BR0109837A - Composição farmacêutica para o tratamento da dor aguda, crÈnica e/ou neuropática e enxaquecas - Google Patents
Composição farmacêutica para o tratamento da dor aguda, crÈnica e/ou neuropática e enxaquecasInfo
- Publication number
- BR0109837A BR0109837A BR0109837-3A BR0109837A BR0109837A BR 0109837 A BR0109837 A BR 0109837A BR 0109837 A BR0109837 A BR 0109837A BR 0109837 A BR0109837 A BR 0109837A
- Authority
- BR
- Brazil
- Prior art keywords
- chronic
- neuropathic pain
- acute
- treatment
- migraines
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 8
- 208000000094 Chronic Pain Diseases 0.000 title abstract 4
- 208000019695 Migraine disease Diseases 0.000 title abstract 4
- 230000001154 acute effect Effects 0.000 title abstract 4
- 208000005298 acute pain Diseases 0.000 title abstract 4
- 230000001684 chronic effect Effects 0.000 title abstract 4
- 208000004296 neuralgia Diseases 0.000 title abstract 4
- 208000021722 neuropathic pain Diseases 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 229940123445 Tricyclic antidepressant Drugs 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010027599 migraine Diseases 0.000 abstract 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 abstract 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 abstract 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 108030001720 Bontoxilysin Proteins 0.000 abstract 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 102000011040 TRPV Cation Channels Human genes 0.000 abstract 1
- 108010062740 TRPV Cation Channels Proteins 0.000 abstract 1
- 101000942305 Zea mays Cytokinin dehydrogenase 1 Proteins 0.000 abstract 1
- 229940035674 anesthetics Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 229940053031 botulinum toxin Drugs 0.000 abstract 1
- 229960001948 caffeine Drugs 0.000 abstract 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003260 cyclooxygenase 1 inhibitor Substances 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 239000003890 substance P antagonist Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA PARA O TRATAMENTO DA DOR AGUDA, CRÈNICA E/OU NEUROPáTICA E ENXAQUECAS". Composições farmacêuticas são descritas para o tratamento da dor aguda, crónica e/ou neuropática. As composições farmacêuticas compreendem uma combinação terapeuticamente eficaz de um agonista parcial do receptor de nicotina e um agente analgésico e um veículo de suporte farmaceuticamente aceitável. O agente analgésico é selecionado de entre analgésicos opióides, antagonistas de NMDA, antagonistas da substância P, inibidores de COX 1 e COX 2, antidepressivos tricíclicos (TCA), inibidores de recaptação de serotonina seletivos (SSRI), agonistas do receptor de capsaicina, agentes anestésicos, benzodiazepinas, relaxantes do músculo esquelético, agentes terapêuticos da enxaqueca, anticonvulsivos, antihipertensivos, antiarrítmicos, antihistaminas, esteróides, cafeína e toxina botulina. O método de utilização destes compostos e um método de tratamento da dor aguda, crónica e/ou neuropática e enxaqueca em um mamífero, incluindo um ser humano, são também descritos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19573800P | 2000-04-07 | 2000-04-07 | |
| PCT/IB2001/000391 WO2001076576A2 (en) | 2000-04-07 | 2001-03-16 | A pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0109837A true BR0109837A (pt) | 2003-01-21 |
Family
ID=22722582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0109837-3A BR0109837A (pt) | 2000-04-07 | 2001-03-16 | Composição farmacêutica para o tratamento da dor aguda, crÈnica e/ou neuropática e enxaquecas |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US20010036943A1 (pt) |
| EP (1) | EP1272218B1 (pt) |
| JP (1) | JP2003530345A (pt) |
| KR (1) | KR20030040201A (pt) |
| CN (1) | CN1468111A (pt) |
| AP (1) | AP2002002642A0 (pt) |
| AR (1) | AR027773A1 (pt) |
| AT (1) | ATE291438T1 (pt) |
| AU (1) | AU3768001A (pt) |
| BG (1) | BG107138A (pt) |
| BR (1) | BR0109837A (pt) |
| CA (1) | CA2405142A1 (pt) |
| CR (1) | CR6767A (pt) |
| CZ (1) | CZ20023214A3 (pt) |
| DE (1) | DE60109589T2 (pt) |
| EA (1) | EA004930B1 (pt) |
| EE (1) | EE200200579A (pt) |
| ES (1) | ES2236185T3 (pt) |
| GT (1) | GT200100055A (pt) |
| HU (1) | HUP0301822A3 (pt) |
| IL (1) | IL152076A0 (pt) |
| IS (1) | IS6560A (pt) |
| MA (1) | MA26889A1 (pt) |
| MX (1) | MXPA02009817A (pt) |
| NO (1) | NO20024734D0 (pt) |
| OA (1) | OA12241A (pt) |
| PA (1) | PA8515001A1 (pt) |
| PE (1) | PE20011307A1 (pt) |
| PL (1) | PL365957A1 (pt) |
| SK (1) | SK13952002A3 (pt) |
| SV (1) | SV2002000377A (pt) |
| TN (1) | TNSN01053A1 (pt) |
| WO (1) | WO2001076576A2 (pt) |
| YU (1) | YU74602A (pt) |
| ZA (1) | ZA200207996B (pt) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| US6464986B1 (en) * | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US7074961B2 (en) | 2000-09-26 | 2006-07-11 | The Brigham And Women's Hospital, Inc. | Antidepressants and their analogues as long-acting local anesthetics and analgesics |
| WO2002026020A2 (en) * | 2000-09-26 | 2002-04-04 | The Brigham And Women's Hospital, Inc. | Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics |
| WO2002085843A2 (en) * | 2001-04-20 | 2002-10-31 | Pfizer Products Inc. | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
| WO2002100434A1 (en) * | 2001-06-07 | 2002-12-19 | The General Hospital Corporation | Treatment of neuropathic pain with n-methyl-d-aspartate (nmda) receptor antagonists |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US20040138239A1 (en) * | 2001-08-23 | 2004-07-15 | Bruce Frome | Compositions and methods for targeting cerebral circulation and treatment of headache |
| CA2458375A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease |
| CA2462453C (en) | 2001-10-02 | 2009-07-28 | Pharmacia & Upjohn Company | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| MXPA04004373A (es) | 2001-11-09 | 2004-08-11 | Upjohn Co | Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades. |
| WO2003049753A1 (en) * | 2001-12-13 | 2003-06-19 | Council Of Scientific And Industrial Research | Bioavailability enhancing activity of zingiber officinale linn and its extracts/fractions thereof |
| HUP0500200A2 (hu) * | 2002-01-17 | 2005-07-28 | Neurogen Corporation | Szubsztituált kinazolin-4-ilamin analógok, mint kapszaicin modulátorok és ezeket tartalmazó gyógyszerkészítmények |
| JP4428053B2 (ja) * | 2002-02-05 | 2010-03-10 | 味の素株式会社 | ガバペンチン若しくはプレガバリンおよびn型カルシウムチャンネル拮抗剤を含有する医薬組成物 |
| CA2475763A1 (en) * | 2002-02-12 | 2003-08-21 | Cypress Bioscience, Inc. | Methods of treating attention deficit/hyperactivity disorder (adhd) |
| EP1480977A2 (en) | 2002-02-15 | 2004-12-01 | PHARMACIA & UPJOHN COMPANY | Substituted aryl compounds for treatment of disease |
| CA2476624A1 (en) | 2002-02-19 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclic compounds for the treatment of disease |
| CA2476681A1 (en) | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| CN1662231A (zh) * | 2002-04-24 | 2005-08-31 | 柏树生物科学公司 | 包括应激相关障碍在内的功能性躯体障碍的预防与治疗 |
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| US20040014681A1 (en) * | 2002-05-14 | 2004-01-22 | Ralph Ryback | Method for treating dermatoses and tissue damage |
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| EP0937077B1 (en) * | 1996-10-30 | 2006-05-17 | Pfizer Inc. | Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy |
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| IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
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