BG60587B1 - Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни - Google Patents

Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни Download PDF

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Publication number
BG60587B1
BG60587B1 BG93298A BG9329890A BG60587B1 BG 60587 B1 BG60587 B1 BG 60587B1 BG 93298 A BG93298 A BG 93298A BG 9329890 A BG9329890 A BG 9329890A BG 60587 B1 BG60587 B1 BG 60587B1
Authority
BG
Bulgaria
Prior art keywords
formula
thiazole
compounds
alkyl
general formula
Prior art date
Application number
BG93298A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG93298A (bg
Inventor
Alfons Raeymaekers
Leopold Roevens
Laerhoven Willy Van
Wauwe Jean Van
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG93298A publication Critical patent/BG93298A/bg
Publication of BG60587B1 publication Critical patent/BG60587B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
BG93298A 1989-11-24 1990-11-22 Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни BG60587B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44084289A 1989-11-24 1989-11-24

Publications (2)

Publication Number Publication Date
BG93298A BG93298A (bg) 1993-12-24
BG60587B1 true BG60587B1 (bg) 1995-09-29

Family

ID=23750399

Family Applications (1)

Application Number Title Priority Date Filing Date
BG93298A BG60587B1 (bg) 1989-11-24 1990-11-22 Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни

Country Status (25)

Country Link
EP (1) EP0430334B1 (de)
JP (1) JPH03170487A (de)
KR (1) KR910009714A (de)
CN (1) CN1032754C (de)
AT (1) ATE127795T1 (de)
AU (1) AU630766B2 (de)
BG (1) BG60587B1 (de)
CA (1) CA2028756A1 (de)
CZ (1) CZ281422B6 (de)
DE (1) DE69022370T2 (de)
FI (1) FI93459C (de)
HU (1) HU206361B (de)
IE (1) IE67656B1 (de)
IL (1) IL96435A (de)
MY (1) MY131024A (de)
NO (1) NO300065B1 (de)
NZ (1) NZ236026A (de)
PL (1) PL165413B1 (de)
PT (1) PT95978B (de)
RO (1) RO108869B1 (de)
RU (1) RU2051153C1 (de)
YU (1) YU47955B (de)
ZA (1) ZA909445B (de)
ZM (1) ZM5390A1 (de)
ZW (1) ZW17890A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524055A1 (de) * 1991-07-19 1993-01-20 Synthelabo Imidazo(2,1-b)benzothiazolderivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung
US6165253A (en) * 1994-05-23 2000-12-26 New Jersey Institute Of Technology Apparatus for removal of volatile organic compounds from gaseous mixtures
RU2129870C1 (ru) * 1998-04-07 1999-05-10 Ливицкий Василий Иванович Способ получения антимикробного и противоопухолевого лечебного средства
EP1797880A3 (de) * 1999-01-29 2010-04-28 Board Of Trustees Of The University Of Illinois Verwendung von P53-Hemmern zur Behandlung der Nebenwirkungen der Krebsbehandlung
NZ513487A (en) 1999-01-29 2003-02-28 Univ Illinois The use of a P53 inhibitor for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant
AU2005288522B2 (en) 2004-09-28 2012-06-28 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
RU2282438C1 (ru) * 2005-03-24 2006-08-27 Александра Петровна Безрукова Средство, обладающее противоопухолевой активностью
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
US7910566B2 (en) 2006-03-09 2011-03-22 Quark Pharmaceuticals Inc. Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
WO2009001359A2 (en) 2007-06-27 2008-12-31 Quark Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of pro-apoptotic genes
CN104557979A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 盐酸左旋咪唑的制备方法
RU2763739C1 (ru) * 2021-06-28 2021-12-30 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) (Z)-9-ароил-8-гидрокси-6-(2-гидроксифенил)-2-(((Z)-2-оксоиндолин-3-илиден)гидразоно)-1-тиа-3,6-диазаспиро[4.4]нон-8-ен-4,7-дионы, обладающие противомикробной активностью
US20250042920A1 (en) * 2021-11-29 2025-02-06 Ocean University Of China Imidazothiazole derivative, preparation method therefor, and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU409983B2 (en) * 1965-07-19 1970-12-31 Imperial Chemical Industries Of Australia New Zealand Limited Process for the manufacture of thia zolidines and thiazolidines produced thereby
GB1444743A (en) * 1973-09-20 1976-08-04 Pfizer Ltd 7-substituted imidazo-1,1-b-thiazolium and 9-substituted thiazolo-3,2-a-benzimidazolium derivatives having hypogly caemic and/or growth promotant properties
US4340738A (en) * 1979-06-21 1982-07-20 Janssen Pharmaceutica, N.V. 2,3-Dihydro-imidazo[2,1-b]benzothiazoles

Also Published As

Publication number Publication date
KR910009714A (ko) 1991-06-28
HUT59414A (en) 1992-05-28
HU907633D0 (en) 1991-06-28
PL287907A1 (en) 1992-04-21
MY131024A (en) 2007-07-31
FI93459C (fi) 1995-04-10
IL96435A (en) 1995-03-15
HU206361B (en) 1992-10-28
CN1052117A (zh) 1991-06-12
DE69022370T2 (de) 1996-03-14
NZ236026A (en) 1992-03-26
ZW17890A1 (en) 1992-07-08
NO905086D0 (no) 1990-11-23
ZM5390A1 (en) 1992-06-30
FI905788A0 (fi) 1990-11-23
EP0430334A1 (de) 1991-06-05
IE67656B1 (en) 1996-04-17
RO108869B1 (ro) 1994-09-30
ATE127795T1 (de) 1995-09-15
YU220890A (sh) 1992-12-21
PL165413B1 (pl) 1994-12-30
CN1032754C (zh) 1996-09-11
RU2051153C1 (ru) 1995-12-27
NO300065B1 (no) 1997-04-01
AU6680990A (en) 1991-05-30
ZA909445B (en) 1992-07-29
JPH03170487A (ja) 1991-07-24
EP0430334B1 (de) 1995-09-13
NO905086L (no) 1991-05-27
BG93298A (bg) 1993-12-24
PT95978B (pt) 1998-01-30
AU630766B2 (en) 1992-11-05
CA2028756A1 (en) 1991-05-25
IL96435A0 (en) 1991-08-16
PT95978A (pt) 1991-09-13
IE904241A1 (en) 1991-06-05
CZ281422B6 (cs) 1996-09-11
YU47955B (sh) 1996-07-24
CZ580390A3 (en) 1996-06-12
FI905788L (fi) 1991-05-25
FI93459B (fi) 1994-12-30
DE69022370D1 (de) 1995-10-19

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