BR0303067A - Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis - Google Patents

Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis

Info

Publication number: BR0303067A
Authority: BR; Brazil
Prior art keywords: pharmaceutically acceptable; acceptable salts; ursodeoxycholic acid; acid; preparation
Prior art date: 2002-02-06

Application number

BR0303067-9A

Other languages

English (en)

Portuguese (pt)

Inventor

Alberto Giraudi

Original Assignee

Abc Internat Pharma S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-06

Filing date

2003-02-06

Publication date

2004-03-09

2003-02-06 Application filed by Abc Internat Pharma S R L filed Critical Abc Internat Pharma S R L

2004-03-09 Publication of BR0303067A publication Critical patent/BR0303067A/pt

Links

RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 4
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title abstract 4
229960001661 ursodiol Drugs 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 3
VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 title abstract 2
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 2
AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
VFNGKCDDZUSWLR-UHFFFAOYSA-N disulfuric acid Chemical compound OS(=O)(=O)OS(O)(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
230000001180 sulfating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

BR0303067-9A 2002-02-06 2003-02-06 Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis BR0303067A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002TO000102A ITTO20020102A1 (it)	2002-02-06	2002-02-06	Procedimento per la preparazione dell'acido ursodesossicolico disolfato e suoi sali farmaceuticamente accettabili.
PCT/IB2003/000479 WO2003066657A1 (en)	2002-02-06	2003-02-06	A process for preparing ursodeoxycholic acid dusulphate and pharmaceutically acceptable salts thereof

Publications (1)

Publication Number	Publication Date
BR0303067A true BR0303067A (pt)	2004-03-09

Family

ID=27638823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR0303067-9A BR0303067A (pt)	2002-02-06	2003-02-06	Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis

Country Status (4)

Country	Link
AU (1)	AU2003244517A1 (it)
BR (1)	BR0303067A (it)
IT (1)	ITTO20020102A1 (it)
WO (1)	WO2003066657A1 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1393095B1 (it)	2009-02-19	2012-04-11	Prodotti Chimici Alimentari	Processo per la sintesi del sale disodico dell'acido ursodesossicolico 3,7-disolfato.
US12186329B2 (en)	2018-08-23	2025-01-07	President And Fellows Of Harvard College	Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
WO2020117945A1 (en)	2018-12-04	2020-06-11	President And Fellows Of Harvard College	Synthetic derivatives of cholic acid 7-sulfate and uses thereof
AU2020274319B2 (en)	2019-05-10	2026-02-12	President And Fellows Of Harvard College	Small molecule modulators of gut bacterial bile acid metabolism

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1221734B (it) *	1983-02-24	1990-07-12	Schiena Michele Giuseppe Di	Ursodesossicolico solfato acido sale sodico
US5763435A (en) *	1995-11-21	1998-06-09	Children's Hospital Medical Center	Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders

2002
- 2002-02-06 IT IT2002TO000102A patent/ITTO20020102A1/it unknown
2003
- 2003-02-06 AU AU2003244517A patent/AU2003244517A1/en not_active Abandoned
- 2003-02-06 BR BR0303067-9A patent/BR0303067A/pt not_active IP Right Cessation
- 2003-02-06 WO PCT/IB2003/000479 patent/WO2003066657A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO2003066657A1 (en)	2003-08-14
ITTO20020102A0 (it)	2002-02-06
ITTO20020102A1 (it)	2003-08-06
AU2003244517A1 (en)	2003-09-02

Similar Documents

Publication	Publication Date	Title
Cohen et al.	1959	Quinazolinone sulfonamides as diuretic agents
Noble et al.	1995	Enoxaparin: a reappraisal of its pharmacology and clinical applications in the prevention and treatment of thromboembolic disease
PE20001049A1 (es)	2000-10-17	Complejos estables de compuestos escasamente solubles
BR0005488A (pt)	2001-08-07	Processo para a preparação de carbonato de vinileno, e o uso do mesmo
SI2348032T1 (sl)	2015-10-30	S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
TR28128A (tr)	1996-01-30	Deterjan bilesimlerinde kir salma maddeleri olarak kullanima müsait sülfone poli-etoksi/propoksi uc-baslikli ester oligomerleri.
BRPI0509827A (pt)	2007-10-23	nanopartìculas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartìculas pegiladas e processo de preparação de nanopartìculas pegiladas
BR0014997A (pt)	2002-06-18	Concentrado anticongelante, e, composição refrigerante aquosa
RU92004362A (ru)	1996-12-20	Производные таксола и водорастворимые производные таксола
BR9815159A (pt)	2000-10-10	Preparação de conjugados de polietileno glicol-grf especìfica ao sìtio
BR0007781A (pt)	2002-02-05	Conjugado fisiologicamente ativo, composição, e, processo para a produção de um conjugado de peg-gcsf
BR9903573A (pt)	2000-09-19	Processo para preparação de haloformiminas, e, compostos de haloforminina
PE20020754A1 (es)	2002-08-23	Complejos de inclusion de ciclodextrina-drospiperona
IT1304501B1 (it)	2001-03-19	Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
BR0303067A (pt)	2004-03-09	Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis
DK1476470T3 (da)	2007-11-12	Stivelsesderivater, stivelse-aktivstof-konjugater, fremgangsmåde til fremstilling af disse og anvendelse af disse som lægemidler
BR9915480A (pt)	2001-07-31	Azalìdeos de 13 membros e a sua utilização como agentes antibióticos
BR0005824A (pt)	2002-02-26	Sais de alquilespiroborato para uso em células eletroquìmicas
BR0015780A (pt)	2002-07-23	Processo para preparar claritromicina
ATE337355T1 (de)	2006-09-15	Sulfoniertes polyetherketonketon
EP0957107A4 (it)	1999-11-17
DE60038106D1 (de)	2008-04-03	Anthelmintische zusammensetzungen
ES2169886T3 (es)	2002-07-16	Derivados condensados de la piperidina como inhibidor de sintesis de monoxido de nitrogeno.
BR0012735A (pt)	2005-02-22	Preparação solida, e, processo para produzir preparações
ITTO20000745A0 (it)	2000-07-28	Nuovi acidi naftilsolfonici e composti ad essi correlati utli come agonisti dell'assorbimento del glucosio.

Legal Events

Date	Code	Title	Description
2010-02-23	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 5O, 6O E 7O ANUIDADE.
2011-04-12	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2042 DE 23/02/2010.