BR0108146A - Processo e intermediários para o preparo de inibidores da protease retroviral - Google Patents

Processo e intermediários para o preparo de inibidores da protease retroviral

Info

Publication number
BR0108146A
BR0108146A BR0108146-2A BR0108146A BR0108146A BR 0108146 A BR0108146 A BR 0108146A BR 0108146 A BR0108146 A BR 0108146A BR 0108146 A BR0108146 A BR 0108146A
Authority
BR
Brazil
Prior art keywords
protease inhibitors
intermediates
preparation
retroviral protease
amino
Prior art date
Application number
BR0108146-2A
Other languages
English (en)
Inventor
Sanjay R Chemburkar
Ketan M Patel
Harry O Spiwek
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24614772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0108146(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR0108146A publication Critical patent/BR0108146A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO E INTERMEDIáRIOS PARA O PREPARO DE INIBIDORES DA PROTEASE RETROVIRAL". A presente invenção fornece processos e intermediários empregados na síntese de ((2S, 3S, 5S)-2-(2,6-dimetilfenoxiacetil)-amino-3-hidroxi-5-(2S- (1-tetraidropirimid-2-onil)-3-metil-butanoil)amino-1,6-difenilhexano e seus análogos.
BR0108146-2A 2000-08-31 2001-08-29 Processo e intermediários para o preparo de inibidores da protease retroviral BR0108146A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65191900A 2000-08-31 2000-08-31
PCT/US2001/026898 WO2002018349A2 (en) 2000-08-31 2001-08-29 Process and intermediates for preparing retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
BR0108146A true BR0108146A (pt) 2004-01-06

Family

ID=24614772

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108146-2A BR0108146A (pt) 2000-08-31 2001-08-29 Processo e intermediários para o preparo de inibidores da protease retroviral

Country Status (16)

Country Link
EP (1) EP1313712B1 (pt)
JP (1) JP5021141B2 (pt)
KR (1) KR100806533B1 (pt)
CN (1) CN1264823C (pt)
AT (1) ATE361913T1 (pt)
AU (1) AU2001286889A1 (pt)
BR (1) BR0108146A (pt)
CA (2) CA2416955C (pt)
CY (1) CY1106738T1 (pt)
DE (1) DE60128367T2 (pt)
DK (1) DK1313712T3 (pt)
ES (1) ES2284684T3 (pt)
IL (1) IL153436A0 (pt)
MX (1) MXPA03001751A (pt)
PT (1) PT1313712E (pt)
WO (1) WO2002018349A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE539074T1 (de) * 2003-12-11 2012-01-15 Abbott Lab Die hiv-protease hemmende verbindungen
CN100358521C (zh) * 2004-12-28 2008-01-02 哈尔滨欧替药业股份有限公司 一种双唑泰栓剂及其制备工艺
CN103910634B (zh) * 2012-12-29 2018-04-27 广东东阳光药业有限公司 西格列汀中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
CA2731273A1 (en) 2002-03-07
EP1313712B1 (en) 2007-05-09
AU2001286889A1 (en) 2002-03-13
WO2002018349A3 (en) 2002-05-10
JP2004507528A (ja) 2004-03-11
KR100806533B1 (ko) 2008-02-25
DE60128367T2 (de) 2008-01-10
CY1106738T1 (el) 2012-05-23
ES2284684T3 (es) 2007-11-16
CN1264823C (zh) 2006-07-19
CN1449388A (zh) 2003-10-15
CA2731273C (en) 2013-10-15
DE60128367D1 (de) 2007-06-21
MXPA03001751A (es) 2003-09-10
EP1313712A2 (en) 2003-05-28
HK1057040A1 (en) 2004-03-12
WO2002018349A2 (en) 2002-03-07
KR20030061787A (ko) 2003-07-22
CA2416955A1 (en) 2002-03-07
JP5021141B2 (ja) 2012-09-05
CA2416955C (en) 2011-04-26
IL153436A0 (en) 2003-07-06
PT1313712E (pt) 2007-07-25
DK1313712T3 (da) 2007-09-10
ATE361913T1 (de) 2007-06-15

Similar Documents

Publication Publication Date Title
BR9812837A (pt) Processo para fazer um composto, e, composto
BR0010555A (pt) Inibidores de neuraminidases
BR0109836A (pt) Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis
BR9809745A (pt) Sal cristalino de amina de cefdinir
BR9912240A (pt) Benzocicloheptenos, processo para a sua preparação, preparados farmacêuticos, que contêm os mesmos bem como seu emprego para a preparação de medicamentos
TW200517374A (en) Cyclohexanecarboxylic acids
BR9815469A (pt) Inibidores de protease
ES2176456T3 (es) Procedimiento de preparacion de un compuesto inhibidor del vih proteasa.
BR9708233A (pt) Processo para sìntese de um composto e composto.
BR0101230A (pt) Processo para a preparação de11-amino-3-cloro-6,11-diidro-5-5-dioxo-6-metil-dibenzo[c,f][1,2]tiazepina e aplicação para a sìntese detianeptina
BR0211691A (pt) Processo para a prepara de tolterodina
BR0212772A (pt) Processo para a preparação de repaglinida
BR0213481A (pt) Sondas
BR0316400A (pt) agentes branqueadores fluorescentes anfotéricos
BR9814495A (pt) Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
BR9705456A (pt) Compostos heterocìclicos, processo de aminometila para sua preparação e composições farmacêuticas que os contêm.
BR0212390A (pt) Processo para a preparação de cilastatina
BR0108146A (pt) Processo e intermediários para o preparo de inibidores da protease retroviral
BR0009453A (pt) Processo para a preparação de um composto
BR0209842A (pt) Processo para a preparação de imipenem
BR0015022A (pt) Processo para a preparação de cloridrato de n-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina
BR0116721A (pt) Processo para a preparação de (±)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperi dina
BR0007183A (pt) Isonipectoamidas para o tratamento de distúrbios mediados por integrina
BR0016400A (pt) Processo para a preparação de sais de sódio de estatinas

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 239/00, A61P 31/00

Ipc: C07D 239/00 (2011.01), A61P 31/00 (2011.01)

B25A Requested transfer of rights approved

Owner name: ABBVIE INC. (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]