BRPI0409686A - derivados de aza espiro alcano como inibidores de metaloproteases - Google Patents

derivados de aza espiro alcano como inibidores de metaloproteases

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Publication number
BRPI0409686A
BRPI0409686A BRPI0409686-0A BRPI0409686A BRPI0409686A BR PI0409686 A BRPI0409686 A BR PI0409686A BR PI0409686 A BRPI0409686 A BR PI0409686A BR PI0409686 A BRPI0409686 A BR PI0409686A
Authority
BR
Brazil
Prior art keywords
formula
metalloprotease inhibitors
alkane derivatives
aza spiro
metalloprotease
Prior art date
Application number
BRPI0409686-0A
Other languages
English (en)
Inventor
Wenqing Yao
Jincong Zhuo
Meizhong Xu
Fenglei Zhang
Brian Metcalf
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BRPI0409686A publication Critical patent/BRPI0409686A/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D471/10—Spiro-condensed systems
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Abstract

"DERIVADOS DE AZA ESPIRO ALCANO COMO INIBIDORES DE METALOPROTEASES". A presente invenção refere-se a um composto de Fórmula I ou Fórmula II: enantiómero, diastereómero, pró-droga, solvato, metabólito, ou sal farmaceuticamente aceitável deste, onde variáveis de constituintes são fornecidas aqui. Os compostos de Fórmula I e II são moduladores de metalloproteases e são úteis em tratamento de doenças associadas com atividade de metaloprotease tais como artrite, câncer, distúrbios cardiovasculares, distúrbios de pele, condições de inflamação e alérgicas.
BRPI0409686-0A 2003-04-24 2004-04-23 derivados de aza espiro alcano como inibidores de metaloproteases BRPI0409686A (pt)

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US7723349B2 (en) 2010-05-25
RU2005136429A (ru) 2006-06-10
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EP1622569A2 (en) 2006-02-08
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US20140187530A1 (en) 2014-07-03
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