DK272884A - 8-chlor-1,5-benzothiazepin-derivater og fremgangsmaade til fremstilling deraf - Google Patents

8-chlor-1,5-benzothiazepin-derivater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK272884A
Authority: DK; Denmark
Prior art keywords: chlor; procedures; preparing; benzothiazepine derivatives; lower alkyl
Prior art date: 1983-06-03

Application number

DK272884A

Other languages

English (en)

Other versions

DK272884D0 (da

DK167185B1 (da

Inventor

Mikio Takeda

Tokuro Oh-Ishi

Hiromichi Nakajima

Taku Nagao

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-03

Filing date

1984-06-01

Publication date

1984-12-04

1983-06-03 Priority claimed from GB838315364A external-priority patent/GB8315364D0/en

1984-01-14 Priority claimed from GB848400983A external-priority patent/GB8400983D0/en

1984-06-01 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

1984-06-01 Publication of DK272884D0 publication Critical patent/DK272884D0/da

1984-12-04 Publication of DK272884A publication Critical patent/DK272884A/da

1993-09-13 Application granted granted Critical

1993-09-13 Publication of DK167185B1 publication Critical patent/DK167185B1/da

Links

JQNJUZUDWVHVHJ-UHFFFAOYSA-N 8-chloro-1,5-benzothiazepine Chemical class N1=CC=CSC2=CC(Cl)=CC=C21 JQNJUZUDWVHVHJ-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000002220 antihypertensive agent Substances 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
- C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J123/04—Homopolymers or copolymers of ethene
- C09J123/08—Copolymers of ethene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK272884A 1983-06-03 1984-06-01 5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater DK167185B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8315364		1983-06-03
GB838315364A GB8315364D0 (en)	1983-06-03	1983-06-03	8-chloro-1 5-benzothiazepine derivatives
GB8400983		1984-01-14
GB848400983A GB8400983D0 (en)	1984-01-14	1984-01-14	8-chloro-1,5-benzothiazepine derivatives

Publications (3)

Publication Number	Publication Date
DK272884D0 DK272884D0 (da)	1984-06-01
DK272884A true DK272884A (da)	1984-12-04
DK167185B1 DK167185B1 (da)	1993-09-13

Family

ID=26286299

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK272884A DK167185B1 (da)	1983-06-03	1984-06-01	5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater
DK104792A DK167186B1 (da)	1983-06-03	1992-08-24	8-chlor-1,5-benzothiazepinderivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK104792A DK167186B1 (da)	1983-06-03	1992-08-24	8-chlor-1,5-benzothiazepinderivater og fremgangsmaade til fremstilling deraf

Country Status (18)

Country	Link
US (1)	US4567175A (da)
EP (1)	EP0127882B1 (da)
KR (1)	KR900005697B1 (da)
AT (1)	ATE22889T1 (da)
AU (1)	AU563093B2 (da)
BG (2)	BG41130A3 (da)
CA (2)	CA1237719A (da)
DD (1)	DD218619A5 (da)
DE (1)	DE3460972D1 (da)
DK (2)	DK167185B1 (da)
ES (2)	ES8506677A1 (da)
HK (1)	HK81888A (da)
HU (2)	HU193865B (da)
MY (1)	MY101748A (da)
NO (2)	NO162518C (da)
PH (1)	PH21627A (da)
PT (1)	PT78682B (da)
SU (2)	SU1299508A3 (da)

Families Citing this family (59)

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US4585768A (en) *	1984-04-10	1986-04-29	Tanabe Seiyaku Co., Ltd.	1,5-benzothiazepine derivatives and processes for preparing the same
GB2167063A (en) *	1984-11-17	1986-05-21	Tanabe Seiyaku Co	6 or 9-chloro-1, 5-benzothiazepine derivatives
US4584131A (en) *	1985-06-20	1986-04-22	E. R. Squibb & Sons, Inc.	Benzothiazepine derivatives
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JPS62161776A (ja) *	1986-01-07	1987-07-17	Tanabe Seiyaku Co Ltd	１，５−ベンゾチアゼピン誘導体の製法
US4652561A (en) *	1986-02-26	1987-03-24	Hoffmann-La Roche Inc.	Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) *	1986-03-24	1987-10-20	Hoffmann La Roche	Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4778791A (en) *	1986-05-16	1988-10-18	Tanabe Seiyaku Co., Ltd.	Pharmaceutical composition for improving constitution of lipids in blood
JPS63107925A (ja) *	1986-05-23	1988-05-12	Tanabe Seiyaku Co Ltd	動脈硬化症予防・治療剤
ATE64925T1 (de) *	1986-08-20	1991-07-15	Mcneilab Inc	Benzothiazepin-vasodilatoren mit aralkylsubstitution.
IL85257A (en) *	1987-02-10	1993-02-21	Tanabe Seiyaku Co	Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
JPS6450872A (en) *	1987-08-21	1989-02-27	Tanabe Seiyaku Co	Production of 1,5-benzothiazepine derivative
JPS6445376A (en) *	1987-08-12	1989-02-17	Tanabe Seiyaku Co	Production of 1,5-benzothiazepine derivative
AT389446B (de) *	1987-10-08	1989-12-11	Tanabe Seiyaku Co	Verwendung eines 8-chlorobenzothiazepins zur herstellung eines arzneimittels
US4808580A (en) *	1987-12-17	1989-02-28	Hoffmann-La Roche Inc.	Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
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US4963545A (en) *	1988-05-24	1990-10-16	Marion Laboratories, Inc.	Benzothiazepine anti-seizure method
US4879289A (en) *	1988-05-24	1989-11-07	Marion Laboratories, Inc.	Method of ameliorating epileptic seizures
US4902684A (en) *	1988-06-20	1990-02-20	E. R. Squibb & Sons, Inc.	Benzazepine and benzothiazepine derivatives
US5002942A (en) *	1988-07-25	1991-03-26	Sankyo Company, Limited	1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1226301B (it) *	1988-07-26	1990-12-27	Zambon Spa	Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2637285B1 (fr) *	1988-10-03	1991-04-12	Synthelabo	Procede de preparation de derives de l'acide propionique et produits obtenus
US4952692A (en) *	1989-04-04	1990-08-28	E. R. Squibb & Sons, Inc.	Benzazepine derivatives
US4946840A (en) *	1989-04-06	1990-08-07	E. R. Squibb & Sons, Inc.	Benzazepine and benzothiazepine derivatives
IT1230057B (it) *	1989-04-13	1991-09-27	Zambon Spa	Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
ES2069003T3 (es) *	1989-04-28	1995-05-01	Tanabe Seiyaku Co	Procedimiento para preparar derivados de 1,5-benzotiazepina.
US5128469A (en) *	1989-04-28	1992-07-07	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivatives
ZA906810B (en) *	1989-08-31	1991-10-30	Marion Merrell Dow Inc	Heterogeneous synthesis of azepinones from esters
US5250680A (en) *	1989-08-31	1993-10-05	Merrell Dow Pharmaceuticals Inc.	Heterogeneous synthesis of azepinones from esters
JPH088879B2 (ja) *	1989-09-13	1996-01-31	田辺製薬株式会社	光学活性３―フェニルグリシッド酸エステル類化合物の製法
US5001236A (en) *	1989-11-22	1991-03-19	Marion Laboratories, Inc.	Benzothiazepines
CA2030159A1 (en) *	1989-11-22	1991-05-23	Nahed K. Ahmed	Anti-cancer drug potentiators
CA2030160A1 (en) *	1989-11-22	1991-05-23	Nahed K. Ahmed	Benzothiazepine metastasis treatment
US5112969A (en) *	1990-04-02	1992-05-12	Merrell Dow Pharmaceuticals Inc.	Cyano esters and azepinones
US5055575A (en) *	1990-04-12	1991-10-08	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivatives
IT1240651B (it) *	1990-05-17	1993-12-17	Zambon Spa	Processo per la risoluzione di derivati glicidici
CA2049655C (en) *	1990-09-17	1996-11-12	Akio Odawara	Pharmaceutical composition for inhibiting platelet aggregation
WO1992020326A1 (en) *	1991-05-20	1992-11-26	Marion Laboratories, Inc.	Multi-layered controlled release formulation
US5378698A (en) *	1991-10-21	1995-01-03	Shionogi & Co., Ltd.	Benzothiazepine derivatives
JP2712144B2 (ja) *	1992-02-06	1998-02-10	田辺製薬株式会社	血小板凝集抑制組成物
KR950003279A (ko) *	1993-07-29	1995-02-16	고사이 아끼오	플루오로알칸 카르복사미드 유도체의 제조방법
US5705638A (en) *	1995-12-05	1998-01-06	Tanabe Seiyaku Co., Ltd.	Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
EP0778272B1 (en) *	1995-12-05	1998-12-23	Tanabe Seiyaku Co., Ltd.	Optically active benzothiazepine compounds and process for preparing the same
SG50796A1 (en) *	1996-02-23	1998-07-20	Tanabe Seiyaku Co	Process for preparing 1,5-benzothiazepine derivative
IT1302261B1 (it)	1998-09-24	2000-09-05	Zambon Spa	Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
EA200500234A1 (ru)	2002-08-19	2005-08-25	Пфайзер Продактс Инк.	Комбинированная терапия гиперпролиферативных болезней
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
CA2574958A1 (en) *	2004-07-26	2006-02-09	Cotherix, Inc.	Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
ES2328384T3 (es) *	2004-11-23	2009-11-12	Warner-Lambert Company Llc	Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
WO2007050783A2 (en)	2005-10-26	2007-05-03	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2012037665A1 (en)	2010-09-24	2012-03-29	Oral Delivery Technology Ltd.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN105143203A (zh)	2013-04-17	2015-12-09	辉瑞大药厂	用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
BR6915295D0 (pt) *	1969-01-25	1973-04-12	Tanabe Seiyaku Co	Indicador cronologico de evento em transmissao televisada

1984
- 1984-05-16 US US06/610,856 patent/US4567175A/en not_active Expired - Lifetime
- 1984-05-29 CA CA000455370A patent/CA1237719A/en not_active Expired
- 1984-05-30 AT AT84106187T patent/ATE22889T1/de active
- 1984-05-30 BG BG069785A patent/BG41130A3/xx unknown
- 1984-05-30 DE DE8484106187T patent/DE3460972D1/de not_active Expired
- 1984-05-30 BG BG065689A patent/BG40964A3/xx unknown
- 1984-05-30 EP EP84106187A patent/EP0127882B1/en not_active Expired
- 1984-05-31 AU AU28873/84A patent/AU563093B2/en not_active Ceased
- 1984-05-31 PH PH30744A patent/PH21627A/en unknown
- 1984-05-31 ES ES533009A patent/ES8506677A1/es not_active Expired
- 1984-06-01 HU HU863905A patent/HU193865B/hu unknown
- 1984-06-01 HU HU842144A patent/HU191933B/hu not_active IP Right Cessation
- 1984-06-01 PT PT78682A patent/PT78682B/pt not_active IP Right Cessation
- 1984-06-01 DK DK272884A patent/DK167185B1/da active
- 1984-06-01 NO NO842203A patent/NO162518C/no unknown
- 1984-06-01 DD DD84263713A patent/DD218619A5/de not_active IP Right Cessation
- 1984-06-01 SU SU843749937A patent/SU1299508A3/ru active
- 1984-06-02 KR KR1019840003088A patent/KR900005697B1/ko not_active Expired
1985
- 1985-02-25 SU SU853856852A patent/SU1362401A3/ru active
- 1985-03-25 ES ES541557A patent/ES8602720A1/es not_active Expired
1986
- 1986-09-25 NO NO863823A patent/NO163566C/no unknown
- 1986-11-27 CA CA000524033A patent/CA1231097A/en not_active Expired
1987
- 1987-06-24 MY MYPI87000877A patent/MY101748A/en unknown
1988
- 1988-10-06 HK HK818/88A patent/HK81888A/en not_active IP Right Cessation
1992
- 1992-08-24 DK DK104792A patent/DK167186B1/da active

Also Published As

Publication number	Publication date
EP0127882B1 (en)	1986-10-15
DK167186B1 (da)	1993-09-13
HUT37929A (en)	1986-03-28
NO163566C (no)	1990-06-27
ES541557A0 (es)	1985-12-01
PH21627A (en)	1987-12-11
ES533009A0 (es)	1985-08-01
BG40964A3 (en)	1987-03-14
HU193865B (en)	1987-12-28
NO162518C (no)	1990-01-10
ES8602720A1 (es)	1985-12-01
DE3460972D1 (en)	1986-11-20
NO162518B (no)	1989-10-02
AU563093B2 (en)	1987-06-25
KR850000033A (ko)	1985-02-25
PT78682B (en)	1986-07-11
HU191933B (en)	1987-04-28
KR900005697B1 (ko)	1990-08-06
DK272884D0 (da)	1984-06-01
DD218619A5 (de)	1985-02-13
PT78682A (pt)	1985-01-01
ES8506677A1 (es)	1985-08-01
US4567175A (en)	1986-01-28
CA1237719A (en)	1988-06-07
CA1231097A (en)	1988-01-05
EP0127882A1 (en)	1984-12-12
DK104792D0 (da)	1992-08-24
HK81888A (en)	1988-10-14
NO163566B (no)	1990-03-12
SU1362401A3 (ru)	1987-12-23
NO842203L (no)	1984-12-04
DK167185B1 (da)	1993-09-13
DK104792A (da)	1992-08-24
NO863823D0 (no)	1986-09-25
ATE22889T1 (de)	1986-11-15
SU1299508A3 (ru)	1987-03-23
AU2887384A (en)	1984-12-06
MY101748A (en)	1992-01-17
NO863823L (no)	1984-12-04
BG41130A3 (en)	1987-04-15

Publication	Publication Date	Title
AU563093B2 (en)	1987-06-25	8-chloro-1, 5-benzothiazepine derivatives
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
AU578755B2 (en)	1988-11-03	Novel 9-chloro-1,5-benzothiazepine derivatives and processes for preparing the same
DK412888D0 (da)	1988-07-22	Piperidin-derivater til terapeutisk anvendelse og fremgangsmaade til fremstilling deraf
DK283984A (da)	1984-12-12	Benzodiazepinderivater og fremgangsmaade til fremstilling deraf
HUT47266A (en)	1989-02-28	Process for production of benzimidasole-derivatives and medical compositions containing them
DE3884518D1 (de)	1993-11-04	Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
GB2017080A (en)	1979-10-03	Benzothiazepines
MY101746A (en)	1992-01-17	1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.