BR0312651A - Processo para preparação de beta-amino alcoóis n-monossubstituìdos - Google Patents

Processo para preparação de beta-amino alcoóis n-monossubstituìdos

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Publication number
BR0312651A
BR0312651A BR0312651A BR0312651A BR0312651A BR 0312651 A BR0312651 A BR 0312651A BR 0312651 A BR0312651 A BR 0312651A BR 0312651 A BR0312651 A BR 0312651A BR 0312651 A BR0312651 A BR 0312651A
Authority
BR
Brazil
Prior art keywords
preparation
amino alcohols
monosubstituted beta
monosubstituted
beta
Prior art date
Application number
BR0312651A
Other languages
English (en)
Other versions
BR0312651B1 (pt
Inventor
Dominique Michel
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0312651(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of BR0312651A publication Critical patent/BR0312651A/pt
Publication of BR0312651B1 publication Critical patent/BR0312651B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE BETA-AMINO ALCOóIS N-MONOSSUBSTITUìDOS". A presente invenção refere-se a um processo para síntese de <225>-amino alcoóis N-monossubstituídos de fórmula (I) e/ou um sal de adição de um ácido protónico, em que R^ 1^ e R^ 2^ representam independentemente alquila, cicloalquila, arila ou aralquila, cada um sendo opcionalmente substituído adicionalmente com alquila, aicóxi e/ou halogênio via preparação direta de <225>-amino cetonas N-monossubstituídas de fórmula seus sais de adição de ácidos protónicos, em que R^ 1^ e R^ 2^ são como definidos acima.
BRPI0312651A 2002-07-09 2003-07-09 Beta-amino n-monosubstitued alcohols and their preparation processes BR0312651B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02015229 2002-07-09
PCT/EP2003/007411 WO2004005239A1 (en) 2002-07-09 2003-07-09 PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS

Publications (2)

Publication Number Publication Date
BR0312651A true BR0312651A (pt) 2005-04-26
BR0312651B1 BR0312651B1 (pt) 2017-10-31

Family

ID=30011063

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0312651A BR0312651B1 (pt) 2002-07-09 2003-07-09 Beta-amino n-monosubstitued alcohols and their preparation processes

Country Status (19)

Country Link
US (7) US20080119661A1 (pt)
JP (1) JP4546242B2 (pt)
KR (2) KR101027358B1 (pt)
CN (4) CN101851168B (pt)
AT (2) ATE374744T1 (pt)
AU (1) AU2010201850B2 (pt)
BR (1) BR0312651B1 (pt)
CA (1) CA2491472C (pt)
CY (1) CY1109691T1 (pt)
DE (2) DE60329640D1 (pt)
DK (1) DK1539673T3 (pt)
EA (1) EA009394B1 (pt)
ES (2) ES2334397T3 (pt)
IL (1) IL166107A (pt)
NO (2) NO329267B1 (pt)
NZ (1) NZ537567A (pt)
PT (2) PT1852415E (pt)
SI (1) SI1852415T1 (pt)
WO (1) WO2004005239A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240026A1 (de) * 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
CA2556891C (en) * 2004-02-19 2012-12-18 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
DE102004021434A1 (de) 2004-04-30 2005-11-24 Basf Ag Schnelle schaumarme Netzer für hydrophobe Oberflächen
EA200701613A1 (ru) 2005-02-21 2008-02-28 Лонца Аг Способ получения энантиомерно чистых 1-замещенных 3-аминоспиртов
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
EP2044049A2 (en) 2006-07-03 2009-04-08 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl- 3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl) propanamine
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
CN108707096B (zh) * 2018-05-07 2021-03-19 上海科技大学 一种制备氨基醇衍生物的方法
CN112961045A (zh) * 2018-05-30 2021-06-15 上海科技大学 一种降解聚合物的方法
CN109134427B (zh) * 2018-10-24 2020-06-30 浙江乐普药业股份有限公司 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法
CN115677512A (zh) * 2022-10-27 2023-02-03 大连万福制药有限公司 一种合成乐卡地平中间体n-甲基-3，3-二苯基丙胺盐酸盐的方法
CN116640115A (zh) * 2023-05-16 2023-08-25 浙江工业大学 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3031248A1 (de) * 1980-08-19 1982-04-01 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US5362866A (en) * 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
CA2042346A1 (en) * 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE10240026A1 (de) 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
EP1510517A1 (en) * 2003-09-01 2005-03-02 Lonza AG Process for the asymmetric hydrogenation of beta-amino ketones

Also Published As

Publication number Publication date
WO2004005239A1 (en) 2004-01-15
SI1852415T1 (sl) 2010-01-29
US20150361064A1 (en) 2015-12-17
NO329267B1 (no) 2010-09-20
DE60316698D1 (de) 2007-11-15
BR0312651B1 (pt) 2017-10-31
US20110004007A1 (en) 2011-01-06
AU2003250924A1 (en) 2004-01-23
EA200500137A1 (ru) 2005-08-25
US8962865B2 (en) 2015-02-24
PT1539673E (pt) 2007-11-14
CN1891683A (zh) 2007-01-10
ATE374744T1 (de) 2007-10-15
US20150112086A1 (en) 2015-04-23
US8558014B2 (en) 2013-10-15
DE60316698T2 (de) 2008-07-17
HK1145317A1 (en) 2011-04-15
IL166107A0 (en) 2006-01-15
CN101851168A (zh) 2010-10-06
NZ537567A (en) 2006-11-30
CY1109691T1 (el) 2014-08-13
CA2491472C (en) 2011-09-27
CN101851168B (zh) 2013-07-03
CN1665773A (zh) 2005-09-07
CA2491472A1 (en) 2004-01-15
EA009394B1 (ru) 2007-12-28
KR20050017092A (ko) 2005-02-21
PT1852415E (pt) 2009-12-18
ES2334397T3 (es) 2010-03-09
JP4546242B2 (ja) 2010-09-15
US20170369467A1 (en) 2017-12-28
US20130310574A1 (en) 2013-11-21
US20080119661A1 (en) 2008-05-22
AU2010201850B2 (en) 2011-08-25
IL166107A (en) 2012-06-28
NO20100728L (no) 2005-03-11
KR20100135331A (ko) 2010-12-24
KR101021460B1 (ko) 2011-03-16
ATE444949T1 (de) 2009-10-15
JP2005532383A (ja) 2005-10-27
HK1079765A1 (en) 2006-04-13
US20100240911A1 (en) 2010-09-23
KR101027358B1 (ko) 2011-04-11
DK1539673T3 (da) 2008-01-21
CN103058986A (zh) 2013-04-24
AU2010201850A1 (en) 2010-05-27
NO20050079L (no) 2005-03-11
DE60329640D1 (de) 2009-11-19
CN100497295C (zh) 2009-06-10
ES2293029T3 (es) 2008-03-16

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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