BG104593A - Carboxyl substituted chroman derivatives useful as a beta 3 adrenoreceptor agonists - Google Patents

Carboxyl substituted chroman derivatives useful as a beta 3 adrenoreceptor agonists

Info

Publication number: BG104593A
Authority: BG; Bulgaria
Prior art keywords: beta; derivatives useful; chroman derivatives; carboxyl substituted; adrenoreceptor agonists
Prior art date: 1997-12-19

Application number

BG104593A

Other languages

Bulgarian (bg)

English (en)

Inventor

Richard CONNEL

Timothy LEASE

Jeremy Baryza

Original Assignee

Bayer Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

2000-07-11

Publication date

2001-09-28

2000-07-11 Application filed by Bayer Corporation filed Critical Bayer Corporation

2001-09-28 Publication of BG104593A publication Critical patent/BG104593A/xx

Links

125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title abstract 2
VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical class C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title abstract 2
239000000556 agonist Substances 0.000 title 1
102000016959 beta-3 Adrenergic Receptors Human genes 0.000 title 1
108010014502 beta-3 Adrenergic Receptors Proteins 0.000 title 1
230000001404 mediated effect Effects 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Peptides Or Proteins (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Detergent Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)

BG104593A 1997-12-19 2000-07-11 Carboxyl substituted chroman derivatives useful as a beta 3 adrenoreceptor agonists BG104593A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99462097A	1997-12-19	1997-12-19
PCT/US1998/026735 WO1999032476A1 (en)	1997-12-19	1998-12-16	Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

Publications (1)

Publication Number	Publication Date
BG104593A true BG104593A (en)	2001-09-28

Family

ID=25540853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104593A BG104593A (en)	1997-12-19	2000-07-11	Carboxyl substituted chroman derivatives useful as a beta 3 adrenoreceptor agonists

Country Status (24)

Country	Link
EP (1)	EP1040106B1 (id)
JP (1)	JP2001526282A (id)
KR (1)	KR20010033188A (id)
CN (1)	CN1284952A (id)
AT (1)	ATE222901T1 (id)
AU (1)	AU749097B2 (id)
BG (1)	BG104593A (id)
BR (1)	BR9814302A (id)
CA (1)	CA2316971A1 (id)
DE (1)	DE69807523T2 (id)
DK (1)	DK1040106T3 (id)
ES (1)	ES2183434T3 (id)
HU (1)	HUP0004565A3 (id)
ID (1)	ID26524A (id)
IL (1)	IL136689A0 (id)
NO (1)	NO20003083L (id)
NZ (1)	NZ505200A (id)
PL (1)	PL341229A1 (id)
PT (1)	PT1040106E (id)
RU (1)	RU2223269C2 (id)
SK (1)	SK9362000A3 (id)
TR (1)	TR200001927T2 (id)
UA (1)	UA62993C2 (id)
WO (1)	WO1999032476A1 (id)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR035605A1 (es)	2000-12-11	2004-06-16	Bayer Corp	Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) *	2001-04-23	2004-07-21	Bayer Corp	Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
WO2003033468A1 (en) *	2001-10-17	2003-04-24	Kaneka Corporation	PROCESS FOR PREPARATION OF (S)-α-HALOMETHYLPYRIDINE- METHANOL DERIVATIVES
MY147767A (en) *	2004-06-16	2013-01-31	Janssen Pharmaceutica Nv	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EP1856126A2 (en)	2005-02-17	2007-11-21	Wyeth a Corporation of the State of Delaware	Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
RU2392277C2 (ru) *	2005-12-28	2010-06-20	Асино Фарма Аг	Способ получения рацемического небиволола
US7560575B2 (en) *	2005-12-28	2009-07-14	Acino Pharma Ag	Process for preparation of racemic Nebivolol
EP1803716B1 (en) *	2005-12-28	2012-07-25	Acino Pharma AG	A process for preparation of racemic nebivolol
ES2534336B1 (es) *	2013-10-18	2016-01-28	Artax Biopharma Inc.	Derivados de cromeno como inhibidores de la interacción TCR-Nck
ES2534318B1 (es) *	2013-10-18	2016-01-28	Artax Biopharma Inc.	Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1337429C (en) *	1983-12-05	1995-10-24	Guy Rosalia Eugene Van Lommen	Derivatives of 2,2'-iminobisethanol
GB8801306D0 (en) *	1988-01-21	1988-02-17	Ici Plc	Chemical compounds
UA35545C2 (uk) *	1991-04-08	2001-04-16	Джон Вайс Енд Бразер Лімітед	Спосіб одержання похідних 4-оксохіноліну або хромону
US5451677A (en) *	1993-02-09	1995-09-19	Merck & Co., Inc.	Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
BR9406823A (pt) *	1993-06-14	1996-03-26	Pfizer	Aminas secundárias e agentes anti-diabéticos e antiobesidade
GB9405019D0 (en) *	1994-03-15	1994-04-27	Smithkline Beecham Plc	Novel compounds
US5561142A (en) *	1994-04-26	1996-10-01	Merck & Co., Inc.	Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (en) *	1996-04-09	1997-10-15	Pfizer Inc.	Heterocyclic Beta-3 Adrenergenic Agonists

1998
- 1998-12-16 ID IDW20001393A patent/ID26524A/id unknown
- 1998-12-16 DK DK98963240T patent/DK1040106T3/da active
- 1998-12-16 BR BR9814302-6A patent/BR9814302A/pt not_active IP Right Cessation
- 1998-12-16 IL IL13668998A patent/IL136689A0/xx unknown
- 1998-12-16 RU RU2000119110/04A patent/RU2223269C2/ru not_active IP Right Cessation
- 1998-12-16 EP EP98963240A patent/EP1040106B1/en not_active Expired - Lifetime
- 1998-12-16 AT AT98963240T patent/ATE222901T1/de not_active IP Right Cessation
- 1998-12-16 DE DE69807523T patent/DE69807523T2/de not_active Expired - Fee Related
- 1998-12-16 CN CN98813619A patent/CN1284952A/zh active Pending
- 1998-12-16 ES ES98963240T patent/ES2183434T3/es not_active Expired - Lifetime
- 1998-12-16 SK SK936-2000A patent/SK9362000A3/sk unknown
- 1998-12-16 JP JP2000525413A patent/JP2001526282A/ja not_active Withdrawn
- 1998-12-16 HU HU0004565A patent/HUP0004565A3/hu unknown
- 1998-12-16 PL PL98341229A patent/PL341229A1/xx not_active Application Discontinuation
- 1998-12-16 NZ NZ505200A patent/NZ505200A/xx unknown
- 1998-12-16 CA CA002316971A patent/CA2316971A1/en not_active Abandoned
- 1998-12-16 AU AU18300/99A patent/AU749097B2/en not_active Ceased
- 1998-12-16 PT PT98963240T patent/PT1040106E/pt unknown
- 1998-12-16 UA UA2000074336A patent/UA62993C2/uk unknown
- 1998-12-16 KR KR1020007006572A patent/KR20010033188A/ko not_active Ceased
- 1998-12-16 TR TR2000/01927T patent/TR200001927T2/xx unknown
- 1998-12-16 WO PCT/US1998/026735 patent/WO1999032476A1/en not_active Ceased
2000
- 2000-06-15 NO NO20003083A patent/NO20003083L/no not_active Application Discontinuation
- 2000-07-11 BG BG104593A patent/BG104593A/xx unknown

Also Published As

Publication number	Publication date
AU749097B2 (en)	2002-06-20
EP1040106A1 (en)	2000-10-04
NO20003083L (no)	2000-08-15
ES2183434T3 (es)	2003-03-16
PL341229A1 (en)	2001-03-26
HUP0004565A3 (en)	2002-12-28
DK1040106T3 (da)	2002-12-02
RU2223269C2 (ru)	2004-02-10
KR20010033188A (ko)	2001-04-25
TR200001927T2 (tr)	2001-06-21
CA2316971A1 (en)	1999-07-01
PT1040106E (pt)	2002-11-29
HUP0004565A2 (hu)	2001-08-28
IL136689A0 (en)	2001-06-14
EP1040106B1 (en)	2002-08-28
BR9814302A (pt)	2000-10-10
AU1830099A (en)	1999-07-12
DE69807523D1 (de)	2002-10-02
NZ505200A (en)	2002-09-27
ID26524A (id)	2001-01-11
WO1999032476A1 (en)	1999-07-01
JP2001526282A (ja)	2001-12-18
NO20003083D0 (no)	2000-06-15
UA62993C2 (en)	2004-01-15
SK9362000A3 (en)	2001-09-11
DE69807523T2 (de)	2003-01-09
CN1284952A (zh)	2001-02-21
ATE222901T1 (de)	2002-09-15

Publication	Publication Date	Title
BG104315A (en)	2000-12-29	Prostaglandine agonists and their application for the treatment of osteal diseases
BG103335A (en)	2000-04-28	Application of fumaric acid derivatives
EP0786995A4 (id)	1997-08-20
GB2209939B (en)	1992-01-02	The use of 13,14-dihydro-15-keto-prostaglandins as ocular hypotensive agents
AU2962295A (en)	1996-02-16	Cannabinoid receptor antagonists
BR9804437A (pt)	2001-05-02	Compostos para a osteoporose
NO940789D0 (no)	1994-03-07	Quinolinkarboksylsyrederivater, deres fremstilling og anvendelse
BG102726A (en)	1999-04-30	Combined therapy for osteoporosis
EP1334719A3 (en)	2003-09-24	Pentafluorobenzenesulfonamides and analogs
ES2189256T3 (es)	2003-07-01	Composiciones de mezclas de ester de cianoacrilato.
BG104593A (en)	2001-09-28	Carboxyl substituted chroman derivatives useful as a beta 3 adrenoreceptor agonists
AP9801269A0 (en)	1999-12-18	Prostaglandin agonists.
MX9804588A (es)	1998-09-30	Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
WO2002048134A3 (en)	2003-02-06	Di-substituted aminomethyl chroman derivative beta-3 adrenoreceptor agonists
ZA977310B (en)	1998-03-27	Transdermal propentofylline compositions for the treatment of Alzheimer's disease.
ES2156642T3 (es)	2001-07-01	Composicion que comprende un derivado de acido cinamico y un polimero poliaminado.
ATE402933T1 (de)	2008-08-15	Neue sulfonamid-substituierte chroman-derivate verwendbar als beta 3 adrenorezeptor agonisten
BR9913649A (pt)	2001-06-05	Rede anelar wdm
BG103649A (en)	2000-06-30	Method for the preparation of eprosartan
AU6808190A (en)	1991-06-27	4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
BG104427A (en)	2001-02-28	Use of ketolides for preparing arterial thrombotic complications related to atherosclerosis
BG103650A (en)	2000-06-30	Method for the preparation of eprosartan
AU2567097A (en)	1997-10-29	Novel vitamin d analogues
BG104373A (en)	2000-12-29	Polymorphous forms of dofetilide
FR2683455B1 (fr)	1994-02-11	Composition pour la stimulation de la synthese localisee des tissus conjonctifs.