BG60680B1 - Р-заместени производни на 4-оксибутанамина, методи за получава- нето и приложението им - Google Patents

Р-заместени производни на 4-оксибутанамина, методи за получава- нето и приложението им Download PDF

Info

Publication number
BG60680B1
BG60680B1 BG96487A BG9648792A BG60680B1 BG 60680 B1 BG60680 B1 BG 60680B1 BG 96487 A BG96487 A BG 96487A BG 9648792 A BG9648792 A BG 9648792A BG 60680 B1 BG60680 B1 BG 60680B1
Authority
BG
Bulgaria
Prior art keywords
general formula
formula
compounds
radical
compound
Prior art date
Application number
BG96487A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96487A (bg
Inventor
Paule Bonnet
Remi Delansorne
Maurice Faure
Michel Lanquetin
Serge Zunino
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of BG96487A publication Critical patent/BG96487A/bg
Publication of BG60680B1 publication Critical patent/BG60680B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG96487A 1990-10-17 1992-06-16 Р-заместени производни на 4-оксибутанамина, методи за получава- нето и приложението им BG60680B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR909012562A FR2668150B1 (fr) 1990-10-17 1990-10-17 Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
PCT/FR1991/000811 WO1992006977A1 (fr) 1990-10-17 1991-10-17 NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT

Publications (2)

Publication Number Publication Date
BG96487A BG96487A (bg) 1993-12-24
BG60680B1 true BG60680B1 (bg) 1995-12-29

Family

ID=9401134

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96487A BG60680B1 (bg) 1990-10-17 1992-06-16 Р-заместени производни на 4-оксибутанамина, методи за получава- нето и приложението им

Country Status (23)

Country Link
US (1) US5461059A (fr)
EP (1) EP0505543A1 (fr)
JP (1) JPH05503298A (fr)
KR (1) KR927003589A (fr)
AP (1) AP282A (fr)
BG (1) BG60680B1 (fr)
BR (1) BR9106188A (fr)
CA (1) CA2071911A1 (fr)
CZ (1) CZ182292A3 (fr)
FI (1) FI922773A7 (fr)
FR (2) FR2668150B1 (fr)
HU (1) HUT61297A (fr)
IE (1) IE913636A1 (fr)
IL (1) IL99776A0 (fr)
MA (1) MA22321A1 (fr)
NO (1) NO922358L (fr)
NZ (1) NZ240274A (fr)
OA (1) OA09835A (fr)
PL (2) PL169022B1 (fr)
PT (1) PT99266A (fr)
RO (1) RO108241B1 (fr)
WO (1) WO1992006977A1 (fr)
ZA (1) ZA918282B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
ES2072193B1 (es) * 1993-05-21 1996-02-16 Espanola Prod Quimicos Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
US5691323A (en) * 1995-05-12 1997-11-25 Merck & Co., Inc. Muscarine antagonists
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
EP0904080A4 (fr) * 1996-04-03 2001-08-01 Merck & Co Inc Inhibiteurs de farnesyle-proteine transferase
WO2002002560A2 (fr) * 2000-07-04 2002-01-10 Novo Nordisk A/S Composes heterocycliques inhibiteurs de l'enzyme dpp-iv
WO2004009091A1 (fr) * 2002-06-17 2004-01-29 Glaxo Group Limited Agonistes des recepteurs x du foie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636717A (fr) * 1962-08-31
US3161645A (en) * 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
SG44477A1 (en) * 1988-04-28 1997-12-19 Schering Corp Fused polycyclic compounds compositions methods of manufacture and their use as paf antaginists anthihistamines and/or antiinflammatory agents
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds

Also Published As

Publication number Publication date
US5461059A (en) 1995-10-24
IL99776A0 (en) 1992-08-18
RO108241B1 (ro) 1994-03-31
FR2668150B1 (fr) 1994-11-18
EP0505543A1 (fr) 1992-09-30
AP282A (en) 1993-09-08
JPH05503298A (ja) 1993-06-03
KR927003589A (ko) 1992-12-18
NO922358L (no) 1992-08-11
HUT61297A (en) 1992-12-28
FI922773L (fi) 1992-06-16
MA22321A1 (fr) 1992-07-01
PL169022B1 (pl) 1996-05-31
FR2670783A1 (fr) 1992-06-26
CZ182292A3 (en) 1993-01-13
IE913636A1 (en) 1992-04-22
PT99266A (pt) 1992-08-31
CA2071911A1 (fr) 1992-04-18
HU9202176D0 (en) 1992-10-28
ZA918282B (en) 1992-07-29
BG96487A (bg) 1993-12-24
FR2670783B1 (fr) 1994-11-18
AP9100328A0 (en) 1991-10-31
FI922773A0 (fi) 1992-06-16
BR9106188A (pt) 1993-03-16
NZ240274A (en) 1995-07-26
FI922773A7 (fi) 1992-06-16
WO1992006977A1 (fr) 1992-04-30
OA09835A (fr) 1994-08-15
FR2668150A1 (fr) 1992-04-24
PL169452B1 (pl) 1996-07-31
NO922358D0 (no) 1992-06-16

Similar Documents

Publication Publication Date Title
US4711899A (en) 2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives
FR2558162A1 (fr) Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
EP1451188B1 (fr) Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo 3.2.2]-nonane, leur preparation et leur application en therapeutique
SK31793A3 (en) Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines and piperazines and compositions and methods of use thereof
DK169546B1 (da) 1,2,4-triazolonderivater, en fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
DE69630717T2 (de) 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidinderivate als für den menschlichen nk3-rezeptor selektive antagonisten
EP0338939B1 (fr) Dérivé de l'histamine, sa préparation et son application en thérapeutique
US20080261976A1 (en) Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
JP3498849B2 (ja) ニューロキニンａ拮抗剤としての二環式複素環化合物
EP2346833A1 (fr) Procédé sans diazonium pour fabriquer un intermédiaire indazole dans la synthèse d'amides bicycliques de l'acide 5-(trifluorométhoxy)-1h-3-indazolecarboxylique
BG60680B1 (bg) Р-заместени производни на 4-оксибутанамина, методи за получава- нето и приложението им
JPH0567624B2 (fr)
US3532702A (en) 2-(o-aminophenoxy or phenylthio) phenyl-1-substituted (piperidyl or pyrrolidinyl) ketones
HK78895A (en) Substituted 1H-imidazoles
EP0739881B1 (fr) Dérivés de pipéridine
US5447931A (en) New therapeutic use of heterocyclylpiperazines as 5-HT3 agonists and new compounds
PL186708B1 (pl) Nowe związki heterocykliczne, sposób ich wytwarzania, kompozycje je zawierające oraz ich stosowaniedo wytwarzania leków
Abou-Gharbia et al. New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists
US5192763A (en) [(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their preparation and their application in therapeutics
JPH06102660B2 (ja) 新規なモルホリン誘導体およびこれらの誘導体を含有する医薬組成物
HU209930B (en) Process for producing of 2-mercapto-2-(1-isoquinolylidene)-acetonitrile derivatives and pharmaceutical compositions comprising them
JPS624250A (ja) ベンズ三置換−２−アミノテトラリン
EP0129136B1 (fr) Composition anti-hypertensive
AU2009304171B2 (en) Diazonium-free method to make an indazole intermediate in the synthesis of bicyclic 5-(trifluormethoxy)-1H-3-indazolecarboxylic acid amides
NZ312577A (en) Use of optionally substituted n-(pyrrol-1-yl)-pyridinamines as anticonvulsant agents