BG104670A - 4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists - Google Patents

4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists

Info

Publication number
BG104670A
BG104670A BG104670A BG10467000A BG104670A BG 104670 A BG104670 A BG 104670A BG 104670 A BG104670 A BG 104670A BG 10467000 A BG10467000 A BG 10467000A BG 104670 A BG104670 A BG 104670A
Authority
BG
Bulgaria
Prior art keywords
receptor agonists
piperidinne
orl1
benzimidazolinyl
keto
Prior art date
Application number
BG104670A
Other languages
Bulgarian (bg)
English (en)
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Yoriko Ohashi
Tatsuya YAMAGICHI
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of BG104670A publication Critical patent/BG104670A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
BG104670A 1998-01-19 2000-08-07 4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists BG104670A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19
PCT/IB1999/000012 WO1999036421A1 (en) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists

Publications (1)

Publication Number Publication Date
BG104670A true BG104670A (en) 2001-05-31

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104670A BG104670A (en) 1998-01-19 2000-08-07 4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists

Country Status (30)

Country Link
US (1) US6423725B1 (de)
EP (1) EP1049689B1 (de)
JP (1) JP3342478B2 (de)
CN (1) CN1288464A (de)
AP (1) AP9901442A0 (de)
AR (1) AR014421A1 (de)
AT (1) ATE219772T1 (de)
AU (1) AU1679099A (de)
BG (1) BG104670A (de)
BR (1) BR9907104A (de)
CA (1) CA2317462C (de)
CO (1) CO4990962A1 (de)
DE (1) DE69901934T2 (de)
DK (1) DK1049689T3 (de)
EA (1) EA200000683A1 (de)
ES (1) ES2175925T3 (de)
GT (1) GT199900008A (de)
IL (1) IL137149A0 (de)
IS (1) IS5539A (de)
MA (1) MA26598A1 (de)
NO (1) NO20003671L (de)
OA (1) OA11445A (de)
PA (1) PA8467101A1 (de)
PE (1) PE20000166A1 (de)
PL (1) PL342046A1 (de)
PT (1) PT1049689E (de)
TN (1) TNSN99006A1 (de)
TR (1) TR200002090T2 (de)
WO (1) WO1999036421A1 (de)
ZA (1) ZA99314B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
EP0997464B1 (de) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ES2223588T3 (es) 1999-10-13 2005-03-01 Banyu Pharmaceutical Co., Ltd. Derivados de imidazolidinona sustituidos.
JP2003524634A (ja) 1999-12-06 2003-08-19 ユーロ−セルティーク，エス．エイ． ノシセプチン受容体親和性を有するベンズイミダゾール化合物
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
HK1049799A1 (zh) 1999-12-06 2003-05-30 Euro-Celtique, S.A. 具有类鸦片受体亲和力的三级氨基化合物
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
US6969712B2 (en) 2000-11-15 2005-11-29 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
CN1516584A (zh) 2001-04-18 2004-07-28 ŷ�����ǹɷ����޹�˾ 螺吡唑化合物
ATE410165T1 (de) 2001-04-18 2008-10-15 Euro Celtique Sa Nociceptin-analoga
ATE403431T1 (de) 2001-04-18 2008-08-15 Euro Celtique Sa Benzimidazolon-verbindungen
EP2033644A1 (de) 2001-04-18 2009-03-11 Euro-Celtique S.A. Spiroinden- und Spiroindan-Verbindungen
RU2268883C2 (ru) 2001-04-18 2006-01-27 Эро-Селтик, С.А. Аналоги ноницептина и фармацевтическая композиция на их основе
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
ATE457299T1 (de) * 2002-11-12 2010-02-15 Gruenenthal Gmbh 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ
SA04250305B1 (ar) * 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
US20090111778A1 (en) * 2005-11-18 2009-04-30 Richard Apodaca 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
JP2009525269A (ja) 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
CA2666630C (en) * 2006-10-16 2012-01-24 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
EP2397477B1 (de) * 2007-01-16 2014-03-05 Purdue Pharma LP Heterocyclisch-substituierte Piperidinverbindungen und Verwendungen davon
CN101622241B (zh) 2007-03-01 2013-05-22 田边三菱制药株式会社 苯并咪唑化合物及其医药用途
WO2009027820A2 (en) 2007-08-31 2009-03-05 Purdue Pharma L.P. Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
JP2013532149A (ja) * 2010-06-17 2013-08-15 ノバルティス アーゲー ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
EP2976077A4 (de) 2013-03-22 2016-11-30 Scripps Research Inst Substituierte benzimidazole als nociceptin-rezeptormodulatoren
BR112019010719A2 (pt) * 2016-11-28 2019-10-01 Mitsubishi Tanabe Pharma Corp composição farmacêutica para tratar a dependência de cocaína ou prevenir a recaída da dependência de cocaína, métodos para tratar a dependência e para prevenir a recaída da dependência de cocaína de cocaína, uso de (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo, e, (r)-2-{3-[1-(5-metil-1,2,3,4-tetra-hidronaftalen-1-il)piperidina-4-il]-2,3-di-hidro-2-oxo-benzimidazol-1-il}-n-metilacetamida ou um sal farmaceuticamente aceitável do mesmo.
WO2019141803A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CN116496270B (zh) * 2022-01-27 2024-09-24 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途
AU2025206007A1 (en) * 2024-01-05 2026-04-16 Yichang Humanwell Pharmaceutical Co., Ltd. Cyclohexyl-substituted piperidine derivative, pharmaceutical composition comprising same, and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
AT388731B (de) 1987-12-15 1989-08-25 Gerot Pharmazeutika Neue derivate von benzimidazol, ihre herstellung und verwendung
AU7478396A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Muscarine agonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
DE69736776T2 (de) 1996-04-19 2007-01-18 Neurosearch A/S 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität
CA2291094C (en) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivative

Also Published As

Publication number Publication date
DE69901934T2 (de) 2002-11-07
AP9901442A0 (en) 1999-03-31
TNSN99006A1 (fr) 2005-11-10
OA11445A (en) 2004-04-30
MA26598A1 (fr) 2004-12-20
CA2317462C (en) 2005-09-13
DK1049689T3 (da) 2002-07-22
PL342046A1 (en) 2001-05-21
BR9907104A (pt) 2000-10-24
IL137149A0 (en) 2001-07-24
PE20000166A1 (es) 2000-03-07
ATE219772T1 (de) 2002-07-15
EP1049689B1 (de) 2002-06-26
NO20003671D0 (no) 2000-07-18
PA8467101A1 (es) 2000-09-29
EA200000683A1 (ru) 2000-12-25
JP3342478B2 (ja) 2002-11-11
CA2317462A1 (en) 1999-07-22
CN1288464A (zh) 2001-03-21
PT1049689E (pt) 2002-09-30
DE69901934D1 (de) 2002-08-01
ES2175925T3 (es) 2002-11-16
GT199900008A (es) 2000-07-12
ZA99314B (en) 2000-07-18
NO20003671L (no) 2000-09-18
WO1999036421A1 (en) 1999-07-22
TR200002090T2 (tr) 2000-11-21
CO4990962A1 (es) 2000-12-26
IS5539A (is) 2000-06-16
AR014421A1 (es) 2001-02-28
EP1049689A1 (de) 2000-11-08
AU1679099A (en) 1999-08-02
US6423725B1 (en) 2002-07-23
JP2002509148A (ja) 2002-03-26

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