BG98761A - Substituted pyrroles - Google Patents

Substituted pyrroles

Info

Publication number: BG98761A
Authority: BG; Bulgaria
Prior art keywords: formula; lower alkyl; amino; compounds; aryl
Prior art date: 1993-05-10

Application number

BG98761A

Other languages

English (en)

Inventor

William Harris

Christopher H Hill

Geoffrey Lawton

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-10

Filing date

1994-05-10

Publication date

1995-03-31

1993-05-10 Priority claimed from GB939309602A external-priority patent/GB9309602D0/en

1994-05-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1995-03-31 Publication of BG98761A publication Critical patent/BG98761A/xx

Links

150000003233 pyrroles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
230000000771 oncological effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Virology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

BG98761A 1993-05-10 1994-05-10 Substituted pyrroles BG98761A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939309602A GB9309602D0 (en)	1993-05-10	1993-05-10	Substituted pyrroles
GB9403249A GB9403249D0 (en)	1993-05-10	1994-02-21	Substituted pyrroles

Publications (1)

Publication Number	Publication Date
BG98761A true BG98761A (en)	1995-03-31

Family

ID=26302877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG98761A BG98761A (en)	1993-05-10	1994-05-10	Substituted pyrroles

Country Status (25)

Country	Link
EP (1)	EP0624586B1 (is)
JP (1)	JP2668818B2 (is)
CN (1)	CN1048014C (is)
AT (1)	ATE184007T1 (is)
AU (1)	AU678435B2 (is)
BG (1)	BG98761A (is)
BR (1)	BR9401935A (is)
CA (1)	CA2121567A1 (is)
CZ (1)	CZ112894A3 (is)
DE (1)	DE69420310T2 (is)
DK (1)	DK0624586T3 (is)
ES (1)	ES2137281T3 (is)
FI (1)	FI106961B (is)
GR (1)	GR3031901T3 (is)
HR (1)	HRP940287B1 (is)
HU (1)	HU215954B (is)
IL (1)	IL109547A (is)
IS (1)	IS1690B (is)
LT (1)	LT3288B (is)
LV (1)	LV11173B (is)
NO (1)	NO301230B1 (is)
NZ (1)	NZ260475A (is)
RU (1)	RU2141960C1 (is)
SI (1)	SI0624586T1 (is)
SK (1)	SK53594A3 (is)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
PL182124B1 (pl) *	1993-12-07	2001-11-30	Lilly Co Eli	Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
DK0817627T3 (da) *	1993-12-23	2005-06-06	Lilly Co Eli	Inhibitorer af proteinkinase C
ES2123873T3 (es) *	1994-08-04	1999-01-16	Hoffmann La Roche	Pirrolocarbazol.
KR20000064764A (ko) *	1996-03-20	2000-11-06	피터지.스트링거	인돌릴말레이미드의제조방법
KR100499190B1 (ko) *	1996-03-29	2006-04-17	교와 핫꼬 고교 가부시끼가이샤	육모제
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
IL153851A0 (en)	2000-07-27	2003-07-31	Hoffmann La Roche	3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
IL161156A0 (en)	2001-10-30	2004-08-31	Novartis Ag	Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
CA2393720C (en)	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
JP2007501774A (ja)	2003-08-08	2007-02-01	ノバルティスアクチエンゲゼルシャフト	スタウロスポリンを含む組み合わせ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
SK75289A3 (en) *	1988-02-10	1998-05-06	Hoffmann La Roche	Substituted pyrroles, their use for producing a drug, and the drug on their base
DE3833008A1 (de) *	1988-09-29	1990-04-05	Goedecke Ag	Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) *	1989-02-23	1991-02-15	Hoffmann La Roche	Pyrroles substitues
CA2046801C (en) *	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles

1994
- 1994-04-15 AU AU60555/94A patent/AU678435B2/en not_active Ceased
- 1994-04-26 CA CA002121567A patent/CA2121567A1/en not_active Abandoned
- 1994-05-02 AT AT94106812T patent/ATE184007T1/de not_active IP Right Cessation
- 1994-05-02 EP EP94106812A patent/EP0624586B1/en not_active Expired - Lifetime
- 1994-05-02 DE DE69420310T patent/DE69420310T2/de not_active Expired - Fee Related
- 1994-05-02 SI SI9430273T patent/SI0624586T1/xx unknown
- 1994-05-02 ES ES94106812T patent/ES2137281T3/es not_active Expired - Lifetime
- 1994-05-02 DK DK94106812T patent/DK0624586T3/da active
- 1994-05-04 HU HU9401298A patent/HU215954B/hu not_active IP Right Cessation
- 1994-05-04 IL IL10954794A patent/IL109547A/en not_active IP Right Cessation
- 1994-05-05 HR HR9309602.2A patent/HRP940287B1/xx not_active IP Right Cessation
- 1994-05-05 RU RU94015830A patent/RU2141960C1/ru active
- 1994-05-06 CZ CZ941128A patent/CZ112894A3/cs unknown
- 1994-05-06 NO NO941682A patent/NO301230B1/no not_active IP Right Cessation
- 1994-05-06 NZ NZ260475A patent/NZ260475A/en unknown
- 1994-05-09 IS IS4162A patent/IS1690B/is unknown
- 1994-05-09 BR BR9401935A patent/BR9401935A/pt not_active Application Discontinuation
- 1994-05-09 JP JP6119542A patent/JP2668818B2/ja not_active Expired - Fee Related
- 1994-05-09 LT LTIP1927A patent/LT3288B/lt not_active IP Right Cessation
- 1994-05-09 LV LVP-94-100A patent/LV11173B/en unknown
- 1994-05-09 CN CN94105846A patent/CN1048014C/zh not_active Expired - Fee Related
- 1994-05-09 SK SK535-94A patent/SK53594A3/sk unknown
- 1994-05-10 FI FI942158A patent/FI106961B/fi not_active IP Right Cessation
- 1994-05-10 BG BG98761A patent/BG98761A/xx unknown
1999
- 1999-11-18 GR GR990402995T patent/GR3031901T3/el unknown

Also Published As

Publication number	Publication date
NZ260475A (en)	1996-02-27
LTIP1927A (en)	1994-11-25
BR9401935A (pt)	1995-03-07
FI942158A0 (fi)	1994-05-10
ES2137281T3 (es)	1999-12-16
NO941682D0 (no)	1994-05-06
EP0624586A1 (en)	1994-11-17
EP0624586B1 (en)	1999-09-01
RU2141960C1 (ru)	1999-11-27
JPH06329672A (ja)	1994-11-29
FI942158A7 (fi)	1994-11-11
NO941682L (no)	1994-11-11
HU215954B (hu)	1999-03-29
ATE184007T1 (de)	1999-09-15
IS4162A (is)	1994-11-11
SI0624586T1 (en)	1999-12-31
HRP940287A2 (en)	1996-12-31
HU9401298D0 (en)	1994-08-29
LV11173B (en)	1996-06-20
DE69420310D1 (de)	1999-10-07
IL109547A (en)	1998-07-15
DK0624586T3 (da)	2000-03-27
HRP940287B1 (en)	2000-02-29
NO301230B1 (no)	1997-09-29
FI106961B (fi)	2001-05-15
JP2668818B2 (ja)	1997-10-27
CA2121567A1 (en)	1994-11-11
CN1103402A (zh)	1995-06-07
IS1690B (is)	1998-04-20
LT3288B (en)	1995-06-26
DE69420310T2 (de)	2000-04-13
GR3031901T3 (en)	2000-02-29
CZ112894A3 (en)	1994-12-15
AU6055594A (en)	1994-11-17
IL109547A0 (en)	1994-08-26
LV11173A (lv)	1996-04-20
HUT71492A (en)	1995-11-28
AU678435B2 (en)	1997-05-29
CN1048014C (zh)	2000-01-05
SK53594A3 (en)	1995-02-08

Publication	Publication Date	Title
YU57599A (sh)	2001-12-26	Primena derivata fumarne kiseline
MX9702658A (es)	1997-06-28	Derivados novedosos de acido carboxilico, su preparacion y uso.
AU3723095A (en)	1996-04-19	Inhibition of hair growth
AU6844790A (en)	1991-07-04	Novel a-nor-steriod-3-carboxylic acid derivatives
AU2787595A (en)	1996-01-15	Novel thrombin inhibitors, the preparation and use thereof
ES8103048A1 (es)	1981-02-16	Un procedimiento para preparar derivados del acido 4-amino-3-quimoleincarboxilico.
EP0528858A4 (en)	1993-04-28	Inhibitors of dipeptidyl-aminopeptidase type iv
ATE124997T1 (de)	1995-07-15	Enzymatische entfernung einer aminoterminalen proteinsequenz.
DK0707591T3 (da)	2002-01-21	Methylphosphonsyreestere, fremgangsmåde til deres fremstilling samt deres anvendelse
NO913051L (no)	1992-02-10	Substituerte pyrroler.
LTIP1927A (en)	1994-11-25	Substituted pyrroles with terapic activity
AU2634597A (en)	1997-11-12	Compounds with growth hormone releasing properties
MY131384A (en)	2007-08-30	Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
RU94015830A (ru)	1996-01-10	Замещенные пирролы
AU2926800A (en)	2000-11-02	Process for the preparation of a diol
ATE83480T1 (de)	1993-01-15	Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen.
AU6306190A (en)	1991-01-31	Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
ATE154608T1 (de)	1997-07-15	Verwendung einer mischung von peptiden and aminosäuren für die prophylaxis oder behandlung von dementia
RO115629B1 (ro)	2000-04-28	Piroli substituiţi, procedeu de obţinere, intermediar în sinteza acestora şi compoziţie farmaceutică care îi conţine
AU2939700A (en)	2000-09-28	Synthesis of alpha-amino-alpha',alpha'-dihaloketones and process for the preparation of beta-amino acid derivatives by the use of the same
ATE196777T1 (de)	2000-10-15	Verfahren zur herstellung von d-prolinderivaten mittels mikroorganismen