BRPI0208535B8 - método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a - Google Patents

método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Info

Publication number
BRPI0208535B8
BRPI0208535B8 BRPI0208535A BR0208535A BRPI0208535B8 BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8 BR PI0208535 A BRPI0208535 A BR PI0208535A BR 0208535 A BR0208535 A BR 0208535A BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8
Authority
BR
Brazil
Prior art keywords
lps
cells
extracting
culture
producing
Prior art date
Application number
BRPI0208535A
Other languages
English (en)
Other versions
BR0208535A (pt
BRPI0208535B1 (pt
Inventor
Scott Snyder D
R Myers Kent
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to BR122015016711A priority Critical patent/BR122015016711B8/pt
Publication of BR0208535A publication Critical patent/BR0208535A/pt
Publication of BRPI0208535B1 publication Critical patent/BRPI0208535B1/pt
Publication of BRPI0208535B8 publication Critical patent/BRPI0208535B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"métodos para a produção de 3-o-4<39>monofosforil desativado lipídeo a (3d-mla)". a invenção refere-se um método para produção de lipopolissacarídeo (lps), que compreende: (a) desenvolver uma cultura de uma cepa bacteriana mutante extremamente rudimentar em um meio; (b) manter a cultura em fase estacionária por pelo menos cerca de 5 horas; (c) colher células da cultura; e (d) extrair lps das células. o método permite para a produção de um lps que pode ser usado para produzir um 3-o-monofosforil desacilado lipídeo a (3d-mla) que apresenta pelo menos cerca de 20% em mol do grupo de congêneres de hexacila. é também apresentado nesta invenção um método de extrair lipopolissacarídeo (lps) de uma cultura de células de cepa bacteriana mutante extremamente rudimentar, que compreende: (a) extrair as células com uma solução que consiste essencialmente pelo menos de cerca de 75% em peso de um álcool alifático que apresenta de 1 a 4 átomos de carbono e o equilíbrio água, produzindo desse modo células com teor de fosfolipídeo reduzido; e (b) extrair as células com teor de fosfolipídeo reduzido com uma solução que compreende clorofórmio e metanol, produzindo desse modo uma solução de lps em clorofórmio e metanol (cm). esse método proporciona soluções de lps em cm que apresentam teor de fosfolípideo reduzido e são produzidas através de etapas de processo relativamente simples e econômico.
BRPI0208535A 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a BRPI0208535B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (3)

Publication Number Publication Date
BR0208535A BR0208535A (pt) 2006-02-21
BRPI0208535B1 BRPI0208535B1 (pt) 2016-03-29
BRPI0208535B8 true BRPI0208535B8 (pt) 2021-05-25

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Country Status (21)

Country Link
US (3) US20030031684A1 (pt)
EP (3) EP2465937B1 (pt)
JP (3) JP4233327B2 (pt)
KR (2) KR100884462B1 (pt)
CN (2) CN1928107B (pt)
AU (1) AU2002306962B2 (pt)
BR (2) BR122015016711B8 (pt)
CA (1) CA2440249C (pt)
CZ (2) CZ305601B6 (pt)
DK (2) DK1461418T3 (pt)
ES (2) ES2415769T3 (pt)
HU (1) HU228688B1 (pt)
IL (3) IL157867A0 (pt)
MX (1) MXPA03008856A (pt)
NZ (2) NZ548595A (pt)
PL (2) PL402939A1 (pt)
PT (2) PT1461418E (pt)
RU (2) RU2302463C2 (pt)
SI (2) SI1461418T1 (pt)
WO (1) WO2002078637A2 (pt)
ZA (1) ZA200307238B (pt)

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CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
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Also Published As

Publication number Publication date
KR100927099B1 (ko) 2009-11-13
JP5730178B2 (ja) 2015-06-03
BR122015016711B8 (pt) 2021-07-27
ZA200307238B (en) 2005-08-31
BR122015016711B1 (pt) 2016-08-02
RU2302463C2 (ru) 2007-07-10
AU2002306962A2 (en) 2002-10-15
JP2004535477A (ja) 2004-11-25
PT2465937E (pt) 2014-11-03
RU2006140606A (ru) 2008-05-27
HUP0304091A3 (en) 2011-04-28
SI1461418T1 (sl) 2013-08-30
AU2002306962B2 (en) 2008-04-24
EP1461418B1 (en) 2013-04-24
CN1928107A (zh) 2007-03-14
MXPA03008856A (es) 2003-12-04
US9512159B2 (en) 2016-12-06
CN100577790C (zh) 2010-01-06
KR20080088666A (ko) 2008-10-02
US20070212758A1 (en) 2007-09-13
JP4233327B2 (ja) 2009-03-04
HK1165494A1 (en) 2012-10-05
HK1075913A1 (zh) 2005-12-30
CA2440249A1 (en) 2002-10-10
WO2002078637A2 (en) 2002-10-10
PL373657A1 (en) 2005-09-05
RU2003131677A (ru) 2005-04-20
BR0208535A (pt) 2006-02-21
NZ528204A (en) 2006-12-22
KR100884462B1 (ko) 2009-02-20
HUP0304091A2 (hu) 2004-03-29
JP2012057170A (ja) 2012-03-22
EP2479280A1 (en) 2012-07-25
EP2465937B1 (en) 2014-08-13
PT1461418E (pt) 2013-07-09
PL402939A1 (pl) 2013-08-19
IL157867A0 (en) 2004-03-28
IL189651A (en) 2011-02-28
CZ20032895A3 (cs) 2004-02-18
WO2002078637A9 (en) 2004-01-15
CZ305601B6 (cs) 2015-12-30
EP1461418A2 (en) 2004-09-29
PL217737B1 (pl) 2014-08-29
DK2465937T3 (da) 2014-11-10
DK1461418T3 (da) 2013-07-08
IL189651A0 (en) 2008-06-05
IL157867A (en) 2011-07-31
BRPI0208535B1 (pt) 2016-03-29
CN1928107B (zh) 2010-12-22
US20030031684A1 (en) 2003-02-13
US20140243513A1 (en) 2014-08-28
CN1608127A (zh) 2005-04-20
EP1461418A4 (en) 2006-05-17
KR20060015704A (ko) 2006-02-20
ES2517391T3 (es) 2014-11-03
CA2440249C (en) 2013-07-09
RU2427378C2 (ru) 2011-08-27
WO2002078637A3 (en) 2004-07-22
SI2465937T1 (sl) 2014-11-28
NZ548595A (en) 2008-04-30
HU228688B1 (en) 2013-05-28
HK1104319A1 (en) 2008-01-11
JP2008255335A (ja) 2008-10-23
EP2465937A1 (en) 2012-06-20
CZ305565B6 (cs) 2015-12-16
ES2415769T3 (es) 2013-07-26

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 1/20

Ipc: C12N 1/20 (2006.01), A61K 31/739 (2006.01), A61P 3

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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