BG60624B1 - Ендогенна модификация на генната експресия чрез регулаторен елемент - Google Patents

Ендогенна модификация на генната експресия чрез регулаторен елемент Download PDF

Info

Publication number
BG60624B1
BG60624B1 BG96515A BG9651592A BG60624B1 BG 60624 B1 BG60624 B1 BG 60624B1 BG 96515 A BG96515 A BG 96515A BG 9651592 A BG9651592 A BG 9651592A BG 60624 B1 BG60624 B1 BG 60624B1
Authority
BG
Bulgaria
Prior art keywords
gene
dna
cell line
genome
expression
Prior art date
Application number
BG96515A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96515A (bg
Inventor
Scott C Chappel
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23806064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG60624(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BG96515A publication Critical patent/BG96515A/bg
Publication of BG60624B1 publication Critical patent/BG60624B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
BG96515A 1989-12-22 1992-06-22 Ендогенна модификация на генната експресия чрез регулаторен елемент BG60624B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45478389A 1989-12-22 1989-12-22
PCT/US1990/007642 WO1991009955A1 (fr) 1989-12-22 1990-12-21 Modification de l'expression de genes endogenes a l'aide d'un element regulateur

Publications (2)

Publication Number Publication Date
BG96515A BG96515A (bg) 1993-12-24
BG60624B1 true BG60624B1 (bg) 1995-10-31

Family

ID=23806064

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96515A BG60624B1 (bg) 1989-12-22 1992-06-22 Ендогенна модификация на генната експресия чрез регулаторен елемент

Country Status (26)

Country Link
EP (5) EP0779362B2 (fr)
JP (3) JP3501286B2 (fr)
KR (1) KR0176693B1 (fr)
AR (1) AR245776A1 (fr)
AT (2) ATE156189T1 (fr)
AU (1) AU645294B2 (fr)
BG (1) BG60624B1 (fr)
BR (1) BR9007937A (fr)
CA (1) CA2071989C (fr)
DE (3) DE69031172T2 (fr)
DK (2) DK0779362T4 (fr)
ES (2) ES2151463T5 (fr)
FI (1) FI107391B (fr)
GR (1) GR3025057T3 (fr)
HK (1) HK1000786A1 (fr)
HU (1) HU217212B (fr)
IL (4) IL96765A0 (fr)
LT (1) LT3998B (fr)
LV (1) LV10655B (fr)
NO (1) NO311896B1 (fr)
OA (1) OA09594A (fr)
RO (1) RO109864B1 (fr)
RU (1) RU2128227C1 (fr)
UA (1) UA42675C2 (fr)
WO (1) WO1991009955A1 (fr)
ZA (1) ZA9010392B (fr)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048729A (en) 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
ATE174058T1 (de) * 1989-11-06 1998-12-15 Cell Genesys Inc Herstellung von proteinen mittels homologer rekombination
GB9008746D0 (en) * 1990-04-18 1990-06-13 Connaught Lab The use of autologous promoters to express gene products in bordetella
US5643753A (en) 1990-04-18 1997-07-01 Connaught Laboratories Limited Use of autologous promoters to express gene products in bordetella
SG93780A1 (en) * 1991-05-06 2003-01-21 Cell Genesys Inc Gene manipulation and expression using genomic elements
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) * 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
NZ245015A (en) * 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
WO1993023553A1 (fr) * 1992-05-19 1993-11-25 Exemplar Corporation Procede de production d'organismes transgeniques par liaison in vivo de regions codantes et de regulation
AU4401993A (en) * 1992-06-04 1993-12-30 Exemplar Corporation Insertion of heterologous dna outside of known chromosomal genes
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
US5733753A (en) * 1992-12-22 1998-03-31 Novo Nordisk A/S Amplification of genomic DNA by site specific integration of a selectable marker construct
DK153992D0 (da) * 1992-12-22 1992-12-22 Novo Nordisk As Metode
JP3654446B2 (ja) 1993-12-23 2005-06-02 メルク アンド カンパニー， インコーポレイテッド マウス細胞のための相同的組換え抗体発現系
AU738395B2 (en) * 1994-05-13 2001-09-20 Transkaryotic Therapies, Inc. DNA construct for effecting homologous recombination and uses thereof
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
US6645933B1 (en) 1995-08-01 2003-11-11 Helsinki University Licensing Ltd. Oy Receptor ligand VEGF-C
US6130071A (en) * 1997-02-05 2000-10-10 Helsinki University Licensing, Ltd. Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US6737513B1 (en) 1996-06-07 2004-05-18 Icos Corporation Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same
US6498015B1 (en) 1995-06-07 2002-12-24 Icos Corporation Methods of identifying agents that modulate the binding between MDC and an MDC receptor
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US7423125B2 (en) 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
US7063958B1 (en) 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
EP0932686A2 (fr) 1996-10-01 1999-08-04 Geron Corporation Transcriptase inverse de la telomerase
US5925544A (en) * 1996-11-18 1999-07-20 Novo Nordisk A/S Method of homologous recombination followed by in vivo selection of DNA amplification
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
US5888809A (en) * 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
EP0986644B1 (fr) * 1997-07-23 2006-10-04 Boehringer Mannheim GmbH Production d'erythropoietine par activation genique endogene avec des promoteurs viraux
PT986644E (pt) 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
US6548296B1 (en) 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
US6897066B1 (en) * 1997-09-26 2005-05-24 Athersys, Inc. Compositions and methods for non-targeted activation of endogenous genes
US5932465A (en) * 1997-10-16 1999-08-03 Icos Corporation Phosphodiesterase 8A
AU757930B2 (en) * 1997-12-01 2003-03-13 Roche Diagnostics Gmbh Optimization of cells for endogenous gene activation
AU3307999A (en) 1998-02-23 1999-09-06 Icos Corporation Phosphodiesterase 10
US6479256B1 (en) 1998-03-04 2002-11-12 Icos Corporation Lectomedin materials and methods
US6200951B1 (en) 1998-03-12 2001-03-13 Icos Corporation Chitinase chitin-binding fragments
US6541623B1 (en) 1998-04-03 2003-04-01 Hyseq, Inc. Interleukin—1 receptor antagonist and uses thereof
US6294655B1 (en) 1998-04-03 2001-09-25 Hyseq, Inc. Anti-interleukin-1 receptor antagonist antibodies and uses thereof
US6426191B1 (en) 1998-04-03 2002-07-30 Hyseq, Inc. Assays involving an IL-1 receptor antagonist
US6337072B1 (en) 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
US6492138B1 (en) 1998-05-21 2002-12-10 Amgen Canada Inc. Polynucleotides encoding a novel SHC-binding protein
JP2002516116A (ja) * 1998-05-27 2002-06-04 ノボザイムス バイオテック，インコーポレイティド 遺伝子のコピー数を変化させることによりポリペプチドを生産するための方法
US6476211B1 (en) 1998-07-16 2002-11-05 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
EP1133563A2 (fr) 1998-07-16 2001-09-19 Hyseq, Inc. Procedes et materiaux associes a de nouveaux polypeptides semblables a cd39
US6447771B1 (en) 1999-03-19 2002-09-10 Hyseq, Inc. Methods and materials relating to novel CD39-like polypeptides
US6387645B1 (en) 1998-07-16 2002-05-14 Hyseq, Inc. Methods and materials relating to novel CD39-like polypeptides
US6773911B1 (en) 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
DE19857609A1 (de) 1998-12-14 2000-06-15 Hannelore Ehrenreich Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
CA2356533C (fr) 1998-12-23 2010-07-13 Mount Sinai School Of Medicine Inhibiteurs de la reaction a la saveur amere
US6899875B1 (en) 1999-01-29 2005-05-31 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6780977B1 (en) 1999-01-29 2004-08-24 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6783959B1 (en) 1999-01-29 2004-08-31 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6350447B1 (en) 1999-01-29 2002-02-26 Hyseq, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
EP1155131B1 (fr) * 1999-02-19 2008-07-23 ABT Holding Company Vector comprenant une trappe d'accepteur d'epissage et une trappe poly a et les cellules eucaryotes correspondantes
US6335013B1 (en) 1999-03-19 2002-01-01 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
WO2000058479A1 (fr) 1999-03-26 2000-10-05 Amgen Inc. Genes et polypeptides beta secretase
EP1192258A2 (fr) 1999-06-16 2002-04-03 Icos Corporation Materiaux poly(adp-ribose) polymerase 2 humains et procedes
US6632665B1 (en) 1999-08-09 2003-10-14 Wake Forest University Human gene encoding 3′-5′ exonuclease
US7408047B1 (en) 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US6900043B1 (en) 1999-09-21 2005-05-31 Amgen Inc. Phosphatases which activate map kinase pathways
US6344549B1 (en) 1999-10-14 2002-02-05 Icos Corporation ATR-2 cell cycle checkpoint
JP2003512838A (ja) 1999-10-22 2003-04-08 ファルマシア・アンド・アップジョン・カンパニー ショウジョウバエｇタンパク質結合レセプター、核酸、およびそれに関連する方法。
US7314716B2 (en) 1999-11-19 2008-01-01 Mount Sinai School Of Medicine Gustducin γ subunit materials and methods
US6465620B1 (en) 2000-01-21 2002-10-15 Hyseq, Inc. Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides
US6635742B1 (en) 2000-01-25 2003-10-21 Nuvelo, Inc. Antibodies specific for semaphorin-like polypeptides
US6586390B1 (en) 2000-01-21 2003-07-01 Hyseq, Inc. Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
EP1297112A2 (fr) 2000-05-22 2003-04-02 PHARMACIA & UPJOHN COMPANY Nouvelles metalloproteinases matricielles
ES2317917T3 (es) 2000-06-28 2009-05-01 Amgen Inc. Moleculas de receptor de linfopoyetina estromal timica y sus usos de las mismas.
US7067626B2 (en) 2000-07-05 2006-06-27 Pharmacia & Upjohn Company Human ion channel proteins
GB0018876D0 (en) * 2000-08-01 2000-09-20 Applied Research Systems Method of producing polypeptides
US6787684B2 (en) 2000-10-16 2004-09-07 E. & J. Gallo Winery Lipoxygenase genes from Vitis vinifera
DE60144439D1 (de) 2000-12-20 2011-05-26 Hoffmann La Roche Konjugate von erythropoietin (epo) mit polyethylenglykol (peg)
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
PT1407787E (pt) 2001-06-20 2009-07-07 Koken Kk Método de promoção da transferência de ácido nucleico
AU2002326315B2 (en) 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
CA2452337A1 (fr) 2001-07-10 2003-01-23 Senomyx, Inc. Utilisation de recepteurs gustatifs specifiques a t2r permettant d'identifier des composes bloquant le gout acide
US7662924B2 (en) 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
AU2003239589A1 (en) 2002-05-24 2003-12-12 Schering-Plough Ltd. Eta-1 gene and methods for use
US7459435B2 (en) 2002-08-29 2008-12-02 Hoffmann-La Roche Inc. Treatment of disturbances of iron distribution
MXPA05003869A (es) 2002-10-08 2005-06-22 Ares Trading Sa El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina.
US7459436B2 (en) 2002-11-22 2008-12-02 Hoffmann-La Roche Inc. Treatment of disturbances of iron distribution
EP2561887B8 (fr) 2003-01-14 2016-12-21 Dana-Farber Cancer Institute, Inc. Sensibilisateur de thérapie anticancéreuse
WO2005005480A2 (fr) 2003-06-27 2005-01-20 Monell Chemical Senses Center Recepteurs gustatifs de la famille des recepteurs t1r du chat domestique
BRPI0413347A (pt) 2003-08-06 2006-10-10 Senomyx Inc novos sabores, modificadores de sabor, agentes de sabor, realçadores de sabor, agentes de sabor e/ou realçadores umami ou doces, e utilização correspondente
BRPI0414887A (pt) 2003-09-29 2006-12-12 Warren Pharmaceuticals Inc E T métodos de tratamento, prevenção, retardo do inìcio ou redução dos efeitos de citocinas pró-inflamatórias em um mamìfero e de tratamento, prevenção, retardo do inìcio de uma condição associada com um efeito de citocinas pró-inflamatórias em um mamìfero, e, composição farmacêutica
EP1696034A4 (fr) * 2003-12-19 2006-12-27 Dainippon Sumitomo Pharma Co Methode de transfert d'acide nucleique
EP1753864A2 (fr) 2004-04-14 2007-02-21 Monell Chemical Senses Center Recepteurs de gout de la famille t1r, provenant d'un chien domestique
WO2005107796A2 (fr) 2004-04-23 2005-11-17 Pharmacia & Upjohn Company, Llc Facteur de permissivite cellulaire pour virus, et son utilisation
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
JP2008511678A (ja) 2004-09-02 2008-04-17 イェール ユニバーシティ マイクロｒｎａによるオンコジーンの調節
US7785807B2 (en) 2004-12-13 2010-08-31 Monell Chemical Senses Center Voltage-gated, pH-sensitive anion channel and its novel splice variant involved in taste sensation
EP3072522B1 (fr) 2005-01-06 2019-04-24 Novo Nordisk A/S Traitements de combinaison anti-kir et procédés
WO2006101629A2 (fr) 2005-02-17 2006-09-28 Vertex Pharmaceuticals Incorporated Variant d'epissage d'une sous-unite alpha de proteine type iii de canal sodique
EP2567976B1 (fr) 2005-03-23 2017-07-19 Genmab A/S Anticorps diriges contre CD38 pour le traitement du myelome multiple
US8354384B2 (en) 2005-06-23 2013-01-15 Yale University Anti-aging micrornas
EP1951395B1 (fr) 2005-09-14 2012-02-29 Ares Trading S.A. Méthode de dosage quantitatif des poloxamères
US7972813B2 (en) 2005-09-30 2011-07-05 Vertex Pharmaceuticals Incorporated Tetrodotoxin-resistant sodium channel alpha subunit
CN101605810B (zh) 2005-10-20 2013-07-17 塞诺米克斯公司 嵌合的人甜味-鲜味和鲜味-甜味受体
AU2006322028C1 (en) 2005-12-08 2025-09-04 Amgen Inc. Improved host cells and culture methods
DE102006004008A1 (de) 2006-01-27 2007-08-02 Hannelore Prof. Dr. Dr. Ehrenreich Verfahren zur Behandlung und/oder Prophylaxe von Multipler Sklerose, sowie Verwendung von Erythropoietin zur Herstellung eines Arzneimittels zur intermittierenden Behandlung und/oder intermittierenden Prophylaxe von Multipler Sklerose
KR101387563B1 (ko) 2006-04-21 2014-04-25 세노믹스, 인코포레이티드 고효능의 조미용 향료를 포함하는 식품 조성물 및 이의 제조 방법
CN101986785A (zh) 2007-05-11 2011-03-16 托马斯杰弗逊大学 治疗和预防神经退行性疾病和紊乱的方法
AU2008251467B2 (en) 2007-05-11 2014-07-31 The Trustees Of The University Of Pennsylvania Methods of treatment of skin ulcers
CL2008002053A1 (es) 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
CL2008002054A1 (es) 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
WO2009010107A1 (fr) 2007-07-19 2009-01-22 Hannelore Ehrenreich Utilisation d'activation ou de stimulation du récepteur de l'epo pour l'amélioration du score edss dans des patients présentant une sclérose en plaques
CA2694476C (fr) 2007-07-27 2017-06-27 Universiteit Gent Cellules permissives et leurs utilisations
KR101558193B1 (ko) 2007-08-21 2015-10-12 세노믹스, 인코포레이티드 인간 ｔ2ｒ 쓴맛 수용체 및 이의 용도
GB0803076D0 (en) 2008-02-20 2008-03-26 Univ Ghent Mucosal Membrane Receptor and uses thereof
EP2296690B1 (fr) 2008-06-04 2016-11-30 Amgen, Inc Mutants fgf21 et leurs utilisations
JP5878757B2 (ja) 2008-10-10 2016-03-08 アムジエン・インコーポレーテツド Ｆｇｆ２１変異体およびその使用
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
EP2427207B1 (fr) 2009-05-05 2017-08-16 Amgen, Inc Mutants de fgf21 et leurs utilisations
HRP20240135T1 (hr) 2009-05-05 2024-04-12 Amgen Inc. Fgf21 mutanti i njihove upotrebe
UA107678C2 (uk) 2009-09-23 2015-02-10 ратіофарм ГмбХ Процес очищення рекомбінантного людського еритропоетину (епо), епо, очищений таким чином, та фармацевтична композиція, що містить його
EP2325194A1 (fr) 2009-11-24 2011-05-25 Glycotope GmbH Processus de purification de glycoprotéines
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
WO2011091982A1 (fr) 2010-01-28 2011-08-04 Glycotope Gmbh Procédé de purification de glycoprotéines
CA2796055A1 (fr) 2010-04-15 2011-10-20 Amgen Inc. Proteines de liaison au recepteur de fgf humain et a ?-klotho
DK2580243T3 (da) 2010-06-09 2020-01-13 Genmab As Antibodies against human cd38
JP6055404B2 (ja) 2010-06-15 2016-12-27 ゲンマブ エー／エス 組織因子に対するヒト抗体薬物結合体
CN103118708B (zh) 2010-09-14 2015-08-26 霍夫曼-拉罗奇有限公司 用于纯化聚乙二醇化的促红细胞生成素的方法
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
WO2013009971A1 (fr) 2011-07-12 2013-01-17 E. I. Du Pont De Nemours And Company Procédé de détection et de criblage et matériaux utiles dans l'exécution de celui-ci
EP2739734A1 (fr) 2011-08-03 2014-06-11 The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System Traitement de fibrose au moyen de microarn-19b
PH12014501360B1 (en) 2011-12-16 2022-05-20 Targetgene Biotechnologies Ltd Compositions and methods for modifying a predetermined target nucleic acid sequence
EP3036254A1 (fr) 2013-08-20 2016-06-29 LEK Pharmaceuticals d.d. Milieux de culture cellulaire et procédé pour réguler l' -amidation et/ou le clivage d'acides aminés c-terminaux de polypeptides
WO2016044271A2 (fr) 2014-09-15 2016-03-24 Children's Medical Center Corporation Méthodes et compositions pour augmenter l'efficacité du transfert nucléaire des cellules somatiques (scnt) par élimination de la triméthylation de la lysine de l'histone h3
HRP20202077T1 (hr) 2016-07-15 2021-02-19 F. Hoffmann - La Roche Ag Postupak za pročišćavanje pegiliranog eritropoetina
HRP20220041T1 (hr) 2017-12-29 2022-04-15 F. Hoffmann - La Roche Ag Postupak za dobivanje pegiliranog proteinskog pripravka
CN111741770A (zh) 2017-12-29 2020-10-02 豪夫迈·罗氏有限公司 用于提供聚乙二醇化蛋白质组合物的方法
WO2019129878A1 (fr) 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Procédé permettant d'obtenir une composition de protéine pegylée
WO2022159414A1 (fr) 2021-01-22 2022-07-28 University Of Rochester Érythropoïétine pour un dysfonctionnement gastrointestinal
WO2024091824A1 (fr) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Différenciation et reprogrammation de chondrocyte
EP4634373A1 (fr) 2022-12-16 2025-10-22 University of Rochester Réparation d'un dysfonctionnement de la barrière dans l'oesophage
WO2025259466A1 (fr) 2024-06-13 2025-12-18 University Of Rochester Cellules dendritiques induites par gm-csf et gm-csf améliorant la cicatrisation de fractures et la réparation osseuse

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3689899T2 (de) * 1985-04-08 1994-09-15 Amgen Verfahren und hybridpromotor zur steuerung der exogenen gentranskription.
EP0273085A1 (fr) * 1986-12-29 1988-07-06 IntraCel Corporation Procédé pour faire entrer des acides nucléiques dans des cellules eucaryotes
ZA88319B (en) * 1987-02-06 1988-08-12 Lubrizol Enterprises, Inc. Ocs enhancer
GB8807683D0 (en) * 1988-03-31 1988-05-05 Ici Plc Regulation of gene expression
FR2646438B1 (fr) * 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
WO1991005052A1 (fr) * 1989-09-28 1991-04-18 Leningradsky Gosudarstvenny Universitet Procede d'obtention d'un polypeptide presentant une activite d'interleukine-2 humaine, secrete par des cellules de levure, saccharomyces cerevisiae
ATE174058T1 (de) * 1989-11-06 1998-12-15 Cell Genesys Inc Herstellung von proteinen mittels homologer rekombination
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production

Also Published As

Publication number Publication date
HU9202068D0 (en) 1992-10-28
BG96515A (bg) 1993-12-24
CA2071989C (fr) 1999-07-27
DK0779362T4 (da) 2012-07-30
RO109864B1 (ro) 1995-06-30
DE69031172D1 (de) 1997-09-04
DE69031172T2 (de) 1998-03-12
UA42675C2 (uk) 2001-11-15
NO922436D0 (no) 1992-06-19
EP1484412A2 (fr) 2004-12-08
EP0779362B1 (fr) 2004-04-21
GR3025057T3 (en) 1998-01-30
AR245776A1 (es) 1994-02-28
ES2151463T1 (es) 2001-01-01
IL116046A0 (en) 1996-01-31
IL164252A0 (en) 2005-12-18
JPH05504682A (ja) 1993-07-22
HU217212B (hu) 1999-12-28
EP0779362A1 (fr) 1997-06-18
EP0505500B1 (fr) 1997-07-30
BR9007937A (pt) 1992-11-17
ES2104690T3 (es) 1997-10-16
CA2071989A1 (fr) 1991-06-23
NO311896B1 (no) 2002-02-11
NO922436L (no) 1992-06-19
IL96765A0 (en) 1991-09-16
EP1375666A3 (fr) 2007-09-26
ES2151463T3 (es) 2004-10-01
JP2004089200A (ja) 2004-03-25
JP2004000233A (ja) 2004-01-08
DE69034135T2 (de) 2004-08-26
IL116046A (en) 2007-03-08
HUT62657A (en) 1993-05-28
HK1000547A1 (en) 1998-04-03
OA09594A (en) 1993-04-30
DK0505500T3 (da) 1997-08-25
ES2151463T5 (es) 2012-10-29
EP1482053A2 (fr) 2004-12-01
DE779362T1 (de) 2001-04-05
LTIP1595A (en) 1995-07-25
ATE156189T1 (de) 1997-08-15
JP3501286B2 (ja) 2004-03-02
EP1375666A2 (fr) 2004-01-02
FI107391B (fi) 2001-07-31
EP1484412A3 (fr) 2007-10-17
FI922863A0 (fi) 1992-06-18
WO1991009955A1 (fr) 1991-07-11
AU645294B2 (en) 1994-01-13
ATE264916T1 (de) 2004-05-15
EP1482053A3 (fr) 2007-10-17
DE69034135T3 (de) 2012-08-23
DK0779362T3 (da) 2004-05-10
FI922863L (fi) 1992-06-18
JP3740134B2 (ja) 2006-02-01
HK1000786A1 (en) 2005-01-14
DE69034135D1 (de) 2004-05-27
KR0176693B1 (ko) 1999-04-01
LV10655B (en) 1995-08-20
AU7183691A (en) 1991-07-24
EP0505500A1 (fr) 1992-09-30
LT3998B (en) 1996-06-25
EP0779362B2 (fr) 2012-06-13
ZA9010392B (en) 1992-01-29
LV10655A (lv) 1995-04-20
RU2128227C1 (ru) 1999-03-27

Similar Documents

Publication Publication Date Title
BG60624B1 (bg) Ендогенна модификация на генната експресия чрез регулаторен елемент
US5272071A (en) Method for the modification of the expression characteristics of an endogenous gene of a given cell line
HK1000786B (en) Dna constructs for endogenous gene activation and expression modification
US5591601A (en) DNA polymerase gene expression system utilizing an RNA polymerase co-delivered with the gene expression vector system
US5721118A (en) Mammalian artificial chromosomes and methods of using same
US6638768B1 (en) Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
US5972605A (en) Assays for regulators of mammalian telomerase expression
US6653132B1 (en) IRES sequences with high translational efficiency and expression vectors containing the sequence
JPH04505104A (ja) 相同組換え法を用いてのタンパク質の生成
CN116157514A (zh) 新颖omni-59、61、67、76、79、80、81和82crispr核酸酶
AU2021252114A1 (en) Methods for targeted integration
EP1975228A1 (fr) Polynucléides pour améliorer l'expression d'un polynucléide intéressant
HK1000547B (en) Endogenous gene expression modification with regulatory element by way of homologous recombination
HK1059279A (en) Eukaryotic host cell line in which an endogenous gene has been activated, and uses thereof
US20240000051A1 (en) Influenza a-resistant animals having edited anp32 genes
WO2005118835A2 (fr) Souches cellulaires et procedes d'evaluation integrant des polynucleotides