DK0624586T3 - Substituerede pyrroler - Google Patents

Substituerede pyrroler

Info

Publication number: DK0624586T3
Authority: DK; Denmark
Prior art keywords: lower alkyl; amino; formula; aryl; prevention
Prior art date: 1993-05-10

Application number

DK94106812T

Other languages

English (en)

Inventor

William Harris

Christopher Huw Hill

Geoffrey Lawton

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-10

Filing date

1994-05-02

Publication date

2000-03-27

1993-05-10 Priority claimed from GB939309602A external-priority patent/GB9309602D0/en

1994-05-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0624586T3 publication Critical patent/DK0624586T3/da

Links

KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
150000007513 acids Chemical class 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
150000007514 bases Chemical class 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000003779 hair growth Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
230000000771 oncological effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Virology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

DK94106812T 1993-05-10 1994-05-02 Substituerede pyrroler DK0624586T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939309602A GB9309602D0 (en)	1993-05-10	1993-05-10	Substituted pyrroles
GB9403249A GB9403249D0 (en)	1993-05-10	1994-02-21	Substituted pyrroles

Publications (1)

Publication Number	Publication Date
DK0624586T3 true DK0624586T3 (da)	2000-03-27

Family

ID=26302877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94106812T DK0624586T3 (da)	1993-05-10	1994-05-02	Substituerede pyrroler

Country Status (25)

Country	Link
EP (1)	EP0624586B1 (da)
JP (1)	JP2668818B2 (da)
CN (1)	CN1048014C (da)
AT (1)	ATE184007T1 (da)
AU (1)	AU678435B2 (da)
BG (1)	BG98761A (da)
BR (1)	BR9401935A (da)
CA (1)	CA2121567A1 (da)
CZ (1)	CZ112894A3 (da)
DE (1)	DE69420310T2 (da)
DK (1)	DK0624586T3 (da)
ES (1)	ES2137281T3 (da)
FI (1)	FI106961B (da)
GR (1)	GR3031901T3 (da)
HR (1)	HRP940287B1 (da)
HU (1)	HU215954B (da)
IL (1)	IL109547A (da)
IS (1)	IS1690B (da)
LT (1)	LT3288B (da)
LV (1)	LV11173B (da)
NO (1)	NO301230B1 (da)
NZ (1)	NZ260475A (da)
RU (1)	RU2141960C1 (da)
SI (1)	SI0624586T1 (da)
SK (1)	SK53594A3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100340159B1 (ko) *	1993-12-07	2002-11-23	일라이 릴리 앤드 캄파니	단백질키나제c억제제
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
EP1449529B1 (en) *	1993-12-23	2010-01-27	Eli Lilly And Company	Protein Kinase C Inhibitors
EP0695755B1 (en) *	1994-08-04	1998-10-21	F. Hoffmann-La Roche AG	Pyrrolocarbazole
JP3258334B2 (ja) *	1996-03-20	2002-02-18	イーライ・リリー・アンド・カンパニー	インドリルマレイミドの合成
KR100499190B1 (ko) *	1996-03-29	2006-04-17	교와 핫꼬 고교 가부시끼가이샤	육모제
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
CA2417277A1 (en)	2000-07-27	2002-02-07	F. Hoffmann-La Roche Ag	3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta.
PT1441737E (pt)	2001-10-30	2006-12-29	Dana Farber Cancer Inst Inc	Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3
CA2393720C (en)	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1653973A1 (en)	2003-08-08	2006-05-10	Novartis AG	Combinations comprising staurosporines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
CZ280738B6 (cs) *	1988-02-10	1996-04-17	F. Hoffmann - La Roche And Co., Aktiengesellschaft	Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE3833008A1 (de) *	1988-09-29	1990-04-05	Goedecke Ag	Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) *	1989-02-23	1991-02-15	Hoffmann La Roche	Pyrroles substitues
CA2046801C (en) *	1990-08-07	2002-02-26	Peter D. Davis	Substituted pyrroles

1994
- 1994-04-15 AU AU60555/94A patent/AU678435B2/en not_active Ceased
- 1994-04-26 CA CA002121567A patent/CA2121567A1/en not_active Abandoned
- 1994-05-02 SI SI9430273T patent/SI0624586T1/xx unknown
- 1994-05-02 DE DE69420310T patent/DE69420310T2/de not_active Expired - Fee Related
- 1994-05-02 EP EP94106812A patent/EP0624586B1/en not_active Expired - Lifetime
- 1994-05-02 DK DK94106812T patent/DK0624586T3/da active
- 1994-05-02 AT AT94106812T patent/ATE184007T1/de not_active IP Right Cessation
- 1994-05-02 ES ES94106812T patent/ES2137281T3/es not_active Expired - Lifetime
- 1994-05-04 IL IL10954794A patent/IL109547A/en not_active IP Right Cessation
- 1994-05-04 HU HU9401298A patent/HU215954B/hu not_active IP Right Cessation
- 1994-05-05 HR HR9309602.2A patent/HRP940287B1/xx not_active IP Right Cessation
- 1994-05-05 RU RU94015830A patent/RU2141960C1/ru active
- 1994-05-06 NO NO941682A patent/NO301230B1/no not_active IP Right Cessation
- 1994-05-06 NZ NZ260475A patent/NZ260475A/en unknown
- 1994-05-06 CZ CZ941128A patent/CZ112894A3/cs unknown
- 1994-05-09 CN CN94105846A patent/CN1048014C/zh not_active Expired - Fee Related
- 1994-05-09 JP JP6119542A patent/JP2668818B2/ja not_active Expired - Fee Related
- 1994-05-09 LV LVP-94-100A patent/LV11173B/en unknown
- 1994-05-09 SK SK535-94A patent/SK53594A3/sk unknown
- 1994-05-09 LT LTIP1927A patent/LT3288B/lt not_active IP Right Cessation
- 1994-05-09 BR BR9401935A patent/BR9401935A/pt not_active Application Discontinuation
- 1994-05-09 IS IS4162A patent/IS1690B/is unknown
- 1994-05-10 BG BG98761A patent/BG98761A/xx unknown
- 1994-05-10 FI FI942158A patent/FI106961B/fi not_active IP Right Cessation
1999
- 1999-11-18 GR GR990402995T patent/GR3031901T3/el unknown

Also Published As

Publication number	Publication date
HRP940287A2 (en)	1996-12-31
IL109547A (en)	1998-07-15
IS4162A (is)	1994-11-11
CN1103402A (zh)	1995-06-07
LT3288B (en)	1995-06-26
DE69420310T2 (de)	2000-04-13
EP0624586A1 (en)	1994-11-17
SI0624586T1 (en)	1999-12-31
RU2141960C1 (ru)	1999-11-27
LV11173B (en)	1996-06-20
HUT71492A (en)	1995-11-28
ES2137281T3 (es)	1999-12-16
NO941682D0 (no)	1994-05-06
ATE184007T1 (de)	1999-09-15
IL109547A0 (en)	1994-08-26
JPH06329672A (ja)	1994-11-29
NO301230B1 (no)	1997-09-29
EP0624586B1 (en)	1999-09-01
BR9401935A (pt)	1995-03-07
LV11173A (lv)	1996-04-20
SK53594A3 (en)	1995-02-08
AU678435B2 (en)	1997-05-29
CZ112894A3 (en)	1994-12-15
NZ260475A (en)	1996-02-27
BG98761A (en)	1995-03-31
FI942158A0 (fi)	1994-05-10
CN1048014C (zh)	2000-01-05
JP2668818B2 (ja)	1997-10-27
AU6055594A (en)	1994-11-17
HU9401298D0 (en)	1994-08-29
LTIP1927A (en)	1994-11-25
FI106961B (fi)	2001-05-15
HU215954B (hu)	1999-03-29
NO941682L (no)	1994-11-11
DE69420310D1 (de)	1999-10-07
FI942158A7 (fi)	1994-11-11
IS1690B (is)	1998-04-20
CA2121567A1 (en)	1994-11-11
GR3031901T3 (en)	2000-02-29
HRP940287B1 (en)	2000-02-29

Publication	Publication Date	Title
NO941682L (no)	1994-11-11	Substituerte pyrroler
DK0470490T3 (da)	1999-11-01	Substituerede pyrroler
DE69434136D1 (de)	2004-12-23	Dolastatin-derivate
FI950309A0 (fi)	1995-01-24	Proliiniamidijohdannaisia
DK0976748T3 (da)	2004-03-22	Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
GEP20074045B (en)	2007-02-26	(4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease
RU94015830A (ru)	1996-01-10	Замещенные пирролы
NO975028L (no)	1997-12-30	Piperazinoderivater som neurokininantagonister
DE60129442D1 (de)	2007-08-30	Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten
ATE180669T1 (de)	1999-06-15	Verwendung von pregnanderivaten zur behandlung von tumoren
NO20051282L (no)	2005-05-11	Antitumorale analoger av lamellariner.
NO173991C (no)	1994-03-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
NO904135L (no)	1991-03-25	Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese.
AU686104B2 (en)	1998-02-05	Substituted amidinonaphthyl ester derivatives
YU19194A (sh)	1997-03-07	Supstituisani piroli
WO2004060862A3 (en)	2004-11-25	Compounds having prolyl oligopeptidase inhibitory activity
EP0573659A4 (en)	1994-09-07	Pyrazolothiazolopyrimidine derivative
TW200621778A (en)	2006-07-01	1β-methyl carbapenem derivatives