BR0014678A - Derivados de pirimidina-2,4,6-triona, processos para a sua produção e agentes farmacêuticos contendo estes compostos - Google Patents

Derivados de pirimidina-2,4,6-triona, processos para a sua produção e agentes farmacêuticos contendo estes compostos

Info

Publication number
BR0014678A
BR0014678A BR0014678-1A BR0014678A BR0014678A BR 0014678 A BR0014678 A BR 0014678A BR 0014678 A BR0014678 A BR 0014678A BR 0014678 A BR0014678 A BR 0014678A
Authority
BR
Brazil
Prior art keywords
compounds
processes
production
pharmaceutical agents
agents containing
Prior art date
Application number
BR0014678-1A
Other languages
English (en)
Inventor
Frank Grams
Hans-Willi Krell
Herbert Leinert
Ernesto Menta
Gerd Zimmermann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0014678A publication Critical patent/BR0014678A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE PIRIMIDINA-2,4,6-TRIONA, PROCESSOS PARA A SUA PRODUçãO E AGENTES FARMACêUTICOS CONTENDO ESTES COMPOSTOS". Compostos de fórmula (1) em que R~ 1~, representa um resíduo de fenóxi, feniltio, fenilsulfinila, fenilsulfonila, fenilamino ou fenilmetila substituído ou não substituído e R~ 2~ representa um resíduo arila ou heteroarila opcionalmente substituído, com atividade inibidora metalo-proteinase.
BR0014678-1A 1999-10-01 2000-09-29 Derivados de pirimidina-2,4,6-triona, processos para a sua produção e agentes farmacêuticos contendo estes compostos BR0014678A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99119506 1999-10-01
PCT/EP2000/009535 WO2001025217A1 (en) 1999-10-01 2000-09-29 New pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds

Publications (1)

Publication Number Publication Date
BR0014678A true BR0014678A (pt) 2002-07-23

Family

ID=8239103

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014678-1A BR0014678A (pt) 1999-10-01 2000-09-29 Derivados de pirimidina-2,4,6-triona, processos para a sua produção e agentes farmacêuticos contendo estes compostos

Country Status (28)

Country Link
US (1) US6498252B1 (pt)
EP (1) EP1226128B1 (pt)
JP (1) JP3848160B2 (pt)
KR (1) KR100459975B1 (pt)
CN (1) CN1157382C (pt)
AR (1) AR033651A1 (pt)
AT (1) ATE289595T1 (pt)
AU (1) AU768309B2 (pt)
BR (1) BR0014678A (pt)
CA (1) CA2385863C (pt)
CO (1) CO5210860A1 (pt)
CZ (1) CZ20021535A3 (pt)
DE (1) DE60018301T2 (pt)
ES (1) ES2235955T3 (pt)
HU (1) HUP0202832A3 (pt)
IL (1) IL148573A0 (pt)
MA (1) MA26823A1 (pt)
MX (1) MXPA02003192A (pt)
NO (1) NO20021380L (pt)
NZ (1) NZ517635A (pt)
PE (1) PE20010659A1 (pt)
PL (1) PL202680B1 (pt)
RU (1) RU2248971C2 (pt)
TR (1) TR200200858T2 (pt)
UY (1) UY26362A1 (pt)
WO (1) WO2001025217A1 (pt)
YU (1) YU22102A (pt)
ZA (1) ZA200201754B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716845B2 (en) 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
WO2003053940A1 (en) 2001-12-20 2003-07-03 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
AU2005230379B2 (en) * 2004-04-01 2010-07-22 Universite De Liege Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
RU2411043C2 (ru) * 2004-04-01 2011-02-10 Юниверсите Де Льеж Фармацевтические композиции пиримидин-2,4,6-трионов
EP1632489A1 (en) * 2004-08-24 2006-03-08 University of Liege 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use.
RU2449994C1 (ru) * 2011-03-10 2012-05-10 Светлана Алексеевна Мещерякова 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
RU2598607C1 (ru) * 2015-07-16 2016-09-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1246743B (de) * 1965-01-12 1967-08-10 Dresden Arzneimittel Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8726714D0 (en) 1987-11-14 1987-12-16 Beecham Group Plc Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
WO1992009565A1 (en) 1990-12-03 1992-06-11 Celltech Limited Peptidyl derivatives
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
CA2238306A1 (en) 1995-12-08 1997-06-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
DE19548624A1 (de) * 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
US6498252B1 (en) 2002-12-24
ES2235955T3 (es) 2005-07-16
HUP0202832A3 (en) 2003-03-28
CA2385863C (en) 2009-04-14
NO20021380D0 (no) 2002-03-20
AR033651A1 (es) 2004-01-07
DE60018301D1 (de) 2005-03-31
PL202680B1 (pl) 2009-07-31
PE20010659A1 (es) 2001-06-20
NO20021380L (no) 2002-03-20
KR20020039356A (ko) 2002-05-25
MXPA02003192A (es) 2002-09-30
ATE289595T1 (de) 2005-03-15
TR200200858T2 (tr) 2002-07-22
KR100459975B1 (ko) 2004-12-03
RU2248971C2 (ru) 2005-03-27
PL357385A1 (en) 2004-07-26
CZ20021535A3 (cs) 2002-11-13
UY26362A1 (es) 2001-04-30
ZA200201754B (en) 2003-06-02
AU7784900A (en) 2001-05-10
EP1226128B1 (en) 2005-02-23
DE60018301T2 (de) 2006-04-06
CN1157382C (zh) 2004-07-14
EP1226128A1 (en) 2002-07-31
MA26823A1 (fr) 2004-12-20
JP3848160B2 (ja) 2006-11-22
NZ517635A (en) 2003-11-28
IL148573A0 (en) 2002-09-12
CA2385863A1 (en) 2001-04-12
WO2001025217A1 (en) 2001-04-12
YU22102A (sh) 2004-11-25
JP2003511376A (ja) 2003-03-25
CN1374954A (zh) 2002-10-16
HK1050198A1 (en) 2003-06-13
CO5210860A1 (es) 2002-10-30
AU768309B2 (en) 2003-12-04
HUP0202832A2 (hu) 2003-02-28

Similar Documents

Publication Publication Date Title
ATE350036T1 (de) Tetrahydroquinolin-derivate
EP0931788A3 (en) Metalloprotease inhibitors
BRPI0215312B8 (pt) composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto
BR0107888A (pt) Pirrolidinas 1,3-dissubstituidas como antagonistas de alfa-2adrenorreceptor
BR0309546A (pt) Composto, composição farmacêutica que compreende o mesmo, processo para a sua preparação e utilização e método para tratamento profilático ou terapêutico de diabetes do tipo ii
BR9909565A (pt) Derivados bicìclicos do ácido hidroxâmico
BR0109650A (pt) 3-cianoquinolinas, 3-ciano-1,6-naftiridinas e 3-ciano-1,7-naftiridinas como inibidores da cinase proteìca
RU94027576A (ru) Производные 1-бензолсульфонил-1,3-дигидро-индол-2-она, способ их получения и содержащие их фармацевтические композиции
BR9916678A (pt) Inibidores de trombina
BR9810829B1 (pt) composto heterocìclico, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica.
TR199800585T2 (xx) COX-2 �nhibit�rleri Olarak (Metils�lfonil)Fenil-2-(5H)-Furanonlar.
ES2175624T3 (es) Derivados de pirazolo(4,3-d)pirimidina y composiciones farmaceuticas que los contienen.
BR0116402A (pt) Derivados de tetrahidropiridina, sua preparação e sua utilização como inibidores de proliferação celular
PT95510A (pt) Processo de preparacao de pirimidina 4'-tionucleosidos e de composicoes farmaceuticas que os contem
TR200000586T2 (tr) Farmasötik maddelerin oral yoldan biyolojik kullanışlılığının arttırılması için bir yöntem, bileşimler ve kitler.
BR0014678A (pt) Derivados de pirimidina-2,4,6-triona, processos para a sua produção e agentes farmacêuticos contendo estes compostos
NO980178D0 (no) Cyklo-oksygenase-inhibitor og amidin-derivatsalter, fremgangsmåte for fremstilling derav, anvendelse derav som legemidler, og farmasöytiske blandinger inneholdende slike derivater
AU2003285143A1 (en) Analysis of pharmaceutical solubility and stability
BR0210746A (pt) Derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral
IL138688A0 (en) Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
BR0014626A (pt) Análise de leptina
BR0308601A (pt) inibidores de carboxipeptidase b de plasma
PT1017681E (pt) Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios
BR9714007A (pt) Novos derivados da eritromicina seu processo de preparação e sua aplicação como medicamentos
BRPI0012329B8 (pt) derivados de benzofurano, processo para sua preparação e uso dos mesmos.

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements