BG107984A - Изоксазолинови производни като антидепресанти - Google Patents

Изоксазолинови производни като антидепресанти Download PDF

Info

Publication number: BG107984A
Authority: BG; Bulgaria
Prior art keywords: compound; group; mol; formula; solvent
Prior art date: 2001-02-21

Application number

BG107984A

Other languages

Bulgarian (bg)

English (en)

Inventor

Jose I. Andres-Gil

Francisco J. Fernandez-Gadea

Manuel J. Alcazar-Vaca

Jose M. Cid-nunez

Joaquin Pastor-Fernandez

Antonius Adrian H. Megens

Godelieve Irma C. Heylen

Xavier J. Langlois

Margaretha H. Bakker

Thomas H. Steckler

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2003-07-08

Publication date

2004-09-30

2003-07-08 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2004-09-30 Publication of BG107984A publication Critical patent/BG107984A/bg

Links

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AXDBMNUQOVZXJM-UHFFFAOYSA-N methyl 4-bromobut-3-enoate Chemical compound COC(=O)CC=CBr AXDBMNUQOVZXJM-UHFFFAOYSA-N 0.000 description 1
125000006431 methyl cyclopropyl group Chemical group 0.000 description 1
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235000020830 overeating Nutrition 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
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239000001301 oxygen Substances 0.000 description 1
229960001528 oxymetazoline Drugs 0.000 description 1
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208000019906 panic disease Diseases 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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208000028173 post-traumatic stress disease Diseases 0.000 description 1
NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
229910000105 potassium hydride Inorganic materials 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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210000002027 skeletal muscle Anatomy 0.000 description 1
208000022925 sleep disturbance Diseases 0.000 description 1
208000020685 sleep-wake disease Diseases 0.000 description 1
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229910052708 sodium Inorganic materials 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
238000003746 solid phase reaction Methods 0.000 description 1
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201000001716 specific phobia Diseases 0.000 description 1
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239000008223 sterile water Substances 0.000 description 1
229960002385 streptomycin sulfate Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
210000003478 temporal lobe Anatomy 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000003325 tomography Methods 0.000 description 1
229960001479 tosylchloramide sodium Drugs 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
230000008733 trauma Effects 0.000 description 1
QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
206010044652 trigeminal neuralgia Diseases 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
HDWHGDDNMJOCCU-UHFFFAOYSA-N trimethyl(pyridin-2-yl)stannane Chemical compound C[Sn](C)(C)C1=CC=CC=N1 HDWHGDDNMJOCCU-UHFFFAOYSA-N 0.000 description 1
210000001364 upper extremity Anatomy 0.000 description 1
208000030401 vitamin deficiency disease Diseases 0.000 description 1
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239000011534 wash buffer Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BG107984A 2001-02-21 2003-07-08 Изоксазолинови производни като антидепресанти BG107984A (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01200611		2001-02-21
EP01201264		2001-04-05
PCT/EP2002/001567 WO2002066484A1 (en)	2001-02-21	2002-02-13	Isoxazoline derivatives as anti-depressants

Publications (1)

Publication Number	Publication Date
BG107984A true BG107984A (bg)	2004-09-30

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ID=26076836

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BG107984A BG107984A (bg)	2001-02-21	2003-07-08	Изоксазолинови производни като антидепресанти

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US (1)	US7169786B2 (cs)
EP (1)	EP1368358B1 (cs)
JP (1)	JP3953424B2 (cs)
KR (1)	KR100848898B1 (cs)
CN (1)	CN100400540C (cs)
AR (1)	AR035685A1 (cs)
AT (1)	ATE337322T1 (cs)
AU (1)	AU2002244717B2 (cs)
BG (1)	BG107984A (cs)
BR (1)	BR0207433A (cs)
CA (1)	CA2437505C (cs)
CY (1)	CY1106448T1 (cs)
CZ (1)	CZ20032515A3 (cs)
DE (1)	DE60214138T2 (cs)
DK (1)	DK1368358T3 (cs)
EA (1)	EA006747B1 (cs)
EE (1)	EE200300398A (cs)
EG (1)	EG23929A (cs)
ES (1)	ES2271230T3 (cs)
HR (1)	HRP20030647A2 (cs)
HU (1)	HUP0303270A3 (cs)
IL (2)	IL157470A0 (cs)
MX (1)	MXPA03007432A (cs)
MY (1)	MY137836A (cs)
NO (1)	NO20033700L (cs)
NZ (1)	NZ526741A (cs)
PL (1)	PL208593B1 (cs)
PT (1)	PT1368358E (cs)
SI (1)	SI1368358T1 (cs)
SK (1)	SK11612003A3 (cs)
TW (1)	TWI257392B (cs)
WO (1)	WO2002066484A1 (cs)

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Publication number	Priority date	Publication date	Assignee	Title
GB0203299D0 (en) *	2002-02-12	2002-03-27	Glaxo Group Ltd	Novel compounds
JP4580653B2 (ja) *	2002-04-02	2010-11-17	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	置換されたアミノイソオキサゾリン誘導体および抗鬱薬としてのそれらの使用
TW200409777A (en) *	2002-08-12	2004-06-16	Janssen Pharmaceutica Nv	C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
CA2494557C (en)	2002-08-15	2011-10-18	Janssen Pharmaceutica N.V.	Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
CA2495058C (en) *	2002-08-21	2012-01-03	Janssen Pharmaceutica N.V.	C6- and c9-substituted isoxazoline derivatives and their use as anti-depressants
US8044206B2 (en)	2003-03-07	2011-10-25	Astellas Pharma Inc.	Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl
EP1905774B1 (en) *	2003-09-17	2013-02-20	Janssen Pharmaceutica N.V.	Fused heterocyclic compounds as serotonin receptor modulators
JP5069907B2 (ja) *	2003-09-17	2012-11-07	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	縮合複素環式化合物
ATE443707T1 (de) *	2004-11-26	2009-10-15	Janssen Pharmaceutica Nv	Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität
RU2470937C2 (ru)	2007-03-09	2012-12-27	Санофи-Авентис	Получение и применение замещенных дигидро- и тетрагидрооксазолопиримидинонов
KR20100038189A (ko) *	2007-06-08	2010-04-13	헬리콘 테라퓨틱스 인코퍼레이티드	치료적 피라졸로퀴놀린 우레아 유도체
EP2236511A4 (en)	2007-12-21	2011-04-13	Alla Chem Llc	LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF
AR078171A1 (es)	2009-09-15	2011-10-19	Sanofi Aventis	Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas

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DE68906340T2 (de) *	1988-09-19	1993-08-12	Akzo Nv	Tetrahydronaphthalin und indan-derivate.
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
DK0892804T3 (da) *	1996-04-12	2002-12-02	Janssen Pharmaceutica Nv	Isoxazolidin derivater
HUP9602763A3 (en) *	1996-10-09	1999-05-28	Egyt Gyogyszervegyeszeti Gyar	3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
JP2002527438A (ja) *	1998-10-09	2002-08-27	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	４，５−ジヒドロ−イソオキサゾール誘導体及びそれらの製薬学的使用

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Also Published As

Publication number	Publication date
DK1368358T3 (da)	2007-01-02
IL157470A (en)	2008-07-08
NZ526741A (en)	2004-04-30
MXPA03007432A (es)	2003-11-18
PT1368358E (pt)	2007-01-31
KR100848898B1 (ko)	2008-07-29
HUP0303270A2 (hu)	2004-01-28
NO20033700L (no)	2003-10-21
AR035685A1 (es)	2004-06-23
CA2437505A1 (en)	2002-08-29
HRP20030647A2 (en)	2005-06-30
NO20033700D0 (no)	2003-08-20
WO2002066484A1 (en)	2002-08-29
CA2437505C (en)	2010-02-09
PL363264A1 (en)	2004-11-15
CN1492871A (zh)	2004-04-28
IL157470A0 (en)	2004-03-28
ES2271230T3 (es)	2007-04-16
JP3953424B2 (ja)	2007-08-08
DE60214138T2 (de)	2007-03-29
US7169786B2 (en)	2007-01-30
EG23929A (en)	2008-01-14
CN100400540C (zh)	2008-07-09
BR0207433A (pt)	2004-06-01
AU2002244717B2 (en)	2007-07-19
ATE337322T1 (de)	2006-09-15
TWI257392B (en)	2006-07-01
EP1368358A1 (en)	2003-12-10
DE60214138D1 (de)	2006-10-05
EE200300398A (et)	2003-12-15
SK11612003A3 (sk)	2004-04-06
EA006747B1 (ru)	2006-04-28
PL208593B1 (pl)	2011-05-31
HUP0303270A3 (en)	2007-03-28
MY137836A (en)	2009-03-31
SI1368358T1 (sl)	2007-02-28
HK1065537A1 (zh)	2005-02-25
US20040122037A1 (en)	2004-06-24
JP2004518748A (ja)	2004-06-24
CZ20032515A3 (cs)	2003-12-17
EP1368358B1 (en)	2006-08-23
KR20030076590A (ko)	2003-09-26
EA200300915A1 (ru)	2004-06-24
CY1106448T1 (el)	2011-10-12

Publication	Publication Date	Title
BG107984A (bg)	2004-09-30	Изоксазолинови производни като антидепресанти
JP2006528957A (ja)	2006-12-28	改善された抗精神病効力を有するインドール誘導体
AU2002244717A1 (en)	2003-02-27	Isoxazoline derivatives as anti-depressants
JP4580653B2 (ja)	2010-11-17	置換されたアミノイソオキサゾリン誘導体および抗鬱薬としてのそれらの使用
JP4478570B2 (ja)	2010-06-09	Ｃ６−およびｃ９−置換’４，３−ｃ！イソキサゾリン誘導体およびそれらの抗鬱薬としての使用
JP4478571B2 (ja)	2010-06-09	縮合複素環式イソオキサゾリン誘導体及び抗うつ薬としてのそれらの使用
JP4681295B2 (ja)	2011-05-11	Ｃ−置換三環式イソオキサゾリン誘導体及び抗−うつ薬としてのそれらの使用
UA77405C2 (en)	2006-12-15	Isoxazolines derivatives as antidepressants
AU2003219111B2 (en)	2008-11-27	Substituted amino isoxazoline derivatives and their use as anti-depressants
HK1065537B (en)	2009-07-03	Isoxazoline derivatives as anti-depressants