BR9711948A - Composto processo para produzir um composto composi-Æo farmac-utica e uso de um composto - Google Patents

Composto processo para produzir um composto composi-Æo farmac-utica e uso de um composto

Info

Publication number: BR9711948A
Authority: BR; Brazil
Prior art keywords: compound; pct; alkyl; different; same
Prior art date: 1996-10-18

Application number

BR9711948A

Other languages

English (en)

Inventor

William Alexander Denny

Swarnalatha Akuritaya Gamage

Julie Ann Spicer

Bruce Charles Baguley

Graeme John Finlay

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-18

Filing date

1997-10-17

Publication date

1999-08-24

1997-10-17 Application filed by Xenova Ltd filed Critical Xenova Ltd

1999-08-24 Publication of BR9711948A publication Critical patent/BR9711948A/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229940125665 acridine carboxamide Drugs 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
-1 methylenedioxy group Chemical group 0.000 abstract 1
XBGNERSKEKDZDS-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]acridine-4-carboxamide Chemical compound C1=CC=C2N=C3C(C(=O)NCCN(C)C)=CC=CC3=CC2=C1 XBGNERSKEKDZDS-UHFFFAOYSA-N 0.000 abstract 1
KPZYYKDXZKFBQU-UHFFFAOYSA-N phenazine-1-carboxamide Chemical class C1=CC=C2N=C3C(C(=O)N)=CC=CC3=NC2=C1 KPZYYKDXZKFBQU-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Multicomponent Fibers (AREA)
Polishing Bodies And Polishing Tools (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BR9711948A 1996-10-18 1997-10-17 Composto processo para produzir um composto composi-Æo farmac-utica e uso de um composto BR9711948A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9621795.5A GB9621795D0 (en)	1996-10-18	1996-10-18	Pharmaceutical compounds
PCT/GB1997/002886 WO1998017650A1 (en)	1996-10-18	1997-10-17	Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents

Publications (1)

Publication Number	Publication Date
BR9711948A true BR9711948A (pt)	1999-08-24

Family

ID=10801674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9711948A BR9711948A (pt)	1996-10-18	1997-10-17	Composto processo para produzir um composto composi-Æo farmac-utica e uso de um composto

Country Status (29)

Country	Link
US (1)	US6114332A (pt)
EP (1)	EP0934278B1 (pt)
JP (1)	JP2001503399A (pt)
KR (1)	KR20000049252A (pt)
CN (1)	CN1116285C (pt)
AT (1)	ATE223381T1 (pt)
AU (1)	AU717724B2 (pt)
BG (1)	BG64555B1 (pt)
BR (1)	BR9711948A (pt)
CA (1)	CA2268411C (pt)
CZ (1)	CZ295302B6 (pt)
DE (1)	DE69715230T2 (pt)
DK (1)	DK0934278T3 (pt)
ES (1)	ES2183142T3 (pt)
GB (2)	GB9621795D0 (pt)
HU (1)	HU221953B1 (pt)
ID (1)	ID22444A (pt)
MY (1)	MY122017A (pt)
NO (1)	NO313381B1 (pt)
NZ (1)	NZ335055A (pt)
PL (1)	PL193669B1 (pt)
PT (1)	PT934278E (pt)
RO (1)	RO120636B1 (pt)
RU (1)	RU2179972C2 (pt)
SK (1)	SK285121B6 (pt)
TW (1)	TW432060B (pt)
UA (1)	UA67729C2 (pt)
WO (1)	WO1998017650A1 (pt)
ZA (2)	ZA979331B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6974878B2 (en)	2001-03-21	2005-12-13	Symyx Technologies, Inc.	Catalyst ligands, catalytic metal complexes and processes using same
AU6040699A (en) *	1999-09-10	2001-04-17	Symyx Technologies, Inc.	Catalyst ligands, catalytic metal complexes and processes using and methods of making same
JP4718328B2 (ja) *	2003-12-31	2011-07-06	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	Ｃ８連結したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アクリドン／アクリジン・ハイブリッド
JP2017500368A (ja) *	2013-12-24	2017-01-05	ユニバーシティーオブフロリダリサーチファンデーション，インク．	抗微生物剤としてのフェナジン誘導体
CN104961801B (zh) *	2015-07-13	2018-01-19	兰州大学	一种具有多靶点的抗菌多肽偶联物及其二聚物的合成和应用
CN106554321B (zh) *	2015-09-25	2019-05-28	陆源	一种吩嗪类物质、其制备方法及其应用
US20240279204A1 (en) *	2021-12-09	2024-08-22	Korea Institute Of Ocean Science & Technology	Novel diphenazine compound, and use thereof for preventing or treating cancer or neuroinflammatory diseases
WO2025043616A1 (zh) *	2023-08-31	2025-03-06	侯明宏	吖啶类衍生物用于抗癌的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ201084A (en) *	1982-06-25	1985-10-11	New Zealand Dev Finance	4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
JPS61112061A (ja) *	1984-08-16	1986-05-30	デベロツプメント　フアイナンス　コ−ポレ−シヨン　オブニユ−ジ−ランド	新規なフエナジン誘導体
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale

1996
- 1996-10-18 GB GBGB9621795.5A patent/GB9621795D0/en active Pending
1997
- 1997-10-17 ES ES97909456T patent/ES2183142T3/es not_active Expired - Lifetime
- 1997-10-17 EP EP97909456A patent/EP0934278B1/en not_active Expired - Lifetime
- 1997-10-17 NZ NZ335055A patent/NZ335055A/xx unknown
- 1997-10-17 RU RU99109978/04A patent/RU2179972C2/ru not_active IP Right Cessation
- 1997-10-17 GB GB9908192A patent/GB2334032B/en not_active Expired - Lifetime
- 1997-10-17 UA UA99042117A patent/UA67729C2/uk unknown
- 1997-10-17 RO RO99-00433A patent/RO120636B1/ro unknown
- 1997-10-17 CN CN97180614A patent/CN1116285C/zh not_active Expired - Fee Related
- 1997-10-17 ZA ZA9709331A patent/ZA979331B/xx unknown
- 1997-10-17 AT AT97909456T patent/ATE223381T1/de not_active IP Right Cessation
- 1997-10-17 AU AU47137/97A patent/AU717724B2/en not_active Ceased
- 1997-10-17 HU HU9902883A patent/HU221953B1/hu not_active IP Right Cessation
- 1997-10-17 PL PL97332877A patent/PL193669B1/pl not_active IP Right Cessation
- 1997-10-17 US US09/284,623 patent/US6114332A/en not_active Expired - Fee Related
- 1997-10-17 ZA ZA979328A patent/ZA979328B/xx unknown
- 1997-10-17 PT PT97909456T patent/PT934278E/pt unknown
- 1997-10-17 DE DE69715230T patent/DE69715230T2/de not_active Expired - Fee Related
- 1997-10-17 WO PCT/GB1997/002886 patent/WO1998017650A1/en not_active Ceased
- 1997-10-17 CZ CZ19991271A patent/CZ295302B6/cs not_active IP Right Cessation
- 1997-10-17 KR KR1019990703357A patent/KR20000049252A/ko not_active Ceased
- 1997-10-17 ID IDW990196A patent/ID22444A/id unknown
- 1997-10-17 MY MYPI97004914A patent/MY122017A/en unknown
- 1997-10-17 DK DK97909456T patent/DK0934278T3/da active
- 1997-10-17 BR BR9711948A patent/BR9711948A/pt not_active Application Discontinuation
- 1997-10-17 SK SK504-99A patent/SK285121B6/sk unknown
- 1997-10-17 JP JP51910998A patent/JP2001503399A/ja not_active Ceased
- 1997-10-17 CA CA002268411A patent/CA2268411C/en not_active Expired - Fee Related
- 1997-10-18 TW TW086115404A patent/TW432060B/zh not_active IP Right Cessation
1999
- 1999-04-13 BG BG103329A patent/BG64555B1/bg unknown
- 1999-04-16 NO NO19991833A patent/NO313381B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG103329A (en)	2000-11-30
RO120636B1 (ro)	2006-05-30
SK285121B6 (sk)	2006-06-01
CA2268411C (en)	2008-07-22
GB2334032B (en)	2000-11-08
PL332877A1 (en)	1999-10-25
DE69715230D1 (de)	2002-10-10
ZA979331B (en)	1998-05-21
NZ335055A (en)	2000-09-29
HU221953B1 (hu)	2003-03-28
ID22444A (id)	1999-10-14
AU717724B2 (en)	2000-03-30
BG64555B1 (bg)	2005-07-29
GB9908192D0 (en)	1999-06-02
EP0934278A1 (en)	1999-08-11
DK0934278T3 (da)	2003-01-06
GB9621795D0 (en)	1996-12-11
ES2183142T3 (es)	2003-03-16
AU4713797A (en)	1998-05-15
DE69715230T2 (de)	2009-09-17
NO991833L (no)	1999-06-03
KR20000049252A (ko)	2000-07-25
EP0934278B1 (en)	2002-09-04
SK50499A3 (en)	2000-05-16
UA67729C2 (uk)	2004-07-15
NO313381B1 (no)	2002-09-23
RU2179972C2 (ru)	2002-02-27
HK1018773A1 (en)	2000-01-07
JP2001503399A (ja)	2001-03-13
CZ295302B6 (cs)	2005-07-13
CZ127199A3 (cs)	1999-09-15
CN1240430A (zh)	2000-01-05
ATE223381T1 (de)	2002-09-15
CN1116285C (zh)	2003-07-30
US6114332A (en)	2000-09-05
CA2268411A1 (en)	1998-04-30
PT934278E (pt)	2003-01-31
MY122017A (en)	2006-03-31
PL193669B1 (pl)	2007-03-30
TW432060B (en)	2001-05-01
HUP9902883A3 (en)	2001-01-29
ZA979328B (en)	1998-07-06
NO991833D0 (no)	1999-04-16
WO1998017650A1 (en)	1998-04-30
GB2334032A (en)	1999-08-11

Legal Events

Date	Code	Title	Description
2007-04-17	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2007-12-26	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 36 DA LPI

Publication	Publication Date	Title
HUP0004076A2 (hu)	2001-04-28	C-4"-Szubsztituált-makrolid-származékok
HUP9802694A1 (hu)	1999-02-01	Benzamidszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
CA2054619A1 (en)	1992-05-02	Aminocoumaran derivatives, their production and use
MX9504287A (es)	1997-05-31	Derivados de camptotecina y proceso para su preparacion.
EP0353955A3 (en)	1991-08-14	Novel compounds
EP0765865A4 (en)	1997-08-13	2-ACYLAMINOPROPANOL COMPOUND AND MEDICINAL COMPOSITION
UA50711C2 (uk)	2002-11-15	Антрациклінові похідні, їх застосування при лікуванні амілоїдозу та фармацевтична композиція
DE68926981D1 (de)	1996-09-26	Cephemverbindungen und Verfahren zu ihrer Herstellung
ZA979331B (en)	1998-05-21	Pharmaceutical compounds.
HUP0203275A2 (hu)	2003-01-28	1-(Gyűrűs amino)-alkilciklohexán-származékok, ezeket tartalmazó görcsoldó hatású gyógyszerkészítmények, valamint ezek alkalmazása
DK0420121T3 (da)	1993-05-03	Antitumormiddel
YU5893A (sh)	1996-07-24	Sulfonilkarbamid i postupak za njegovo dobijanje
HUP9702393A2 (hu)	1998-04-28	bisz(2-Halogén-etil)-amino-fenil szubsztituált distamycinszármazékok, tumorellenes és vírusellenes hatóanyagok
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
PT92540A (pt)	1990-06-29	Processo para a preparacao de derivados de anfotericina b
ES2002036A6 (es)	1988-07-01	Un procedimiento para la preparacion de derivados de dicloroanilina.
NO955197L (no)	1996-02-16	Nye carbosykliske nukleoside midler som er anvendbare som selektive inhibitorer av pro-inflammatoriske cytokiner
ATE62663T1 (de)	1991-05-15	Indan-derivate, verfahren zu ihrer herstellung und die erhaltenen zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
RU99109978A (ru)	2001-03-20	Бис(акридинкарбоксамид) и бис(феназинкарбоксамид), полезные в качестве противоопухолевых агентов
IL115085A0 (en)	1995-12-08	Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
RU96120092A (ru)	1998-12-27	Новые производные пиперазина и способы их получения и содержащие их композиции
HUP0202057A2 (hu)	2003-01-28	3-Fenil-3,7-diazabiciklo[3.3.1]nonán-vegyületek, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények
MY111111A (en)	1999-08-30	Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl -1-heterocyclyl) methylamine drrivatives
MY104048A (en)	1993-10-30	New allylaminoethylazoles.
RU92004544A (ru)	1995-06-19	Замещенные производные бензоилмочевины, способ их получения, противоопухолевая композиция и способ лечения