BG103114A - Fluorine-containing, 1,4-disubstituted derivatives of piperidine - Google Patents
Fluorine-containing, 1,4-disubstituted derivatives of piperidineInfo
- Publication number
- BG103114A BG103114A BG103114A BG10311499A BG103114A BG 103114 A BG103114 A BG 103114A BG 103114 A BG103114 A BG 103114A BG 10311499 A BG10311499 A BG 10311499A BG 103114 A BG103114 A BG 103114A
- Authority
- BG
- Bulgaria
- Prior art keywords
- hydrogen atoms
- groups
- group
- arylalkenyl
- heteroarylalkyl
- Prior art date
Links
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 102000017925 CHRM3 Human genes 0.000 abstract 1
- 101150060249 CHRM3 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000002844 continuous effect Effects 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- DOTMOQHOJINYBL-UHFFFAOYSA-N molecular nitrogen;molecular oxygen Chemical compound N#N.O=O DOTMOQHOJINYBL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21943696 | 1996-08-01 | ||
| JP5397997 | 1997-02-21 | ||
| PCT/JP1997/002600 WO1998005641A1 (en) | 1996-08-01 | 1997-07-28 | Fluorinated 1,4-disubstituted piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103114A true BG103114A (en) | 1999-11-30 |
Family
ID=26394715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103114A BG103114A (en) | 1996-08-01 | 1999-01-25 | Fluorine-containing, 1,4-disubstituted derivatives of piperidine |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5948792A (de) |
| EP (1) | EP0930298B1 (de) |
| JP (1) | JP3063164B2 (de) |
| KR (1) | KR20000022214A (de) |
| CN (1) | CN1226888A (de) |
| AR (3) | AR008272A1 (de) |
| AT (1) | ATE229941T1 (de) |
| AU (1) | AU716050B2 (de) |
| BG (1) | BG103114A (de) |
| BR (1) | BR9711108A (de) |
| CA (1) | CA2261680C (de) |
| CO (1) | CO4960641A1 (de) |
| CZ (1) | CZ33199A3 (de) |
| DE (1) | DE69718026T2 (de) |
| EE (1) | EE9900038A (de) |
| ES (1) | ES2188961T3 (de) |
| HR (1) | HRP970426A2 (de) |
| HU (1) | HUP9902381A3 (de) |
| ID (1) | ID17259A (de) |
| IL (1) | IL127685A0 (de) |
| IS (1) | IS4960A (de) |
| NO (1) | NO990472L (de) |
| NZ (1) | NZ333842A (de) |
| PE (1) | PE92198A1 (de) |
| PL (1) | PL331431A1 (de) |
| SK (1) | SK12299A3 (de) |
| TR (2) | TR199900204T2 (de) |
| WO (1) | WO1998005641A1 (de) |
| YU (1) | YU1299A (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| WO2000061572A1 (en) * | 1999-04-08 | 2000-10-19 | Merck & Co., Inc. | Diastereoselective preparation of michael adducts |
| WO2000066579A1 (en) * | 1999-04-28 | 2000-11-09 | Banyu Pharmaceutical Co., Ltd. | Processes for the preparation of piperidylmethylpyridine derivatives |
| AU6686700A (en) * | 1999-08-23 | 2001-03-19 | H. Lundbeck A/S | Treatment of urinary incontinence |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| CA2392028C (en) * | 1999-12-07 | 2009-08-18 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
| JP4782342B2 (ja) * | 1999-12-17 | 2011-09-28 | サノフィ−アベンティス | フェノキシプロパノールアミン類、それらの製造方法およびそれらを含む医薬組成物 |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| CA2415468A1 (en) * | 2000-07-11 | 2003-01-10 | Yoshio Ogino | Ester derivatives |
| NZ526580A (en) | 2000-12-22 | 2005-04-29 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as M3 antagonists |
| WO2002053564A2 (en) | 2000-12-28 | 2002-07-11 | Almirall Prodesfarma Ag | Quinuclidine derivatives and their use as m3 antagonists |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
| EP1438035A2 (de) * | 2001-09-27 | 2004-07-21 | Pharmacia AB | Pharmazeutische zusammensetzungen zur behandlung von harnerkrankungen |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| DE60230683D1 (de) * | 2002-07-08 | 2009-02-12 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat |
| DE60226906D1 (de) | 2002-07-31 | 2008-07-10 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen |
| AU2002321711A1 (en) | 2002-08-09 | 2004-02-25 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist |
| US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
| WO2004018422A1 (en) | 2002-08-23 | 2004-03-04 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
| WO2004039374A1 (en) * | 2002-10-29 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Quaternary ammonium compounds as muscarinic receptor antagonists |
| TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| DE60227576D1 (de) | 2002-12-10 | 2008-08-21 | Ranbaxy Lab Ltd | 3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS |
| ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
| EP1583741A1 (de) | 2002-12-23 | 2005-10-12 | Ranbaxy Laboratories, Limited | 1-substituierte-3-pyrrolidin-derivate als muscarinrezeptor-antagonisten |
| AU2002347553A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| US7560479B2 (en) | 2003-04-10 | 2009-07-14 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| JP2006514978A (ja) | 2003-04-10 | 2006-05-18 | ランバクシー ラボラトリーズ リミテッド | ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体 |
| CA2522071A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| EP1644356A1 (de) | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituierte 4-amino-1-benzylpiperidinverbindungen |
| JP4851937B2 (ja) | 2003-11-21 | 2012-01-11 | セラヴァンス， インコーポレーテッド | β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物 |
| JP4707560B2 (ja) * | 2003-12-29 | 2011-06-22 | Ｍｓｄ株式会社 | 新規２−ヘテロアリール置換ベンズイミダゾール誘導体 |
| US20080319002A1 (en) * | 2004-06-16 | 2008-12-25 | Ranbaxy Laboratories Limited | Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists |
| WO2006018708A2 (en) * | 2004-08-19 | 2006-02-23 | Ranbaxy Laboratories Limited | Pyrrolidine derivatives as muscarinic receptor antagonists |
| WO2006032994A2 (en) * | 2004-09-24 | 2006-03-30 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| US20090105221A1 (en) * | 2004-09-29 | 2009-04-23 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| BRPI0517232A (pt) | 2004-11-02 | 2008-10-07 | Banyu Pharma Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, ativador da glicocinase, e, agentes terapêuticos e/ou profiláticos para diabetes e para obesidade |
| EP1828174A1 (de) * | 2004-11-19 | 2007-09-05 | Ranbaxy Laboratories Limited | Azabicyclische antagonisten des muskarinrezeptors |
| US20100035954A1 (en) * | 2004-12-15 | 2010-02-11 | Mohammad Salman | Acid addition salts of muscarinic receptor antagonists |
| US20080319043A1 (en) * | 2005-05-03 | 2008-12-25 | Mohammad Salman | 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists |
| AU2006295645B2 (en) * | 2005-09-30 | 2011-09-29 | Msd K.K. | 2-heteroaryl-substituted indole derivative |
| EP1934184A1 (de) * | 2005-10-05 | 2008-06-25 | Ranbaxy Laboratories, Ltd. | 3 -azabicyclooctanderivate als antagonisten des muscarinrezeptors |
| RU2008119323A (ru) | 2005-10-19 | 2009-11-27 | Рэнбакси Лабораториз Лимитед (In) | Фармацевтические композиции мускаринового рецептора |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
| JP5656288B2 (ja) | 2007-09-07 | 2015-01-21 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物 |
| DK2234600T3 (da) * | 2007-12-21 | 2014-09-08 | Hoffmann La Roche | Antistofformulering |
| CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
| GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| WO1995006635A1 (en) * | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
| JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
| AU700837B2 (en) * | 1995-04-28 | 1999-01-14 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
| CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
-
1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Ceased
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Ceased
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-28 EP EP97933037A patent/EP0930298B1/de not_active Expired - Lifetime
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 ID IDP972666A patent/ID17259A/id unknown
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
- 1997-08-01 CO CO97044382A patent/CO4960641A1/es unknown
-
1998
- 1998-08-25 AR ARP980104219A patent/AR017021A1/es unknown
- 1998-08-25 AR ARP980104218A patent/AR016877A2/es unknown
-
1999
- 1999-01-25 BG BG103114A patent/BG103114A/xx unknown
- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472L/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
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