BG107899A - Б...нзимидазолови и пиридилимидазолови производни ка'о лиганди на gaba р...-...п'ори - Google Patents

Б...нзимидазолови и пиридилимидазолови производни ка'о лиганди на gaba р...-...п'ори Download PDF

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Publication number: BG107899A
Authority: BG; Bulgaria
Prior art keywords: alkyl; compound; group; cycloalkyl; alkoxy
Prior art date: 2000-12-21

Application number

BG107899A

Other languages

Bulgarian (bg)

English (en)

Inventor

Guiying Li

John M. Peterson

Pamela Albaugh

Kevin S. Currie

Guolin Cai

Linda M. Gustavson

Kyungae Lee

Alan Hutchison

Vinod Singh

George D. Maynard

Jun Yuan

Xie Ling Hong

Manuka Ghosh

Nian Liu

George P. Luke

Scott Mitchell

Martin P. Allen

Spiros Liras

Original Assignee

Neurogen Corporation

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-21

Filing date

2003-06-11

Publication date

2004-08-31

2003-06-11 Application filed by Neurogen Corporation, Pfizer Inc. filed Critical Neurogen Corporation

2004-08-31 Publication of BG107899A publication Critical patent/BG107899A/bg

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG107899A 2000-12-21 2003-06-11 Б...нзимидазолови и пиридилимидазолови производни ка'о лиганди на gaba р...-...п'ори BG107899A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25749200P	2000-12-21	2000-12-21
PCT/US2001/050038 WO2002050062A2 (fr)	2000-12-21	2001-12-21	Derives de benzimidazole et de pyridylimidazole

Publications (1)

Publication Number	Publication Date
BG107899A true BG107899A (bg)	2004-08-31

Family

ID=22976520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107899A BG107899A (bg)	2000-12-21	2003-06-11	Б...нзимидазолови и пиридилимидазолови производни ка'о лиганди на gaba р...-...п'ори

Country Status (40)

Country	Link
US (4)	US6916819B2 (fr)
EP (1)	EP1368342B3 (fr)
JP (1)	JP2004536782A (fr)
KR (1)	KR100854174B1 (fr)
CN (1)	CN1553909A (fr)
AP (1)	AP1503A (fr)
AR (1)	AR035774A1 (fr)
AT (1)	ATE304008T1 (fr)
AU (2)	AU3276802A (fr)
BG (1)	BG107899A (fr)
BR (1)	BR0116385A (fr)
CA (1)	CA2431592A1 (fr)
CO (1)	CO5390086A1 (fr)
CZ (1)	CZ20031676A3 (fr)
DE (1)	DE60113302T2 (fr)
EA (1)	EA007157B1 (fr)
EC (1)	ECSP034656A (fr)
EE (1)	EE05108B1 (fr)
EG (1)	EG24590A (fr)
ES (1)	ES2256325T3 (fr)
HR (1)	HRP20030483A9 (fr)
HU (1)	HUP0303849A3 (fr)
IL (1)	IL156294A0 (fr)
IS (1)	IS6855A (fr)
MA (1)	MA26974A1 (fr)
MX (1)	MXPA03005493A (fr)
MY (1)	MY141733A (fr)
NO (1)	NO326558B1 (fr)
NZ (1)	NZ526330A (fr)
OA (1)	OA12539A (fr)
PA (1)	PA8535601A1 (fr)
PE (1)	PE20020720A1 (fr)
PL (1)	PL366243A1 (fr)
SK (1)	SK7672003A3 (fr)
TW (1)	TWI304402B (fr)
UA (1)	UA75902C2 (fr)
UY (1)	UY27095A1 (fr)
WO (1)	WO2002050062A2 (fr)
YU (1)	YU51703A (fr)
ZA (1)	ZA200304544B (fr)

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US7582636B2 (en)	2005-05-26	2009-09-01	Wyeth	Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
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2001
- 2001-12-20 PA PA20018535601A patent/PA8535601A1/es unknown
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- 2001-12-21 KR KR1020037008480A patent/KR100854174B1/ko not_active Expired - Fee Related
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- 2001-12-21 DE DE60113302T patent/DE60113302T2/de not_active Expired - Lifetime
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- 2001-12-21 TW TW090131848A patent/TWI304402B/zh not_active IP Right Cessation
- 2001-12-21 MX MXPA03005493A patent/MXPA03005493A/es active IP Right Grant
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- 2001-12-21 AU AU3276802A patent/AU3276802A/xx active Pending
- 2001-12-21 WO PCT/US2001/050038 patent/WO2002050062A2/fr not_active Ceased
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- 2001-12-21 CA CA002431592A patent/CA2431592A1/fr not_active Abandoned
- 2001-12-21 NZ NZ526330A patent/NZ526330A/en active IP Right Revival
- 2001-12-21 AT AT01992307T patent/ATE304008T1/de not_active IP Right Cessation
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Also Published As

Publication number	Publication date
US20100267698A1 (en)	2010-10-21
EA200300713A1 (ru)	2004-02-26
AU2002232768B2 (en)	2007-09-06
HUP0303849A2 (hu)	2004-03-01
EP1368342A2 (fr)	2003-12-10
KR20030071789A (ko)	2003-09-06
US20080227793A1 (en)	2008-09-18
WO2002050062A3 (fr)	2003-01-16
NO20032834L (no)	2003-08-08
OA12539A (en)	2006-06-05
IS6855A (is)	2003-06-20
DE60113302D1 (de)	2005-10-13
AR035774A1 (es)	2004-07-14
NZ526330A (en)	2006-09-29
PL366243A1 (en)	2005-01-24
US20030069257A1 (en)	2003-04-10
DE60113302T2 (de)	2006-06-29
EA007157B1 (ru)	2006-08-25
KR100854174B1 (ko)	2008-08-26
US6916819B2 (en)	2005-07-12
US7642267B2 (en)	2010-01-05
NO326558B1 (no)	2009-01-12
NO20032834D0 (no)	2003-06-20
MXPA03005493A (es)	2004-04-20
EE200300304A (et)	2003-12-15
CO5390086A1 (es)	2004-04-30
BR0116385A (pt)	2005-12-13
UA75902C2 (en)	2006-06-15
AP1503A (en)	2005-12-24
CZ20031676A3 (en)	2004-03-17
YU51703A (sh)	2006-05-25
HRP20030483A2 (en)	2005-04-30
ES2256325T3 (es)	2006-07-16
CN1553909A (zh)	2004-12-08
PA8535601A1 (es)	2002-11-28
MA26974A1 (fr)	2004-12-20
US20060025425A1 (en)	2006-02-02
WO2002050062A2 (fr)	2002-06-27
ECSP034656A (es)	2003-10-28
CA2431592A1 (fr)	2002-06-27
PE20020720A1 (es)	2002-08-12
JP2004536782A (ja)	2004-12-09
IL156294A0 (en)	2004-01-04
SK7672003A3 (en)	2004-07-07
EP1368342B1 (fr)	2005-09-07
AP2003002818A0 (en)	2003-06-30
AU3276802A (en)	2002-07-01
EG24590A (en)	2009-12-07
ZA200304544B (en)	2005-05-25
EP1368342B3 (fr)	2010-12-01
HRP20030483A9 (en)	2007-11-30
HUP0303849A3 (en)	2009-08-28
US7300945B2 (en)	2007-11-27
UY27095A1 (es)	2002-07-31
ATE304008T1 (de)	2005-09-15
EE05108B1 (et)	2008-12-15
MY141733A (en)	2010-06-15
TWI304402B (en)	2008-12-21

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