IL159080A0 - Dry powder inhalation system for transpulmonary administration - Google Patents

Dry powder inhalation system for transpulmonary administration

Info

Publication number
IL159080A0
IL159080A0 IL15908002A IL15908002A IL159080A0 IL 159080 A0 IL159080 A0 IL 159080A0 IL 15908002 A IL15908002 A IL 15908002A IL 15908002 A IL15908002 A IL 15908002A IL 159080 A0 IL159080 A0 IL 159080A0
Authority
IL
Israel
Prior art keywords
dry powder
powder inhalation
inhalation system
transpulmonary administration
transpulmonary
Prior art date
Application number
IL15908002A
Other languages
English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IL159080A0 publication Critical patent/IL159080A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL15908002A 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration IL159080A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001182504 2001-06-15
JP2001400871 2001-12-28
JP2002111131 2002-04-12
PCT/JP2002/005955 WO2002102445A1 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration
JP2002363158 2002-12-13

Publications (1)

Publication Number Publication Date
IL159080A0 true IL159080A0 (en) 2004-05-12

Family

ID=32931499

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15908002A IL159080A0 (en) 2001-06-15 2002-06-14 Dry powder inhalation system for transpulmonary administration

Country Status (32)

Country Link
US (4) US7448379B2 (cs)
EP (4) EP1688133A1 (cs)
JP (1) JP3635353B2 (cs)
KR (3) KR100907333B1 (cs)
CN (2) CN100427077C (cs)
AP (1) AP1861A (cs)
AT (1) ATE336989T1 (cs)
AU (3) AU2002311213B2 (cs)
BG (1) BG108517A (cs)
BR (2) BR0210425B1 (cs)
CA (2) CA2449954C (cs)
CY (1) CY1105755T1 (cs)
CZ (1) CZ200470A3 (cs)
DE (1) DE60214184T2 (cs)
DK (1) DK1402913T3 (cs)
EA (1) EA005025B1 (cs)
EE (1) EE04956B1 (cs)
EG (2) EG24184A (cs)
ES (1) ES2271266T3 (cs)
HR (2) HRP20040033B8 (cs)
HU (1) HU227300B1 (cs)
IL (1) IL159080A0 (cs)
MA (1) MA27131A1 (cs)
MX (1) MXPA05006322A (cs)
NO (2) NO334652B1 (cs)
NZ (2) NZ530044A (cs)
PL (2) PL205104B1 (cs)
PT (1) PT1402913E (cs)
SI (1) SI1402913T1 (cs)
TW (1) TW570819B (cs)
UA (1) UA81280C2 (cs)
WO (2) WO2002102445A1 (cs)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
GB2380410B (en) * 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
USD514698S1 (en) * 2002-10-07 2006-02-07 Cadila Healthcare Limited Inhalation device for the delivery and storage of powdered medicaments
EA007730B1 (ru) * 2002-12-13 2006-12-29 Оцука Фармасьютикал Ко., Лтд. Ингаляционное устройство для транспульмонального введения
AR042453A1 (es) * 2002-12-13 2005-06-22 Otsuka Pharma Co Ltd Una composicion de interferon-gamma liofilizada para administracion transpulmonar y un sistema para su inhalacion
US20040187866A1 (en) * 2003-03-31 2004-09-30 Nathaniel Hughes Liquid medicament delivery system
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
JP5183068B2 (ja) * 2003-12-22 2013-04-17 フィンレイ，ウォーレン，エイチ 大気噴出凍結乾燥法による粉末形成
EP1593376A1 (en) * 2004-05-04 2005-11-09 Warner-Lambert Company LLC Improved pullulan capsules
US20060021613A1 (en) * 2004-08-02 2006-02-02 Robert Overlander Accessory for nebulizer inhaler system
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
NZ555365A (en) * 2004-11-10 2009-11-27 Cipla Ltd Inhaler with movement of closure to cause piercing of capsule
FR2877925B1 (fr) * 2004-11-16 2008-09-19 Valois Sas Dispositif de distribution de produit fluide.
DE102005016230A1 (de) * 2005-04-08 2006-10-19 Altana Pharma Ag Vorrichtung zur Trockenvernebelung
EP1901793A1 (en) * 2005-07-13 2008-03-26 Cipla Ltd. Inhaler device
DE102005038619A1 (de) * 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
KR100777249B1 (ko) * 2006-02-14 2007-11-28 (주)바이오니아 건조 올리고뉴클레오티드 조성물 및 이의 제조 방법
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
DE102006010089A1 (de) * 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh Trockenpulver-Inhalator
WO2007103152A2 (en) * 2006-03-03 2007-09-13 Stc.Unm Dry powder inhaler with aeroelastic dispersion mechanism
US8360057B2 (en) * 2006-03-10 2013-01-29 Dose One, Llc Medication inhaler for dispensing multiple capsules
US7832399B2 (en) * 2006-03-10 2010-11-16 One Dose, Llc Medication inhaler
WO2008008021A1 (en) * 2006-07-14 2008-01-17 Astrazeneca Ab Inhalation system and delivery device for the administration of a drug in the form of dry powder.
DE102006047668B3 (de) * 2006-09-28 2008-04-24 Ing. Erich Pfeiffer Gmbh Inhalationsvorrichtung
AR065640A1 (es) * 2007-03-09 2009-06-17 Otsuka Pharma Co Ltd Preparado liofilizado que contiene una vacuna contra la influenza y metodo para producir la misma
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
MX2010006657A (es) 2007-12-20 2010-10-05 Astrazeneca Ab Dispositivo y metodo para desagregar polvo 854.
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
USD635241S1 (en) 2008-06-13 2011-03-29 Mannkind Corporation Dry powder inhaler
USD605752S1 (en) 2008-06-13 2009-12-08 Mannkind Corporation Dry powder inhaler
CN101827626B (zh) 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CN102438602B (zh) * 2009-03-04 2016-04-13 曼金德公司 改进的干燥粉末药物输送系统
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN101884593B (zh) * 2009-05-14 2013-09-18 许清萍 由高剂量冻干制剂调配液态制剂的方法
US8118777B2 (en) * 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
KR102584844B1 (ko) 2009-06-12 2023-10-04 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
AU2010266754B2 (en) 2009-07-01 2013-12-05 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
UA107095C2 (uk) 2009-12-14 2014-11-25 Антибіотичні мікрочастинки для інгаляції
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HUE041858T2 (hu) * 2011-08-01 2019-05-28 Univ Monash Inhalálásra szolgáló eljárás és kiszerelés
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
DE102012103000A1 (de) * 2012-04-05 2013-10-10 Rpc Formatec Gmbh Spender zur Ausbringung einer insbesondere körnigen oder pulverförmigen Substanz und Verfahren zur Entleerung einer Substanz-Aufnahme
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
EP2708219A1 (en) * 2012-09-12 2014-03-19 PARI Pharma GmbH Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US20150367366A1 (en) * 2012-12-06 2015-12-24 Aerodesigns, Inc. Aerosol dispenser with edible cartridge
CN103110611A (zh) * 2012-12-11 2013-05-22 苏州惠仁生物科技有限公司 吸入剂及其制备方法与普鲁兰糖作为吸入剂载体的应用
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
DE102014215064A1 (de) 2014-07-31 2016-02-04 Pari GmbH Spezialisten für effektive Inhalation Vernebler
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016067252A1 (en) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Powder formulation
MX2017009112A (es) 2015-01-14 2018-06-15 Respira Therapeutics Inc Metodos y dispositivos de dispersion de polvo.
WO2016193956A1 (en) * 2015-06-04 2016-12-08 Lameplast S.P.A. Device for the spray dispensing of a liquid product
US20180303753A1 (en) * 2015-09-09 2018-10-25 Keith Try Ung Targeted delivery of spray-dried formulations to the lungs
CN105616390B (zh) * 2016-03-24 2019-07-23 李浩莹 普鲁兰多糖及衍生物在制备缓控释放药物颗粒中的应用
US10898494B2 (en) 2016-05-05 2021-01-26 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
JP6853275B2 (ja) * 2016-12-05 2021-03-31 微邦科技股▲ふん▼有限公司Ｍｉｃｒｏｂａｓｅ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． 切替え可能な部分を有するエアゾール発生装置
WO2018113891A1 (en) * 2016-12-23 2018-06-28 University Of Copenhagen A co-amorphous form of a substance and a dipeptide
ES2684403B1 (es) * 2017-03-31 2019-07-09 Farm Rovi Lab Sa Procedimiento para el llenado gravimetrico en condiciones esteriles de solidos en un contenedor farmaceutico y contenedor farmaceutico utilizable en el mismo
FI3612262T3 (fi) * 2017-04-18 2024-01-16 Inspiring Pty Ltd Kuivajauheinhalaattori ja kuivajauheinhalaattorin tilanjatkeväline
US10252283B2 (en) * 2017-07-17 2019-04-09 Yoanna Gouchtchina Dermal spray apparatus and method
EP3704448B1 (en) 2017-11-02 2022-06-01 F. Hoffmann-La Roche AG Droplet dispensing device and system
JP6489669B1 (ja) * 2018-10-30 2019-03-27 ルアン株式会社 スクイズ容器
CN109954200A (zh) * 2019-04-16 2019-07-02 郑州大学第一附属医院 一种呼吸内科护理用给药装置
US20220091089A1 (en) * 2019-04-25 2022-03-24 Agco Corporation Apparatus and methods for measuring soil conditions
CN112237668A (zh) * 2019-07-17 2021-01-19 杭州亿脑创新工场有限公司 多剂量粉末药物给药装置及适用于该装置的药联
US11944178B2 (en) 2020-04-07 2024-04-02 Kozhya LLC SP Z.O.O. Dermal spray apparatus and method
WO2021211624A1 (en) * 2020-04-14 2021-10-21 Qool Therapeutics, Inc. Frozen particle generator using liquid micro-dispenser
WO2022132776A1 (en) * 2020-12-15 2022-06-23 Sanara Medtech Inc. Powder applicator
TWI763510B (zh) * 2021-05-28 2022-05-01 林錫璋 藥粉輸送裝置
US12376665B2 (en) 2021-10-14 2025-08-05 Kozhya LLC Sp. z o.o. Dermal spray apparatus with disposable cartrdige and method
USD1046122S1 (en) 2022-05-09 2024-10-08 Quantum Skin Limited Liability Company Dermal spray cartridge
USD1033635S1 (en) 2022-05-09 2024-07-02 Quantum Skin SP Z O.O Dermal spray nozzle
USD1035867S1 (en) 2022-05-09 2024-07-16 Kozhya LLC Sp. z o.o. Dermal spray apparatus
USD1038383S1 (en) 2022-05-09 2024-08-06 Kozhya LLC Sp. z o.o. Dermal spray apparatus
CN116350607A (zh) * 2023-04-11 2023-06-30 胡崇茂 一种干细胞吸入组合物及其制备方法和应用
WO2025225923A1 (ko) * 2024-04-25 2025-10-30 주식회사 리센스메디컬 조성물 분사 장치 및 이를 포함한 분사 시스템

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1950926A (en) * 1932-10-05 1934-03-13 Lobl Frederick Nasal inhaler
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
US3874381A (en) * 1974-05-28 1975-04-01 Smithkline Corp Dual nozzle intranasal delivery device
GB1521000A (en) * 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
JPS58152498A (ja) * 1982-03-06 1983-09-10 Terumo Corp 低分子ペプチド混合物の製造方法
JPS61500431A (ja) 1982-12-09 1986-03-13 ビルトン，ジエラルド　エル． 傷治癒に有用な活性化され、安定化された酵素
EP0133767B1 (en) 1983-08-04 1991-04-03 The Green Cross Corporation Gamma interferon composition
JPS6052847A (ja) 1983-09-01 1985-03-26 Konishiroku Photo Ind Co Ltd ハロゲン化銀感光材料の現像処理方法
EP0168008A3 (en) 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
JPH01116045A (ja) * 1987-10-29 1989-05-09 Toshiba Corp 耐食性ジルコニウム合金
EP0360340A1 (en) 1988-09-19 1990-03-28 Akzo N.V. Composition for nasal administration containing a peptide
JPH07116022B2 (ja) * 1989-04-18 1995-12-13 三共株式会社 凍結乾燥製剤の製法
DE407028T1 (de) * 1989-05-31 1994-03-17 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
FR2649323B1 (fr) 1989-07-04 1995-06-30 Valois Dispositif de projection et de pulverisation d'une dose d'un produit divisable
JPH0341033A (ja) 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
DK544589D0 (da) 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
KR910014122A (ko) 1990-01-19 1991-08-31 디께다 가즈히꼬 에토포시드-2-디메틸아미노 화합물의 동결건조 제제
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
JPH0464878A (ja) * 1990-07-04 1992-02-28 Mitsubishi Heavy Ind Ltd 吸収冷凍機の吸収器
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
WO1992017209A1 (fr) 1991-04-08 1992-10-15 Sumitomo Pharmaceuticals Company, Limited Preparation solide poreuse contenant une substance proteique physiologiquement active
JP3131271B2 (ja) 1992-03-24 2001-01-31 住友ゴム工業株式会社 防振支承
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
JPH06186141A (ja) * 1992-12-16 1994-07-08 Hitachi Ltd 残留応力予測法
WO1994014492A2 (en) * 1992-12-18 1994-07-07 Schering Corporation Inhaler for powdered medications
JPH0652847U (ja) 1992-12-28 1994-07-19 セントラル自動車株式会社 防火シャッター付き搬送装置
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
JP3007785B2 (ja) 1993-03-16 2000-02-07 旭化成工業株式会社 トロンボモジュリン組成物およびその変性防止方法
US5533502A (en) * 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
WO1994028876A1 (en) * 1993-06-07 1994-12-22 Advanced Therapies, Inc. Liposome powders
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
ES2245780T3 (es) 1994-05-18 2006-01-16 Nektar Therapeutics Metodos y composiciones para la formulacion de interferones como un polvo seco.
CZ289029B6 (cs) * 1994-09-21 2001-10-17 Inhale Therapeutic Systems Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
JPH08103499A (ja) * 1994-10-04 1996-04-23 Unisia Jecs Corp 吸入式投薬器
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP3317827B2 (ja) * 1995-10-09 2002-08-26 株式会社ユニシアジェックス 投薬器
US20030138402A1 (en) * 1995-12-25 2003-07-24 Otsuka Pharmaceutical Co., Ltd. Dry compositions
TW403653B (en) 1995-12-25 2000-09-01 Otsuka Pharma Co Ltd Dry compositions
JP3328132B2 (ja) * 1996-03-21 2002-09-24 株式会社ユニシアジェックス 吸入式投薬器
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
AUPN976496A0 (en) * 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US5663492A (en) * 1996-06-05 1997-09-02 Alapati; Rama Rao System for continuous analysis and modification of characteristics of a liquid hydrocarbon stream
AU718967B2 (en) * 1997-02-05 2000-05-04 Jagotec Ag Medical aerosol formulations
DE19704849B4 (de) * 1997-02-08 2011-02-17 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
US6503537B2 (en) * 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
US6394085B1 (en) * 1997-09-25 2002-05-28 Norton Healthcare Ltd. Inhaler spacer
ATE215820T1 (de) * 1997-10-08 2002-04-15 Sepracor Inc Dosierungsform zur verabreichung von aerosolen
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
JP4266399B2 (ja) 1997-12-04 2009-05-20 帝人株式会社 粉末状吸入用医薬品組成物
EP1080720A4 (en) * 1998-03-05 2002-06-05 Nippon Shinyaku Co Ltd FAT EMULSIONS FOR INHALATIVE ADMINISTRATION
JP3547612B2 (ja) * 1998-03-20 2004-07-28 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
MA25590A1 (fr) * 1998-09-14 2002-12-31 Inhale Therapeutic Syst Agent actif de delivraison de poudre seche
US5952232A (en) 1998-09-17 1999-09-14 Rothman; James Edward Expandible microparticle intracellular delivery system
US6745763B2 (en) * 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
JP2000233023A (ja) 1999-02-15 2000-08-29 Hiroshi Matsuzawa 鼻腔内洗浄器
GB2353222B (en) * 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
GB9919693D0 (en) * 1999-08-19 1999-10-20 Rhone Poulenc Rorer Ltd Process
JP2001151673A (ja) 1999-09-06 2001-06-05 Nikken Chem Co Ltd 吸入用粉末製剤の製造方法
DE60025019T2 (de) * 1999-10-29 2006-08-24 Nektar Therapeutics, San Carlos Trockenpulverzusammensetzungen mit verbesserter dispersivität
JP4931282B2 (ja) * 2000-10-02 2012-05-16 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
JP3943845B2 (ja) * 2001-02-15 2007-07-11 芳枝 米谷 リポソームベクター
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
EA007730B1 (ru) * 2002-12-13 2006-12-29 Оцука Фармасьютикал Ко., Лтд. Ингаляционное устройство для транспульмонального введения

Also Published As

Publication number Publication date
MA27131A1 (fr) 2005-01-03
EP1402913B1 (en) 2006-08-23
US20090095293A1 (en) 2009-04-16
KR20050084272A (ko) 2005-08-26
PL377554A1 (pl) 2006-02-06
EG24184A (en) 2008-10-08
CA2449954A1 (en) 2002-12-27
EP1688134A3 (en) 2009-11-18
AU2003289051A1 (en) 2004-07-09
HRP20050639A2 (en) 2006-07-31
CN100427077C (zh) 2008-10-22
ES2271266T3 (es) 2007-04-16
MXPA05006322A (es) 2005-08-26
KR20070048813A (ko) 2007-05-09
ATE336989T1 (de) 2006-09-15
KR100907333B1 (ko) 2009-07-13
EE04956B1 (et) 2008-02-15
CN1323658C (zh) 2007-07-04
PT1402913E (pt) 2006-12-29
NO20053300D0 (no) 2005-07-05
KR100906754B1 (ko) 2009-07-09
EG23775A (en) 2007-08-08
US8333193B2 (en) 2012-12-18
EP1402913A1 (en) 2004-03-31
AP2003002945A0 (en) 2003-12-31
PL367161A1 (en) 2005-02-21
PL209876B1 (pl) 2011-10-31
HRP20040033B1 (en) 2007-11-30
HRP20040033A2 (en) 2004-08-31
CY1105755T1 (el) 2010-12-22
DE60214184T2 (de) 2007-06-28
US20090126732A1 (en) 2009-05-21
AU2003289051B2 (en) 2008-06-26
EP1688133A1 (en) 2006-08-09
BR0210425A (pt) 2004-08-17
NZ530044A (en) 2005-09-30
EA005025B1 (ru) 2004-10-28
WO2002102445A1 (en) 2002-12-27
JPWO2002102445A1 (ja) 2004-09-30
US20070065371A2 (en) 2007-03-22
BR0210425B1 (pt) 2012-12-11
NZ540935A (en) 2007-06-29
AU2008200583A1 (en) 2008-02-28
HK1082403A1 (en) 2006-06-09
CZ200470A3 (cs) 2004-07-14
KR20070050105A (ko) 2007-05-14
BR0316754A (pt) 2005-10-25
CN1516606A (zh) 2004-07-28
EE200400011A (et) 2004-02-16
US7448379B2 (en) 2008-11-11
EP1688134A2 (en) 2006-08-09
HUP0400217A2 (en) 2004-09-28
EA200400045A1 (ru) 2004-06-24
JP3635353B2 (ja) 2005-04-06
CN1726014A (zh) 2006-01-25
UA81280C2 (uk) 2007-12-25
NO334652B1 (no) 2014-05-05
KR101049914B1 (ko) 2011-07-15
HRP20040033B8 (hr) 2008-09-30
US8443799B2 (en) 2013-05-21
AP1861A (en) 2008-07-02
DE60214184D1 (de) 2006-10-05
EP1579855A1 (en) 2005-09-28
WO2004054555A1 (ja) 2004-07-01
EP1402913A4 (en) 2004-12-01
HU227300B1 (en) 2011-02-28
US7735485B2 (en) 2010-06-15
PL205104B1 (pl) 2010-03-31
AU2002311213B2 (en) 2007-12-13
NO20053300L (no) 2005-09-12
DK1402913T3 (da) 2006-12-11
CA2449954C (en) 2011-08-23
US20060073105A1 (en) 2006-04-06
NO20035554D0 (no) 2003-12-12
BG108517A (en) 2005-02-28
TW570819B (en) 2004-01-11
CA2507766A1 (en) 2004-07-01
AU2008200583B2 (en) 2011-05-19
SI1402913T1 (sl) 2007-02-28
CA2507766C (en) 2011-11-01
EP1579855A4 (en) 2009-11-04
NO20035554L (no) 2004-02-12
US20030101995A1 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
EG23775A (en) Novel dry powder inhalation system for transpulmonary administration
AU2002311213A1 (en) Dry powder inhalation system for transpulmonary administration
HUP0200818A2 (en) Powder inhaler for combined medicament
HUP0200855A2 (en) Powder inhaler for combined medicament
GB0115520D0 (en) De-agglomerator for breath-actuated dry powder inhaler
EP1487417A4 (en) DRY POWDER DRUG FORMULATIONS
IL133031A0 (en) Powder inhaler
EG23792A (en) Inhalation device for transpulmonary administration
PL369072A1 (en) Metered dose inhaler
EG24227A (en) Capsules for inhalation
AU9043201A (en) Continuous dry powder inhaler
EP1307256A4 (en) dry powder inhaler
HUP0200185A3 (en) Improved powdery pharmaceutical compositions for inhalation
IL157580A0 (en) Inhalation drug combination
GB0011807D0 (en) Formulation for inhalation
GB0003935D0 (en) Formulation for dry powder inhaler
ZA200309550B (en) Dry powder inhalation system for transpulmonary administration
AP2008004396A0 (en) Dry Powder inhalation system for transpulmonary administration
AU6028101A (en) Medicament for combating respiratory depression
GB0226274D0 (en) Metered dose inhalation preparations
GB0108136D0 (en) Respiratory system drug applicator
EP1237605A4 (en) powder inhaler
GB0127359D0 (en) Pharmaceutical compositions for inhalation
GB0124010D0 (en) Pharmaceutical compositions for inhalation
HK1069784A (en) Metered dose inhaler

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed