BG42189A3 - Method for preparing of ripe human leucocytic interferon - Google Patents

Method for preparing of ripe human leucocytic interferon

Info

Publication number: BG42189A3
Authority: BG; Bulgaria
Prior art keywords: human leukocyte; interferon; leukocyte interferon; coli; transformed
Prior art date: 1980-07-01

Application number

BG052673A

Other languages

Bulgarian (bg)

English (en)

Inventor

David Norman

Sidney Pestka

Original Assignee

F. Hoffmann - La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-01

Filing date

1981-06-29

Publication date

1987-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG42189(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-04-21 Priority claimed from US06/256,204 external-priority patent/US6610830B1/en

1981-06-29 Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag

1987-10-15 Publication of BG42189A3 publication Critical patent/BG42189A3/xx

Links

102000014150 Interferons Human genes 0.000 title abstract 2
108010050904 Interferons Proteins 0.000 title abstract 2
229940079322 interferon Drugs 0.000 title abstract 2
230000001527 leucocytic effect Effects 0.000 title 1
102000006992 Interferon-alpha Human genes 0.000 abstract 5
108010047761 Interferon-alpha Proteins 0.000 abstract 5
241000588724 Escherichia coli Species 0.000 abstract 4
108020004414 DNA Proteins 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
235000015097 nutrients Nutrition 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
230000034659 glycolysis Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BG052673A 1980-07-01 1981-06-29 Method for preparing of ripe human leucocytic interferon BG42189A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US16498680A	1980-07-01	1980-07-01
US18490980A	1980-09-08	1980-09-08
US20557880A	1980-11-10	1980-11-10
US06/256,204 US6610830B1 (en)	1980-07-01	1981-04-21	Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number	Publication Date
BG42189A3 true BG42189A3 (en)	1987-10-15

Family

ID=27496622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG052673A BG42189A3 (en)	1980-07-01	1981-06-29	Method for preparing of ripe human leucocytic interferon

Country Status (36)

Country	Link
EP (2)	EP0043980B1 (de)
AR (1)	AR242833A1 (de)
AT (3)	AT380272B (de)
AU (1)	AU552004B2 (de)
BG (1)	BG42189A3 (de)
BR (1)	BR8104189A (de)
CH (2)	CH657141A5 (de)
CS (1)	CS273152B2 (de)
DD (3)	DD202307A5 (de)
DE (3)	DE3177288T3 (de)
DK (1)	DK173543B1 (de)
DZ (1)	DZ312A1 (de)
ES (1)	ES503528A0 (de)
FI (1)	FI82712C (de)
FR (1)	FR2486098B1 (de)
GB (1)	GB2079291B (de)
GE (1)	GEP19960519B (de)
GR (1)	GR75714B (de)
HK (1)	HK49285A (de)
HU (1)	HU196457B (de)
IE (1)	IE49255B1 (de)
IT (1)	IT1137272B (de)
KE (1)	KE3534A (de)
LU (1)	LU83461A1 (de)
MC (1)	MC1396A1 (de)
MY (1)	MY8700711A (de)
NL (1)	NL8103151A (de)
NO (1)	NO159392C (de)
NZ (1)	NZ197572A (de)
PH (1)	PH18036A (de)
PL (3)	PL148261B1 (de)
PT (1)	PT73289B (de)
RO (1)	RO87590A (de)
SE (2)	SE465223C5 (de)
SU (1)	SU1414319A3 (de)
YU (1)	YU47700B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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ZA811368B (en) *	1980-03-24	1982-04-28	Genentech Inc	Bacterial polypedtide expression employing tryptophan promoter-operator
FI88175C (fi)	1980-04-03	1993-04-13	Biogen Inc	Rekombinant-dna-molekyler och foerfaranden foer framstaellning av polypeptider liknande humant -interferon
DE3176011D1 (en) *	1980-06-12	1987-04-23	Japan Found Cancer	Plasmid
DK489481A (da) *	1980-11-10	1982-05-11	Searle & Co	Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) *	1981-02-25	1985-12-13	Genentech Inc	Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) *	1981-08-14	1983-03-03	Berg, Kurt, Frimann	SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) *	1981-12-24	1983-07-01	Asahi Chem Ind Co Ltd	新規な生理活性ペプチド
US5098703A (en) *	1982-01-15	1992-03-24	Cetus Corporation	Interferon-alpha 76
US4973479A (en) *	1982-01-15	1990-11-27	Cetus Corporation	Interferon-α61
US4975276A (en) *	1982-01-15	1990-12-04	Cetus Corporation	Interferon-alpha 54
IE54592B1 (en) *	1982-03-08	1989-12-06	Genentech Inc	Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) *	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en)	1982-03-08	2002-08-13	Genentech, Inc.	Non-human animal interferons
US5827694A (en) *	1982-03-08	1998-10-27	Genentech, Inc.	DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
DE3382317D1 (de) *	1982-03-15	1991-07-25	Schering Corp	Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
CA1210714A (en) *	1982-03-23	1986-09-02	Alan Sloma	.alpha.-INTERFERON GX-1
US4748233A (en) *	1982-03-23	1988-05-31	Bristol-Myers Company	Alpha-interferon Gx-1
US4695543A (en) *	1982-03-23	1987-09-22	Bristol-Myers Company	Alpha Interferon GX-1
US6936694B1 (en)	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
US5831023A (en) *	1982-11-01	1998-11-03	Genentech, Inc.	Recombinant animal interferon polypeptides
JPS60500574A (ja) *	1983-02-24	1985-04-25	インステイチユト　オルガニチエスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスア−ル	ヒト白血球インタ−フェロンｎ及び細菌細胞におけるその製造方法
EP0165942A1 (de) *	1983-12-23	1986-01-02	Monash University	Herstellung menschlichen g(a)-interferons
SU1364343A1 (ru) *	1984-07-13	1988-01-07	Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов	Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en)	1984-09-26	1986-01-31	Takeda Chemical Industries Ltd	Mutual separation of proteins
WO1986002068A1 (fr) *	1984-09-26	1986-04-10	Takeda Chemical Industries, Ltd.	Separation mutuelle de proteines
US5196323A (en) *	1985-04-27	1993-03-23	Boehringer Ingelheim International Gmbh	Process for preparing and purifying alpha-interferon
DE3515336C2 (de) *	1985-04-27	1994-01-20	Boehringer Ingelheim Int	Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) *	1986-03-10	1996-07-10	エフ・ホフマン―ラロシユアーゲー	化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) *	1987-05-04	1989-03-09	Oncogen	Oncostatin m and novel composition having antitumor activity
CA1309044C (en) *	1987-11-09	1992-10-20	Toshiya Takano	Method of producing foreign gene products
GB8813032D0 (en) *	1988-06-02	1988-07-06	Boehringer Ingelheim Int	Antiviral pharmaceutical composition
WO1991003251A1 (en) *	1989-09-08	1991-03-21	California Institute Of Biological Research	Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) *	1989-09-28	1991-04-11	Boehringer Ingelheim Int	Verfahren zur reinigung von beta-interferon
AU1854695A (en) *	1994-03-07	1995-09-25	Imperial College Of Science, Technology And Medicine	The use of interferon subtypes in the preparation of medicaments to treat viral infections
DK0679718T3 (da) *	1994-04-09	2001-10-22	Hoffmann La Roche	Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) *	1996-05-13	1996-07-17	Hoffmann La Roche	Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en)	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
ZA9811070B (en)	1997-12-08	2000-07-03	Genentech Inc	Type I interferons.
EP1037995A1 (de)	1997-12-08	2000-09-27	Genentech, Inc.	Menschliches interferon-epsilon: ein typ 1 interferon
US6783965B1 (en)	2000-02-10	2004-08-31	Mountain View Pharmaceuticals, Inc.	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ES2245114T3 (es)	1998-08-06	2005-12-16	Mountain View Pharmaceuticals, Inc.	Conjugados de peg-oxidasa de urato y su uso.
US6268178B1 (en)	1999-05-25	2001-07-31	Phage Biotechnology Corp.	Phage-dependent super-production of biologically active protein and peptides
CA2427850A1 (en) *	2000-11-03	2002-05-10	Sidney Pestka	Interferons, uses and compositions related thereto
FR2822845B1 (fr)	2001-03-30	2003-12-12	Genodyssee	Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr)	2001-04-04	2003-12-12	Genodyssee	Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr)	2001-06-11	2004-09-24	Genodyssee	Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
HUE052976T2 (hu)	2005-04-11	2021-06-28	Horizon Pharma Rheumatology Llc	Urát-oxidáz variáns formái és azok alkalmazása
WO2009090056A2 (en) *	2008-01-18	2009-07-23	F. Hoffmann-La Roche Ag	Purification of not-glycosylated polypeptides
HUP1200205A3 (en)	2009-06-25	2012-09-28	Savient Pharmaceuticals	Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
CN110234340A (zh)	2016-11-11	2019-09-13	好利恩风湿病制药有限责任公司	泼尼松和尿酸酶分子的组合疗法及其用途
US20200237881A1 (en)	2019-01-30	2020-07-30	Horizon Pharma Rheumatology Llc	Reducing immunogenicity to pegloticase
WO2018087345A1 (en)	2016-11-14	2018-05-17	F. Hoffmann-La Roche Ag	COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
US12269875B2 (en)	2023-08-03	2025-04-08	Jeff R. Peterson	Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN150740B (de) *	1978-11-24	1982-12-04	Hoffmann La Roche
FI77877C (fi) *	1979-04-20	1989-05-10	Technobiotic Ltd	Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
IE54096B1 (en) *	1980-01-08	1989-06-21	Biogen Nv	Dn sequences, recombinant dna molecules and processes for producing human interferon - like polypeptides
DE3005897A1 (de) *	1980-02-16	1981-09-03	Hoechst Ag, 6000 Frankfurt	Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) *	1980-06-12	1987-04-23	Japan Found Cancer	Plasmid
ES8302778A1 (es) *	1980-11-10	1983-02-01	Genentech Inc	Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) *	1980-12-31	1984-01-10	Ilkka Antero Palva	Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) *	1981-03-27	1990-04-12	Ici Plc	Genetisch modifizierte mikroorganismen.

1981
- 1981-06-26 CH CH1475/85A patent/CH657141A5/de not_active IP Right Cessation
- 1981-06-26 CH CH4244/81A patent/CH651308A5/de not_active IP Right Cessation
- 1981-06-29 BG BG052673A patent/BG42189A3/xx unknown
- 1981-06-29 DZ DZ816241A patent/DZ312A1/fr active
- 1981-06-29 HU HU811882A patent/HU196457B/hu unknown
- 1981-06-29 FR FR8112724A patent/FR2486098B1/fr not_active Expired
- 1981-06-29 MC MC811525A patent/MC1396A1/fr unknown
- 1981-06-30 RO RO81104732A patent/RO87590A/ro unknown
- 1981-06-30 ES ES503528A patent/ES503528A0/es active Granted
- 1981-06-30 DE DE3177288T patent/DE3177288T3/de not_active Expired - Lifetime
- 1981-06-30 DE DE3125706A patent/DE3125706C2/de not_active Expired - Lifetime
- 1981-06-30 DE DE8181105067T patent/DE3176448D1/de not_active Expired
- 1981-06-30 PT PT73289A patent/PT73289B/pt unknown
- 1981-06-30 LU LU83461A patent/LU83461A1/de unknown
- 1981-06-30 PL PL1981255773A patent/PL148261B1/pl unknown
- 1981-06-30 PL PL1981255774A patent/PL148276B1/pl unknown
- 1981-06-30 EP EP81105067A patent/EP0043980B1/de not_active Expired
- 1981-06-30 AR AR81285934A patent/AR242833A1/es active
- 1981-06-30 NO NO812247A patent/NO159392C/no not_active IP Right Cessation
- 1981-06-30 AT AT0290981A patent/AT380272B/de not_active IP Right Cessation
- 1981-06-30 SU SU813302642A patent/SU1414319A3/ru active
- 1981-06-30 SE SE8104093A patent/SE465223C5/xx not_active IP Right Cessation
- 1981-06-30 PL PL1981231940A patent/PL148260B1/pl unknown
- 1981-06-30 CS CS503781A patent/CS273152B2/cs unknown
- 1981-06-30 NZ NZ197572A patent/NZ197572A/en unknown
- 1981-06-30 AT AT86105365T patent/ATE79901T1/de not_active IP Right Cessation
- 1981-06-30 SE SE8104093D patent/SE8104093L/xx not_active Application Discontinuation
- 1981-06-30 NL NL8103151A patent/NL8103151A/nl not_active Application Discontinuation
- 1981-06-30 EP EP86105365A patent/EP0211148B2/de not_active Expired - Lifetime
- 1981-06-30 IE IE1463/81A patent/IE49255B1/en not_active IP Right Cessation
- 1981-06-30 GR GR65379A patent/GR75714B/el unknown
- 1981-06-30 AT AT81105067T patent/ATE29727T1/de not_active IP Right Cessation
- 1981-06-30 DK DK198102910A patent/DK173543B1/da not_active IP Right Cessation
- 1981-06-30 YU YU162281A patent/YU47700B/sh unknown
- 1981-07-01 FI FI812067A patent/FI82712C/fi not_active IP Right Cessation
- 1981-07-01 DD DD81231371A patent/DD202307A5/de not_active IP Right Cessation
- 1981-07-01 AU AU72462/81A patent/AU552004B2/en not_active Expired
- 1981-07-01 DD DD81255299A patent/DD210304A5/de not_active IP Right Cessation
- 1981-07-01 IT IT22682/81A patent/IT1137272B/it active Protection Beyond IP Right Term
- 1981-07-01 GB GB8120279A patent/GB2079291B/en not_active Expired
- 1981-07-01 PH PH25843A patent/PH18036A/en unknown
- 1981-07-01 BR BR8104189A patent/BR8104189A/pt unknown
- 1981-07-01 DD DD81255300A patent/DD210305A5/de not_active IP Right Cessation
1985
- 1985-05-21 KE KE3534A patent/KE3534A/xx unknown
- 1985-06-27 HK HK492/85A patent/HK49285A/xx not_active IP Right Cessation
1987
- 1987-12-30 MY MY711/87A patent/MY8700711A/xx unknown
1993
- 1993-07-12 GE GEAP1993999A patent/GEP19960519B/en unknown

Also Published As

Publication number	Publication date
FI82712B (fi)	1990-12-31
CH651308A5 (de)	1985-09-13
DK291081A (da)	1982-01-02
MY8700711A (en)	1987-12-31
ES8207514A1 (es)	1982-10-01
PT73289A (en)	1981-07-01
ATA290981A (de)	1985-09-15
LU83461A1 (de)	1983-04-06
NO812247L (no)	1982-01-04
FR2486098B1 (fr)	1985-12-27
HK49285A (en)	1985-07-05
MC1396A1 (fr)	1982-04-27
IE49255B1 (en)	1985-09-04
EP0043980A3 (en)	1982-09-15
DE3176448D1 (en)	1987-10-22
PL231940A1 (en)	1983-07-18
SU1414319A3 (ru)	1988-07-30
ATE79901T1 (de)	1992-09-15
DD210304A5 (de)	1984-06-06
EP0211148A1 (de)	1987-02-25
NO159392C (no)	1988-12-21
CS273152B2 (en)	1991-03-12
KE3534A (en)	1985-06-07
NO159392B (no)	1988-09-12
NZ197572A (en)	1985-07-31
AU7246281A (en)	1982-01-07
ATE29727T1 (de)	1987-10-15
GR75714B (de)	1984-08-02
DE3177288D1 (de)	1992-10-01
SE465223B (sv)	1991-08-12
FR2486098A1 (fr)	1982-01-08
GB2079291B (en)	1984-06-13
IT1137272B (it)	1986-09-03
AR242833A1 (es)	1993-05-31
GB2079291A (en)	1982-01-20
DE3177288T2 (de)	1992-12-10
ES503528A0 (es)	1982-10-01
HU196457B (en)	1988-11-28
EP0043980A2 (de)	1982-01-20
SE465223C5 (sv)	1998-02-10
RO87590A (ro)	1986-07-30
YU162281A (en)	1984-02-29
PT73289B (en)	1983-05-11
PH18036A (en)	1985-03-06
CH657141A5 (de)	1986-08-15
DZ312A1 (fr)	2004-09-13
EP0211148B1 (de)	1992-08-26
YU47700B (sh)	1996-01-08
PL148276B1 (en)	1989-09-30
EP0043980B1 (de)	1987-09-16
AT380272B (de)	1986-05-12
EP0211148B2 (de)	1999-11-24
CS503781A2 (en)	1990-07-12
GEP19960519B (en)	1996-07-02
IE811463L (en)	1982-01-01
DE3125706A1 (de)	1982-04-15
DD202307A5 (de)	1983-09-07
DK173543B1 (da)	2001-02-05
PL148261B1 (en)	1989-09-30
IT8122682A0 (it)	1981-07-01
SE8104093L (sv)	1982-01-02
BR8104189A (pt)	1982-03-16
PL148260B1 (en)	1989-09-30
DD210305A5 (de)	1984-06-06
DE3177288T3 (de)	2000-03-16
NL8103151A (nl)	1982-02-01
DE3125706C2 (de)	1995-05-24
FI82712C (fi)	1991-04-10
FI812067L (fi)	1982-01-02
AU552004B2 (en)	1986-05-22

Publication	Publication Date	Title
BG42189A3 (en)	1987-10-15	Method for preparing of ripe human leucocytic interferon
Gasson	1991	Molecular physiology of granulocyte-macrophage colony-stimulating factor
BG43355A3 (en)	1988-05-16	Method for preparing of physiologically active polypeptide
MY104344A (en)	1994-03-31	Human immunoglobulins produced by recombinant dna techniques
ATE249476T1 (de)	2003-09-15	Cyclin d1 und seine cdna
MY104556A (en)	1994-06-30	Anoxic slaughtering of poultry
EP0419080A3 (en)	1991-05-22	Cold particle suspension and injection process for meat
DE3175580D1 (en)	1987-01-02	Method for enhancing the growth rate of meat-producing animals and for improving the lean meat to fat ratio thereof
DE3382171D1 (de)	1991-04-04	Verfahren zur herstellung eines dem menschlichen gamma-interferon aehnlichen polypeptids.
King	1993	Potential fecundity of redclaw crayfish, Cherax quadricarinatus von Martens, in culture
BG41136A3 (bg)	1987-04-15	Метод за получаване на днк преносен вектор,предназначен за поддържане и репликация на дезоксинуклеотидна последователност, кодираща човешки проинсулин
CA1262533C (en)	1989-10-31	HIGH YIELD PRODUCTION OF SWINE GROWTH HORMONE
FR2556365B1 (fr)	1987-07-31	Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g
DeWitt et al.	1959	Reproduction in Physa pomilia and Helisoma duryi
Porter et al.	2003	The use of additional lighting and artificial photoperiods to recondition early maturing Atlantic salmon (Salmo salar) in Tasmania
Jordan et al.	1982	First record of the great auk (Pinguinus impennis) from Labrador
Toth	1966	An occurrence of nutritive to generative zooid transformation in the hydroid Podocoryne carnea
JPS6413928A (en)	1989-01-18	Method for rearing fry and young fishes
Machena et al.	1986	Comparison of fish yields from prediction models between Lakes Tanganyika and Kariba
Zurlini et al.	1979	Growth of marine copepod populations in excess food supply
SU1658949A1 (ru)	1991-06-30	Способ селекции свиней
Anderbrant	1989	Reproduction and competition in the spruce bark beetle Ips typographus.
Buzu et al.	0	ELITE TYPE OF SHEEP OF MOLDAVIAN TSIGAIE OF ALEXANDERFELD
FI863001L (fi)	1986-07-21	Replikerande expressionsvektor, foerfarande foer dess framstaellning samt dess anvaendning vid framstaellning av human leukocytinterferon.
ES465232A1 (es)	1978-09-16	Un metodo para producir jaleas proteinicas de peces y crus- taceos.