BG105693A - Метод за производство на l- фенилефринхидрохлорид - Google Patents

Метод за производство на l- фенилефринхидрохлорид

Info

Publication number
BG105693A
BG105693A BG105693A BG10569301A BG105693A BG 105693 A BG105693 A BG 105693A BG 105693 A BG105693 A BG 105693A BG 10569301 A BG10569301 A BG 10569301A BG 105693 A BG105693 A BG 105693A
Authority
BG
Bulgaria
Prior art keywords
phenylfenhydrochloride
manufacture
catalyst
dicyclohexylphosphino
diphenylphosphino
Prior art date
Application number
BG105693A
Other languages
English (en)
Other versions
BG64620B1 (bg
Inventor
Franz Klingler
Lienhard Wolter
Wolfgang Dietrich
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of BG105693A publication Critical patent/BG105693A/bg
Publication of BG64620B1 publication Critical patent/BG64620B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретението се отнася до подобрен метод за производство на L-фенилефринхидрохлорид 3 в промишлен мащаб при използване на асиметрично хидриране катоключов етап и на специална последователност от етапи, при които като катализатор се използва [Rh(COD)Cl]2, а като катализаторна система - един хирален фосфинов лиганд с две разклонения като (2R,4R) -4- (дициклохексилфосфино)-2- (дифенилфосфино-метил) -N-аминокарбонил-пиролидин.
BG105693A 1999-01-21 2001-07-10 Метод за производство на l- фенилефринхидрохлорид BG64620B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19902229A DE19902229C2 (de) 1999-01-21 1999-01-21 Verfahren zur Herstellung von L-Phenylephrinhydrochlorid

Publications (2)

Publication Number Publication Date
BG105693A true BG105693A (bg) 2002-03-29
BG64620B1 BG64620B1 (bg) 2005-09-30

Family

ID=7894915

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105693A BG64620B1 (bg) 1999-01-21 2001-07-10 Метод за производство на l- фенилефринхидрохлорид

Country Status (41)

Country Link
US (1) US6187956B1 (bg)
EP (1) EP1147075B1 (bg)
JP (1) JP4263367B2 (bg)
KR (1) KR100655104B1 (bg)
CN (1) CN100357255C (bg)
AR (1) AR031064A1 (bg)
AT (1) ATE249417T1 (bg)
AU (1) AU760405B2 (bg)
BG (1) BG64620B1 (bg)
BR (1) BR0007610B1 (bg)
CA (1) CA2355938C (bg)
CO (1) CO5150188A1 (bg)
CZ (1) CZ299660B6 (bg)
DE (2) DE19902229C2 (bg)
DK (1) DK1147075T3 (bg)
EE (1) EE04234B1 (bg)
EG (1) EG23819A (bg)
ES (1) ES2204512T3 (bg)
HK (1) HK1041873B (bg)
HR (1) HRP20010513B1 (bg)
HU (1) HU228925B1 (bg)
ID (1) ID30091A (bg)
IL (1) IL144454A (bg)
ME (1) ME00749B (bg)
MY (1) MY117204A (bg)
NO (1) NO327634B1 (bg)
NZ (1) NZ513628A (bg)
PE (1) PE20001417A1 (bg)
PL (1) PL197539B1 (bg)
PT (1) PT1147075E (bg)
RS (1) RS49892B (bg)
RU (1) RU2237655C2 (bg)
SA (1) SA00200921B1 (bg)
SI (1) SI1147075T1 (bg)
SK (1) SK285043B6 (bg)
TR (1) TR200102108T2 (bg)
TW (1) TW499409B (bg)
UA (1) UA64835C2 (bg)
UY (1) UY25984A1 (bg)
WO (1) WO2000043345A1 (bg)
ZA (1) ZA200105294B (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19938709C1 (de) * 1999-08-14 2001-01-18 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Adrenalin
EP1340743A4 (en) * 2000-11-09 2007-04-25 Mitsui Chemicals Inc OPTICALLY ACTIVE AMINO DERIVATIVE AND METHOD OF SYNTHESIS
JP3504254B2 (ja) * 2001-10-31 2004-03-08 関東化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
US7049469B2 (en) 2002-10-24 2006-05-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing (R)-salbutamol
DE10249576B3 (de) * 2002-10-24 2004-04-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von (R)-Salbutamol
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
DE102004033313A1 (de) * 2004-07-08 2006-01-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Enantiomeren 3-hydroxy-3-phenyl-propylaminen
DE102004034682A1 (de) * 2004-07-17 2006-02-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verkürztes Verfahren zur Herstellung von chiralem Lobelin
JP4834333B2 (ja) * 2005-06-27 2011-12-14 アルプス薬品工業株式会社 光学活性ベンジルアミン誘導体の製造方法
CN100448842C (zh) * 2006-06-02 2009-01-07 台州明翔化工有限公司 α-(N-甲基-N-苄胺基)-3-羟基苯乙酮盐酸盐合成方法
RU2419770C2 (ru) * 2006-07-28 2011-05-27 Майкро Моушн, Инк. Расходомер с тремя тензодатчиками
WO2008077560A1 (en) * 2006-12-22 2008-07-03 Lonza Ag Process for the preparation of optically active 2-amino-1-phenylethanols
WO2008095678A1 (en) * 2007-02-05 2008-08-14 Lonza Ag Process for the preparation of optically active 2-amino-1-phenylethanols
MX2009014055A (es) 2007-06-20 2010-04-27 Basf Se Metodo para producir alcoholes opticamente activos usando una dehidrogenasa azoarcus sp ebn1.
WO2009086283A1 (en) * 2007-12-21 2009-07-09 Cambrex Charles City, Inc. Synthesis of enantiomerically pure 2-hydroxy-2-aryl-ethylamines
CN102159719B (zh) * 2008-09-17 2015-03-11 巴斯夫欧洲公司 使用aromatoleum aromaticum ebn1(固氮弧菌属物种ebn1)的醇脱氢酶生产l-去氧肾上腺素的方法
CN102234237B (zh) * 2010-04-22 2014-03-26 赤峰艾克制药科技股份有限公司 L-苯福林盐酸盐的制备方法
CN102381990A (zh) * 2010-08-31 2012-03-21 凯瑞斯德生化(苏州)有限公司 一种光学活性的n-苄基新福林的制备方法
US8455692B2 (en) 2010-11-01 2013-06-04 Divi's Laboratories, Ltd. Process for resolution of 1-(3-hydroxyphenyl)-2-methylamino ethanol
CN103553942B (zh) * 2013-11-13 2015-11-18 武汉武药科技有限公司 一种盐酸去氧肾上腺素杂质的制备方法
CN113173859B (zh) * 2021-04-28 2022-08-19 温州大学 一种合成手性α-胺基醇化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1000293A (en) * 1972-03-16 1976-11-23 Arthur J. Solodar Asymmetric reduction of ketones to form optically active alcohols
US5767276A (en) * 1995-10-13 1998-06-16 The Penn State Research Foundation Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands
CA2258018A1 (en) * 1996-06-14 1997-12-18 The Penn State Research Foundation Asymmetric synthesis catalyzed by transition metal complexes with cyclic chiral phosphine ligands

Also Published As

Publication number Publication date
EP1147075A1 (de) 2001-10-24
AR031064A1 (es) 2003-09-10
CN100357255C (zh) 2007-12-26
EE200100383A (et) 2002-12-16
DE19902229A1 (de) 2000-08-03
SK285043B6 (sk) 2006-05-04
CZ299660B6 (cs) 2008-10-08
CZ20012655A3 (cs) 2001-11-14
BG64620B1 (bg) 2005-09-30
EP1147075B1 (de) 2003-09-10
CA2355938C (en) 2009-03-24
JP4263367B2 (ja) 2009-05-13
SA00200921B1 (ar) 2006-06-10
ATE249417T1 (de) 2003-09-15
DE19902229C2 (de) 2000-11-02
DK1147075T3 (da) 2003-12-08
CN1336909A (zh) 2002-02-20
NO20013569D0 (no) 2001-07-19
SI1147075T1 (sl) 2004-02-29
ES2204512T3 (es) 2004-05-01
UA64835C2 (uk) 2004-03-15
PT1147075E (pt) 2004-01-30
NZ513628A (en) 2001-09-28
RS49892B (sr) 2008-08-07
PL197539B1 (pl) 2008-04-30
IL144454A (en) 2004-06-01
MY117204A (en) 2004-05-31
JP2002535298A (ja) 2002-10-22
HU228925B1 (en) 2013-06-28
HK1041873A1 (zh) 2002-07-26
US6187956B1 (en) 2001-02-13
NO20013569L (no) 2001-07-19
AU2663400A (en) 2000-08-07
BR0007610B1 (pt) 2011-08-09
ID30091A (id) 2001-11-01
EE04234B1 (et) 2004-02-16
NO327634B1 (no) 2009-09-07
HRP20010513B1 (en) 2010-02-28
CA2355938A1 (en) 2000-07-27
WO2000043345A1 (de) 2000-07-27
AU760405B2 (en) 2003-05-15
TR200102108T2 (tr) 2001-12-21
HUP0202651A2 (hu) 2003-02-28
EG23819A (en) 2007-09-19
DE50003632D1 (de) 2003-10-16
PE20001417A1 (es) 2001-01-03
ZA200105294B (en) 2002-02-21
HUP0202651A3 (en) 2006-03-28
TW499409B (en) 2002-08-21
IL144454A0 (en) 2002-05-23
HK1041873B (zh) 2008-03-28
YU51001A (sh) 2004-03-12
SK10282001A3 (sk) 2001-12-03
KR100655104B1 (ko) 2006-12-21
UY25984A1 (es) 2000-09-29
BR0007610A (pt) 2001-10-30
HRP20010513A2 (en) 2002-08-31
ME00749B (me) 2008-08-07
RU2237655C2 (ru) 2004-10-10
PL348858A1 (en) 2002-06-17
KR20010101608A (ko) 2001-11-14
CO5150188A1 (es) 2002-04-29

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