BG105332A - Трициклични делта 3-пиперидини, като алфа долу 2 -антагонисти - Google Patents

Трициклични делта 3-пиперидини, като алфа долу 2 -антагонисти

Info

Publication number
BG105332A
BG105332A BG105332A BG10533201A BG105332A BG 105332 A BG105332 A BG 105332A BG 105332 A BG105332 A BG 105332A BG 10533201 A BG10533201 A BG 10533201A BG 105332 A BG105332 A BG 105332A
Authority
BG
Bulgaria
Prior art keywords
alpha2
piperidines
antagonists
tricyclic
delta
Prior art date
Application number
BG105332A
Other languages
English (en)
Other versions
BG64872B1 (bg
Inventor
Ludo Kennis
Den Keybus Frans Maria Van
Josephus MERTENS
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG105332A publication Critical patent/BG105332A/bg
Publication of BG64872B1 publication Critical patent/BG64872B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретението се отнася до съединения с формула@@до техните N-оксидни форми, фармацевтично приемливи присъединителни соли и стереохимични изомерни форми. Във формулата Alk e С1-6-алкандиил; n има стойност 1 или 2; Х1 е -О-, -S-, -S(=О)- или -S(=О)2-; всеки R1 е независимо водород, халоген, С1-6-алкил, нитро, хидрокси или С1-4-алкилокси; D е евентуално заместен моно-, би- или трицикличен азот, съдържащ хетероцикъл, 2Н-бензопиранон, бензамид, бензофенон или феноксифенил. Посочените съединения проявяват централна алфа2-адреноцепторна антагонистична активност. Изобретението се отнася и до тяхнотополучаване, до фармацевтичната им употреба и до състави, които ги съдържат.
BG105332A 1998-10-06 2001-03-12 Трициклични делта 3-пиперидини, като алфа долу 2 -антагонисти BG64872B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203370 1998-10-06

Publications (2)

Publication Number Publication Date
BG105332A true BG105332A (bg) 2001-11-30
BG64872B1 BG64872B1 (bg) 2006-07-31

Family

ID=8234191

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105332A BG64872B1 (bg) 1998-10-06 2001-03-12 Трициклични делта 3-пиперидини, като алфа долу 2 -антагонисти

Country Status (30)

Country Link
US (1) US6495555B1 (bg)
EP (1) EP1119571B1 (bg)
JP (1) JP4590101B2 (bg)
KR (1) KR20010071843A (bg)
CN (1) CN1131230C (bg)
AR (1) AR024216A1 (bg)
AT (1) ATE232869T1 (bg)
AU (1) AU760502B2 (bg)
BG (1) BG64872B1 (bg)
BR (1) BR9913507A (bg)
CA (1) CA2345622C (bg)
CZ (1) CZ20011104A3 (bg)
DE (1) DE69905478T2 (bg)
DK (1) DK1119571T3 (bg)
EE (1) EE04770B1 (bg)
ES (1) ES2193751T3 (bg)
HU (1) HUP0104002A3 (bg)
ID (1) ID28032A (bg)
IL (1) IL142443A0 (bg)
NO (1) NO20011270L (bg)
NZ (1) NZ510115A (bg)
PL (1) PL347894A1 (bg)
PT (1) PT1119571E (bg)
RU (1) RU2230744C2 (bg)
SI (1) SI1119571T1 (bg)
SK (1) SK285585B6 (bg)
TR (1) TR200100952T2 (bg)
TW (1) TWI248441B (bg)
UA (1) UA69420C2 (bg)
WO (1) WO2000020421A2 (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID28451A (id) * 1998-10-06 2001-05-24 Janssen Pharmaceutica Nv Trisiklik piperidin-δ3 sebagai bahan farmasi
ATE521593T1 (de) * 2002-04-03 2011-09-15 Orion Corp Verwendung eines alfa2-adrenorezeptorantagonisten bei mit dem zns zusammenhängenden erkrankungen
WO2005100355A1 (ja) 2004-04-12 2005-10-27 Taisho Pharmaceutical Co., Ltd. 環状アミン化合物
WO2006006740A1 (ja) * 2004-07-14 2006-01-19 Japan Tobacco Inc. ３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤
MX2007000480A (es) * 2004-07-15 2007-03-29 Japan Tobacco Inc Compuesto de benzamida fusionado e inhibidor de actividad de receptor de vainilloide 1.
US7906508B2 (en) * 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
US8399465B2 (en) 2009-05-14 2013-03-19 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase
EP3083610A1 (de) 2013-12-19 2016-10-26 Bayer Pharma Aktiengesellschaft Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
KR20160098424A (ko) * 2013-12-19 2016-08-18 바이엘 파마 악티엔게젤샤프트 치환된 피페리디닐-테트라히드로퀴놀린
CR20160276A (es) * 2013-12-19 2016-10-20 Bayer Pharma AG "piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c"
CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU926914A1 (ru) * 1980-05-26 1992-04-23 Научно-исследовательский институт фармакологии АМН СССР Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
DE3522959A1 (de) * 1985-06-27 1987-01-08 Merck Patent Gmbh Indolderivate
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
US4971974A (en) * 1988-06-16 1990-11-20 Neurex Corporation Benzothiophenes as appetite suppressants
US5100891A (en) * 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
AU735764B2 (en) * 1996-12-06 2001-07-12 Abbott Laboratories Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic compounds
DE69829317T2 (de) 1997-12-25 2006-04-06 Meiji Seika Kaisha Ltd. Tetrahydrobenzindol-derivate
ID28451A (id) * 1998-10-06 2001-05-24 Janssen Pharmaceutica Nv Trisiklik piperidin-δ3 sebagai bahan farmasi

Also Published As

Publication number Publication date
DE69905478D1 (de) 2003-03-27
WO2000020421A2 (en) 2000-04-13
NO20011270D0 (no) 2001-03-13
ES2193751T3 (es) 2003-11-01
BG64872B1 (bg) 2006-07-31
TWI248441B (en) 2006-02-01
NO20011270L (no) 2001-03-13
JP4590101B2 (ja) 2010-12-01
UA69420C2 (uk) 2004-09-15
WO2000020421A3 (en) 2000-08-03
SK285585B6 (sk) 2007-04-05
PL347894A1 (en) 2002-04-22
SK4322001A3 (en) 2002-01-07
BR9913507A (pt) 2001-06-05
AU760502B2 (en) 2003-05-15
HUP0104002A2 (hu) 2002-03-28
KR20010071843A (ko) 2001-07-31
EP1119571B1 (en) 2003-02-19
CN1332744A (zh) 2002-01-23
DK1119571T3 (da) 2003-05-26
EE200100209A (et) 2002-06-17
CA2345622C (en) 2007-12-04
EE04770B1 (et) 2007-02-15
CZ20011104A3 (cs) 2001-12-12
HK1038010A1 (en) 2002-03-01
US6495555B1 (en) 2002-12-17
RU2230744C2 (ru) 2004-06-20
PT1119571E (pt) 2003-06-30
JP2002526545A (ja) 2002-08-20
AR024216A1 (es) 2002-09-25
SI1119571T1 (en) 2003-08-31
CN1131230C (zh) 2003-12-17
AU6334199A (en) 2000-04-26
TR200100952T2 (tr) 2001-10-22
NZ510115A (en) 2002-11-26
HUP0104002A3 (en) 2003-12-29
ID28032A (id) 2001-05-03
EP1119571A2 (en) 2001-08-01
ATE232869T1 (de) 2003-03-15
IL142443A0 (en) 2002-03-10
CA2345622A1 (en) 2000-04-13
DE69905478T2 (de) 2004-03-18

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