BG103112A - Substituted triazolo-pyuridazin derivatives as ligands for gaba receptors - Google Patents

Substituted triazolo-pyuridazin derivatives as ligands for gaba receptors

Info

Publication number: BG103112A
Authority: BG; Bulgaria
Prior art keywords: ligands; derivatives; pyuridazin; substituted; gaba receptors
Prior art date: 1996-07-25

Application number

BG103112A

Other languages

Bulgarian (bg)

English (en)

Inventor

Howard BROUGHTON

William Carling

Pineiro Jose Luis Castro

Alexander GUIBLIN

Andrew Madin

Kevin Moore

Michael Russell

Leslie STREET

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1999-01-25

Publication date

1999-09-30

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1999-01-25 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

1999-09-30 Publication of BG103112A publication Critical patent/BG103112A/xx

Links

239000003446 ligand Substances 0.000 title abstract 2
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
206010010904 Convulsion Diseases 0.000 abstract 1
102000027484 GABAA receptors Human genes 0.000 abstract 1
108091008681 GABAA receptors Proteins 0.000 abstract 1
YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical class C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BG103112A 1996-07-25 1999-01-25 Substituted triazolo-pyuridazin derivatives as ligands for gaba receptors BG103112A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
BG103112A true BG103112A (en)	1999-09-30

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103112A BG103112A (en)	1996-07-25	1999-01-25	Substituted triazolo-pyuridazin derivatives as ligands for gaba receptors

Country Status (24)

Country	Link
US (1)	US6255305B1 (de)
EP (1)	EP0915875B1 (de)
JP (1)	JP4216905B2 (de)
KR (1)	KR20000029548A (de)
CN (1)	CN1251589A (de)
AT (1)	ATE236904T1 (de)
AU (1)	AU723098B2 (de)
BG (1)	BG103112A (de)
BR (1)	BR9710729A (de)
CZ (1)	CZ18199A3 (de)
DE (1)	DE69720732T2 (de)
EA (1)	EA002436B1 (de)
EE (1)	EE9900027A (de)
ES (1)	ES2194205T3 (de)
HU (1)	HUP0600527A2 (de)
IL (1)	IL127911A0 (de)
IS (1)	IS4949A (de)
NO (1)	NO990304L (de)
NZ (1)	NZ333768A (de)
PL (1)	PL331072A1 (de)
SK (1)	SK9399A3 (de)
TR (1)	TR199900047T2 (de)
WO (1)	WO1998004559A2 (de)
YU (1)	YU2899A (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998050385A1 (en) *	1997-05-08	1998-11-12	Merck Sharp & Dohme Limited	SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en) *	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
WO1999025353A1 (en) *	1997-11-13	1999-05-27	Merck Sharp & Dohme Limited	Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) *	1998-01-14	2002-05-02	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
MXPA00007135A (es) *	1998-01-21	2002-11-07	Merck Sharp & Dohme	Derivados de triazolo-piridazina como ligandos para receptores gaba.
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
US6479506B1 (en)	1998-06-16	2002-11-12	Merck Sharp & Dohme Ltd.	Triazolo-pyridine derivatives as ligands for GABA receptors
GB9813576D0 (en)	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
AU6003099A (en) *	1998-10-06	2000-04-26	Takeda Chemical Industries Ltd.	Fused pyridazine compounds, process for the preparation of the same and uses thereof
DE69936998T2 (de)	1998-10-16	2008-05-21	Merck Sharp & Dohme Ltd., Hoddesdon	Pyrazolotriazinderivate als gaba-rezeptorliganden
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
JP2002535407A (ja) *	1999-01-27	2002-10-22	メルクシャープエンドドームリミテッド	Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) *	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en) *	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en)	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en)	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
GB0108475D0 (en) *	2001-04-04	2001-05-23	Merck Sharp & Dohme	New compounds
US6960584B2 (en)	2001-04-10	2005-11-01	Merck & Co., Inc.	Inhibitors of Akt activity
JP2004527531A (ja) *	2001-04-10	2004-09-09	メルク　エンド　カムパニー　インコーポレーテッド	癌を治療する方法
WO2002083139A1 (en)	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
WO2002083140A1 (en)	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
GB0122696D0 (en)	2001-09-20	2001-11-14	Merck Sharp & Dohme	Therapeutic agents
GB0128499D0 (en) *	2001-11-28	2002-01-23	Merck Sharp & Dohme	Therapeutic agents
AU2003226301A1 (en) *	2002-04-08	2003-10-20	Merck And Co., Inc.	Method of treating cancer
CA2495285A1 (en) *	2002-08-13	2004-02-19	Merck Sharp & Dohme Limited	Phenylpyridazine derivatives as ligands for gaba receptors
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
AU2003297161B8 (en)	2002-12-18	2011-03-31	Vertex Pharmaceuticals Incorporated	Triazolopyridazines as protein kinases inhibitors
PT1697371E (pt)	2003-12-19	2007-08-03	Bristol Myers Squibb Co	Heterocíclos azabicíclicos como moduladores do receptor de canabinóides
WO2006024640A2 (en) *	2004-09-02	2006-03-09	Altana Pharma Ag	Triazolophthalazines
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
MX2007008137A (es)	2005-01-05	2007-07-19	Altana Pharma Ag	Triazoloftalazinas como inhibidores de pde2.
JP5130053B2 (ja)	2005-01-05	2013-01-30	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	トリアゾロフタラジン
US7572807B2 (en)	2005-06-09	2009-08-11	Bristol-Myers Squibb Company	Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2275096A3 (de)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenese durch modulation des Muscarinrezeptors
EP2258357A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese mit Acetylcholinesterasehemmer
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (de)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2021000A2 (de)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenese mittels angiotensin-modulation
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US7638541B2 (en)	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2008279447A1 (en) *	2007-07-19	2009-01-29	Metabolex, Inc.	N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
PL2288612T3 (pl) *	2008-04-04	2015-12-31	Gabather Ab	Modulatory receptora GABAA
HRP20140195T1 (hr) *	2008-08-29	2014-04-11	Concert Pharmaceuticals Inc.	Supstituirani derivati triazolopiridazina
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (de)	2009-06-23	2012-05-23	Concert Pharmaceuticals Inc.	Deuterium-modifizierte triazolpyridinderivate als gaba-rezeptormodulatoren
EP2483281B1 (de)	2009-10-01	2014-06-04	Cymabay Therapeutics, Inc.	Substituierte tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidinsalze
US8278460B2 (en)	2009-10-15	2012-10-02	Concert Pharmaceuticals, Inc.	Substituted benzimidazoles
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en)	2011-01-18	2012-07-26	Centro Nacional De Investigaciones Oncológicas (Cnio)	6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013004984A1 (en)	2011-07-07	2013-01-10	Centro Nacional De Investigaciones Oncologicas (Cnio)	Tricyclic compounds for use as kinase inhibitors
WO2013005041A1 (en)	2011-07-07	2013-01-10	Centro Nacional De Investigaciones Oncológicas (Cnio)	Tricyclic heterocyclic compounds as kinase inhibitors
WO2013005057A1 (en)	2011-07-07	2013-01-10	Centro Nacional De Investigaciones Oncológicas (Cnio)	New compounds
MX2015005375A (es) *	2012-11-07	2015-07-21	Hoffmann La Roche	Compuestos de triazolo.
BR112018015386A2 (pt) *	2016-01-27	2019-03-19	Universität Zürich	uso de moduladores de receptor gabaa para tratamento de prurido
CN107344938B (zh) *	2016-05-06	2022-05-06	上海赛默罗生物科技有限公司	吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
WO2018026890A1 (en)	2016-08-03	2018-02-08	Cymabay Therapeutics	Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
WO2019226820A1 (en)	2018-05-22	2019-11-28	Neurocycle Therapeutics, Inc.	Gabaa positive allosteric modulator compounds for treatment of itch and/ or dermatitis
CA3155618A1 (en) *	2019-10-23	2021-04-29	Jed Hubbs	Treatment of epileptic conditions with gabaa receptor modulators
US20250136617A1 (en) *	2022-02-07	2025-05-01	The Regents Of The University Of Colorado, A Body Corporate	Small molecules cxcr4 agonists, method of synthesis, and method of use
CN115433137B (zh) *	2022-04-15	2025-03-07	内蒙古京科医药科技有限公司	1-甲基-1，2，4-三氮唑-3-甲醇的制备方法
CN114591352B (zh) *	2022-05-11	2022-09-09	上海赛默罗生物科技有限公司	一种三唑并哒嗪类化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1080712A (en)	1976-09-22	1980-07-01	Jay D. Albright	Hypotensive agents
PH21834A (en)	1982-01-18	1988-03-17	Lepetit Spa	New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4487930A (en) *	1982-09-07	1984-12-11	The Dow Chemical Company	6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) *	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4578464A (en) *	1983-11-22	1986-03-25	Merrell Dow Pharmaceuticals Inc.	6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
FR2562071B1 (fr) *	1984-03-30	1986-12-19	Sanofi Sa	Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9321162D0 (en) *	1993-10-13	1993-12-01	Boots Co Plc	Therapeutic agents
GB9507348D0 (en) *	1995-04-08	1995-05-31	Knoll Ag	Therapeutic agents
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use

1997
- 1997-07-17 EP EP97931960A patent/EP0915875B1/de not_active Expired - Lifetime
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
PL331072A1 (en)	1999-06-21
DE69720732T2 (de)	2004-01-29
WO1998004559A2 (en)	1998-02-05
EE9900027A (et)	1999-08-16
US6255305B1 (en)	2001-07-03
ES2194205T3 (es)	2003-11-16
JP2002514169A (ja)	2002-05-14
DE69720732D1 (de)	2003-05-15
IS4949A (is)	1999-01-19
ATE236904T1 (de)	2003-04-15
EA199900164A1 (ru)	2000-04-24
SK9399A3 (en)	2000-04-10
TR199900047T2 (xx)	1999-03-22
AU723098B2 (en)	2000-08-17
NZ333768A (en)	2000-09-29
YU2899A (sh)	2000-03-21
BR9710729A (pt)	1999-08-17
KR20000029548A (ko)	2000-05-25
AU3553997A (en)	1998-02-20
JP4216905B2 (ja)	2009-01-28
EP0915875B1 (de)	2003-04-09
IL127911A0 (en)	1999-11-30
NO990304L (no)	1999-03-25
EP0915875A2 (de)	1999-05-19
CZ18199A3 (cs)	1999-06-16
HUP0600527A2 (en)	2006-11-28
CN1251589A (zh)	2000-04-26
EA002436B1 (ru)	2002-04-25
NO990304D0 (no)	1999-01-22

Publication	Publication Date	Title
NO990304L (no)	1999-03-25	Substituerte triazol-pyridazolderivater som ligander for GABA reseptorer
YU43800A (sh)	2002-12-10	Triazolo-piridazin derivati kao ligandi za gaba receptore
CA2359008A1 (en)	2000-08-03	Triazolo-pyridazine derivatives as ligands for gaba receptors
ZA9710098B (en)	1998-05-25	Halogenopyrimidines.
BG103310A (en)	2000-05-31	Benzonaphthyridins as bronchial therapeutical means
BG108166A (en)	2004-09-30	Imidazo-pyrimidine derivatives as liigands for gaba receptors
YU77800A (sh)	2003-10-31	Supstituisani derivat triazolo-piradizina, farmaceutske smeše koje se sa njim proizvode
DK0693070T3 (da)	2002-11-11	Pyrido[2,3-b][1,4]benzodiazepinoner som M2-receptorligand til behandling af neurologiske lidelser
DK0935598T3 (da)	2004-03-29	5-heteroatom-alkylsubstituerede 3-oxopyrido(1,2-a)benzimidazol-4-carboxamidderivater egnede til behandling af sygdomme i centralnervesystemet
EE200000391A (et)	2002-02-15	Triasiiniühendid kesknärvisüsteemihäirete raviks
DK0922048T3 (da)	2001-01-08	Fremgangsmåde til fremstilling af N-[(1-n-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]-indol-10-carboxami
PL355637A1 (en)	2004-05-04	Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition
ZA9710864B (en)	1998-06-23	Process for the purification of an aminoalcohol.
ZA9710317B (en)	1998-06-10	Process for the preparation of benzyl-ethers by use of phase transfer.
FR2676735B1 (fr)	1994-01-28	Procede de preparation de benzothiazepines par cyclisation avec des acides phosphoniques.
DK0593286T3 (da)	2000-03-27	Mellemprodukter til fremstilling af antifolatforbindelser og fremgangsmåder dertil
CA2260774A1 (en)	1998-02-05	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
IL119868A0 (en)	1997-03-18	Process for the preparation of 4,4'-oxybisphthalic dianhydride
AU4947197A (en)	1998-05-11	Tetrahydro-6h-pyrazino{1,2-b}isoquinoline 1,4-diones as apoprotein b-100 inhibitors
PE44299A1 (es)	1999-05-06	Derivados sustituidos de triazolo-piridacina como ligandos para receptores gaba
ZA9711432B (en)	1998-06-22	Compositions for the preparation of leather.
TW239116B (de)	1995-01-21
ATE321044T1 (de)	2006-04-15	C-6 ringsubstituierte pyrido(1,2- a)benzimidazolderivate zur behandlung von störungen des zentralen nervensystems
AU5170698A (en)	1998-06-03	Substituted tetrahydro-1,3,5-triazin-2{1h}-thiones as anti-atherosclerotic agents
IT240445Y1 (it)	2001-04-02	Struttura di impianto per il trattamento di acque reflue,di tipoanaerobico