PL380275A1 - Pochodne azaspiroalkanów jako inhibitory metaloproteaz - Google Patents

Pochodne azaspiroalkanów jako inhibitory metaloproteaz

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Publication number
PL380275A1
PL380275A1 PL380275A PL38027504A PL380275A1 PL 380275 A1 PL380275 A1 PL 380275A1 PL 380275 A PL380275 A PL 380275A PL 38027504 A PL38027504 A PL 38027504A PL 380275 A1 PL380275 A1 PL 380275A1
Authority
PL
Poland
Prior art keywords
metalloproteases
inhibitors
alkane derivatives
aza spiro
spiro alkane
Prior art date
Application number
PL380275A
Other languages
English (en)
Other versions
PL217630B1 (pl
Inventor
Wenqing Yao
Jincong Zhuo
Meizhong Xu
Fenglei Zhang
Brian Metcalf
Original Assignee
Incyte Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of PL380275A1 publication Critical patent/PL380275A1/pl
Publication of PL217630B1 publication Critical patent/PL217630B1/pl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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