BG49826A3 - Method for preparing derivatives of thilosine and 10, 11, 12, 13- tetrahydrothilosine - Google Patents

Method for preparing derivatives of thilosine and 10, 11, 12, 13- tetrahydrothilosine

Info

Publication number: BG49826A3
Authority: BG; Bulgaria
Prior art keywords: thilosine; tetrahydrothilosine; preparing derivatives; tylosin; derivatives
Prior art date: 1987-04-14

Application number

BG083745A

Other languages

Bulgarian (bg)

English (en)

Inventor

Amalija Narandja

Bozidar Suskovic

Slobodan Djokic

Nevenka Lopotar

Original Assignee

Sour Pliva Farmaceutska, Kemijska

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-14

Filing date

1988-04-13

Publication date

1992-02-14

1988-04-13 Application filed by Sour Pliva Farmaceutska, Kemijska filed Critical Sour Pliva Farmaceutska, Kemijska

1992-02-14 Publication of BG49826A3 publication Critical patent/BG49826A3/xx

Links

238000000034 method Methods 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229930194936 Tylosin Natural products 0.000 abstract 1
239000004182 Tylosin Substances 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910000510 noble metal Inorganic materials 0.000 abstract 1
229960004059 tylosin Drugs 0.000 abstract 1
235000019375 tylosin Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG083745A 1987-04-14 1988-04-13 Method for preparing derivatives of thilosine and 10, 11, 12, 13- tetrahydrothilosine BG49826A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU674/87A YU45033B (en)	1987-04-14	1987-04-14	Process for preparing 10,11,12,13-tetrahydro derivative

Publications (1)

Publication Number	Publication Date
BG49826A3 true BG49826A3 (en)	1992-02-14

Family

ID=25550944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG083745A BG49826A3 (en)	1987-04-14	1988-04-13	Method for preparing derivatives of thilosine and 10, 11, 12, 13- tetrahydrothilosine

Country Status (18)

Country	Link
US (1)	US5023240A (cs)
EP (1)	EP0287082B1 (cs)
JP (1)	JPS63313797A (cs)
CN (1)	CN1022569C (cs)
AT (1)	ATE103289T1 (cs)
BG (1)	BG49826A3 (cs)
CA (1)	CA1325424C (cs)
CZ (2)	CZ283995B6 (cs)
DD (1)	DD272304A5 (cs)
DE (1)	DE3888563T2 (cs)
ES (1)	ES2053605T3 (cs)
HU (2)	HU201089B (cs)
PL (1)	PL155812B1 (cs)
RO (2)	RO113349B1 (cs)
SI (1)	SI8710674B (cs)
SK (1)	SK253488A3 (cs)
SU (2)	SU1708158A3 (cs)
YU (1)	YU45033B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2638458A1 (fr) *	1988-10-27	1990-05-04	Adir	Nouveaux derives de la tylosine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
YU149889A (en) *	1989-07-26	1991-02-28	Pliva Zagreb	Process for preparing biologically active derivatives of tylozine
US5140014A (en) *	1989-11-13	1992-08-18	Abbott Laboratories	Rosaramicin derivatives and method of treating bacterial infections
JPH04164093A (ja) *	1990-10-25	1992-06-09	Mercian Corp	新タイロシン誘導体
SI9012363A (sl) *	1990-12-14	1998-04-30	Pliva	Derivati 10,11,12,13-tetrahidro-desmikozina, postopki za njihovo pripravo in postopki za pripravo farmacevtskih preparatov
HRP960509A2 (en) *	1996-10-30	1998-06-30	Pliva Pharm & Chem Works	Novel polyhydro tylosin derivatives and a process for the preparation thereof
CZ211798A3 (cs) *	1997-07-16	1999-02-17	Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmetička Industrije, Dioničko Društvo	Lineární 8a-sekoazalidy a způsob jejich výroby
HRP980496B1 (en) *	1998-09-10	2007-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	New thilozine hydroxy derivatives and a process for the preparation thereof
HRP990129B1 (en) *	1999-05-03	2003-10-31	Pliva D D	New compounds of 3-deoxy-desmycosin class and process for the preparation thereof
HRP990192A2 (en) *	1999-06-11	2001-04-30	Pliva D D	4'-DEMICAROZYL-8a-AZA-8a-HOMOTHILOSINE DERIVATIVES
US7247617B2 (en) *	2004-07-13	2007-07-24	Kosan Biosciences Incorporated	Sixteen-member macrolide antiinfective agents
MX2009000393A (es) *	2006-07-13	2009-01-29	Eco Animal Health Ltd	Uso de la tilvalosina como agente antiviral.
WO2008012343A2 (en)	2006-07-28	2008-01-31	Intervet International B.V.	Macrolide synthesis process
CN117510561B (zh) *	2023-11-30	2024-04-02	中国农业科学院饲料研究所	一种泰乐菌素衍生物及其制备方法与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3910892A (en) *	1971-03-23	1975-10-07	Hoffmann La Roche	Benzodioxane derivatives
CH630391A5 (en) *	1975-02-28	1982-06-15	Scherico Ltd	Process for preparing derivatives of rosaramicin
US4205163A (en) *	1977-11-08	1980-05-27	Sanraku-Ocean Co., Ltd.	Tylosin derivatives
DE2826760A1 (de) *	1978-06-19	1980-01-03	Hoechst Ag	Derivate des 1,2,4-triazols
NL8004922A (nl) *	1979-09-19	1981-03-23	Toyo Jozo Kk	Deformyltylosinederivaten.
US4357325A (en) *	1981-04-20	1982-11-02	Eli Lilly And Company	Methods of controlling Pasteurella infections
AU551142B2 (en) *	1981-07-09	1986-04-17	Zaidan Hojin Biseibutsu Kagaku Kenkyukai	Tylosin derivatives
NZ203684A (en) *	1982-04-05	1986-06-11	Merck Sharp & Dohme	Granular formulation for the stabilization of unstable drugs or food supplements
US4443436A (en) *	1982-09-13	1984-04-17	Eli Lilly And Company	C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
GB8405087D0 (en) *	1984-02-27	1984-04-04	Omura S	Antibiotic
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
JPS61191692A (ja) *	1985-02-20	1986-08-26	Toyo Jozo Co Ltd	Ｃ−１９−修飾デホルミルデスマイコシン誘導体
JPS62221695A (ja) *	1986-03-24	1987-09-29	Microbial Chem Res Found	タイロシンオキシム誘導体およびその製造法
PT87417B (pt) *	1987-05-06	1992-08-31	Adir	Processo para a preparacao de novos compostos macrolidos
JPH02221695A (ja) *	1989-02-22	1990-09-04	Hitachi Ltd	ロータリ圧縮機
JP3141148B2 (ja) *	1995-08-08	2001-03-05	大鵬薬品工業株式会社	縮合インダン誘導体及びその塩

1987
- 1987-04-14 YU YU674/87A patent/YU45033B/xx unknown
- 1987-04-14 SI SI8710674A patent/SI8710674B/sl unknown
1988
- 1988-04-12 RO RO148895A patent/RO113349B1/ro unknown
- 1988-04-12 RO RO133024A patent/RO104952B1/ro unknown
- 1988-04-13 SK SK2534-88A patent/SK253488A3/sk unknown
- 1988-04-13 HU HU881898A patent/HU201089B/hu not_active IP Right Cessation
- 1988-04-13 PL PL1988271797A patent/PL155812B1/pl unknown
- 1988-04-13 AT AT88105905T patent/ATE103289T1/de not_active IP Right Cessation
- 1988-04-13 JP JP63089161A patent/JPS63313797A/ja active Pending
- 1988-04-13 SU SU884355567A patent/SU1708158A3/ru active
- 1988-04-13 EP EP88105905A patent/EP0287082B1/en not_active Expired - Lifetime
- 1988-04-13 CA CA000564033A patent/CA1325424C/en not_active Expired - Fee Related
- 1988-04-13 BG BG083745A patent/BG49826A3/xx unknown
- 1988-04-13 CZ CS882534A patent/CZ283995B6/cs not_active IP Right Cessation
- 1988-04-13 ES ES88105905T patent/ES2053605T3/es not_active Expired - Lifetime
- 1988-04-13 US US07/180,940 patent/US5023240A/en not_active Expired - Fee Related
- 1988-04-13 CN CN88102128A patent/CN1022569C/zh not_active Expired - Fee Related
- 1988-04-13 DE DE3888563T patent/DE3888563T2/de not_active Expired - Fee Related
- 1988-04-13 DD DD88314704A patent/DD272304A5/de not_active IP Right Cessation
- 1988-04-13 CZ CZ973998A patent/CZ285278B6/cs not_active IP Right Cessation
1989
- 1989-03-27 SU SU894613684A patent/SU1731063A3/ru active
1995
- 1995-06-30 HU HU95P/P00625P patent/HU211975A9/hu unknown

Also Published As

Publication number	Publication date
PL271797A1 (en)	1989-01-23
DD272304A5 (de)	1989-10-04
YU67487A (en)	1988-12-31
DE3888563T2 (de)	1994-09-29
CN88102128A (zh)	1988-12-21
SK278558B6 (en)	1997-09-10
SI8710674B (sl)	1998-06-30
SU1708158A3 (ru)	1992-01-23
EP0287082A2 (en)	1988-10-19
HU201089B (en)	1990-09-28
CZ253488A3 (cs)	1998-06-17
SI8710674A (en)	1996-08-31
SK253488A3 (en)	1997-09-10
JPS63313797A (ja)	1988-12-21
SU1731063A3 (ru)	1992-04-30
CA1325424C (en)	1993-12-21
RO104952B1 (en)	1995-01-23
EP0287082A3 (en)	1990-04-18
ATE103289T1 (de)	1994-04-15
CZ283995B6 (cs)	1998-07-15
HU211975A9 (en)	1996-01-29
HUT46924A (en)	1988-12-28
RO113349B1 (ro)	1998-06-30
CZ285278B6 (cs)	1999-06-16
ES2053605T3 (es)	1994-08-01
US5023240A (en)	1991-06-11
PL155812B1 (en)	1992-01-31
DE3888563D1 (de)	1994-04-28
EP0287082B1 (en)	1994-03-23
YU45033B (en)	1991-06-30
CN1022569C (zh)	1993-10-27

Publication	Publication Date	Title
BG49826A3 (en)	1992-02-14	Method for preparing derivatives of thilosine and 10, 11, 12, 13- tetrahydrothilosine
BG47033A3 (en)	1990-04-16	Method for preparing of derivatives of imidazolamine
DE3764754D1 (de)	1990-10-11	Katalysator fuer die umwandlung von synthesegas, seine herstellung und seine verwendung.
GB1416659A (en)	1975-12-03	Preparation of 4-isopropylcyclohexylmethanol
IT1232318B (it)	1992-01-28	Composizioni ad uso topico contenenti acidi nucleici depolimerizzati per la cosmesi della pelle e del corpo.
DE2860242D1 (en)	1980-12-04	Supported ruthenium catalyst, process for its preparation, and its use as a hydrogenation catalyst
GB1509784A (en)	1978-05-04	Stabilized ruthenium catalyst for selective reduction of oxides of nitrogen
ES8302090A1 (es)	1983-01-01	Un procedimiento para la preparacion del nuevo antibiotico bmo162-af2, obtenido mediante el cultivo de una cepa perte- neciente al genero bacillus.
JPS51149248A (en)	1976-12-22	Process for preparing o-phenylphenol
ES396244A1 (es)	1974-04-16	Procedimiento para la obtencion de peroxido de hidrogeno.
GB1229707A (cs)	1971-04-28
FR2404636A1 (fr)	1979-04-27	Procede de preparation simultanee d'un (amino-2 alcoxy)-2 alcanol et d'un compose de type morpholine
GB1323374A (en)	1973-07-11	Preparation of 2-pyrrolidinone
ES485319A1 (es)	1980-05-16	Un metodo para preparar alcohol furfurilico
FI882894A0 (fi)	1988-06-16	Menetelmä 2-kinoksalinoliyhdisteen valmistamiseksi
GB1226132A (cs)	1971-03-24
JPS539705A (en)	1978-01-28	Hydrogenation of organic peroxides
IT1207299B (it)	1989-05-17	Uniforme di un letto catalizzaotre dispositivo per l'alimentazione con un gas di scarico da depurare.
GB1269862A (en)	1972-04-06	Process for regenerating a hydrogenation catalyst
DE3061278D1 (en)	1983-01-13	Process for the preparation of phenylacetic acid and its simple derivatives
DE59007103D1 (de)	1994-10-20	Verfahren zur Herstellung von Di-(p-glycidoxicyclohexyl)-methan.
ES447827A1 (es)	1977-07-01	Procedimiento para la obtencion de 2,5-dimetoxi-4-cloroani- lina.
EP0295815A3 (en)	1989-11-15	Process for production of 2-quinoxalines
ES411143A1 (es)	1975-12-01	Un procedimiento para la produccion de 3-fluor-d-alanina y sus deutero-analogos.
FR2558826B1 (fr)	1986-11-28	Synthese d'alcool tertio-butylique par oxydation catalytique, en phase liquide de l'isobutane par l'oxygene