BRPI0406855A - Métodos para produzir um beta-éster de alfa-l-aspartil-fenilalanina e para produzir um alfa-éster metìlico de alfa-l-aspartil-l-fenilalanina - Google Patents
Métodos para produzir um beta-éster de alfa-l-aspartil-fenilalanina e para produzir um alfa-éster metìlico de alfa-l-aspartil-l-fenilalaninaInfo
- Publication number
- BRPI0406855A BRPI0406855A BR0406855-6A BRPI0406855A BRPI0406855A BR PI0406855 A BRPI0406855 A BR PI0406855A BR PI0406855 A BRPI0406855 A BR PI0406855A BR PI0406855 A BRPI0406855 A BR PI0406855A
- Authority
- BR
- Brazil
- Prior art keywords
- phenylalanine
- ester
- aspartyl
- alpha
- producing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- REJGTIJQSDMJJZ-YNDOSBHVSA-N (3S)-3-amino-4-[1-[(1R)-1-amino-1-carboxyethyl]cyclohexa-2,4-dien-1-yl]-4-oxobutanoic acid Chemical compound OC(=O)C[C@H](N)C(=O)C1([C@@](N)(C(O)=O)C)CC=CC=C1 REJGTIJQSDMJJZ-YNDOSBHVSA-N 0.000 title 1
- 229960005190 phenylalanine Drugs 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- 230000000269 nucleophilic effect Effects 0.000 abstract 2
- 108010011485 Aspartame Proteins 0.000 abstract 1
- -1 L-aspartic acid-L-phenylalanine ester Chemical class 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODOS PARA PRODUZIR UM BETA-éSTER DE ALFA-L-ASPARTIL-L-FENILALANINA E PARA PRODUZIR UM ALFA-éSTER METìLICO DE ALFA-L-ASPARTIL-L-FENILALANINA". Um método para produzir <225>-éster de <244>-L-aspartil-L-fenilalanina (também chamado <244>-L-(<225>-o-aspartil substituído)-L-fenilalanina), que é um intermediário de um <244>-éster metílico de <244>-L-aspartil-L-fenilalanina (também chamado éster metílico de <244>-L-aspartil-L-fenilalanina; nome do produto: aspartame), facilmente, em elevado rendimento e de modo barato sem precisar passar através de um método de síntese complexo é provido. Além disso, um método de produção fácil, barato e de elevado rendimento para um <244>-éster metílico de <244>-L-aspartil-L-fenilalanina é provido. <244>-éster metílico de <244>-L-aspartil-L-fenilalanina é produzido a partir de um <244>,<225>-diéster de ácido L-aspártico e L-fenilalanina usando uma enzima ou substância contendo enzima que tem uma capacidade para catalisar uma reaçãa em que L-fenilalanina não realiza ataque nucleofílico em um sítio <225>-éster de <244>,<225>-diéster de ácido L-aspártico mas realiza um ataque nucleofílico em um sítio <244>-éster do mesmo.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003016764 | 2003-01-24 | ||
| JP2003-016764 | 2003-01-24 | ||
| JP2003-201819 | 2003-07-25 | ||
| JP2003201819 | 2003-07-25 | ||
| US49154603P | 2003-08-01 | 2003-08-01 | |
| US60/491,546 | 2003-08-01 | ||
| PCT/JP2004/000620 WO2004065610A1 (en) | 2003-01-24 | 2004-01-23 | METHOD FOR PRODUCING α- L-ASPARTYL-L-PHENYLALANINE-β-ESTER AND METHOD FOR PRODUCING α-L-ASPARTYL-L-PHENYLALANINE-α-METHYL ESTER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0406855A true BRPI0406855A (pt) | 2005-12-27 |
| BRPI0406855B1 BRPI0406855B1 (pt) | 2014-02-25 |
Family
ID=32776813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0406855-6A BRPI0406855B1 (pt) | 2003-01-24 | 2004-01-23 | Métodos para produzir um beta-éster de alfa-l-aspartil-l-fenilalanina e para produzir um alfa-éster metílico de alfa-l-aspartil-l-fenilalanina |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US7361458B2 (pt) |
| EP (6) | EP1587941B1 (pt) |
| KR (1) | KR100733741B1 (pt) |
| BR (1) | BRPI0406855B1 (pt) |
| CA (1) | CA2512442C (pt) |
| DE (1) | DE602004022385D1 (pt) |
| PL (1) | PL209701B1 (pt) |
| WO (1) | WO2004065610A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2298906B1 (en) | 2002-07-26 | 2014-01-08 | Ajinomoto Co., Inc. | Novel peptide-forming enzyme gene |
| JP2005040037A (ja) * | 2003-07-25 | 2005-02-17 | Ajinomoto Co Inc | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
| RU2007127719A (ru) * | 2004-12-20 | 2009-01-27 | Адзиномото Ко., Инк. (Jp) | Мутантный белок, имеющий пептидсинтезирующую активность |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
| JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59198994A (ja) | 1983-04-28 | 1984-11-10 | Ajinomoto Co Inc | Ｌ−アスパルチル−ｌ−フエニルアラニンメチルエステルの製造法 |
| JPS59225152A (ja) * | 1983-06-02 | 1984-12-18 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
| US4618695A (en) * | 1983-06-02 | 1986-10-21 | Ajinomoto Co., Inc. | Method of preparing methyl ester and its hydrochloride |
| CA1339674C (en) * | 1986-11-21 | 1998-02-17 | Genencor, Inc. | Enzymatic l-aspartyl-l-phenylalanine alkyl ester production |
| US4892820A (en) * | 1987-06-10 | 1990-01-09 | The Nutrasweet Company | Solvent system for enzymatic coupling process |
| JPH0215196A (ja) | 1988-07-01 | 1990-01-18 | Taisei Corp | 開口を有する被メッキ物の、メッキ用ジグに対する自動着脱機構 |
| JPH0441155A (ja) | 1990-06-07 | 1992-02-12 | Mitsubishi Electric Corp | ワイヤ放電加工機 |
| JPH04311389A (ja) * | 1991-04-05 | 1992-11-04 | Mercian Corp | 新規なチオールプロテアーゼ |
| EP1096011A1 (en) * | 1999-05-10 | 2001-05-02 | Holland Sweetener Company V.o.F. | Microbiological production method for alpha-l-aspartyl-l-phenylalanine |
| EP2298906B1 (en) * | 2002-07-26 | 2014-01-08 | Ajinomoto Co., Inc. | Novel peptide-forming enzyme gene |
| JP2005040037A (ja) * | 2003-07-25 | 2005-02-17 | Ajinomoto Co Inc | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| JP4311389B2 (ja) | 2004-12-13 | 2009-08-12 | セイコーエプソン株式会社 | 印刷装置、印刷装置制御プログラム及び印刷装置制御方法、並びに印刷用データ生成装置、印刷用データ生成プログラム及び印刷用データ生成方法 |
| US20070190602A1 (en) * | 2005-12-27 | 2007-08-16 | Ajinomoto Co., Inc | Mutant protein having the peptide-synthesizing activity |
-
2004
- 2004-01-23 PL PL377835A patent/PL209701B1/pl unknown
- 2004-01-23 EP EP04704772A patent/EP1587941B1/en not_active Expired - Lifetime
- 2004-01-23 EP EP09011831A patent/EP2180060B1/en not_active Expired - Lifetime
- 2004-01-23 KR KR1020057013516A patent/KR100733741B1/ko not_active Expired - Lifetime
- 2004-01-23 WO PCT/JP2004/000620 patent/WO2004065610A1/en not_active Ceased
- 2004-01-23 DE DE602004022385T patent/DE602004022385D1/de not_active Expired - Lifetime
- 2004-01-23 EP EP09011829A patent/EP2180059B1/en not_active Expired - Lifetime
- 2004-01-23 EP EP09011832A patent/EP2180061B1/en not_active Expired - Lifetime
- 2004-01-23 BR BRPI0406855-6A patent/BRPI0406855B1/pt not_active IP Right Cessation
- 2004-01-23 EP EP09011830A patent/EP2166109B1/en not_active Expired - Lifetime
- 2004-01-23 EP EP09006965A patent/EP2157188B1/en not_active Expired - Lifetime
- 2004-01-23 CA CA2512442A patent/CA2512442C/en not_active Expired - Fee Related
- 2004-06-28 US US10/876,673 patent/US7361458B2/en not_active Expired - Lifetime
-
2008
- 2008-01-07 US US11/970,203 patent/US7745172B2/en not_active Expired - Lifetime
-
2010
- 2010-03-30 US US12/749,966 patent/US8034584B2/en not_active Expired - Lifetime
-
2011
- 2011-08-04 US US13/198,075 patent/US8247193B2/en not_active Expired - Fee Related
-
2012
- 2012-06-20 US US13/528,126 patent/US8389240B2/en not_active Expired - Fee Related
- 2012-06-20 US US13/528,162 patent/US8361748B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/02/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |