BR0215216A - Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii - Google Patents

Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii

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Publication number
BR0215216A
BR0215216A BR0215216-9A BR0215216A BR0215216A BR 0215216 A BR0215216 A BR 0215216A BR 0215216 A BR0215216 A BR 0215216A BR 0215216 A BR0215216 A BR 0215216A
Authority
BR
Brazil
Prior art keywords
aqueous composition
liquid aqueous
factor vii
treating
preparing
Prior art date
Application number
BR0215216-9A
Other languages
English (en)
Inventor
Birthe Lykkegaard Hansen
Michael Bech Jensen
Troels Kornfelt
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of BR0215216A publication Critical patent/BR0215216A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"COMPOSIçãO AQUOSA LìQUIDA, MéTODO PARA PREPARAR UMA COMPOSIçãO AQUOSA LìQUIDA DE UM POLIPEPTìDEO DE FATOR VII, USO DE UMA COMPOSIçãO AQUOSA LìQUIDA, E, MéTODO PARA O TRATAMENTO DE UMA SìNDROME DE RESPOSTA AO FATOR VII". Uma composição aquosa líquida compreendendo (i) um polipeptídeo de fator VII, (ii) um agente adequado para manter o pH na faixa de cerca de 4,0 a cerca de 8,0; (iii) um agente escolhido da lista de: um sal de cálcio, um sal de magnésio, ou uma mistura dos mesmos; onde a concentração de (iii) é pelo menos 15 mM.
BR0215216-9A 2001-12-21 2002-12-20 Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii BR0215216A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101948 2001-12-21
US34688802P 2002-01-07 2002-01-07
PCT/DK2002/000895 WO2003055512A1 (en) 2001-12-21 2002-12-20 Liquid composition of factor vii polypeptides

Publications (1)

Publication Number Publication Date
BR0215216A true BR0215216A (pt) 2004-11-16

Family

ID=26069118

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215216-9A BR0215216A (pt) 2001-12-21 2002-12-20 Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii

Country Status (15)

Country Link
US (2) US8022031B2 (pt)
EP (1) EP1458408B1 (pt)
JP (1) JP2005530683A (pt)
CN (1) CN1607958A (pt)
AT (1) ATE428439T1 (pt)
AU (1) AU2002351756A1 (pt)
BR (1) BR0215216A (pt)
CA (1) CA2470511C (pt)
DE (1) DE60232017D1 (pt)
ES (1) ES2325653T3 (pt)
HU (1) HUP0402315A3 (pt)
IL (1) IL162239A0 (pt)
PL (1) PL370652A1 (pt)
RU (1) RU2357751C2 (pt)
WO (1) WO2003055512A1 (pt)

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US8022031B2 (en) 2011-09-20
EP1458408A1 (en) 2004-09-22
CA2470511C (en) 2014-05-27
IL162239A0 (en) 2005-11-20
WO2003055512A1 (en) 2003-07-10
HUP0402315A2 (hu) 2005-02-28
EP1458408B1 (en) 2009-04-15
RU2357751C2 (ru) 2009-06-10
JP2005530683A (ja) 2005-10-13
RU2004122398A (ru) 2005-03-20
CN1607958A (zh) 2005-04-20
PL370652A1 (en) 2005-05-30
HUP0402315A3 (en) 2009-03-30
ES2325653T3 (es) 2009-09-11
DE60232017D1 (de) 2009-05-28
US8461116B2 (en) 2013-06-11
US20040037893A1 (en) 2004-02-26
ATE428439T1 (de) 2009-05-15
CA2470511A1 (en) 2003-07-10

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