PL1622569T3 - Pochodne aza spiro alkanów jako inhibitory metaloproteaz - Google Patents

Pochodne aza spiro alkanów jako inhibitory metaloproteaz

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Publication number
PL1622569T3
PL1622569T3 PL04760368T PL04760368T PL1622569T3 PL 1622569 T3 PL1622569 T3 PL 1622569T3 PL 04760368 T PL04760368 T PL 04760368T PL 04760368 T PL04760368 T PL 04760368T PL 1622569 T3 PL1622569 T3 PL 1622569T3
Authority
PL
Poland
Prior art keywords
metallproteases
inhibitors
alkane derivatives
aza spiro
spiro alkane
Prior art date
Application number
PL04760368T
Other languages
English (en)
Inventor
Wenqing Yao
Jincong Zhou
Meizhong Xu
Fenglei Zhang
Brian Metcalf
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of PL1622569T3 publication Critical patent/PL1622569T3/pl

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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