BG96202A - Заместени 3-(пиридиниламино)-индоли и бензо(в)тиофени, метод за получаването им и приложението им като лекарствени средства - Google Patents

Заместени 3-(пиридиниламино)-индоли и бензо(в)тиофени, метод за получаването им и приложението им като лекарствени средства

Info

Publication number
BG96202A
BG96202A BG096202A BG9620292A BG96202A BG 96202 A BG96202 A BG 96202A BG 096202 A BG096202 A BG 096202A BG 9620292 A BG9620292 A BG 9620292A BG 96202 A BG96202 A BG 96202A
Authority
BG
Bulgaria
Prior art keywords
pyridinylamino
thiophenes
indoles
benzo
medicines
Prior art date
Application number
BG096202A
Other languages
English (en)
Other versions
BG61034B1 (bg
Inventor
Richard Effland
Joseph Klein
Lawrence Martin
Original Assignee
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Inc. filed Critical Hoechst Marion Roussel, Inc.
Publication of BG96202A publication Critical patent/BG96202A/bg
Publication of BG61034B1 publication Critical patent/BG61034B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до съединения с формула в която буквените означения имат значенията, посочени в описанието. Съединенията са приложими за лечение на различни нарушения на паметта, например болестта на алцхаймер, като модулатори на невротрансмисионната функция серотонергична или адренергична. Те могат да се използват също и като антидепресанти, седативни средства, атипични антипсихотици, като лекарствени средства против повръщане и за лечение на болестни промени в характера, например натрапчиви идеи и други. 8 претенции
BG96202A 1991-04-17 1992-04-09 Заместени 3-(пиридиниламино)-индоли и бензо(в)тиофени, метод за получаването им и приложението им като лекарствени средства BG61034B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/688,964 US5177088A (en) 1991-04-17 1991-04-17 Substituted 3-(pyridinylamino)-indoles

Publications (2)

Publication Number Publication Date
BG96202A true BG96202A (bg) 1993-12-24
BG61034B1 BG61034B1 (bg) 1996-09-30

Family

ID=24766519

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96202A BG61034B1 (bg) 1991-04-17 1992-04-09 Заместени 3-(пиридиниламино)-индоли и бензо(в)тиофени, метод за получаването им и приложението им като лекарствени средства

Country Status (25)

Country Link
US (1) US5177088A (bg)
EP (1) EP0509402B1 (bg)
JP (1) JP2617650B2 (bg)
KR (1) KR100254027B1 (bg)
AT (1) ATE161840T1 (bg)
AU (1) AU655253B2 (bg)
BG (1) BG61034B1 (bg)
CA (1) CA2066332C (bg)
CS (1) CS117192A3 (bg)
DE (1) DE69223837T2 (bg)
DK (1) DK0509402T3 (bg)
ES (1) ES2111580T3 (bg)
FI (1) FI105096B (bg)
GR (1) GR3026317T3 (bg)
HU (1) HU215113B (bg)
IE (1) IE921235A1 (bg)
IL (1) IL101599A (bg)
MX (1) MX9201759A (bg)
NO (1) NO180486C (bg)
NZ (1) NZ242359A (bg)
PL (1) PL168905B1 (bg)
RO (1) RO109847B1 (bg)
RU (1) RU2060254C1 (bg)
TW (1) TW200477B (bg)
ZA (1) ZA922807B (bg)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
HUP9802492A3 (en) * 1995-06-06 1999-10-28 Hoechst Marion Roussel Inc Cin Benzisoxazole and indazole derivatives as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same
US5668154A (en) * 1995-06-06 1997-09-16 Hoechst Marion Roussel Inc. Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
IL130642A0 (en) * 1996-12-27 2000-06-01 Hoechst Marion Roussel Ltd N-(pyridinylamino)isoindolines and related compounds
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
EA200200356A1 (ru) * 1999-09-14 2002-10-31 Авентис Фармасьютикалз Инк. Бензизоксазолил-, пиридоизоксазолил- и бензтиенилфеноксипроизводные, используемые в качестве антагонистов рецептора d4
DE10029371A1 (de) * 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
DE602005020280D1 (de) 2004-06-01 2010-05-12 Hoffmann La Roche 3-amino-1-arylpropyl-indole als monoamin-wiederaufnahmehemmer
BRPI0619263A2 (pt) * 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
EP2351737A1 (en) * 2005-11-30 2011-08-03 F. Hoffmann-La Roche AG 3-Amino-1-arylpropyl indoles and aza-substituted indoles
AU2006319233B9 (en) 2005-11-30 2011-09-29 F. Hoffmann-La Roche Ag 3-amino-2-arylpropyl azaindoles and uses thereof
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049779B1 (en) * 1980-09-18 1984-10-31 Asahi Kasei Kogyo Kabushiki Kaisha 3-aminoindazole derivatives and process for preparation thereof
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
EP0402644B1 (en) * 1989-05-19 1995-08-16 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives

Also Published As

Publication number Publication date
AU1512192A (en) 1992-10-22
FI921693A7 (fi) 1992-10-18
KR920019777A (ko) 1992-11-20
NO180486B (no) 1997-01-20
PL168905B1 (pl) 1996-05-31
IL101599A0 (en) 1992-12-30
GR3026317T3 (en) 1998-06-30
NO921505D0 (no) 1992-04-15
JP2617650B2 (ja) 1997-06-04
AU655253B2 (en) 1994-12-08
KR100254027B1 (ko) 2000-05-01
ATE161840T1 (de) 1998-01-15
EP0509402A1 (en) 1992-10-21
HU215113B (hu) 1998-12-28
NO180486C (no) 1997-04-30
MX9201759A (es) 1992-10-01
DK0509402T3 (da) 1998-09-07
EP0509402B1 (en) 1998-01-07
CA2066332C (en) 2003-07-29
RU2060254C1 (ru) 1996-05-20
NZ242359A (en) 1995-03-28
RO109847B1 (ro) 1995-06-30
DE69223837T2 (de) 1998-06-25
DE69223837D1 (de) 1998-02-12
HU9201297D0 (en) 1992-07-28
NO921505L (no) 1992-10-19
CS117192A3 (en) 1992-11-18
CA2066332A1 (en) 1992-10-18
HUT62572A (en) 1993-05-28
BG61034B1 (bg) 1996-09-30
IE921235A1 (en) 1992-10-21
PL294239A1 (en) 1993-06-14
US5177088A (en) 1993-01-05
IL101599A (en) 1996-05-14
TW200477B (bg) 1993-02-21
FI921693A0 (fi) 1992-04-15
ZA922807B (en) 1992-11-25
ES2111580T3 (es) 1998-03-16
JPH05117266A (ja) 1993-05-14
FI105096B (fi) 2000-06-15

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