BR0314512A - Célula hospedeira recombinante procariótica, método para a produção de um plasmìdeo, plasmìdeo e método para a detecção de uma mutação de cópia plasmìdea - Google Patents

Célula hospedeira recombinante procariótica, método para a produção de um plasmìdeo, plasmìdeo e método para a detecção de uma mutação de cópia plasmìdea

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Publication number
BR0314512A
BR0314512A BR0314512-3A BR0314512A BR0314512A BR 0314512 A BR0314512 A BR 0314512A BR 0314512 A BR0314512 A BR 0314512A BR 0314512 A BR0314512 A BR 0314512A
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BR
Brazil
Prior art keywords
plasmid
host cell
detecting
producing
recombinant host
Prior art date
Application number
BR0314512-3A
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English (en)
Inventor
Fabienne Soubrier
Original Assignee
Centelion
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Centelion, Aventis Pharma Inc filed Critical Centelion
Publication of BR0314512A publication Critical patent/BR0314512A/pt

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

"CéLULA HOSPEDEIRA RECOMBINANTE PROCARIóTICA, MéTODO PARA A PRODUçãO DE UM PLASMìDEO, PLASMìDEO E MéTODO PARA A DETECçãO DE UMA MUTAçãO DE CóPIA PLASMìDEA". A presente invenção trata de célula hospedeira recombinante procariótica compreendendo uma proteína de iniciação de replicação heteróloga que ativa uma origem condicional de replicação e uma molécula DNA extracromossómica que compreende um gene terapêutico heterólogo e uma origem condicional de replicação, cuja funcionalidade na célula hospedeira recombinante procariótica requer uma proteína de iniciação de replicação estranha à célula hospedeira.
BR0314512-3A 2002-10-11 2003-10-14 Célula hospedeira recombinante procariótica, método para a produção de um plasmìdeo, plasmìdeo e método para a detecção de uma mutação de cópia plasmìdea BR0314512A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/268,948 US7279313B2 (en) 1995-09-15 2002-10-11 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
PCT/US2003/032512 WO2004033664A2 (en) 2002-10-11 2003-10-14 Circular dna molecule having a conditional origin of replication, process for their preparation and their use in gene therapy

Publications (1)

Publication Number Publication Date
BR0314512A true BR0314512A (pt) 2005-07-26

Family

ID=32092417

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314512-3A BR0314512A (pt) 2002-10-11 2003-10-14 Célula hospedeira recombinante procariótica, método para a produção de um plasmìdeo, plasmìdeo e método para a detecção de uma mutação de cópia plasmìdea

Country Status (22)

Country Link
US (3) US7279313B2 (pt)
EP (1) EP1549735B1 (pt)
JP (2) JP4522861B2 (pt)
KR (1) KR101323542B1 (pt)
CN (2) CN101182534B (pt)
AT (1) ATE521695T1 (pt)
AU (2) AU2003287078B2 (pt)
BR (1) BR0314512A (pt)
CA (1) CA2501851C (pt)
CY (1) CY1112110T1 (pt)
DK (1) DK1549735T3 (pt)
ES (1) ES2372599T3 (pt)
HK (1) HK1082761B (pt)
IL (1) IL167706A (pt)
MX (1) MXPA05003857A (pt)
NO (1) NO333932B1 (pt)
NZ (2) NZ539311A (pt)
PT (1) PT1549735E (pt)
RU (1) RU2307870C2 (pt)
SI (1) SI1549735T1 (pt)
WO (1) WO2004033664A2 (pt)
ZA (1) ZA200503039B (pt)

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CN100491521C (zh) 2009-05-27
CY1112110T1 (el) 2015-11-04
NO20052276L (no) 2005-07-06
EP1549735A2 (en) 2005-07-06
US20090252713A1 (en) 2009-10-08
NO20052276D0 (no) 2005-05-10
NO333932B1 (no) 2013-10-21
HK1082761A1 (en) 2006-06-16
JP2010057493A (ja) 2010-03-18
US7807444B2 (en) 2010-10-05
NZ539311A (en) 2008-06-30
EP1549735A4 (en) 2006-05-03
JP2006502714A (ja) 2006-01-26
ES2372599T3 (es) 2012-01-24
MXPA05003857A (es) 2005-06-22
JP4522861B2 (ja) 2010-08-11
CN101182534B (zh) 2013-04-24
AU2003287078A1 (en) 2004-05-04
HK1082761B (en) 2012-05-18
KR101323542B1 (ko) 2013-10-29
US20070015282A1 (en) 2007-01-18
US7279313B2 (en) 2007-10-09
AU2003287078B2 (en) 2009-01-15
CA2501851C (en) 2014-03-11
EP1549735B1 (en) 2011-08-24
HK1086297A1 (zh) 2006-09-15
DK1549735T3 (da) 2011-12-12
SI1549735T1 (sl) 2011-12-30
US20070141708A2 (en) 2007-06-21
ATE521695T1 (de) 2011-09-15
AU2009201405A1 (en) 2009-05-07
RU2307870C2 (ru) 2007-10-10
NZ566205A (en) 2009-02-28
CA2501851A1 (en) 2004-04-22
RU2005114367A (ru) 2005-12-20
IL167706A (en) 2012-05-31
CN101182534A (zh) 2008-05-21
WO2004033664A3 (en) 2004-12-29
JP4750203B2 (ja) 2011-08-17
US20030161844A1 (en) 2003-08-28
WO2004033664A2 (en) 2004-04-22
ZA200503039B (en) 2006-11-29
CN1717476A (zh) 2006-01-04
KR20050084847A (ko) 2005-08-29
PT1549735E (pt) 2011-11-30

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