BRPI0408996A - saia de inibidores tricìclicos de poli(adpp-ribose) polimerases - Google Patents

saia de inibidores tricìclicos de poli(adpp-ribose) polimerases

Info

Publication number
BRPI0408996A
BRPI0408996A BRPI0408996-0A BRPI0408996A BRPI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A BR PI0408996 A BRPI0408996 A BR PI0408996A
Authority
BR
Brazil
Prior art keywords
poly
tricyclic
adpp
ribose
skirt
Prior art date
Application number
BRPI0408996-0A
Other languages
English (en)
Inventor
Stacie Sara Canan-Koch
Jan-Jon Chu
Jia Liu
Jean Joo Matthews
Original Assignee
Pfizer
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Cancer Rec Tech Ltd filed Critical Pfizer
Publication of BRPI0408996A publication Critical patent/BRPI0408996A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"SAIS DE INIBIDORES TRICìCLICOS DE POLI(ADPRIBOSE) POLIMERASES". A presente invenção refere-se aos sais farmaceuticamente aceitáveis de compostos de fórmula (I) que são inibidores da poli(ADP-ribosil)transferase (PARP), e que são úteis como terapêutica no tratamento de cânceres e melhoria dos efeitos de acidente vascular cerebral, traumatismo craniano e doença neurodegenerativa. Como terapêutica do câncer, os compostos da invenção podem ser utilizados, por exemplo, em combinação com agentes citotóxicos e/ou radiação.
BRPI0408996-0A 2003-03-31 2004-03-19 saia de inibidores tricìclicos de poli(adpp-ribose) polimerases BRPI0408996A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45943303P 2003-03-31 2003-03-31
PCT/IB2004/000915 WO2004087713A1 (en) 2003-03-31 2004-03-19 Salts of tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (1)

Publication Number Publication Date
BRPI0408996A true BRPI0408996A (pt) 2006-03-28

Family

ID=33131884

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408996-0A BRPI0408996A (pt) 2003-03-31 2004-03-19 saia de inibidores tricìclicos de poli(adpp-ribose) polimerases

Country Status (12)

Country Link
US (1) US20040248879A1 (pt)
EP (1) EP1611137A1 (pt)
JP (1) JP2006522088A (pt)
AR (1) AR043950A1 (pt)
BR (1) BRPI0408996A (pt)
CA (1) CA2520997A1 (pt)
MX (1) MXPA05010563A (pt)
NL (1) NL1025842C2 (pt)
PA (1) PA8598801A1 (pt)
TW (1) TW200424206A (pt)
UY (1) UY28245A1 (pt)
WO (1) WO2004087713A1 (pt)

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RU2344138C2 (ru) 2004-09-22 2009-01-20 Пфайзер Инк. Способ получения ингибиторов поли(адф-рибоза)полимераз
MX2007003314A (es) * 2004-09-22 2007-08-06 Pfizer Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas.
ATE551345T1 (de) * 2004-09-22 2012-04-15 Pfizer Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on
CN101242822B (zh) 2005-07-18 2011-08-24 彼帕科学公司 治疗卵巢癌的药物
PL2338487T3 (pl) * 2006-01-17 2014-03-31 Abbvie Bahamas Ltd Terapia skojarzona z inhibitorami PARP
WO2008030883A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
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SI2534153T2 (sl) 2010-02-12 2024-07-31 Pfizer Inc. Soli in polimorfi 8-fluoro-2-(4-((metilamino)metil)fenil)-1,3,4,5-tetrahidro-6H-azepino (5,4,3-cd)indol-6-ona
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CA2909091C (en) 2013-04-09 2021-11-02 The Board Of Trustees Of The University Of Illinois Tumor-selective combination therapy
RS67356B1 (sr) 2014-08-22 2025-11-28 Pharma& Schweiz Gmbh Tablete rukapariba visoke doze
CN104592232A (zh) * 2015-03-02 2015-05-06 中国药科大学 8,9-二氢-2,4,7,9a-四氮杂苯并薁-6(7H)-酮类衍生物
ES2742197T7 (es) 2015-07-23 2021-10-06 Inst Curie Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
US10874641B2 (en) 2016-07-28 2020-12-29 Mitobridge, Inc. Methods of treating acute kidney injury
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WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
EP3573990B1 (en) * 2017-01-24 2024-07-10 Assia Chemical Industries Ltd. Solid state forms of rucaparib and of rucaparib salts
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
EP3615026B1 (en) 2017-04-28 2021-03-03 Akribes Biomedical GmbH A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing
WO2019086509A1 (en) 2017-11-03 2019-05-09 Sandoz Ag Crystalline salt of a tricyclic poly(adp-ribose) polymerase inhibitor
KR20200121800A (ko) 2018-01-05 2020-10-26 싸이브렉사 1, 인크. 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법
EP3765613A1 (en) 2018-03-13 2021-01-20 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
PE20220563A1 (es) 2019-07-10 2022-04-13 Cybrexa 2 Inc Conjugados peptidicos de citotoxinas como terapeuticos
MX2022000450A (es) 2019-07-10 2022-04-25 Cybrexa 3 Inc Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos.
CN114072410B (zh) * 2019-08-01 2023-08-01 正大天晴药业集团股份有限公司 作为parp抑制剂吲哚并七元酰肟化合物
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IL297537B1 (en) 2020-04-28 2025-12-01 Rhizen Pharmaceuticals Ag Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
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WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
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WO2024261243A1 (en) 2023-06-21 2024-12-26 Hemispherian As Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer

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Also Published As

Publication number Publication date
PA8598801A1 (es) 2004-11-26
NL1025842A1 (nl) 2004-10-01
US20040248879A1 (en) 2004-12-09
TW200424206A (en) 2004-11-16
WO2004087713A1 (en) 2004-10-14
CA2520997A1 (en) 2004-10-14
JP2006522088A (ja) 2006-09-28
MXPA05010563A (es) 2005-11-23
WO2004087713A8 (en) 2005-01-20
EP1611137A1 (en) 2006-01-04
UY28245A1 (es) 2004-11-08
AR043950A1 (es) 2005-08-17
NL1025842C2 (nl) 2005-11-15

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.