BRPI0409955A - uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções - Google Patents

uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções

Info

Publication number
BRPI0409955A
BRPI0409955A BRPI0409955-9A BRPI0409955A BRPI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A
Authority
BR
Brazil
Prior art keywords
oxazolidinone
infections
hybrid
anthrax
treat anthrax
Prior art date
Application number
BRPI0409955-9A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Daniel K Baeschlin
Hans Locher
Christine Schmitt
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Publication of BRPI0409955A publication Critical patent/BRPI0409955A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"USO DE ANTIBIóTICOS HìBRIDOS DE OXAZOLIDINONA - QUINOLINA PARA O TRATAMENTO DE ANTRAX E OUTRAS INFECçõES". A presente invenção refere-se ao uso de compostos, nos quais os farmacóforos de quinolona e oxazolidinona são ligados quimicamente através de um ligador que é estável sob condições fisiológicas, para o tratamento de antrax e outras infecções.
BRPI0409955-9A 2003-04-30 2004-04-06 uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções BRPI0409955A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46694503P 2003-04-30 2003-04-30
US53082203P 2003-12-18 2003-12-18
PCT/EP2004/003650 WO2004096221A1 (en) 2003-04-30 2004-04-06 Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections

Publications (1)

Publication Number Publication Date
BRPI0409955A true BRPI0409955A (pt) 2006-04-25

Family

ID=33423632

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409955-9A BRPI0409955A (pt) 2003-04-30 2004-04-06 uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções

Country Status (15)

Country Link
US (3) US20070155714A1 (pt)
EP (1) EP1620098B1 (pt)
JP (2) JP4805139B2 (pt)
KR (1) KR101101982B1 (pt)
AT (1) ATE397930T1 (pt)
AU (2) AU2004233557B2 (pt)
BR (1) BRPI0409955A (pt)
CA (1) CA2529347C (pt)
DE (1) DE602004014361D1 (pt)
ES (1) ES2308171T3 (pt)
IL (1) IL171546A (pt)
MX (1) MXPA05011654A (pt)
NZ (1) NZ543757A (pt)
RU (1) RU2351335C2 (pt)
WO (1) WO2004096221A1 (pt)

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EP1620098B1 (en) 2003-04-30 2008-06-11 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
NZ547382A (en) * 2003-12-18 2009-11-27 Morphochem Ag Komb Chemie Oxazolidinone-quinolone hybrid antibiotics
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
EP2383271B1 (en) 2006-03-13 2013-07-10 Kyorin Pharmaceutical Co., Ltd. Aminoquinolones as GSK-3 Inhibitors
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US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
CN101855228B (zh) 2007-09-11 2012-10-24 杏林制药株式会社 作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
BRPI0816814B1 (pt) 2007-09-12 2021-08-31 Kyorin Pharmaceutical Co. Ltd Composto, composição farmacêutica e uso de um composto
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
RU2504547C2 (ru) * 2008-03-26 2014-01-20 Глоубал Элаенс Фор Тб Драг Дивелопмент Бициклические нитроимидазолы, ковалентно соединенные с замещенными фенилоксазолидинонами
HRP20120791T1 (hr) * 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd. Derivati 5-hidroksimetil-oksazolidin-2-ona za lijeäśenje bakterijskih bolesti crijeva
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
JP5478499B2 (ja) * 2008-10-27 2014-04-23 田辺三菱製薬株式会社 新規アミド誘導体およびその医薬としての用途
MX2011009414A (es) 2009-03-11 2011-10-19 Kyorin Seiyaku Kk 7-cicloalquiloaminoquinolonas como inhibidores de gsk-3.
JP5796412B2 (ja) 2011-08-26 2015-10-21 三菱電機株式会社 半導体素子の製造方法
PH12014500831A1 (en) * 2011-11-08 2019-08-07 Actelion Pharmaceuticalds Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
RU2015138891A (ru) 2013-03-08 2017-04-11 Аллерган, Инк. Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами
WO2014138403A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Antibiotic conjugates
RU2675847C2 (ru) * 2013-05-28 2018-12-25 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Комбинированные терапевтические средства, содержащие оксазолидинон-хинолоны, предназначенные для лечения бактериальных инфекций
HUE043786T2 (hu) * 2013-05-28 2019-09-30 Morphochem Gmbh Oxazolidinon-kinolon hibrid antibakteriális hatóanyagok adagolása
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
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US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
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EP1620098B1 (en) * 2003-04-30 2008-06-11 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
NZ547382A (en) 2003-12-18 2009-11-27 Morphochem Ag Komb Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
ES2380388T3 (es) 2006-11-10 2012-05-11 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
HRP20120791T1 (hr) 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd. Derivati 5-hidroksimetil-oksazolidin-2-ona za lijeäśenje bakterijskih bolesti crijeva

Also Published As

Publication number Publication date
EP1620098B1 (en) 2008-06-11
CA2529347C (en) 2011-09-06
MXPA05011654A (es) 2005-12-15
KR101101982B1 (ko) 2012-01-02
KR20060025525A (ko) 2006-03-21
DE602004014361D1 (de) 2008-07-24
JP2011184441A (ja) 2011-09-22
ATE397930T1 (de) 2008-07-15
US8268812B2 (en) 2012-09-18
US8513231B2 (en) 2013-08-20
US20070155714A1 (en) 2007-07-05
NZ543757A (en) 2009-02-28
AU2004233557B2 (en) 2010-02-18
US20120322766A1 (en) 2012-12-20
EP1620098A1 (en) 2006-02-01
IL171546A (en) 2014-06-30
JP4805139B2 (ja) 2011-11-02
CA2529347A1 (en) 2004-11-11
ES2308171T3 (es) 2008-12-01
JP5536706B2 (ja) 2014-07-02
RU2351335C2 (ru) 2009-04-10
HK1078806A1 (en) 2006-03-24
RU2005137032A (ru) 2007-06-10
WO2004096221A1 (en) 2004-11-11
AU2010201659A1 (en) 2010-05-20
AU2004233557A1 (en) 2004-11-11
JP2006526577A (ja) 2006-11-24
US20120135961A1 (en) 2012-05-31

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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