BG62381B1 - Офталмологичен препарат - Google Patents

Офталмологичен препарат Download PDF

Info

Publication number: BG62381B1
Authority: BG; Bulgaria
Prior art keywords: viscosity; pilocarpine; mpas; timolol; beta
Prior art date: 1992-08-20

Application number

BG99483A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG99483A (bg

Inventor

Kari Lehmussaari

Olli Oksala

Timo Reunamaeki

Original Assignee

Santen Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-20

Filing date

1995-03-08

Publication date

1999-10-29

1995-03-08 Application filed by Santen Oy filed Critical Santen Oy

1995-12-29 Publication of BG99483A publication Critical patent/BG99483A/bg

1999-10-29 Publication of BG62381B1 publication Critical patent/BG62381B1/bg

Links

238000002360 preparation method Methods 0.000 title claims description 10
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims abstract description 19
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims abstract description 19
229960001416 pilocarpine Drugs 0.000 claims abstract description 19
239000000654 additive Substances 0.000 claims abstract description 5
238000000034 method Methods 0.000 claims abstract description 5
208000010412 Glaucoma Diseases 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims description 22
239000003889 eye drop Substances 0.000 claims description 13
238000009472 formulation Methods 0.000 claims description 13
239000002876 beta blocker Substances 0.000 claims description 8
229940097320 beta blocking agent Drugs 0.000 claims description 8
TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims description 7
229940012356 eye drops Drugs 0.000 claims description 7
WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 claims description 6
239000000872 buffer Substances 0.000 claims description 6
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
229960004605 timolol Drugs 0.000 claims description 6
-1 timolol compound Chemical class 0.000 claims description 6
229960005221 timolol maleate Drugs 0.000 claims description 6
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
239000007979 citrate buffer Substances 0.000 claims description 2
239000002552 dosage form Substances 0.000 claims 1
239000003623 enhancer Substances 0.000 claims 1
229960000454 timolol hemihydrate Drugs 0.000 claims 1
210000005252 bulbus oculi Anatomy 0.000 abstract 1
239000000243 solution Substances 0.000 description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
239000008223 sterile water Substances 0.000 description 10
229960000686 benzalkonium chloride Drugs 0.000 description 8
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 8
239000001509 sodium citrate Substances 0.000 description 7
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 7
239000002253 acid Substances 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 5
238000004806 packaging method and process Methods 0.000 description 4
239000003755 preservative agent Substances 0.000 description 4
244000248349 Citrus limon Species 0.000 description 3
235000005979 Citrus limon Nutrition 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000000845 anti-microbial effect Effects 0.000 description 3
239000003814 drug Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
229920002451 polyvinyl alcohol Polymers 0.000 description 3
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
229960004324 betaxolol Drugs 0.000 description 2
CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
230000007423 decrease Effects 0.000 description 2
230000000694 effects Effects 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
230000035515 penetration Effects 0.000 description 2
RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 2
235000019422 polyvinyl alcohol Nutrition 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
235000002639 sodium chloride Nutrition 0.000 description 2
239000000126 substance Substances 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
108060003345 Adrenergic Receptor Proteins 0.000 description 1
102000017910 Adrenergic receptor Human genes 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
208000003556 Dry Eye Syndromes Diseases 0.000 description 1
206010013774 Dry eye Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920003072 Plasdone™ povidone Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000003868 ammonium compounds Chemical class 0.000 description 1
229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
229960004374 befunolol Drugs 0.000 description 1
ZPQPDBIHYCBNIG-UHFFFAOYSA-N befunolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1OC(C(C)=O)=C2 ZPQPDBIHYCBNIG-UHFFFAOYSA-N 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
239000003489 carbonate dehydratase inhibitor Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000002716 delivery method Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229940094443 oxytocics prostaglandins Drugs 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
238000012536 packaging technology Methods 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
229960002139 pilocarpine hydrochloride Drugs 0.000 description 1
229960002508 pindolol Drugs 0.000 description 1
PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229960001790 sodium citrate Drugs 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Ophthalmology & Optometry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Radiation-Therapy Devices (AREA)
Laser Surgery Devices (AREA)

BG99483A 1992-08-20 1995-03-08 Офталмологичен препарат BG62381B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9202398A SE512871C2 (sv)	1992-08-20	1992-08-20	Oftalmologisk beredning innehållande pilokarpin och ytterligare medel för behandling av okular hypertension
PCT/FI1993/000326 WO1994004134A1 (en)	1992-08-20	1993-08-18	Ophthalmological preparation

Publications (2)

Publication Number	Publication Date
BG99483A BG99483A (bg)	1995-12-29
BG62381B1 true BG62381B1 (bg)	1999-10-29

Family

ID=20386970

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG99483A BG62381B1 (bg)	1992-08-20	1995-03-08	Офталмологичен препарат

Country Status (26)

Country	Link
US (1)	US5767143A (de)
EP (1)	EP0655911B1 (de)
JP (1)	JPH08500354A (de)
KR (1)	KR100295407B1 (de)
CN (1)	CN1041795C (de)
AT (1)	ATE175867T1 (de)
AU (1)	AU674335B2 (de)
BG (1)	BG62381B1 (de)
BR (1)	BR9307099A (de)
CZ (1)	CZ283895B6 (de)
DE (2)	DE69323202T2 (de)
DK (1)	DK0655911T3 (de)
EE (1)	EE03188B1 (de)
ES (1)	ES2080031T3 (de)
GR (2)	GR960300003T1 (de)
HU (1)	HU226829B1 (de)
MX (1)	MX9305043A (de)
NO (1)	NO307952B1 (de)
PL (1)	PL175860B1 (de)
RO (1)	RO111988B1 (de)
SE (1)	SE512871C2 (de)
SG (1)	SG49041A1 (de)
SK (1)	SK281092B6 (de)
TW (1)	TW427913B (de)
WO (1)	WO1994004134A1 (de)
ZA (1)	ZA936094B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2402316C2 (ru) *	2009-01-11	2010-10-27	Пшеничников Виталий Георгиевич	Фармацевтическая антиглаукомная композиция

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2161473T3 (es) *	1996-09-20	2001-12-01	Bausch & Lomb	Metodo y composicion para rehumedecer lentes de contacto y aliviar la sequedad ocular.
KR20010031804A (ko) *	1997-11-05	2001-04-16	요시다 쇼지	지속성 점안제
US6335335B2 (en)	1997-11-05	2002-01-01	Senju Pharmaceutical Co., Ltd.	Prolonged-action eye drop
MY116782A (en)	1997-12-22	2004-03-31	Otsuka Pharma Co Ltd	Water-soluble eye drop
JP2005247875A (ja) *	2000-07-21	2005-09-15	Rohto Pharmaceut Co Ltd	点眼剤
JP5364658B2 (ja) *	2000-07-21	2013-12-11	ロート製薬株式会社	点眼剤
JP2002097129A (ja) *	2000-07-21	2002-04-02	Rohto Pharmaceut Co Ltd	点眼剤
WO2002058668A2 (en) *	2000-12-21	2002-08-01	Alcon, Inc	Artificial tear composition adapted to be used with contact lenses
CN100483106C (zh) *	2002-09-29	2009-04-29	天津市先石光学技术有限公司	可分离介质表层与深层信息的光学检测方法
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
BRPI0909797A2 (pt) *	2008-03-07	2017-08-22	Sun Pharma Advanced Res Co Ltd	Composição oftálmica
UA113525C2 (xx)	2011-09-20	2017-02-10		Спосіб лікування пресбіопії
PL3681500T3 (pl)	2018-04-24	2022-08-01	Allergan, Inc.	Zastosowanie chlorowodorku pilokarpiny w leczeniu starczowzroczności
WO2023234423A1 (en) *	2022-06-03	2023-12-07	Amd Therapeutics Llc	Rifamycin ophthalmic composition and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601247A1 (fr) *	1986-07-09	1988-01-15	Merk Sharp Dohme Chibret Labor	Combinaison d'agents beta-bloquants et de pilocarpine.
US5252318A (en) *	1990-06-15	1993-10-12	Allergan, Inc.	Reversible gelation compositions and methods of use

1992
- 1992-08-20 SE SE9202398A patent/SE512871C2/sv not_active IP Right Cessation
1993
- 1993-08-17 TW TW082106600A patent/TW427913B/zh not_active IP Right Cessation
- 1993-08-18 BR BR9307099A patent/BR9307099A/pt not_active Application Discontinuation
- 1993-08-18 DE DE69323202T patent/DE69323202T2/de not_active Expired - Lifetime
- 1993-08-18 SG SG1996005479A patent/SG49041A1/en unknown
- 1993-08-18 DE DE0655911T patent/DE655911T1/de active Pending
- 1993-08-18 WO PCT/FI1993/000326 patent/WO1994004134A1/en not_active Ceased
- 1993-08-18 ES ES93917820T patent/ES2080031T3/es not_active Expired - Lifetime
- 1993-08-18 PL PL93307526A patent/PL175860B1/pl unknown
- 1993-08-18 JP JP6505943A patent/JPH08500354A/ja active Pending
- 1993-08-18 AU AU47117/93A patent/AU674335B2/en not_active Ceased
- 1993-08-18 HU HU9500501A patent/HU226829B1/hu unknown
- 1993-08-18 KR KR1019950700483A patent/KR100295407B1/ko not_active Expired - Fee Related
- 1993-08-18 DK DK93917820T patent/DK0655911T3/da active
- 1993-08-18 SK SK209-95A patent/SK281092B6/sk unknown
- 1993-08-18 EP EP93917820A patent/EP0655911B1/de not_active Expired - Lifetime
- 1993-08-18 RO RO95-00317A patent/RO111988B1/ro unknown
- 1993-08-18 AT AT93917820T patent/ATE175867T1/de active
- 1993-08-18 CZ CZ95414A patent/CZ283895B6/cs not_active IP Right Cessation
- 1993-08-19 ZA ZA936094A patent/ZA936094B/xx unknown
- 1993-08-19 MX MX9305043A patent/MX9305043A/es unknown
- 1993-08-19 CN CN93116550A patent/CN1041795C/zh not_active Expired - Fee Related
1994
- 1994-10-28 EE EE9400263A patent/EE03188B1/xx unknown
1995
- 1995-02-17 NO NO950595A patent/NO307952B1/no not_active IP Right Cessation
- 1995-03-08 BG BG99483A patent/BG62381B1/bg unknown
- 1995-10-13 US US08/542,714 patent/US5767143A/en not_active Expired - Fee Related
1996
- 1996-02-29 GR GR960300003T patent/GR960300003T1/el unknown
1999
- 1999-04-19 GR GR990401071T patent/GR3029992T3/el unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2402316C2 (ru) *	2009-01-11	2010-10-27	Пшеничников Виталий Георгиевич	Фармацевтическая антиглаукомная композиция

Also Published As

Publication number	Publication date
EP0655911B1 (de)	1999-01-20
TW427913B (en)	2001-04-01
ES2080031T1 (es)	1996-02-01
CZ283895B6 (cs)	1998-07-15
HUT71897A (en)	1996-02-28
KR100295407B1 (ko)	2001-09-17
BG99483A (bg)	1995-12-29
CN1041795C (zh)	1999-01-27
MX9305043A (es)	1994-02-28
ATE175867T1 (de)	1999-02-15
PL175860B1 (pl)	1999-02-26
ZA936094B (en)	1994-03-28
PL307526A1 (en)	1995-05-29
EE03188B1 (et)	1999-06-15
HK1013955A1 (en)	1999-09-17
SE512871C2 (sv)	2000-05-29
SG49041A1 (en)	1998-05-18
CN1089837A (zh)	1994-07-27
GR960300003T1 (en)	1996-02-29
ES2080031T3 (es)	1999-05-01
GR3029992T3 (en)	1999-07-30
HU226829B1 (en)	2009-11-30
SE9202398L (sv)	1994-02-21
DE69323202T2 (de)	1999-07-01
NO950595L (no)	1995-02-17
EP0655911A1 (de)	1995-06-07
US5767143A (en)	1998-06-16
NO307952B1 (no)	2000-06-26
HU9500501D0 (en)	1995-04-28
AU674335B2 (en)	1996-12-19
NO950595D0 (no)	1995-02-17
SK281092B6 (sk)	2000-11-07
DK0655911T3 (da)	1999-09-13
SK20995A3 (en)	1997-01-08
JPH08500354A (ja)	1996-01-16
CZ41495A3 (en)	1995-10-18
DE69323202D1 (de)	1999-03-04
SE9202398D0 (sv)	1992-08-20
WO1994004134A1 (en)	1994-03-03
DE655911T1 (de)	1996-02-29
AU4711793A (en)	1994-03-15
RO111988B1 (ro)	1997-04-30
BR9307099A (pt)	1999-06-01

Publication	Publication Date	Title
SK280492B6 (sk)	2000-03-13	Očný prípravok so zníženou viskozitou
BG62381B1 (bg)	1999-10-29	Офталмологичен препарат
AU2025203019A1 (en)	2025-05-15	Ophthalmic Compositions Containing A Nitric Oxide Releasing Prostamide
EP0664705B1 (de)	2000-10-04	Zusammensetzungen von ergolinderivaten zur behandlung des glaukoms
RU2099049C1 (ru)	1997-12-20	Капли для лечения глазной гипертензии и глаукомы и способ их получения
EP0375299A1 (de)	1990-06-27	Mischungen von ACE- und CA-Inhibitoren zur Behandlung von Glaucoma
FI111334B (fi)	2003-07-15	Menetelmä silmätippavalmisteen valmistamiseksi
EA004050B1 (ru)	2003-12-25	Способ изготовления состава местных бета-блокаторов улучшенного действия
HK1013955B (en)	2000-06-23	Ophthalmological preparation
HK40018890A (en)	2020-10-09	Ophthalmic compositions containing a nitric oxide releasing prostamide
HK40018890B (en)	2021-05-28	Ophthalmic compositions containing a nitric oxide releasing prostamide
EP0375319A2 (de)	1990-06-27	Angiotensin konvertierende Enzym-Inhibitoren zur Behandlung von Glaukomen

BG62381B1 - Офталмологичен препарат - Google Patents

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