BG40964A3 - Method for preparing 8- chlor- 1, 5- benzothiazepin derivatives - Google Patents

Method for preparing 8- chlor- 1, 5- benzothiazepin derivatives

Info

Publication number
BG40964A3
BG40964A3 BG065689A BG6568984A BG40964A3 BG 40964 A3 BG40964 A3 BG 40964A3 BG 065689 A BG065689 A BG 065689A BG 6568984 A BG6568984 A BG 6568984A BG 40964 A3 BG40964 A3 BG 40964A3
Authority
BG
Bulgaria
Prior art keywords
preparing
chlor
derivatives
benzothiazepin
benzothiazepin derivatives
Prior art date
Application number
BG065689A
Other languages
Bulgarian (bg)
English (en)
Inventor
Mikio Takeda
Tokuro Oh-Ishi
Hiromichi Nakajima
Taku Nagao
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838315364A external-priority patent/GB8315364D0/en
Priority claimed from GB848400983A external-priority patent/GB8400983D0/en
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of BG40964A3 publication Critical patent/BG40964A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
    • C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
    • C09J123/04—Homopolymers or copolymers of ethene
    • C09J123/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG065689A 1983-06-03 1984-05-30 Method for preparing 8- chlor- 1, 5- benzothiazepin derivatives BG40964A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838315364A GB8315364D0 (en) 1983-06-03 1983-06-03 8-chloro-1 5-benzothiazepine derivatives
GB848400983A GB8400983D0 (en) 1984-01-14 1984-01-14 8-chloro-1,5-benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
BG40964A3 true BG40964A3 (en) 1987-03-14

Family

ID=26286299

Family Applications (2)

Application Number Title Priority Date Filing Date
BG065689A BG40964A3 (en) 1983-06-03 1984-05-30 Method for preparing 8- chlor- 1, 5- benzothiazepin derivatives
BG069785A BG41130A3 (en) 1983-06-03 1984-05-30 Method for preparing 8- chlor-1, 5- benzo- thiazepine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG069785A BG41130A3 (en) 1983-06-03 1984-05-30 Method for preparing 8- chlor-1, 5- benzo- thiazepine derivatives

Country Status (18)

Country Link
US (1) US4567175A (da)
EP (1) EP0127882B1 (da)
KR (1) KR900005697B1 (da)
AT (1) ATE22889T1 (da)
AU (1) AU563093B2 (da)
BG (2) BG40964A3 (da)
CA (2) CA1237719A (da)
DD (1) DD218619A5 (da)
DE (1) DE3460972D1 (da)
DK (2) DK167185B1 (da)
ES (2) ES533009A0 (da)
HK (1) HK81888A (da)
HU (2) HU191933B (da)
MY (1) MY101748A (da)
NO (2) NO162518C (da)
PH (1) PH21627A (da)
PT (1) PT78682B (da)
SU (2) SU1299508A3 (da)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
USRE33072E (en) * 1985-06-20 1989-09-26 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
JPS62161776A (ja) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
US4652561A (en) * 1986-02-26 1987-03-24 Hoffmann-La Roche Inc. Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) * 1986-03-24 1987-10-20 Hoffmann La Roche Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4778791A (en) * 1986-05-16 1988-10-18 Tanabe Seiyaku Co., Ltd. Pharmaceutical composition for improving constitution of lipids in blood
JPS63107925A (ja) * 1986-05-23 1988-05-12 Tanabe Seiyaku Co Ltd 動脈硬化症予防・治療剤
DE3771143D1 (de) * 1986-08-20 1991-08-08 Mcneilab Inc Benzothiazepin-vasodilatoren mit aralkylsubstitution.
IL85257A (en) * 1987-02-10 1993-02-21 Tanabe Seiyaku Co Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
JPS6445376A (en) * 1987-08-12 1989-02-17 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
AT389446B (de) * 1987-10-08 1989-12-11 Tanabe Seiyaku Co Verwendung eines 8-chlorobenzothiazepins zur herstellung eines arzneimittels
US4808580A (en) * 1987-12-17 1989-02-28 Hoffmann-La Roche Inc. Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
US4879289A (en) * 1988-05-24 1989-11-07 Marion Laboratories, Inc. Method of ameliorating epileptic seizures
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5002942A (en) * 1988-07-25 1991-03-26 Sankyo Company, Limited 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1226301B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
US5250680A (en) * 1989-08-31 1993-10-05 Merrell Dow Pharmaceuticals Inc. Heterogeneous synthesis of azepinones from esters
AU628217B2 (en) * 1989-08-31 1992-09-10 Marion Merrell Dow Inc. Heterogeneous synthesis of azepinones from esters
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
CA2030160A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Benzothiazepine metastasis treatment
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines
US5112969A (en) * 1990-04-02 1992-05-12 Merrell Dow Pharmaceuticals Inc. Cyano esters and azepinones
US5055575A (en) * 1990-04-12 1991-10-08 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
CA2049655C (en) * 1990-09-17 1996-11-12 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
DK0585355T3 (da) * 1991-05-20 1995-06-06 Tanabe Seiyaku Co Flerlagspræparat med reguleret frigivelse
US5378698A (en) * 1991-10-21 1995-01-03 Shionogi & Co., Ltd. Benzothiazepine derivatives
CA2087743C (en) * 1992-02-06 1999-04-27 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
KR950003279A (ko) * 1993-07-29 1995-02-16 고사이 아끼오 플루오로알칸 카르복사미드 유도체의 제조방법
US5705638A (en) * 1995-12-05 1998-01-06 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
EP0778272B1 (en) * 1995-12-05 1998-12-23 Tanabe Seiyaku Co., Ltd. Optically active benzothiazepine compounds and process for preparing the same
SG50796A1 (en) * 1996-02-23 1998-07-20 Tanabe Seiyaku Co Process for preparing 1,5-benzothiazepine derivative
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CA2574958A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
MX2007005137A (es) * 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
JP2009513660A (ja) * 2005-10-26 2009-04-02 旭化成ファーマ株式会社 肺動脈性高血圧の治療用併用療法におけるファスジル
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
RS66416B1 (sr) 2019-01-18 2025-02-28 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
BR6915295D0 (pt) * 1969-01-25 1973-04-12 Tanabe Seiyaku Co Indicador cronologico de evento em transmissao televisada

Also Published As

Publication number Publication date
HUT37929A (en) 1986-03-28
ES541557A0 (es) 1985-12-01
BG41130A3 (en) 1987-04-15
PT78682A (pt) 1985-01-01
ES8506677A1 (es) 1985-08-01
NO863823D0 (no) 1986-09-25
NO162518C (no) 1990-01-10
KR900005697B1 (ko) 1990-08-06
ES8602720A1 (es) 1985-12-01
SU1362401A3 (ru) 1987-12-23
DK104792A (da) 1992-08-24
CA1231097A (en) 1988-01-05
KR850000033A (ko) 1985-02-25
EP0127882A1 (en) 1984-12-12
PH21627A (en) 1987-12-11
NO163566C (no) 1990-06-27
DK272884A (da) 1984-12-04
NO842203L (no) 1984-12-04
ATE22889T1 (de) 1986-11-15
ES533009A0 (es) 1985-08-01
NO163566B (no) 1990-03-12
DD218619A5 (de) 1985-02-13
AU563093B2 (en) 1987-06-25
DK167185B1 (da) 1993-09-13
DK167186B1 (da) 1993-09-13
US4567175A (en) 1986-01-28
DE3460972D1 (en) 1986-11-20
DK104792D0 (da) 1992-08-24
PT78682B (en) 1986-07-11
AU2887384A (en) 1984-12-06
HU191933B (en) 1987-04-28
CA1237719A (en) 1988-06-07
HK81888A (en) 1988-10-14
NO863823L (no) 1984-12-04
DK272884D0 (da) 1984-06-01
HU193865B (en) 1987-12-28
MY101748A (en) 1992-01-17
SU1299508A3 (ru) 1987-03-23
NO162518B (no) 1989-10-02
EP0127882B1 (en) 1986-10-15

Similar Documents

Publication Publication Date Title
BG40964A3 (en) Method for preparing 8- chlor- 1, 5- benzothiazepin derivatives
ES543653A0 (es) Procedimiento de preparar derivados de 1,4-dihidropiridinas
DK165409C (da) 3-aminopyrazolooe3,4-daapyrimidinderivater
BG40963A3 (en) Method for preparing 1, 3- disubstituted 2- oxyindols
BG42185A3 (en) Method for preparing pyridylic compounds
BG42355A3 (en) Method for preparing aminoguanidinic derivatives
FI863776A7 (fi) Menetelmä 7-aminomitosaanijohdannaisten valmistamiseksi.
BG39976A3 (en) Method for preparing benzamides
KR850004570A (ko) 2,2-디플루오로프로피온산 유도체의 제조방법
BG40147A3 (bg) Метод за получаване на хетероциклични съединения
BG36932A3 (bg) Метод за получаване на 1-(3-хидрокси-4-метаксибензоил)-3- хидрокси-2-пиролидинон
BG40803A3 (bg) Метод за получаване на арилциклобутилалкиламинови производни
BG33292A3 (bg) Метод за получаване на пенамсулфоокисни производни
BG38637A3 (en) Method for preparing 2- exo- hydroxy- 7- oxabicyclo [2, 2, 1] heptanes
BG40143A3 (en) Method for preparing acetamide derivatives
BG37840A3 (bg) Метод за получаване на производни на ортокондензиран пирол
DK505684A (da) 1,2-dithiolanderivater
NO841965L (no) Fremgangsmaate for fremstilling av 1,8-dihydroksy-10-acyl-9-antron-derivater
BG40808A3 (bg) Метод за получаване на производни на пиролидина
BG38940A3 (en) Method for preparing penicillanoyloxymethyl penicillanate- 1, 1- dioxide
BG38337A3 (en) Method for preparing 6 alpha- methylhydrocortisonic derivatives
BG40809A3 (bg) Метод за получаване на органични съединения
DE3469732D1 (de) 3,5-dialkyl-4-hydroxyphenyl-substituted derivatives
KR860005812A (ko) 4,4-디알킬-2-아제티디논의 제조 방법
BG39977A3 (en) Method for preparing derivatives of furyloxazolylacetic acid