BRPI0406265A - Método para análise eletroforética capilar, métodos para pesquisa e tipagem de proteìnas monoclonais, processo para preparação de anticorpos modificados, anticorpos modificados, kit para detecção e tipagem de proteìnas monoclonais e uso de anticorpos - Google Patents

Método para análise eletroforética capilar, métodos para pesquisa e tipagem de proteìnas monoclonais, processo para preparação de anticorpos modificados, anticorpos modificados, kit para detecção e tipagem de proteìnas monoclonais e uso de anticorpos

Info

Publication number
BRPI0406265A
BRPI0406265A BR0406265-5A BRPI0406265A BRPI0406265A BR PI0406265 A BRPI0406265 A BR PI0406265A BR PI0406265 A BRPI0406265 A BR PI0406265A BR PI0406265 A BRPI0406265 A BR PI0406265A
Authority
BR
Brazil
Prior art keywords
monoclonal protein
typing
modified
preparation process
electrophoretic analysis
Prior art date
Application number
BR0406265-5A
Other languages
English (en)
Inventor
Frederic Robert
Regis Andre
Original Assignee
Sebia Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sebia Sa filed Critical Sebia Sa
Publication of BRPI0406265A publication Critical patent/BRPI0406265A/pt
Publication of BRPI0406265B1 publication Critical patent/BRPI0406265B1/pt
Publication of BRPI0406265B8 publication Critical patent/BRPI0406265B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MéTODO PARA ANáLISE ELETROFORéTICA CAPILAR, MéTODOS PARA PESQUISA E TIPAGEM DE PROTEìNAS MONOCLONAIS, PROCESSO PARA PREPARAçãO DE ANTICORPOS MODIFICADOS, ANTICORPOS MODIFICADOS, KIT PARA DETECçãO E TIPAGEM DE PROTEìNAS MONOCLONAIS E USO DE ANTICORPOS". A presente invenção trata de um método para a análise eletroforética capilar de uma amostra biológica que compreende a utilização de anticorpos modificados carregados negativamente de modo tal que eles migrem para uma zona situada fora da zona de migração das proteínas da amostra biológica quando são separadas durante a eletroforese, sendo que os referidos anticorpos possuem uma especificidade antigênica para uma proteína alvo determinada.
BRPI0406265A 2003-11-12 2004-11-10 método para análise por eletroforese capilar, método para pesquisa e tipagem de proteínas monoclonais, método de preparação de anticorpos modificados sobrecarregados negativamente e kit para detecção e tipagem de proteínas monoclonais BRPI0406265B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0313246A FR2862134B1 (fr) 2003-11-12 2003-11-12 Analyse et typage de proteines monoclonales par electrophorese capillaire et immunodeplacement

Publications (3)

Publication Number Publication Date
BRPI0406265A true BRPI0406265A (pt) 2005-08-23
BRPI0406265B1 BRPI0406265B1 (pt) 2016-11-01
BRPI0406265B8 BRPI0406265B8 (pt) 2021-07-27

Family

ID=34429975

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0406265A BRPI0406265B8 (pt) 2003-11-12 2004-11-10 método para análise por eletroforese capilar, método para pesquisa e tipagem de proteínas monoclonais, método de preparação de anticorpos modificados sobrecarregados negativamente e kit para detecção e tipagem de proteínas monoclonais

Country Status (15)

Country Link
US (1) US8609435B2 (pt)
EP (1) EP1531332B1 (pt)
JP (1) JP4693392B2 (pt)
CN (1) CN1641353B (pt)
AR (1) AR046834A1 (pt)
AT (1) ATE418735T1 (pt)
BR (1) BRPI0406265B8 (pt)
CY (1) CY1110461T1 (pt)
DE (1) DE602004018598D1 (pt)
DK (1) DK1531332T3 (pt)
ES (1) ES2318251T3 (pt)
FR (1) FR2862134B1 (pt)
PL (1) PL1531332T3 (pt)
PT (1) PT1531332E (pt)
SI (1) SI1531332T1 (pt)

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FR2878033B1 (fr) * 2004-11-18 2007-05-04 Sebia Sa Procede d'analyse de l'hemoglobine par electrophorese capillaire, trousse pour electrophorese capillaire et utilisation de ralentisseur de flux dans un tel procede
WO2007027495A1 (en) * 2005-09-02 2007-03-08 Wako Pure Chemical Industries, Ltd Complex formation method and separation method
CA2646944A1 (en) * 2007-11-30 2009-05-30 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Serum components that bind to threat agents
ES2546758T3 (es) * 2008-11-03 2015-09-28 Helena Laboratories (Uk) Ltd. Electroforesis con inmunodesplazamiento
GB201010405D0 (en) * 2010-06-21 2010-08-04 Binding Site Group The Ltd Assay
US20120077184A1 (en) * 2010-09-28 2012-03-29 Starkdx Incorporated Electromagnetic multiplex assay biosensor
CN104508473B (zh) * 2012-05-29 2017-10-13 健康诊断实验室有限公司 用于具有原位校准的凝胶电泳的组合物和方法
HUE051200T2 (hu) * 2016-07-27 2021-03-01 Sebia Sa Immunfixációs elektroforézis módszer a célkomponens géles immunáthelyezésével
GB201709387D0 (en) * 2017-06-13 2017-07-26 Genetic Microdevices Ltd Method
CA3126712A1 (en) * 2019-01-31 2020-08-06 Regeneron Pharmaceuticals, Inc. Native microfluidic ce-ms analysis of antibody charge heterogeneity
BR112021023206A2 (pt) * 2019-05-21 2022-01-04 Regeneron Pharma Métodos para identificar e quantificar proteína de célula hospedeira
IT202000006694A1 (it) * 2020-03-31 2021-10-01 Bioci Di Ciaiolo Carlo Procedimento per la rivelazione di componenti immunoglobuliniche monoclonali in un fluido biologico e relativo kit
CN113552370B (zh) * 2021-09-23 2021-12-28 北京小蝇科技有限责任公司 一种毛细管免疫分型单克隆免疫球蛋白定量分析方法

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JP2564540B2 (ja) * 1987-04-01 1996-12-18 株式会社日立製作所 免疫分析方法
US5010176A (en) * 1988-11-10 1991-04-23 Eli Lilly And Company Antibody-drug conjugates
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5459272A (en) * 1990-10-16 1995-10-17 Research Corporation Technologies Quinoline-2-(carboxaldehyde) reagents for detection of primary amines
NL9100434A (nl) * 1991-03-11 1992-10-01 Rijksuniversiteit Farmaceutische preparaten voor de bestrijding van virale infecties en immuundeficientieziekten, de bereiding en toepassing daarvan.
US5228960A (en) * 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
US5958202A (en) * 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
US5567282A (en) * 1994-01-25 1996-10-22 Wang; Hann-Ping On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins
DE69422604T2 (de) * 1994-03-08 2000-06-08 Zeptosens Ag, Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
US5431793A (en) * 1994-07-29 1995-07-11 Beckman Instruments, Inc. Quantitative analysis of glycosylated hemoglobin by immunocappillary electrophoresis
JP3596821B2 (ja) * 1994-09-09 2004-12-02 キヤノン株式会社 画像形成装置
US5985275A (en) * 1995-04-12 1999-11-16 New York Blood Center β-Lactoglobulin modified with aromatic anhydride compound for preventing HIV infection
US5630924A (en) * 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
US5753094A (en) * 1995-09-20 1998-05-19 Beckman Instruments, Inc. Borate storage buffer and sample diluent
JPH10307376A (ja) * 1997-03-05 1998-11-17 Fuji Photo Film Co Ltd ハロゲン化銀感光材料および画像形成方法
US6156179A (en) * 1998-07-09 2000-12-05 Bio-Rad Laboratories Computer directed identification of paraproteins
BR0013246A (pt) * 1999-08-10 2002-04-16 Procter & Gamble Detergentes lìquidos não-aquosos com partìculas de densidade baixa solúvel em água
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FR2819889B1 (fr) 2001-01-19 2003-08-01 Sebia Sa Procede d'electrophorese capillaire en solution libre a ph alcalin

Also Published As

Publication number Publication date
PT1531332E (pt) 2009-02-03
CY1110461T1 (el) 2015-04-29
AR046834A1 (es) 2005-12-28
BRPI0406265B8 (pt) 2021-07-27
FR2862134B1 (fr) 2007-07-27
DK1531332T3 (da) 2009-04-14
FR2862134A1 (fr) 2005-05-13
ATE418735T1 (de) 2009-01-15
US20050164302A1 (en) 2005-07-28
US8609435B2 (en) 2013-12-17
EP1531332B1 (fr) 2008-12-24
CN1641353A (zh) 2005-07-20
JP2005181299A (ja) 2005-07-07
EP1531332A1 (fr) 2005-05-18
JP4693392B2 (ja) 2011-06-01
CN1641353B (zh) 2012-06-06
DE602004018598D1 (de) 2009-02-05
PL1531332T3 (pl) 2009-06-30
SI1531332T1 (sl) 2009-04-30
ES2318251T3 (es) 2009-05-01
BRPI0406265B1 (pt) 2016-11-01

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

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