BG60033B2 - METHOD FOR THE PREPARATION OF 4-(5,6,7,8-TETRAHYDROIMIDAZO-1,5-a/-PYRIDINE-5-YL) BENZONITRILE-HYDROCHLORIDE IN CRYSTAL SEMIHYDRATE FORM - Google Patents

METHOD FOR THE PREPARATION OF 4-(5,6,7,8-TETRAHYDROIMIDAZO-1,5-a/-PYRIDINE-5-YL) BENZONITRILE-HYDROCHLORIDE IN CRYSTAL SEMIHYDRATE FORM

Info

Publication number: BG60033B2
Authority: BG; Bulgaria
Prior art keywords: hydrochloride; tetrahydroimidazo; benzonitrile; hemihydrate; water
Prior art date: 1990-01-12

Application number

BG093623A

Other languages

Bulgarian (bg)

English (en)

Inventor

Jutta Ibrahim

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-12

Filing date

1991-01-14

Publication date

1993-07-15

1991-01-14 Application filed by Novartis Ag filed Critical Novartis Ag

1993-07-15 Publication of BG60033B2 publication Critical patent/BG60033B2/xx

Links

XDFORSMZCYHNBG-UHFFFAOYSA-N benzonitrile;hydrochloride Chemical compound Cl.N#CC1=CC=CC=C1 XDFORSMZCYHNBG-UHFFFAOYSA-N 0.000 title 1
239000013078 crystal Substances 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 abstract 1
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Lubricants (AREA)
Liquid Crystal Substances (AREA)
Pyridine Compounds (AREA)
Photoreceptors In Electrophotography (AREA)

BG093623A 1990-01-12 1991-01-14 METHOD FOR THE PREPARATION OF 4-(5,6,7,8-TETRAHYDROIMIDAZO-1,5-a/-PYRIDINE-5-YL) BENZONITRILE-HYDROCHLORIDE IN CRYSTAL SEMIHYDRATE FORM BG60033B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH10090		1990-01-12

Publications (1)

Publication Number	Publication Date
BG60033B2 true BG60033B2 (en)	1993-07-15

Family

ID=4179261

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BG093623A BG60033B2 (en)	1990-01-12	1991-01-14	METHOD FOR THE PREPARATION OF 4-(5,6,7,8-TETRAHYDROIMIDAZO-1,5-a/-PYRIDINE-5-YL) BENZONITRILE-HYDROCHLORIDE IN CRYSTAL SEMIHYDRATE FORM
BG096793A BG61489B2 (bg)	1990-01-12	1992-08-18	Хемихидрат на 4-(5,6,7,8-тетрахидроимидазо (1,5-а) пиридин-5-ил/-бензонитрил хидрохлорид

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG096793A BG61489B2 (bg)	1990-01-12	1992-08-18	Хемихидрат на 4-(5,6,7,8-тетрахидроимидазо (1,5-а) пиридин-5-ил/-бензонитрил хидрохлорид

Country Status (33)

Country	Link
US (1)	US5098911A (id)
EP (1)	EP0437415B1 (id)
JP (1)	JP2694186B2 (id)
KR (1)	KR100191360B1 (id)
CN (1)	CN1037966C (id)
AT (1)	ATE125809T1 (id)
AU (1)	AU638085B2 (id)
BG (2)	BG60033B2 (id)
CA (1)	CA2033937C (id)
CZ (1)	CZ279823B6 (id)
DE (1)	DE59106101D1 (id)
DK (1)	DK0437415T3 (id)
DZ (1)	DZ1482A1 (id)
ES (1)	ES2075399T3 (id)
FI (1)	FI94528C (id)
GR (1)	GR3017027T3 (id)
HK (1)	HK1000663A1 (id)
HU (1)	HU216192B (id)
ID (1)	ID964B (id)
IE (1)	IE67512B1 (id)
IL (1)	IL96879A (id)
MA (1)	MA22040A1 (id)
MT (1)	MTP1076B (id)
NO (1)	NO175747C (id)
NZ (1)	NZ236735A (id)
PH (1)	PH27601A (id)
PL (3)	PL167164B1 (id)
PT (1)	PT96447B (id)
RO (1)	RO107408B1 (id)
RU (2)	RU2021271C1 (id)
SA (1)	SA93140021B1 (id)
TN (1)	TNSN91001A1 (id)
ZA (1)	ZA91229B (id)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW208013B (id) *	1990-03-01	1993-06-21	Daiichi Co Ltd
EP0457716A1 (de) *	1990-04-20	1991-11-21	Ciba-Geigy Ag	Naphthalinderivate
TW224461B (id) *	1990-09-18	1994-06-01	Ciba Geigy Ag
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
JP2914324B2 (ja) *	1995-10-23	1999-06-28	味の素株式会社	ピペリジン誘導体の結晶並びにその製造中間体及び製造方法
SE9902550D0 (sv) *	1999-07-02	1999-07-02	Astra Ab	New crystalline forms
EP3485878A1 (en)	2010-09-01	2019-05-22	Arena Pharmaceuticals, Inc.	Modified-release dosage forms of 5-ht2c agonists useful for weight management
KR20140091458A (ko)	2010-09-01	2014-07-21	아레나 파마슈티칼스, 인크.	신장 손상을 갖는 개체에 대한 로카세린의 투여
JO3137B1 (ar)	2012-01-17	2017-09-20	Novartis Ag	أملاح وأشكال جديدة لمثبط إنزيم سينثاز أو أروماتاز ثنائي هيدروبيرولو [2،1-c] إيميدازوليل ألدوستيرون
WO2018078049A1 (en)	2016-10-27	2018-05-03	Damian Pharma Ag	Aldosterone synthase inhibitor
CN109890389B (zh)	2016-10-27	2022-07-01	达米安制药股份公司	醛固酮合酶抑制剂
JP7470050B2 (ja)	2018-05-03	2024-04-17	ダミアンファーマアーゲー	アルドステロン症の治療における使用のためのｒ－ファドロゾール

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588732A (en) *	1982-12-21	1986-05-13	Ciba-Geigy Corporation	Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4617307A (en) *	1984-06-20	1986-10-14	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

1990
- 1990-12-14 MT MT1076A patent/MTP1076B/xx unknown
1991
- 1991-01-02 US US07/636,816 patent/US5098911A/en not_active Expired - Lifetime
- 1991-01-02 PH PH41805A patent/PH27601A/en unknown
- 1991-01-03 DE DE59106101T patent/DE59106101D1/de not_active Expired - Lifetime
- 1991-01-03 EP EP91810003A patent/EP0437415B1/de not_active Expired - Lifetime
- 1991-01-03 ES ES91810003T patent/ES2075399T3/es not_active Expired - Lifetime
- 1991-01-03 AT AT91810003T patent/ATE125809T1/de not_active IP Right Cessation
- 1991-01-03 DK DK91810003.3T patent/DK0437415T3/da active
- 1991-01-04 IL IL9687991A patent/IL96879A/en not_active IP Right Cessation
- 1991-01-07 MA MA22312A patent/MA22040A1/fr unknown
- 1991-01-09 DZ DZ910008A patent/DZ1482A1/fr active
- 1991-01-09 FI FI910126A patent/FI94528C/fi active
- 1991-01-10 PL PL91304084A patent/PL167164B1/pl unknown
- 1991-01-10 KR KR1019910000244A patent/KR100191360B1/ko not_active Expired - Lifetime
- 1991-01-10 PL PL91288653A patent/PL166157B1/pl unknown
- 1991-01-10 NZ NZ236735A patent/NZ236735A/xx unknown
- 1991-01-10 CA CA002033937A patent/CA2033937C/en not_active Expired - Lifetime
- 1991-01-10 RO RO146713A patent/RO107408B1/ro unknown
- 1991-01-10 PL PL91304087A patent/PL166500B1/pl unknown
- 1991-01-10 PT PT96447A patent/PT96447B/pt not_active IP Right Cessation
- 1991-01-10 AU AU69280/91A patent/AU638085B2/en not_active Expired
- 1991-01-11 NO NO910137A patent/NO175747C/no not_active IP Right Cessation
- 1991-01-11 ZA ZA91229A patent/ZA91229B/xx unknown
- 1991-01-11 CN CN91101118A patent/CN1037966C/zh not_active Expired - Lifetime
- 1991-01-11 IE IE10391A patent/IE67512B1/en not_active IP Right Cessation
- 1991-01-11 HU HU4/91A patent/HU216192B/hu unknown
- 1991-01-11 RU SU914894233A patent/RU2021271C1/ru active
- 1991-01-11 CZ CS9155A patent/CZ279823B6/cs not_active IP Right Cessation
- 1991-01-11 TN TNTNSN91001A patent/TNSN91001A1/fr unknown
- 1991-01-11 JP JP3065711A patent/JP2694186B2/ja not_active Expired - Lifetime
- 1991-01-14 BG BG093623A patent/BG60033B2/xx unknown
1992
- 1992-01-30 ID IDP190792A patent/ID964B/id unknown
- 1992-04-07 RU SU925011257A patent/RU2088584C1/ru active
- 1992-08-18 BG BG096793A patent/BG61489B2/bg unknown
1993
- 1993-06-29 SA SA93140021A patent/SA93140021B1/ar unknown
1995
- 1995-08-03 GR GR950401945T patent/GR3017027T3/el unknown
1997
- 1997-11-24 HK HK97102235A patent/HK1000663A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ID964B (id)	1996-09-30
PH27601A (en)	1993-08-31
CZ279823B6 (cs)	1995-07-12
AU6928091A (en)	1991-07-18
KR910014376A (ko)	1991-08-31
RO107408B1 (ro)	1993-11-30
MTP1076B (en)	1991-09-30
BG61489B2 (bg)	1997-09-30
IL96879A0 (en)	1992-03-29
AU638085B2 (en)	1993-06-17
PL166500B1 (pl)	1995-05-31
EP0437415A3 (en)	1992-01-22
NO175747B (no)	1994-08-22
CN1037966C (zh)	1998-04-08
IE910103A1 (en)	1991-07-17
PT96447A (pt)	1991-10-15
RU2021271C1 (ru)	1994-10-15
DK0437415T3 (da)	1995-09-18
FI94528B (fi)	1995-06-15
EP0437415A2 (de)	1991-07-17
CN1055739A (zh)	1991-10-30
IE67512B1 (en)	1996-04-03
NO175747C (no)	1994-11-30
GR3017027T3 (en)	1995-11-30
NO910137D0 (no)	1991-01-11
JPH04210982A (ja)	1992-08-03
HUT56568A (en)	1991-09-30
ZA91229B (en)	1991-08-28
EP0437415B1 (de)	1995-08-02
IL96879A (en)	1995-06-29
MA22040A1 (fr)	1991-10-01
TNSN91001A1 (en)	1992-10-25
US5098911A (en)	1992-03-24
DE59106101D1 (de)	1995-09-07
ATE125809T1 (de)	1995-08-15
PT96447B (pt)	1998-09-30
PL288653A1 (en)	1991-12-16
PL167164B1 (pl)	1995-08-31
FI910126A0 (fi)	1991-01-09
SA93140021B1 (ar)	2006-07-11
HK1000663A1 (en)	1998-04-17
CS9100055A2 (en)	1991-08-13
DZ1482A1 (fr)	2004-09-13
ES2075399T3 (es)	1995-10-01
HU910084D0 (en)	1991-08-28
KR100191360B1 (ko)	1999-06-15
JP2694186B2 (ja)	1997-12-24
NZ236735A (en)	1992-10-28
CA2033937A1 (en)	1991-07-13
HU216192B (en)	2001-03-28
NO910137L (no)	1991-07-15
RU2088584C1 (ru)	1997-08-27
CA2033937C (en)	2001-03-13
FI910126L (fi)	1991-07-13
PL166157B1 (pl)	1995-04-28
FI94528C (fi)	1995-09-25

Publication	Publication Date	Title
BG60033B2 (en)	1993-07-15	METHOD FOR THE PREPARATION OF 4-(5,6,7,8-TETRAHYDROIMIDAZO-1,5-a/-PYRIDINE-5-YL) BENZONITRILE-HYDROCHLORIDE IN CRYSTAL SEMIHYDRATE FORM
IE781878L (en)	1979-03-19	Imidazole derivatives
DK0598770T3 (da)	1997-12-15	Pyrazinderivater samt fremstilling og anvendelse deraf
ES2125000T3 (es)	1999-02-16	Nuevas mezclas terapeuticas de hidratos de carbono utiles para ayudar en el sindrome premenstrual.
MY110092A (en)	1997-12-31	Butyric acid derivatives
ES8501380A1 (es)	1984-11-16	Un procedimiento para preparar l-tiazolidin-4-carboxilato de zinc
ES8401074A1 (es)	1983-12-01	Sal de n-metil-d-glucamina.
EP0188383A3 (en)	1988-06-22	Imidazole derivatives, their preparation and therapeutic use
ES2006099A6 (es)	1989-04-01	Procedimiento para la obtencion de hidrocloruro de ciprofloxacina monohidrato.
IE890232L (en)	1989-07-27	Condensed diazepinones
JPS5612392A (en)	1981-02-06	Novel camptothecin derivative and its preparation
EP0363326A3 (en)	1991-10-09	Fungicidal amines
JPS5353698A (en)	1978-05-16	Pyrrolotriazolopyrimidine derivatives and their preparation
JPS5344597A (en)	1978-04-21	Condensed quinazolinol derivative
MY102063A (en)	1992-03-31	New use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
JPS54109971A (en)	1979-08-29	Novel furanoside derivative and its preparation
JPS5368800A (en)	1978-06-19	Cycloalkyl substd. pyrrolotriazolopyrimidine derivatives
JPS5363383A (en)	1978-06-06	2-oxopiperidine derivatives and their preparation
JPS545997A (en)	1979-01-17	Novel hetrocyclic compounds and process for their preparation
JPS5345048A (en)	1978-04-22	Advanced treatment of waste water
JPS649992A (en)	1989-01-13	1,8-crosslinked quinolincarboxylic acid derivative, ester thereof and salt thereof
SU1836846A3 (ru)	1995-10-10	Способ получения раствора бромида кальция
JPS5356695A (en)	1978-05-23	Pyridobenzoazepines and their preparation
SU1533391A1 (ru)	1999-11-27	Состав для обработки призабойной зоны скважины
TH893A (th)	1983-04-08	การเตรียมอนุพันธ์ของเบนซิมิดาโซลและสารผสมของสารเหล่านี้