BR0114031A - Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina - Google Patents

Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina

Info

Publication number
BR0114031A
BR0114031A BR0114031-0A BR0114031A BR0114031A BR 0114031 A BR0114031 A BR 0114031A BR 0114031 A BR0114031 A BR 0114031A BR 0114031 A BR0114031 A BR 0114031A
Authority
BR
Brazil
Prior art keywords
olanzapine
hydrates
preparation
conversion
crystalline forms
Prior art date
Application number
BR0114031-0A
Other languages
English (en)
Inventor
Buchi Reddy Reguri
Ramesh Chakka
Robert Koprowaski
Original Assignee
Reddy S Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddy S Lab Ltd filed Critical Reddy S Lab Ltd
Publication of BR0114031A publication Critical patent/BR0114031A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE HIDRATOS DE OLANZAPINA E SUA CONVERSãO EM FORMAS CRISTALINAS DE OLANZAPINA". A presente invenção refere-se a um método para a preparação de hidratos de 2-metil-4-(4-metil-1-piperazinil)-10H-tieno[2,3-b][1,5]-benzodiazepina (aqui doravante referida como OLANZAPINA). A presente invenção refere-se também a um processo para a conversão destes hidratos em uma forma cristalina de OLANZAPINA referida como Forma 1. A presente invenção refere-se também a um método para converter a Forma 2 de OLANZAPINA na Forma 1.
BR0114031-0A 2000-08-31 2001-03-07 Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina BR0114031A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN711CH2000 2000-08-31
IN709CH2000 2000-08-31
PCT/US2001/007258 WO2002018390A1 (en) 2000-08-31 2001-03-07 Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Publications (1)

Publication Number Publication Date
BR0114031A true BR0114031A (pt) 2003-09-09

Family

ID=26324874

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114031-0A BR0114031A (pt) 2000-08-31 2001-03-07 Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina

Country Status (12)

Country Link
EP (1) EP1313742A1 (pt)
JP (1) JP2004507548A (pt)
AU (1) AU2001243475A1 (pt)
BR (1) BR0114031A (pt)
CA (1) CA2420987A1 (pt)
CZ (1) CZ2003566A3 (pt)
HU (1) HUP0300875A3 (pt)
IL (1) IL154688A0 (pt)
NO (1) NO20030926L (pt)
RU (1) RU2003108745A (pt)
SK (1) SK2502003A3 (pt)
WO (1) WO2002018390A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2464306A1 (en) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
WO2003090730A1 (en) * 2002-04-25 2003-11-06 Generics [Uk] Limited Novel crystalline forms of celecoxib and other compounds
PL196814B1 (pl) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
AU2003300324A1 (en) 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
CA2551806A1 (en) 2003-12-22 2005-07-14 Teva Pharmaceutical Industries, Ltd. Methods of preparing olanzapine
AR047460A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)
AR047459A1 (es) 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
WO2005107375A2 (en) * 2004-05-06 2005-11-17 Matrix Laboratories Ltd Process for the preparation of olanzapine form-i
ES2289974T1 (es) * 2004-07-14 2008-02-16 Shasun Chemicals And Drugs Limited Metodo mejorado para producir la forma i de la olanzapina.
EP2264016B1 (en) 2004-07-14 2013-05-01 Jubilant Organosys Limited A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
WO2006025065A1 (en) * 2004-08-31 2006-03-09 Lee Pharma Private Limited A process for the preparation of anhydrous olanzopine hydrochloride of form-1
WO2006027800A1 (en) 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited A novel process for preparation of a pharmaceutically pure polymorphic form 1 of olanzapine
SI1838716T1 (sl) * 2005-01-05 2011-10-28 Lilly Co Eli Olanzapin pamoat dihidrat
KR20070113277A (ko) * 2005-03-21 2007-11-28 닥터 레디스 레보러터리즈 리미티드 올란자핀의 결정 형태 ｉ의 제조방법
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
AU2008249766A1 (en) * 2007-05-15 2008-11-20 Generics [Uk] Limited Process for the purification of olanzapine
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine
CN102093386B (zh) * 2011-01-05 2016-06-01 浙江华海药业股份有限公司 一种制备奥兰扎平晶型ⅱ的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法
HUE067028T2 (hu) 2016-05-31 2024-09-28 Taiho Pharmaceutical Co Ltd Ribonukleotid reduktáz inhibitor szulfonamid vegyületek vagy sóik rák kezelésére
ES2969901T3 (es) 2017-11-29 2024-05-23 Taiho Pharmaceutical Co Ltd Cocristal de ácido benzoico y compuesto de sulfonamida para el tratamiento de tumores

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009229D0 (en) 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
JP2001500878A (ja) * 1996-09-23 2001-01-23 イーライ・リリー・アンド・カンパニー オランザピン二水和物ｄ

Also Published As

Publication number Publication date
WO2002018390A1 (en) 2002-03-07
SK2502003A3 (en) 2004-03-02
EP1313742A1 (en) 2003-05-28
CA2420987A1 (en) 2002-03-07
NO20030926L (no) 2003-04-24
NO20030926D0 (no) 2003-02-27
IL154688A0 (en) 2003-09-17
RU2003108745A (ru) 2005-01-10
HUP0300875A2 (hu) 2003-12-29
HUP0300875A3 (en) 2005-09-28
CZ2003566A3 (cs) 2004-01-14
AU2001243475A1 (en) 2002-03-13
JP2004507548A (ja) 2004-03-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.