098A BG102510A BG 102510 A BG102510 A BG 102510A BG 102510 A BG102510 A BG 102510A BG 10251098 A BG10251098 A BG 10251098A BG 102510 A BG102510 A BG 102510A
Authority
BG
Bulgaria
Prior art keywords
forms
preparation
pharmaceutical
solvates
intermediate compounds
Prior art date
Application number
BG102510A
Other languages
English (en)
Other versions
BG64279B1 (bg
Inventor
Scott ZOOK
JR. Raymond DAGNINO
Michael Deason
Steven Bender
Original Assignee
Agouron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals, Inc. filed Critical Agouron Pharmaceuticals, Inc.
Publication of BG102510A publication Critical patent/BG102510A/bg
Publication of BG64279B1 publication Critical patent/BG64279B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретението се отнася до съединения с формула, в която Z e 0 или S, V е двувалентен радикал, който заедно с C* и N образува пръстен, съдържащ 6 пръстенни атома, като всеки от тези атоми, различен от C* и N, независимо един от друг е незаместен илизаместен с подходящ заместител и поне един от тези други пръстенни атоми е хетероатом, избран от O,N и S, а останалите са въглеродни атоми, Ar е арилна или хетероарилна група. Изобретението се отнася също до фармацевтично приемливи пролекарствени средства, соли и солвати на тези съединения, както и до метод за инхибиране активността на металопротеиназите чрез прилагане на посочените съединения или техните пролекарствени средства, или соли, или солвати. Изобретението се отнася и до фармацевтични състави, съдържащи ефективно количество от съединенията, пролекарствените средства, солите или солватите, както и до методите и междинните съединения за получаването им.
BG102510A 1995-12-08 1998-06-05 Инхиби'ори на м...'алпро'...иназа, "арма-...в'и-ни 'ъ''ави, кои'о ги 'ъдържа', "арма-...в'и-но'о им прилож...ни... и м...'оди и м...ждинни 'ъ...дин...ния, използвани за 'яхно'о пол"-аван... BG64279B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56976695A 1995-12-08 1995-12-08
PCT/US1996/019328 WO1997020824A1 (en) 1995-12-08 1996-12-05 Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation

Publications (2)

Publication Number Publication Date
BG102510A true BG102510A (bg) 1999-08-31
BG64279B1 BG64279B1 (bg) 2004-08-31

Family

ID=24276764

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102510A BG64279B1 (bg) 1995-12-08 1998-06-05 Инхиби'ори на м...'алпро'...иназа, "арма-...в'и-ни 'ъ''ави, кои'о ги 'ъдържа', "арма-...в'и-но'о им прилож...ни... и м...'оди и м...ждинни 'ъ...дин...ния, използвани за 'яхно'о пол"-аван...

Country Status (39)

Country Link
US (1) US6153757A (bg)
EP (2) EP0874830B1 (bg)
JP (1) JP2000502330A (bg)
KR (1) KR19990072009A (bg)
CN (2) CN1542002A (bg)
AP (2) AP1288A (bg)
AT (2) ATE234291T1 (bg)
AU (1) AU725831C (bg)
BG (1) BG64279B1 (bg)
BR (1) BR9611929A (bg)
CA (1) CA2238306A1 (bg)
CO (1) CO4790150A1 (bg)
CZ (1) CZ292942B6 (bg)
DE (2) DE69626684T2 (bg)
DK (1) DK0874830T3 (bg)
EA (1) EA003294B1 (bg)
ES (2) ES2233275T3 (bg)
GE (1) GEP20012388B (bg)
GT (2) GT199700015A (bg)
HR (1) HRP970031A2 (bg)
HU (1) HUP9902092A3 (bg)
ID (1) ID17624A (bg)
IL (6) IL134816A (bg)
MX (1) MX9804457A (bg)
MY (1) MY117290A (bg)
NO (1) NO311360B1 (bg)
NZ (1) NZ325559A (bg)
OA (1) OA10794A (bg)
PA (1) PA8431301A1 (bg)
PE (1) PE69298A1 (bg)
PL (1) PL327275A1 (bg)
PT (1) PT874830E (bg)
SI (1) SI0874830T1 (bg)
SK (1) SK73898A3 (bg)
SV (1) SV1997000008A (bg)
TR (1) TR199800990T2 (bg)
TW (1) TW546293B (bg)
WO (1) WO1997020824A1 (bg)
YU (1) YU21597A (bg)

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