SK9362000A3 - Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists - Google Patents

Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists Download PDF

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Publication number
SK9362000A3
SK9362000A3 SK936-2000A SK9362000A SK9362000A3 SK 9362000 A3 SK9362000 A3 SK 9362000A3 SK 9362000 A SK9362000 A SK 9362000A SK 9362000 A3 SK9362000 A3 SK 9362000A3
Authority
SK
Slovakia
Prior art keywords
compound
alkyl
group
mixture
hydroxy
Prior art date
Application number
SK936-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Richard D Connell
Timothy G Lease
Jeremy Baryza
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK9362000A3 publication Critical patent/SK9362000A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Detergent Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK936-2000A 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists SK9362000A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99462097A 1997-12-19 1997-12-19
PCT/US1998/026735 WO1999032476A1 (en) 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

Publications (1)

Publication Number Publication Date
SK9362000A3 true SK9362000A3 (en) 2001-09-11

Family

ID=25540853

Family Applications (1)

Application Number Title Priority Date Filing Date
SK936-2000A SK9362000A3 (en) 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists

Country Status (24)

Country Link
EP (1) EP1040106B1 (id)
JP (1) JP2001526282A (id)
KR (1) KR20010033188A (id)
CN (1) CN1284952A (id)
AT (1) ATE222901T1 (id)
AU (1) AU749097B2 (id)
BG (1) BG104593A (id)
BR (1) BR9814302A (id)
CA (1) CA2316971A1 (id)
DE (1) DE69807523T2 (id)
DK (1) DK1040106T3 (id)
ES (1) ES2183434T3 (id)
HU (1) HUP0004565A3 (id)
ID (1) ID26524A (id)
IL (1) IL136689A0 (id)
NO (1) NO20003083L (id)
NZ (1) NZ505200A (id)
PL (1) PL341229A1 (id)
PT (1) PT1040106E (id)
RU (1) RU2223269C2 (id)
SK (1) SK9362000A3 (id)
TR (1) TR200001927T2 (id)
UA (1) UA62993C2 (id)
WO (1) WO1999032476A1 (id)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035605A1 (es) * 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
WO2003033468A1 (en) * 2001-10-17 2003-04-24 Kaneka Corporation PROCESS FOR PREPARATION OF (S)-α-HALOMETHYLPYRIDINE- METHANOL DERIVATIVES
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2597616A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
UA35545C2 (uk) * 1991-04-08 2001-04-16 Джон Вайс Енд Бразер Лімітед Спосіб одержання похідних 4-оксохіноліну або хромону
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
CN1129443A (zh) * 1993-06-14 1996-08-21 美国辉瑞有限公司 仲胺用作治糖尿病和治肥胖病药物
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (en) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclic Beta-3 Adrenergenic Agonists

Also Published As

Publication number Publication date
NO20003083L (no) 2000-08-15
EP1040106A1 (en) 2000-10-04
KR20010033188A (ko) 2001-04-25
AU1830099A (en) 1999-07-12
DK1040106T3 (da) 2002-12-02
RU2223269C2 (ru) 2004-02-10
TR200001927T2 (tr) 2001-06-21
CN1284952A (zh) 2001-02-21
DE69807523T2 (de) 2003-01-09
BG104593A (en) 2001-09-28
WO1999032476A1 (en) 1999-07-01
UA62993C2 (en) 2004-01-15
AU749097B2 (en) 2002-06-20
IL136689A0 (en) 2001-06-14
EP1040106B1 (en) 2002-08-28
ES2183434T3 (es) 2003-03-16
DE69807523D1 (de) 2002-10-02
ID26524A (id) 2001-01-11
ATE222901T1 (de) 2002-09-15
PT1040106E (pt) 2002-11-29
PL341229A1 (en) 2001-03-26
HUP0004565A2 (hu) 2001-08-28
BR9814302A (pt) 2000-10-10
NO20003083D0 (no) 2000-06-15
JP2001526282A (ja) 2001-12-18
NZ505200A (en) 2002-09-27
CA2316971A1 (en) 1999-07-01
HUP0004565A3 (en) 2002-12-28

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