BG104671A - Triazolo-pyridazine derivatives as ligands for gaba receptors - Google Patents
Triazolo-pyridazine derivatives as ligands for gaba receptorsInfo
- Publication number
- BG104671A BG104671A BG104671A BG10467100A BG104671A BG 104671 A BG104671 A BG 104671A BG 104671 A BG104671 A BG 104671A BG 10467100 A BG10467100 A BG 10467100A BG 104671 A BG104671 A BG 104671A
- Authority
- BG
- Bulgaria
- Prior art keywords
- triazolo
- ligands
- pyridazine derivatives
- gaba receptors
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801233.9A GB9801233D0 (en) | 1998-01-21 | 1998-01-21 | Therapeutic agents |
| GBGB9821517.1A GB9821517D0 (en) | 1998-10-02 | 1998-10-02 | Therapeutic agents |
| PCT/GB1999/000103 WO1999037644A1 (en) | 1998-01-21 | 1999-01-13 | Triazolo-pyridazine derivatives as ligands for gaba receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104671A true BG104671A (en) | 2001-05-31 |
Family
ID=26312988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104671A BG104671A (en) | 1998-01-21 | 2000-08-07 | Triazolo-pyridazine derivatives as ligands for gaba receptors |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6579875B1 (cs) |
| EP (1) | EP1049696A1 (cs) |
| JP (1) | JP2002501066A (cs) |
| KR (1) | KR20010034257A (cs) |
| CN (1) | CN1110498C (cs) |
| AU (1) | AU748737B2 (cs) |
| BG (1) | BG104671A (cs) |
| BR (1) | BR9906905A (cs) |
| CA (1) | CA2315763A1 (cs) |
| CZ (1) | CZ290883B6 (cs) |
| EA (1) | EA002755B1 (cs) |
| EE (1) | EE200000430A (cs) |
| GE (1) | GEP20032868B (cs) |
| HR (1) | HRP20000492A2 (cs) |
| HU (1) | HUP0100575A3 (cs) |
| IL (1) | IL136442A0 (cs) |
| IS (1) | IS5540A (cs) |
| MX (1) | MXPA00007135A (cs) |
| NO (1) | NO315516B1 (cs) |
| NZ (1) | NZ504870A (cs) |
| PL (1) | PL341652A1 (cs) |
| SK (1) | SK10922000A3 (cs) |
| WO (1) | WO1999037644A1 (cs) |
| YU (1) | YU43800A (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0100575A3 (en) * | 1998-01-21 | 2003-03-28 | Merck Sharp & Dohme Ltd Hoddes | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9929685D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| GB0017543D0 (en) * | 2000-07-17 | 2000-09-06 | Merck Sharp & Dohme | Therapeutic agents |
| JP4867350B2 (ja) * | 2003-12-19 | 2012-02-01 | 宇部興産株式会社 | ４−置換−４−シアノテトラヒドロピラン化合物の製法 |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| HRP20170103T1 (hr) * | 2005-12-21 | 2017-03-24 | Janssen Pharmaceutica N.V. | Triazolopiridazini kao modulatori tirozin kinaze |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2123619A1 (de) | 2008-05-20 | 2009-11-25 | Bayer Schering Pharma AG | Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung |
| CN104098578A (zh) * | 2008-08-29 | 2014-10-15 | 康瑟特制药公司 | 取代的三唑并哒嗪衍生物 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| JP2012531419A (ja) * | 2009-06-23 | 2012-12-10 | コンサート ファーマシューティカルズ インコーポレイテッド | Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体 |
| ES2642586T3 (es) | 2009-07-27 | 2017-11-16 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de canales iónicos |
| DK2621282T3 (da) | 2010-09-28 | 2020-05-04 | Univ California | Gaba-agonister i behandlingen af forstyrrelser forbundet med metabolisk syndrom og gaba-kombinationer i behandling eller profylakse af type i diabetes |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| NO3175985T3 (cs) | 2011-07-01 | 2018-04-28 | ||
| UY34171A (es) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CA3014442A1 (en) | 2016-02-29 | 2017-09-08 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
| AU2018304230A1 (en) | 2017-07-19 | 2020-02-06 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1080712A (en) | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
| US4230705A (en) * | 1976-09-22 | 1980-10-28 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
| US4112095A (en) | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
| PH12424A (en) * | 1976-10-26 | 1979-02-15 | American Cyanamid Co | Method of treating anxiety in mammals |
| US4260755A (en) | 1979-10-31 | 1981-04-07 | American Cyanamid Company | Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines |
| US4260756A (en) | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
| PH21834A (en) * | 1982-01-18 | 1988-03-17 | Lepetit Spa | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives |
| IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
| KR20000029548A (ko) | 1996-07-25 | 2000-05-25 | 더블유. 지. 콜 | 가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체 |
| HUP0100575A3 (en) | 1998-01-21 | 2003-03-28 | Merck Sharp & Dohme Ltd Hoddes | Triazolo-pyridazine derivatives as ligands for gaba receptors |
-
1999
- 1999-01-13 HU HU0100575A patent/HUP0100575A3/hu unknown
- 1999-01-13 HR HR20000492A patent/HRP20000492A2/hr not_active Application Discontinuation
- 1999-01-13 AU AU20657/99A patent/AU748737B2/en not_active Ceased
- 1999-01-13 CZ CZ20002691A patent/CZ290883B6/cs not_active IP Right Cessation
- 1999-01-13 WO PCT/GB1999/000103 patent/WO1999037644A1/en not_active Ceased
- 1999-01-13 BR BR9906905-9A patent/BR9906905A/pt not_active IP Right Cessation
- 1999-01-13 NZ NZ504870A patent/NZ504870A/xx unknown
- 1999-01-13 KR KR1020007007937A patent/KR20010034257A/ko not_active Withdrawn
- 1999-01-13 US US09/582,589 patent/US6579875B1/en not_active Expired - Fee Related
- 1999-01-13 EP EP99901025A patent/EP1049696A1/en not_active Withdrawn
- 1999-01-13 CA CA002315763A patent/CA2315763A1/en not_active Abandoned
- 1999-01-13 EA EA200000783A patent/EA002755B1/ru not_active IP Right Cessation
- 1999-01-13 IL IL13644299A patent/IL136442A0/xx unknown
- 1999-01-13 SK SK1092-2000A patent/SK10922000A3/sk unknown
- 1999-01-13 MX MXPA00007135A patent/MXPA00007135A/es unknown
- 1999-01-13 YU YU43800A patent/YU43800A/sh unknown
- 1999-01-13 EE EEP200000430A patent/EE200000430A/xx unknown
- 1999-01-13 CN CN99802249A patent/CN1110498C/zh not_active Expired - Fee Related
- 1999-01-13 GE GEAP19995511A patent/GEP20032868B/en unknown
- 1999-01-13 JP JP2000528565A patent/JP2002501066A/ja not_active Withdrawn
- 1999-01-13 PL PL99341652A patent/PL341652A1/xx not_active Application Discontinuation
-
2000
- 2000-06-16 IS IS5540A patent/IS5540A/is unknown
- 2000-07-20 NO NO20003730A patent/NO315516B1/no not_active IP Right Cessation
- 2000-08-07 BG BG104671A patent/BG104671A/xx unknown
-
2003
- 2003-06-17 US US10/463,075 patent/US6828322B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20002691A3 (cs) | 2000-12-13 |
| NO20003730D0 (no) | 2000-07-20 |
| CN1110498C (zh) | 2003-06-04 |
| HRP20000492A2 (en) | 2000-12-31 |
| US6579875B1 (en) | 2003-06-17 |
| SK10922000A3 (sk) | 2001-03-12 |
| EE200000430A (et) | 2001-12-17 |
| PL341652A1 (en) | 2001-04-23 |
| BR9906905A (pt) | 2000-10-10 |
| CN1288465A (zh) | 2001-03-21 |
| EA200000783A1 (ru) | 2000-12-25 |
| AU2065799A (en) | 1999-08-09 |
| EA002755B1 (ru) | 2002-08-29 |
| EP1049696A1 (en) | 2000-11-08 |
| NZ504870A (en) | 2002-11-26 |
| WO1999037644A1 (en) | 1999-07-29 |
| YU43800A (sh) | 2002-12-10 |
| NO20003730L (no) | 2000-09-20 |
| JP2002501066A (ja) | 2002-01-15 |
| IL136442A0 (en) | 2001-06-14 |
| GEP20032868B (en) | 2003-01-27 |
| CZ290883B6 (cs) | 2002-11-13 |
| US6828322B2 (en) | 2004-12-07 |
| KR20010034257A (ko) | 2001-04-25 |
| AU748737B2 (en) | 2002-06-13 |
| HUP0100575A3 (en) | 2003-03-28 |
| IS5540A (is) | 2000-06-16 |
| MXPA00007135A (es) | 2002-11-07 |
| CA2315763A1 (en) | 1999-07-29 |
| NO315516B1 (no) | 2003-09-15 |
| US20040063714A1 (en) | 2004-04-01 |
| HUP0100575A2 (hu) | 2001-09-28 |
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