BG108517A - Dry powder inhalation system for transpulmonary administration - Google Patents

Dry powder inhalation system for transpulmonary administration

Info

Publication number
BG108517A
BG108517A BG108517A BG10851704A BG108517A BG 108517 A BG108517 A BG 108517A BG 108517 A BG108517 A BG 108517A BG 10851704 A BG10851704 A BG 10851704A BG 108517 A BG108517 A BG 108517A
Authority
BG
Bulgaria
Prior art keywords
freeze
dry powder
dried composition
powder inhalation
transpulmonary administration
Prior art date
Application number
BG108517A
Other languages
Bulgarian (bg)
English (en)
Inventor
Chikamasa Yamashita
Shigeru Ibaragi
Yuichiro Fukunaga
Akitsuna Akagi
Original Assignee
Otsuka Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of BG108517A publication Critical patent/BG108517A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG108517A 2001-06-15 2004-01-08 Dry powder inhalation system for transpulmonary administration BG108517A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001182504 2001-06-15
JP2001400871 2001-12-28
JP2002111131 2002-04-12
JP2002363158 2002-12-13

Publications (1)

Publication Number Publication Date
BG108517A true BG108517A (en) 2005-02-28

Family

ID=32931499

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108517A BG108517A (en) 2001-06-15 2004-01-08 Dry powder inhalation system for transpulmonary administration

Country Status (32)

Country Link
US (4) US7448379B2 (cs)
EP (4) EP1402913B1 (cs)
JP (1) JP3635353B2 (cs)
KR (3) KR100906754B1 (cs)
CN (2) CN100427077C (cs)
AP (1) AP1861A (cs)
AT (1) ATE336989T1 (cs)
AU (3) AU2002311213B2 (cs)
BG (1) BG108517A (cs)
BR (2) BR0210425B1 (cs)
CA (2) CA2449954C (cs)
CY (1) CY1105755T1 (cs)
CZ (1) CZ200470A3 (cs)
DE (1) DE60214184T2 (cs)
DK (1) DK1402913T3 (cs)
EA (1) EA005025B1 (cs)
EE (1) EE04956B1 (cs)
EG (2) EG24184A (cs)
ES (1) ES2271266T3 (cs)
HR (2) HRP20040033B8 (cs)
HU (1) HU227300B1 (cs)
IL (1) IL159080A0 (cs)
MA (1) MA27131A1 (cs)
MX (1) MXPA05006322A (cs)
NO (2) NO334652B1 (cs)
NZ (2) NZ530044A (cs)
PL (2) PL205104B1 (cs)
PT (1) PT1402913E (cs)
SI (1) SI1402913T1 (cs)
TW (1) TW570819B (cs)
UA (1) UA81280C2 (cs)
WO (2) WO2002102445A1 (cs)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
GB2380410B (en) * 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
USD514698S1 (en) * 2002-10-07 2006-02-07 Cadila Healthcare Limited Inhalation device for the delivery and storage of powdered medicaments
WO2004054605A1 (en) * 2002-12-13 2004-07-01 Otsuka Pharmaceutical Co., Ltd. Freeze-dried interferon-ϝ composition for transpulmonary administration and inhalation system therefor
JP4562528B2 (ja) * 2002-12-13 2010-10-13 大塚製薬株式会社 経肺投与用の吸入式デバイス
US20040187866A1 (en) * 2003-03-31 2004-09-30 Nathaniel Hughes Liquid medicament delivery system
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
JP5183068B2 (ja) * 2003-12-22 2013-04-17 フィンレイ，ウォーレン，エイチ 大気噴出凍結乾燥法による粉末形成
EP1593376A1 (en) * 2004-05-04 2005-11-09 Warner-Lambert Company LLC Improved pullulan capsules
US20060021613A1 (en) * 2004-08-02 2006-02-02 Robert Overlander Accessory for nebulizer inhaler system
BRPI0514263B8 (pt) 2004-08-20 2021-05-25 Mannkind Corp método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
JP5188183B2 (ja) * 2004-11-10 2013-04-24 シプラ・リミテッド 吸入器
FR2877925B1 (fr) * 2004-11-16 2008-09-19 Valois Sas Dispositif de distribution de produit fluide.
DE102005016230A1 (de) * 2005-04-08 2006-10-19 Altana Pharma Ag Vorrichtung zur Trockenvernebelung
WO2007007110A1 (en) * 2005-07-13 2007-01-18 Cipla Limited Inhaler device
DE102005038619A1 (de) * 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
AU2006290870B2 (en) 2005-09-14 2013-02-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
KR100777249B1 (ko) * 2006-02-14 2007-11-28 (주)바이오니아 건조 올리고뉴클레오티드 조성물 및 이의 제조 방법
JP5599975B2 (ja) 2006-02-22 2014-10-01 マンカインド コーポレイション ジケトピペラジン及び活性薬剤を含有する微粒子の製剤特性の改善方法
DE102006010089A1 (de) * 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh Trockenpulver-Inhalator
WO2007103152A2 (en) * 2006-03-03 2007-09-13 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
US7832399B2 (en) * 2006-03-10 2010-11-16 One Dose, Llc Medication inhaler
US8360057B2 (en) * 2006-03-10 2013-01-29 Dose One, Llc Medication inhaler for dispensing multiple capsules
EP2043717A1 (en) * 2006-07-14 2009-04-08 Astra Zeneca AB Inhalation system and delivery device for the administration of a drug in the form of dry powder
DE102006047668B3 (de) * 2006-09-28 2008-04-24 Ing. Erich Pfeiffer Gmbh Inhalationsvorrichtung
AU2008225501B2 (en) * 2007-03-09 2013-08-29 Otsuka Pharmaceutical Co., Ltd. Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
EP2224984A4 (en) 2007-12-20 2013-10-30 Astrazeneca Ab DISPENSER AND METHOD FOR DRIVING POWDER IN AIR FLOW 537
US8499757B2 (en) 2008-06-13 2013-08-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
USD605752S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Dry powder inhaler
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
USD635241S1 (en) 2008-06-13 2011-03-29 Mannkind Corporation Dry powder inhaler
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
TWI528982B (zh) * 2009-03-04 2016-04-11 曼凱公司 改良的乾粉藥物輸送系統
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
CN101884593B (zh) * 2009-05-14 2013-09-18 许清萍 由高剂量冻干制剂调配液态制剂的方法
US8118777B2 (en) * 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
RU2509555C2 (ru) 2009-06-12 2014-03-20 Маннкайнд Корпорейшн Микрочастицы дикетопиперазина с определенными удельными площадями поверхности
KR20120107845A (ko) 2009-07-01 2012-10-04 아스트라제네카 아베 기류에 분말을 비말동반시키기 위한 분배기 및 방법
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CA2779488A1 (en) 2009-11-12 2011-05-19 Stc.Unm Dry powder inhaler with flutter dispersion member
CN102655855B (zh) * 2009-12-14 2015-03-11 奇斯药制品公司 用于吸入的抗生素微粒
MX359281B (es) 2010-06-21 2018-09-21 Mannkind Corp Sistema y metodos para suministrar un farmaco en polvo seco.
JP6050758B2 (ja) 2010-12-07 2016-12-21 レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 乾燥粉末吸入器及びその作動方法
US8925726B2 (en) 2011-04-01 2015-01-06 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
ES2708218T3 (es) * 2011-08-01 2019-04-09 Univ Monash Método y formulación para inhalación
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
DE102012103000A1 (de) * 2012-04-05 2013-10-10 Rpc Formatec Gmbh Spender zur Ausbringung einer insbesondere körnigen oder pulverförmigen Substanz und Verfahren zur Entleerung einer Substanz-Aufnahme
MX354163B (es) 2012-07-12 2018-02-15 Mannkind Corp Sistemas y métodos de suministro de fármaco en polvo seco.
EP2708219A1 (en) * 2012-09-12 2014-03-19 PARI Pharma GmbH Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US20150367366A1 (en) * 2012-12-06 2015-12-24 Aerodesigns, Inc. Aerosol dispenser with edible cartridge
CN103110611A (zh) * 2012-12-11 2013-05-22 苏州惠仁生物科技有限公司 吸入剂及其制备方法与普鲁兰糖作为吸入剂载体的应用
SG10201708090TA (en) 2013-03-15 2017-11-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
KR102321339B1 (ko) 2013-07-18 2021-11-02 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
DE102014215064A1 (de) 2014-07-31 2016-02-04 Pari GmbH Spezialisten für effektive Inhalation Vernebler
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
ES2841933T3 (es) 2014-10-31 2021-07-12 Univ Monash Formulación en polvo
MX2017009112A (es) 2015-01-14 2018-06-15 Respira Therapeutics Inc Metodos y dispositivos de dispersion de polvo.
WO2016193956A1 (en) * 2015-06-04 2016-12-08 Lameplast S.P.A. Device for the spray dispensing of a liquid product
JP7077219B2 (ja) * 2015-09-09 2022-05-30 ノバルティス アーゲー 噴霧乾燥製剤の肺への標的化送達
CN105616390B (zh) * 2016-03-24 2019-07-23 李浩莹 普鲁兰多糖及衍生物在制备缓控释放药物颗粒中的应用
US10898494B2 (en) 2016-05-05 2021-01-26 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
AU2017370805B2 (en) * 2016-12-05 2021-11-25 Microbase Technology Corp. Aerosol generating apparatus with replaceable parts
WO2018113891A1 (en) * 2016-12-23 2018-06-28 University Of Copenhagen A co-amorphous form of a substance and a dipeptide
ES2684403B1 (es) * 2017-03-31 2019-07-09 Farm Rovi Lab Sa Procedimiento para el llenado gravimetrico en condiciones esteriles de solidos en un contenedor farmaceutico y contenedor farmaceutico utilizable en el mismo
DK3612262T3 (da) * 2017-04-18 2025-10-27 Inspiring Pty Ltd Tørpulverinhalator og afstandsindretning til en tørpulverinhalator
US10252283B2 (en) * 2017-07-17 2019-04-09 Yoanna Gouchtchina Dermal spray apparatus and method
CN111279161A (zh) * 2017-11-02 2020-06-12 豪夫迈·罗氏有限公司 液滴分配装置及系统
JP6489669B1 (ja) * 2018-10-30 2019-03-27 ルアン株式会社 スクイズ容器
CN109954200A (zh) * 2019-04-16 2019-07-02 郑州大学第一附属医院 一种呼吸内科护理用给药装置
US20220091089A1 (en) * 2019-04-25 2022-03-24 Agco Corporation Apparatus and methods for measuring soil conditions
CN112237668A (zh) * 2019-07-17 2021-01-19 杭州亿脑创新工场有限公司 多剂量粉末药物给药装置及适用于该装置的药联
US11944178B2 (en) 2020-04-07 2024-04-02 Kozhya LLC SP Z.O.O. Dermal spray apparatus and method
WO2021211624A1 (en) * 2020-04-14 2021-10-21 Qool Therapeutics, Inc. Frozen particle generator using liquid micro-dispenser
US20220184325A1 (en) * 2020-12-15 2022-06-16 Sanara Medtech Inc. Powder applicator
TWI763510B (zh) * 2021-05-28 2022-05-01 林錫璋 藥粉輸送裝置
US12376665B2 (en) 2021-10-14 2025-08-05 Kozhya LLC Sp. z o.o. Dermal spray apparatus with disposable cartrdige and method
USD1046122S1 (en) 2022-05-09 2024-10-08 Quantum Skin Limited Liability Company Dermal spray cartridge
USD1035867S1 (en) 2022-05-09 2024-07-16 Kozhya LLC Sp. z o.o. Dermal spray apparatus
USD1033635S1 (en) 2022-05-09 2024-07-02 Quantum Skin SP Z O.O Dermal spray nozzle
USD1038383S1 (en) 2022-05-09 2024-08-06 Kozhya LLC Sp. z o.o. Dermal spray apparatus
CN116350607A (zh) * 2023-04-11 2023-06-30 胡崇茂 一种干细胞吸入组合物及其制备方法和应用
WO2025225923A1 (ko) * 2024-04-25 2025-10-30 주식회사 리센스메디컬 조성물 분사 장치 및 이를 포함한 분사 시스템

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1950926A (en) * 1932-10-05 1934-03-13 Lobl Frederick Nasal inhaler
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
US3874381A (en) * 1974-05-28 1975-04-01 Smithkline Corp Dual nozzle intranasal delivery device
GB1521000A (en) * 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
JPS58152498A (ja) 1982-03-06 1983-09-10 Terumo Corp 低分子ペプチド混合物の製造方法
EP0128205A4 (en) 1982-12-09 1987-01-10 Hafsten Raymond J Jr STABILIZED AND ACTIVE ENZYMES USED TO HEAL INJURIES.
EP0133767B1 (en) 1983-08-04 1991-04-03 The Green Cross Corporation Gamma interferon composition
JPS6052847A (ja) 1983-09-01 1985-03-26 Konishiroku Photo Ind Co Ltd ハロゲン化銀感光材料の現像処理方法
EP0168008A3 (en) 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
DE3729863A1 (de) 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
JPH01116045A (ja) * 1987-10-29 1989-05-09 Toshiba Corp 耐食性ジルコニウム合金
EP0360340A1 (en) 1988-09-19 1990-03-28 Akzo N.V. Composition for nasal administration containing a peptide
JPH07116022B2 (ja) * 1989-04-18 1995-12-13 三共株式会社 凍結乾燥製剤の製法
ATE111364T1 (de) * 1989-05-31 1994-09-15 Fisons Plc Medikament und inhalationsvorrichtung dafür.
FR2649323B1 (fr) * 1989-07-04 1995-06-30 Valois Dispositif de projection et de pulverisation d'une dose d'un produit divisable
JPH0341033A (ja) 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
DK544589D0 (da) * 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
KR910014122A (ko) * 1990-01-19 1991-08-31 디께다 가즈히꼬 에토포시드-2-디메틸아미노 화합물의 동결건조 제제
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
JPH0464878A (ja) * 1990-07-04 1992-02-28 Mitsubishi Heavy Ind Ltd 吸収冷凍機の吸収器
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
WO1992017209A1 (fr) 1991-04-08 1992-10-15 Sumitomo Pharmaceuticals Company, Limited Preparation solide poreuse contenant une substance proteique physiologiquement active
JP3131271B2 (ja) 1992-03-24 2001-01-31 住友ゴム工業株式会社 防振支承
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
JPH06186141A (ja) * 1992-12-16 1994-07-08 Hitachi Ltd 残留応力予測法
ES2128550T3 (es) * 1992-12-18 1999-05-16 Schering Corp Inhalador para medicamentos en polvo.
JPH0652847U (ja) 1992-12-28 1994-07-19 セントラル自動車株式会社 防火シャッター付き搬送装置
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
JP3007785B2 (ja) 1993-03-16 2000-02-07 旭化成工業株式会社 トロンボモジュリン組成物およびその変性防止方法
US5533502A (en) * 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
WO1994028876A1 (en) * 1993-06-07 1994-12-22 Advanced Therapies, Inc. Liposome powders
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
CN1073119C (zh) 1994-05-18 2001-10-17 吸入治疗系统公司 干扰素干粉配方的方法及组合物
CZ289029B6 (cs) 1994-09-21 2001-10-17 Inhale Therapeutic Systems Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
JPH08103499A (ja) * 1994-10-04 1996-04-23 Unisia Jecs Corp 吸入式投薬器
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP3317827B2 (ja) * 1995-10-09 2002-08-26 株式会社ユニシアジェックス 投薬器
US20030138402A1 (en) 1995-12-25 2003-07-24 Otsuka Pharmaceutical Co., Ltd. Dry compositions
TW403653B (en) * 1995-12-25 2000-09-01 Otsuka Pharma Co Ltd Dry compositions
JP3328132B2 (ja) * 1996-03-21 2002-09-24 株式会社ユニシアジェックス 吸入式投薬器
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
AUPN976496A0 (en) * 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US5663492A (en) * 1996-06-05 1997-09-02 Alapati; Rama Rao System for continuous analysis and modification of characteristics of a liquid hydrocarbon stream
WO1998034595A1 (de) * 1997-02-05 1998-08-13 Jago Research Ag Medizinische aerosolformulierungen
DE19704849B4 (de) * 1997-02-08 2011-02-17 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
US6503537B2 (en) * 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
US6394085B1 (en) * 1997-09-25 2002-05-28 Norton Healthcare Ltd. Inhaler spacer
EP1021172B1 (en) * 1997-10-08 2002-04-10 Sepracor, Inc. Dosage form for aerosol administration
NZ504021A (en) * 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
JP4266399B2 (ja) 1997-12-04 2009-05-20 帝人株式会社 粉末状吸入用医薬品組成物
CN1138536C (zh) 1998-03-05 2004-02-18 日本新药株式会社 油／水型脂肪乳或其冻干组合物的应用
JP3547612B2 (ja) * 1998-03-20 2004-07-28 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
MA25590A1 (fr) * 1998-09-14 2002-12-31 Inhale Therapeutic Syst Agent actif de delivraison de poudre seche
US5952232A (en) 1998-09-17 1999-09-14 Rothman; James Edward Expandible microparticle intracellular delivery system
US6745763B2 (en) * 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
JP2000233023A (ja) 1999-02-15 2000-08-29 Hiroshi Matsuzawa 鼻腔内洗浄器
GB2353222B (en) * 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
GB9919693D0 (en) * 1999-08-19 1999-10-20 Rhone Poulenc Rorer Ltd Process
JP2001151673A (ja) 1999-09-06 2001-06-05 Nikken Chem Co Ltd 吸入用粉末製剤の製造方法
CN1188111C (zh) * 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
JP4931282B2 (ja) * 2000-10-02 2012-05-16 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
JP3943845B2 (ja) * 2001-02-15 2007-07-11 芳枝 米谷 リポソームベクター
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
JP4562528B2 (ja) * 2002-12-13 2010-10-13 大塚製薬株式会社 経肺投与用の吸入式デバイス

Also Published As

Publication number Publication date
EE04956B1 (et) 2008-02-15
EP1579855A1 (en) 2005-09-28
AP1861A (en) 2008-07-02
US8333193B2 (en) 2012-12-18
ES2271266T3 (es) 2007-04-16
DE60214184T2 (de) 2007-06-28
DK1402913T3 (da) 2006-12-11
US7735485B2 (en) 2010-06-15
US7448379B2 (en) 2008-11-11
EG23775A (en) 2007-08-08
DE60214184D1 (de) 2006-10-05
NO20035554D0 (no) 2003-12-12
EE200400011A (et) 2004-02-16
EP1402913A4 (en) 2004-12-01
NO20053300D0 (no) 2005-07-05
NO20035554L (no) 2004-02-12
KR100907333B1 (ko) 2009-07-13
HK1082403A1 (en) 2006-06-09
UA81280C2 (uk) 2007-12-25
CA2449954C (en) 2011-08-23
NO334652B1 (no) 2014-05-05
US20060073105A1 (en) 2006-04-06
SI1402913T1 (sl) 2007-02-28
MXPA05006322A (es) 2005-08-26
PL205104B1 (pl) 2010-03-31
AU2003289051A1 (en) 2004-07-09
HRP20040033A2 (en) 2004-08-31
KR100906754B1 (ko) 2009-07-09
US20090126732A1 (en) 2009-05-21
EA200400045A1 (ru) 2004-06-24
CZ200470A3 (cs) 2004-07-14
HRP20040033B1 (en) 2007-11-30
WO2004054555A1 (ja) 2004-07-01
PL377554A1 (pl) 2006-02-06
MA27131A1 (fr) 2005-01-03
IL159080A0 (en) 2004-05-12
US20090095293A1 (en) 2009-04-16
AU2002311213B2 (en) 2007-12-13
PL209876B1 (pl) 2011-10-31
JPWO2002102445A1 (ja) 2004-09-30
CA2507766C (en) 2011-11-01
JP3635353B2 (ja) 2005-04-06
KR20070048813A (ko) 2007-05-09
EG24184A (en) 2008-10-08
EP1579855A4 (en) 2009-11-04
HU227300B1 (en) 2011-02-28
EP1402913A1 (en) 2004-03-31
AU2008200583A1 (en) 2008-02-28
BR0210425B1 (pt) 2012-12-11
TW570819B (en) 2004-01-11
NZ540935A (en) 2007-06-29
HRP20050639A2 (en) 2006-07-31
HUP0400217A2 (en) 2004-09-28
ATE336989T1 (de) 2006-09-15
KR20050084272A (ko) 2005-08-26
NO20053300L (no) 2005-09-12
EP1402913B1 (en) 2006-08-23
EP1688134A3 (en) 2009-11-18
CY1105755T1 (el) 2010-12-22
PT1402913E (pt) 2006-12-29
AU2008200583B2 (en) 2011-05-19
WO2002102445A1 (en) 2002-12-27
CN100427077C (zh) 2008-10-22
BR0210425A (pt) 2004-08-17
KR101049914B1 (ko) 2011-07-15
US20030101995A1 (en) 2003-06-05
US8443799B2 (en) 2013-05-21
CN1726014A (zh) 2006-01-25
HRP20040033B8 (hr) 2008-09-30
KR20070050105A (ko) 2007-05-14
EP1688133A1 (en) 2006-08-09
EP1688134A2 (en) 2006-08-09
NZ530044A (en) 2005-09-30
CA2507766A1 (en) 2004-07-01
EA005025B1 (ru) 2004-10-28
CN1323658C (zh) 2007-07-04
CA2449954A1 (en) 2002-12-27
AU2003289051B2 (en) 2008-06-26
PL367161A1 (en) 2005-02-21
US20070065371A2 (en) 2007-03-22
AP2003002945A0 (en) 2003-12-31
BR0316754A (pt) 2005-10-25
CN1516606A (zh) 2004-07-28

Similar Documents

Publication Publication Date Title
BG108517A (en) Dry powder inhalation system for transpulmonary administration
AU2003212518A1 (en) Medicament delivery and packaging
IE40616L (en) Dispensing medicament for inhalation.
CA2322434A1 (en) Medicament delivery and packaging
CA2706634A1 (en) Preparation of powder agglomerates
YU34187A (en) Device for inhalators of powdery substances
IE901344L (en) Meterest dose aerosol device.
GB2248400B (en) Powder inhaler
CA2091366A1 (en) Powdered medicament dispensing device
KR840000226A (ko) 신규한 형태의 의약품의 제조방법
PL354841A1 (en) Improved powdery pharmaceutical compositions for inhalation
MY136601A (en) Dry powder inhalation system for transpulmonary administration, method of manufacturing a dry powdered preparation, and use of a freeze dried composition
UA88863C2 (ru) Система для ингаляции сухим порошком, лиофилизированный состав, ингалятор сухого порошка (варианты), способ изготовления сухого порошкообразного препарата для транспульмонарного применения, способ транспульмонарного применения, применение лиофилизированного состава для транспульмонарного применения при помощи ингаляции (варианты)
MXPA03011541A (es) Sistema de inhalacion de polvo seco para administrar transpulmonar.
MY154957A (en) Dry powder inhalation system for transpulmonary administration
MY113458A (en) Medicament dispensing device.
ECSP034905A (es) Sistema de inhalación de polvo seco para administración transpulmonar