BRPI0208535B8 - método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a - Google Patents

método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Info

Publication number
BRPI0208535B8
BRPI0208535B8 BRPI0208535A BR0208535A BRPI0208535B8 BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8 BR PI0208535 A BRPI0208535 A BR PI0208535A BR 0208535 A BR0208535 A BR 0208535A BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8
Authority
BR
Brazil
Prior art keywords
lps
cells
extracting
culture
producing
Prior art date
Application number
BRPI0208535A
Other languages
English (en)
Other versions
BRPI0208535B1 (pt
BR0208535A (pt
Inventor
Scott Snyder D
R Myers Kent
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to BR122015016711A priority Critical patent/BR122015016711B8/pt
Publication of BR0208535A publication Critical patent/BR0208535A/pt
Publication of BRPI0208535B1 publication Critical patent/BRPI0208535B1/pt
Publication of BRPI0208535B8 publication Critical patent/BRPI0208535B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"métodos para a produção de 3-o-4<39>monofosforil desativado lipídeo a (3d-mla)". a invenção refere-se um método para produção de lipopolissacarídeo (lps), que compreende: (a) desenvolver uma cultura de uma cepa bacteriana mutante extremamente rudimentar em um meio; (b) manter a cultura em fase estacionária por pelo menos cerca de 5 horas; (c) colher células da cultura; e (d) extrair lps das células. o método permite para a produção de um lps que pode ser usado para produzir um 3-o-monofosforil desacilado lipídeo a (3d-mla) que apresenta pelo menos cerca de 20% em mol do grupo de congêneres de hexacila. é também apresentado nesta invenção um método de extrair lipopolissacarídeo (lps) de uma cultura de células de cepa bacteriana mutante extremamente rudimentar, que compreende: (a) extrair as células com uma solução que consiste essencialmente pelo menos de cerca de 75% em peso de um álcool alifático que apresenta de 1 a 4 átomos de carbono e o equilíbrio água, produzindo desse modo células com teor de fosfolipídeo reduzido; e (b) extrair as células com teor de fosfolipídeo reduzido com uma solução que compreende clorofórmio e metanol, produzindo desse modo uma solução de lps em clorofórmio e metanol (cm). esse método proporciona soluções de lps em cm que apresentam teor de fosfolípideo reduzido e são produzidas através de etapas de processo relativamente simples e econômico.
BRPI0208535A 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a BRPI0208535B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (3)

Publication Number Publication Date
BR0208535A BR0208535A (pt) 2006-02-21
BRPI0208535B1 BRPI0208535B1 (pt) 2016-03-29
BRPI0208535B8 true BRPI0208535B8 (pt) 2021-05-25

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Country Status (21)

Country Link
US (3) US20030031684A1 (pt)
EP (3) EP1461418B1 (pt)
JP (3) JP4233327B2 (pt)
KR (2) KR100884462B1 (pt)
CN (2) CN100577790C (pt)
AU (1) AU2002306962B2 (pt)
BR (2) BR122015016711B8 (pt)
CA (1) CA2440249C (pt)
CZ (2) CZ305565B6 (pt)
DK (2) DK2465937T3 (pt)
ES (2) ES2517391T3 (pt)
HU (1) HU228688B1 (pt)
IL (3) IL157867A0 (pt)
MX (1) MXPA03008856A (pt)
NZ (2) NZ528204A (pt)
PL (2) PL402939A1 (pt)
PT (2) PT2465937E (pt)
RU (2) RU2302463C2 (pt)
SI (2) SI2465937T1 (pt)
WO (1) WO2002078637A2 (pt)
ZA (1) ZA200307238B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
PL1973564T3 (pl) 2005-12-22 2017-04-28 Glaxosmithkline Biologicals S.A. Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
BRPI0721393B8 (pt) * 2007-03-22 2022-09-06 Fund Butantan método para obter lipídeo a monofosforilado da bordetella pertussis como um subproduto da produção de vacina celular contra coqueluche
BRPI0811228A2 (pt) 2007-05-24 2014-10-21 Glaxonsmithkline Biolog S A Composição liofilizada, e, métodos para produzir uma composição liofilizada e para produzir uma composição imunológica.
US20130066064A1 (en) 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
WO2012156391A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017109733A2 (en) 2015-12-22 2017-06-29 Glaxosmithkline Biologicals Sa Process
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US12173342B2 (en) 2019-08-29 2024-12-24 Eubiologics Co., Ltd. Method for producing monophosphoryl lipid A
KR102748233B1 (ko) * 2019-08-29 2024-12-31 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
US20230045642A1 (en) 2019-12-19 2023-02-09 Glaxosmithkline Biologicals Sa S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
DE3132497A1 (de) * 1980-08-19 1982-05-27 Shell Internationale Research Maatschappij B.V., 2596 's-Gravenhage Verfahren zur bildung eines polysaccharids durch mikroorganismen
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4612304A (en) * 1985-06-11 1986-09-16 Ss Pharmaceutical Co., Ltd. Antitumor formulation containing lipopolysaccharide with trehalose derivatives
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5068191A (en) * 1989-08-31 1991-11-26 The Biomembrane Institute Purified histo-blood group a glycosyltransferase and antibodies thereto
US5552141A (en) * 1991-10-30 1996-09-03 Ribi; Hans O. Polymeric immunological adjuvants
DK0671948T3 (da) 1992-06-25 1997-09-01 Smithkline Beecham Biolog Vaccinepræparat indeholdende adjuvanser
RU2051969C1 (ru) * 1992-07-31 1996-01-10 Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока Способ получения бактериальных липополисахаридов
ATE157882T1 (de) 1993-03-23 1997-09-15 Smithkline Beecham Biolog 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US5762943A (en) * 1996-05-14 1998-06-09 Ribi Immunochem Research, Inc. Methods of treating type I hypersensitivity using monophosphoryl lipid A
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
JP3595966B2 (ja) * 1996-12-25 2004-12-02 カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法
NZ338101A (en) 1997-04-01 2002-03-28 Corixa Corp Adjuvant compositions of Monophosphoryl Lipid A (MPL) and a phospholipid based surfactant (1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)) suitable for intranasal administration
US6491919B2 (en) * 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
HK1039072A1 (zh) * 1998-05-07 2002-04-12 科里克萨有限公司 佐剂组合物及其使用方法
DE10013539B4 (de) * 2000-03-20 2006-07-13 Pharma-Zentrale Gmbh Lipopolysaccharide aus Escherichia coli, Verfahren zu deren Herstellung und deren Verwendungen
US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)

Also Published As

Publication number Publication date
EP2465937A1 (en) 2012-06-20
KR100884462B1 (ko) 2009-02-20
JP4233327B2 (ja) 2009-03-04
HUP0304091A2 (hu) 2004-03-29
DK1461418T3 (da) 2013-07-08
JP2012057170A (ja) 2012-03-22
ES2517391T3 (es) 2014-11-03
US9512159B2 (en) 2016-12-06
WO2002078637A2 (en) 2002-10-10
PT2465937E (pt) 2014-11-03
CA2440249A1 (en) 2002-10-10
PL402939A1 (pl) 2013-08-19
CA2440249C (en) 2013-07-09
SI1461418T1 (sl) 2013-08-30
HU228688B1 (en) 2013-05-28
EP2465937B1 (en) 2014-08-13
US20070212758A1 (en) 2007-09-13
CN1608127A (zh) 2005-04-20
EP1461418B1 (en) 2013-04-24
NZ528204A (en) 2006-12-22
HK1165494A1 (en) 2012-10-05
SI2465937T1 (sl) 2014-11-28
RU2006140606A (ru) 2008-05-27
EP1461418A4 (en) 2006-05-17
RU2302463C2 (ru) 2007-07-10
HK1075913A1 (zh) 2005-12-30
JP5730178B2 (ja) 2015-06-03
ES2415769T3 (es) 2013-07-26
IL189651A0 (en) 2008-06-05
PL373657A1 (en) 2005-09-05
RU2003131677A (ru) 2005-04-20
EP1461418A2 (en) 2004-09-29
KR100927099B1 (ko) 2009-11-13
JP2008255335A (ja) 2008-10-23
BRPI0208535B1 (pt) 2016-03-29
KR20080088666A (ko) 2008-10-02
US20030031684A1 (en) 2003-02-13
US20140243513A1 (en) 2014-08-28
WO2002078637A9 (en) 2004-01-15
WO2002078637A3 (en) 2004-07-22
BR122015016711B8 (pt) 2021-07-27
HK1104319A1 (en) 2008-01-11
CZ305601B6 (cs) 2015-12-30
PT1461418E (pt) 2013-07-09
BR122015016711B1 (pt) 2016-08-02
HUP0304091A3 (en) 2011-04-28
IL189651A (en) 2011-02-28
JP2004535477A (ja) 2004-11-25
CZ20032895A3 (cs) 2004-02-18
DK2465937T3 (da) 2014-11-10
IL157867A0 (en) 2004-03-28
CN100577790C (zh) 2010-01-06
AU2002306962A2 (en) 2002-10-15
IL157867A (en) 2011-07-31
ZA200307238B (en) 2005-08-31
AU2002306962B2 (en) 2008-04-24
CN1928107B (zh) 2010-12-22
PL217737B1 (pl) 2014-08-29
CZ305565B6 (cs) 2015-12-16
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
RU2427378C2 (ru) 2011-08-27
BR0208535A (pt) 2006-02-21
EP2479280A1 (en) 2012-07-25
CN1928107A (zh) 2007-03-14
NZ548595A (en) 2008-04-30

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 1/20

Ipc: C12N 1/20 (2006.01), A61K 31/739 (2006.01), A61P 3

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

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