BG106848A - Заместени пиперидини, лекарствени седства, които ги съдържат и методи за тяхното получаване - Google Patents

Заместени пиперидини, лекарствени седства, които ги съдържат и методи за тяхното получаване Download PDF

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Publication number
BG106848A
BG106848A BG106848A BG10684802A BG106848A BG 106848 A BG106848 A BG 106848A BG 106848 A BG106848 A BG 106848A BG 10684802 A BG10684802 A BG 10684802A BG 106848 A BG106848 A BG 106848A
Authority
BG
Bulgaria
Prior art keywords
amino
piperidinyl
group
methyl
piperazinyl
Prior art date
Application number
BG106848A
Other languages
Bulgarian (bg)
English (en)
Inventor
Klaus Rudolf
Wolfgang Eberlein
Alexander Dreyer
Stephan Mueller
Henri Doods
Eckhart Bauer
Rudolf Hurnaus
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of BG106848A publication Critical patent/BG106848A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG106848A 1999-12-30 2002-06-20 Заместени пиперидини, лекарствени седства, които ги съдържат и методи за тяхното получаване BG106848A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963868A DE19963868A1 (de) 1999-12-30 1999-12-30 Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP2000/013236 WO2001049676A1 (fr) 1999-12-30 2000-12-22 Piperidines substituees, medicaments contenant ces composes et procedes permettant de les preparer

Publications (1)

Publication Number Publication Date
BG106848A true BG106848A (bg) 2002-12-29

Family

ID=7935059

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106848A BG106848A (bg) 1999-12-30 2002-06-20 Заместени пиперидини, лекарствени седства, които ги съдържат и методи за тяхното получаване

Country Status (28)

Country Link
US (1) US6949541B2 (fr)
EP (1) EP1252153A1 (fr)
JP (1) JP2003519222A (fr)
KR (1) KR100736063B1 (fr)
CN (1) CN1203069C (fr)
AR (1) AR027113A1 (fr)
AU (1) AU783275B2 (fr)
BG (1) BG106848A (fr)
BR (1) BR0017063A (fr)
CA (1) CA2395541C (fr)
CZ (1) CZ20022628A3 (fr)
DE (1) DE19963868A1 (fr)
EA (1) EA005600B1 (fr)
EE (1) EE200200369A (fr)
HR (1) HRP20020560A2 (fr)
HU (1) HUP0300002A3 (fr)
IL (2) IL150377A0 (fr)
MX (1) MXPA02006509A (fr)
NO (1) NO323700B1 (fr)
NZ (1) NZ519939A (fr)
PL (1) PL356400A1 (fr)
SK (1) SK9412002A3 (fr)
TW (1) TWI255267B (fr)
UA (1) UA75346C2 (fr)
UY (1) UY26513A1 (fr)
WO (1) WO2001049676A1 (fr)
YU (1) YU50002A (fr)
ZA (1) ZA200205181B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211770A1 (de) * 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7842808B2 (en) * 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
RS52552B (sr) * 2002-06-05 2013-04-30 Bristol-Myers Squibb Company Antagonisti, peptidnog receptora koji je u vezi sa kalcitoninskim genom
US7220862B2 (en) * 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
ATE466860T1 (de) * 2003-04-15 2010-05-15 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
CA2529227A1 (fr) * 2003-06-26 2005-01-06 Merck & Co., Inc. Antagonistes du recepteur cgrp de benzodiazepine
EP1641423B1 (fr) * 2003-06-26 2010-03-17 Merck Sharp & Dohme Corp. Benzodiazepines antagonistes du recepteur cgrp
TW200524601A (en) * 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
RS20060382A (sr) 2003-12-05 2008-09-29 Bristol-Myers Squibb Company, Antagonisti receptora za peptid povezan sa genom za kalcitonin
EP1695961A4 (fr) * 2003-12-17 2007-10-24 Takeda Pharmaceutical Derives d'uree, processus de production correspondant et utilisation
CN101124217A (zh) * 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂
US20050192230A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim International Gambh Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
DE102004006893A1 (de) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
CN101014345A (zh) * 2004-09-09 2007-08-08 默克公司 三环酰苯胺螺环内酰胺cgrp受体拮抗剂
US7750010B2 (en) * 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) * 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
EP1770091A1 (fr) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Antagonistes CGRP, leur procédé de préparation ansi que leur utilisation comme médicaments
WO2006103701A1 (fr) * 2005-04-01 2006-10-05 Pankaj Kehr Manche reutilisable pour lame metallique
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
AR127170A1 (es) * 2021-09-30 2023-12-27 Crinetics Pharmaceuticals Inc Antagonistas del receptor de la hormona paratiroidea (pth) y sus usos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5011390A (fr) * 1973-05-30 1975-02-05
WO1996035713A1 (fr) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides stimulant la liberation de l'hormone de croissance
DE19636623A1 (de) 1996-09-10 1998-03-12 Thomae Gmbh Dr K Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
SK285631B6 (sk) 1996-09-10 2007-05-03 Dr. Karl Thomae Gmbh Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie
WO2000018764A1 (fr) 1998-09-30 2000-04-06 Merck Sharp & Dohme Limited Piperidines de benzimidazolinyle en tant que ligands de cgrp
DE10250080A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DE19963868A1 (de) 2001-07-12
IL150377A (en) 2007-06-17
NO20023161D0 (no) 2002-06-28
NZ519939A (en) 2006-08-31
US20030212057A1 (en) 2003-11-13
NO323700B1 (no) 2007-06-25
TWI255267B (en) 2006-05-21
CZ20022628A3 (cs) 2002-10-16
ZA200205181B (en) 2003-09-30
US6949541B2 (en) 2005-09-27
NO20023161L (no) 2002-06-28
HUP0300002A3 (en) 2006-01-30
EE200200369A (et) 2003-10-15
HK1054026A1 (en) 2003-11-14
MXPA02006509A (es) 2002-11-29
KR100736063B1 (ko) 2007-07-06
UA75346C2 (en) 2006-04-17
AR027113A1 (es) 2003-03-12
CA2395541A1 (fr) 2001-07-12
JP2003519222A (ja) 2003-06-17
SK9412002A3 (en) 2002-11-06
PL356400A1 (en) 2004-06-28
HUP0300002A2 (en) 2003-05-28
AU3537901A (en) 2001-07-16
EP1252153A1 (fr) 2002-10-30
IL150377A0 (en) 2002-12-01
WO2001049676A1 (fr) 2001-07-12
KR20020073493A (ko) 2002-09-26
YU50002A (sh) 2005-11-28
EA200200651A1 (ru) 2002-12-26
HRP20020560A2 (en) 2005-04-30
UY26513A1 (es) 2001-07-31
CA2395541C (fr) 2008-09-23
CN1203069C (zh) 2005-05-25
AU783275B2 (en) 2005-10-06
CN1414960A (zh) 2003-04-30
BR0017063A (pt) 2002-10-22
EA005600B1 (ru) 2005-04-28

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